Home Other Building Blocks 537034-15-4
537034-15-4,MFCD16293760
Catalog No.:AA00DB87

537034-15-4 | Nkl 22

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$77.00   $54.00
- +
25mg
98%
in stock  
$132.00   $93.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB87
Chemical Name:
Nkl 22
CAS Number:
537034-15-4
Molecular Formula:
C19H23N3O2
Molecular Weight:
325.4048
MDL Number:
MFCD16293760
SMILES:
O=C(Nc1ccccc1)CCCCCC(=O)Nc1ccccc1N
Properties
Computed Properties
 
Complexity:
394  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
2.4  

Literature

Title: Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.

Journal: Bioorganic & medicinal chemistry letters 20080415

Title: Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

Journal: Nature chemical biology 20061001

Title: Jia H, et, al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012 May;46(2):351-61.

Title: D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.

Title: Thomas EA, et, al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.

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SDS
Tags:537034-15-4 Molecular Formula|537034-15-4 MDL|537034-15-4 SMILES|537034-15-4 Nkl 22