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534-64-5,MFCD00058193
Catalog No.:AA003U08

534-64-5 | Pyrithiamine

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1mg
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5mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003U08
Chemical Name:
Pyrithiamine
CAS Number:
534-64-5
Molecular Formula:
C14H20Br2N4O
Molecular Weight:
420.1428
MDL Number:
MFCD00058193
SMILES:
OCCc1ccc[n+](c1C)Cc1cnc(nc1N)C.Br.[Br-]
Properties
Properties
 
Form:
Solid  
MP:
205-207°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
276  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  

Literature

Title: Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat.

Journal: Neurotoxicology 20161201

Title: Sustaining high acetylcholine levels in the frontal cortex, but not retrosplenial cortex, recovers spatial memory performance in a rodent model of diencephalic amnesia.

Journal: Behavioral neuroscience 20120401

Title: Plasma leptin levels in rats with induced Toxoplasma gondii infection.

Journal: Bratislavske lekarske listy 20120101

Title: Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal host.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome.

Journal: Brain research 20110519

Title: Exposure to pyrithiamine increases β-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain.

Journal: Neurotoxicity research 20110501

Title: Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides.

Journal: Neurobiology of aging 20110101

Title: Memory for reward location is enhanced even though acetylcholine efflux within the amygdala is impaired in rats with damage to the diencephalon produced by thiamine deficiency.

Journal: Neurobiology of learning and memory 20101101

Title: Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain.

Journal: Journal of neurochemistry 20101001

Title: Cortical cholinergic abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat.

Journal: The European journal of neuroscience 20100901

Title: Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats.

Journal: Behavioural brain research 20100626

Title: Development and refinement of a high-efficiency gene-targeting system for Aspergillus flavus.

Journal: Journal of microbiological methods 20100601

Title: eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain.

Journal: Journal of neurochemistry 20091001

Title: The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia.

Journal: Neuroscience 20090421

Title: Isolation of industrial strains of Aspergillus oryzae lacking ferrichrysin by disruption of the dffA gene.

Journal: Journal of bioscience and bioengineering 20081101

Title: Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia.

Journal: Brain research 20081009

Title: Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy.

Journal: Journal of neurochemistry 20080701

Title: Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.

Journal: FEMS yeast research 20080301

Title: Comparative characteristic of thiamine antagonists on apoptosis induction in different types of nerve cell lines.

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

Title: Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20071001

Title: Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070501

Title: Selective septohippocampal - but not forebrain amygdalar - cholinergic dysfunction in diencephalic amnesia.

Journal: Brain research 20070330

Title: Blunted hippocampal, but not striatal, acetylcholine efflux parallels learning impairment in diencephalic-lesioned rats.

Journal: Neurobiology of learning and memory 20070101

Title: Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells.

Journal: Acta biochimica Polonica 20070101

Title: Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.

Journal: Science (New York, N.Y.) 20060526

Title: Pyrithiamine as a substrate for thiamine pyrophosphokinase.

Journal: The Journal of biological chemistry 20060310

Title: Susceptibility of the cerebellum to thiamine deficiency.

Journal: Cerebellum (London, England) 20060101

Title: Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine.

Journal: Chemistry & biology 20051201

Title: Downregulation of complexin I and complexin II in the medial thalamus is blocked by N-acetylcysteine in experimental Wernicke's encephalopathy.

Journal: Journal of neuroscience research 20050101

Title: Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy.

Journal: Journal of neuroscience research 20050101

Title: Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro.

Journal: Neuroscience 20050101

Title: Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels.

Journal: Neuroscience letters 20040819

Title: Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult.

Journal: Behavioural brain research 20040105

Title: Thiamine-regulated gene expression of Aspergillus oryzae thiA requires splicing of the intron containing a riboswitch-like domain in the 5'-UTR.

Journal: FEBS letters 20031218

Title: Transformation of Aspergillus aculeatus using the drug resistance gene of Aspergillus oryzae and the pyrG gene of Aspergillus nidulans.

Journal: Bioscience, biotechnology, and biochemistry 20031201

Title: Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats.

Journal: Metabolic brain disease 20031201

Title: Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes.

Journal: Glia 20030801

Title: Neuropathological study of the role of mast cells and histamine-positive neurons in selective vulnerability of the thalamus and inferior colliculus in thiamine-deficient encephalopathy.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20030301

Title: Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20030101

Title: Physiological, biochemical and morphological studies of Baltic salmon yolk-sac fry with an experimental thiamine deficiency: relations to the M74 syndrome.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20021113

Title: Depletion of brain histamine produces regionally selective protection against thiamine deficiency-induced lesions in the rat.

Journal: Metabolic brain disease 20020901

Title: Transformation of Aspergillus sp. and Trichoderma reesei using the pyrithiamine resistance gene (ptrA) of Aspergillus oryzae.

Journal: Bioscience, biotechnology, and biochemistry 20020201

Title: Mechanism of thiamine uptake by human jejunal brush-border membrane vesicles.

Journal: American journal of physiology. Cell physiology 20010901

Title: Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy.

Journal: Journal of neurochemistry 20010801

Title: The use of thiamine and thiamine antagonists to investigate the etiology of early mortality syndrome in lake trout (Salvelinus namaycush).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20010501

Title: Aging potentiates the acute and chronic neurological symptoms of pyrithiamine-induced thiamine deficiency in the rodent.

Journal: Behavioural brain research 20010315

Title: Glucose induced IEG expression in the thiamin-deficient rat brain.

Journal: Brain research 20010216

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