Home Iodos 54-77-3
54-77-3,MFCD00011976
Catalog No.:AA00DEKK

54-77-3 | 1,1-Dimethyl-4-phenylpiperazinium iodide

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250mg
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1g
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5g
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00DEKK
Chemical Name:
1,1-Dimethyl-4-phenylpiperazinium iodide
CAS Number:
54-77-3
Molecular Formula:
C12H19IN2
Molecular Weight:
318.1971
MDL Number:
MFCD00011976
SMILES:
C[N+]1(C)CCN(CC1)c1ccccc1.[I-]
NSC Number:
89754
Properties
Properties
 
Storage:
Room Temperature;Light sensitive;  

Computed Properties
 
Complexity:
173  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  

Literature

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Journal: Neuroscience 20121206

Title: Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120801

Title: Early emergence of neural activity in the developing mouse enteric nervous system.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111026

Title: α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension.

Journal: Basic & clinical pharmacology & toxicology 20111001

Title: Mutants of β-strand β3 and the loop B in the interface between α7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations.

Journal: Journal of neurochemistry 20110901

Title: Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig.

Journal: Peptides 20110901

Title: Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus.

Journal: Neuroscience research 20110301

Title: Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans.

Journal: Genetics 20110101

Title: Colon-specific contractile responses to tetrodotoxin in the isolated mouse gastrointestinal tract.

Journal: Autonomic & autacoid pharmacology 20110101

Title: Activation of neuronal SST₁ and SST₂ receptors decreases neurogenic secretion in the guinea-pig jejunum.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101101

Title: Characterization of Ca2+ signaling pathways in mouse adrenal medullary chromaffin cells.

Journal: Journal of neurochemistry 20100301

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens.

Journal: European journal of pharmacology 20090815

Title: Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor.

Journal: Anesthesiology 20090601

Title: Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus.

Journal: Regulatory peptides 20090410

Title: Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor A single channel pharmacological study.

Journal: Biochimica et biophysica acta 20090201

Title: Nongenomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells.

Journal: Endocrinology 20081001

Title: Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor.

Journal: Journal of neuroscience research 20081001

Title: Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors.

Journal: Acta pharmacologica Sinica 20080301

Title: Effects of nonylphenol on the calcium signal and catecholamine secretion coupled with nicotinic acetylcholine receptors in bovine adrenal chromaffin cells.

Journal: Toxicology 20080203

Title: Beta-adrenoceptor-mediated vasodilation of retinal blood vessels is reduced in streptozotocin-induced diabetic rats.

Journal: Vascular pharmacology 20080101

Title: Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla.

Journal: Journal of cardiology 20071201

Title: Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Non-charged amino acids from three different domains contribute to link agonist binding to channel gating in alpha7 nicotinic acetylcholine receptors.

Journal: Journal of neurochemistry 20071001

Title: Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla.

Journal: Archives of pharmacal research 20071001

Title: Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation.

Journal: British journal of pharmacology 20070601

Title: Modulation of eosinophil activation in vitro by a nicotinic receptor agonist.

Journal: Journal of leukocyte biology 20070501

Title: Nerve growth factor acutely potentiates synaptic transmission in vitro and induces dendritic growth in vivo on adult neurons in airway parasympathetic ganglia.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070401

Title: The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function.

Journal: Development (Cambridge, England) 20070301

Title: Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine.

Journal: Neuroscience letters 20070208

Title: Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070101

Title: Real-time detection of dopamine released from a nerve model cell by an enzyme-catalyzed luminescence method and its application to drug assessment.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070101

Title: Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro.

Journal: Neuropharmacology 20061201

Title: Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.

Journal: British journal of pharmacology 20061201

Title: Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20061001

Title: Inhibition by SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, of Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells.

Journal: Journal of pharmacological sciences 20060901

Title: Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans.

Journal: Development (Cambridge, England) 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine.

Journal: European journal of pharmacology 20060327

Title: Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.

Journal: Molecular pharmacology 20060301

Title: Arecoline inhibits catecholamine release from perfused rat adrenal gland.

Journal: Acta pharmacologica Sinica 20060101

Title: Measurement of Ca2+ entry using 45Ca2+.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells.

Journal: Journal of molecular neuroscience : MN 20060101

Title: Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.

Journal: Journal of neurophysiology 20051201

Title: Carrier-mediated release of monoamines induced by the nicotinic acetylcholine receptor agonist DMPP.

Journal: Neuropharmacology 20050901

Title: Comparison of green tea extract and epigallocatechin gallate on secretion of catecholamines from the rabbit adrenal medulla.

Journal: Archives of pharmacal research 20050801

Title: Modulation of airway inflammation and resistance in mice by a nicotinic receptor agonist.

Journal: The European respiratory journal 20050701

Title: Opposing muscarinic and nicotinic modulation of hypoglossal motor output to genioglossus muscle in rats in vivo.

Journal: The Journal of physiology 20050615

Title: Effect of 1,1-dimethylphenyl 1,4-piperazinium on mouse tracheal smooth muscle responsiveness.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050601

Title: Influence of naloxone on catecholamine release evoked by nicotinic receptor stimulation in the isolated rat adrenal gland.

Journal: Archives of pharmacal research 20050601

Title: Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells.

Journal: European journal of pharmacology 20050516

Title: Progesterone regulation of catecholamine secretion from chromaffin cells.

Journal: Brain research 20050510

Title: Rigid analogs of DMPP as probes for the nicotinic receptors.

Journal: Farmaco (Societa chimica italiana : 1989) 20050201

Title: Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats.

Journal: Neuroscience 20050101

Title: Prevention of diminished parasympathetic control of the heart in experimental heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20041001

Title: Generation of functionally competent single bovine adrenal chromaffin cells from cell aggregates using the neutral protease dispase.

Journal: Journal of neuroscience methods 20040830

Title: Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.

Journal: Brain research 20040827

Title: Differential effects of FK506 and cyclosporin A on catecholamine release from bovine adrenal chromaffin cells.

Journal: Autonomic & autacoid pharmacology 20040701

Title: Inhibitory effects of galanin on evoked [Ca2+]i responses in cultured myenteric neurons.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040601

Title: Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: TNF-alpha hyperpolarizes membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurones.

Journal: Acta physiologica Scandinavica 20040501

Title: Mechanism of action of botulinum toxin on the internal anal sphincter.

Journal: The British journal of surgery 20040201

Title: Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland.

Journal: Autonomic neuroscience : basic & clinical 20040130

Title: Nicotinic stimulation modulates tyrosine hydroxylase mRNA half-life and protein binding to the 3'UTR in a manner that requires transcription.

Journal: Brain research. Molecular brain research 20040105

Title: Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein.

Journal: Pharmacology 20040101

Title: Nicotinic activation of mesolimbic neurons assessed by rubidium efflux in rat accumbens and ventral tegmentum.

Journal: Neuro-Signals 20040101

Title: Presynaptic alpha-7 nicotinic acetylcholine receptors modulate excitatory synaptic transmission in hippocampal neurons.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20031225

Title: Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20031201

Title: Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.

Journal: Molecular pharmacology 20031201

Title: Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.

Journal: Brain research 20031114

Title: A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon.

Journal: The Journal of physiology 20030915

Title: GABAergic systems modulate nicotinic receptor-mediated seizures in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20030901

Title: Cotinine inhibits catecholamine release evoked by cholinergic stimulation from the rat adrenal medulla.

Journal: Archives of pharmacal research 20030901

Title: Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells.

Journal: Neuroscience letters 20030612

Title: Catecholamine release from cultured bovine adrenal medullary chromaffin cells in the presence of 60-Hz magnetic fields.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20030401

Title: Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells.

Journal: Journal of pharmacological sciences 20030301

Title: Muscularis mucosae contraction evokes colonic secretion via prostaglandin synthesis and nerve stimulation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030201

Title: Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases.

Journal: Chemico-biological interactions 20030106

Title: Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030101

Title: Adenosine-acetylcholine interactions at the rat carotid body.

Journal: Advances in experimental medicine and biology 20030101

Title: Intracellular calcium activity in isolated bovine adrenal chromaffin cells in the presence and absence of 60 Hz magnetic fields.

Journal: Bioelectromagnetics 20021201

Title: Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord.

Journal: The Journal of physiology 20021101

Title: Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord.

Journal: Neuropharmacology 20021101

Title: Inhibition of autonomic nerve-mediated inotropic responses in guinea pig atrium by bafilomycin A.

Journal: Synapse (New York, N.Y.) 20020901

Title: Inhibitory mechanism of bromocriptine on catecholamine release evoked by cholinergic stimulation and membrane depolarization from the rat adrenal medulla.

Journal: Archives of pharmacal research 20020801

Title: Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit.

Journal: The Journal of physiology 20020715

Title: Novel tacrine derivatives that block neuronal calcium channels.

Journal: Bioorganic & medicinal chemistry 20020601

Title: Electrophysiological effects of tachykinin agonists on sympathetic ganglia of spontaneously hypertensive rats.

Journal: Autonomic neuroscience : basic & clinical 20020418

Title: A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons.

Journal: Journal of neurophysiology 20020301

Title: Nicotinic excitation of rat hypoglossal motoneurons.

Journal: Neuroscience 20020101

Title: Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201

Title: Functional nicotinic acetylcholine receptor expression in stem and progenitor cells of the early embryonic mouse cerebral cortex.

Journal: Developmental biology 20011201

Title: Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).

Journal: Journal of medicinal chemistry 20011108

Title: Determinants of agonist binding affinity on neuronal nicotinic receptor beta subunits.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Interrelationship between colonic muscularis mucosae activity and changes in transmucosal potential difference.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010801

Title: Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.

Journal: British journal of pharmacology 20010801

Title: Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum.

Journal: British journal of pharmacology 20010701

Title: Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction.

Journal: The Journal of physiology 20010501

Title: Noncompetitive inhibition by camphor of nicotinic acetylcholine receptors.

Journal: Biochemical pharmacology 20010401

Title: Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta.

Journal: British journal of pharmacology 20010401

Title: Nitric oxide modulates evoked catecholamine release from canine adrenal medulla.

Journal: Neuroscience 20010101

Title: Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype.

Journal: Molecular pharmacology 20000801

Title: Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.

Journal: Brain research 19990417

Title: Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.

Journal: European journal of pharmacology 19990205

Title: Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.

Journal: The Journal of pharmacology and experimental therapeutics 19980201

Title: Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970501

Title: Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes.

Journal: European journal of pharmacology 19960815

Title: Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type.

Journal: Neuropharmacology 19830301

Title: Effects of nicergoline on the cardiovascular system of dogs and rats.

Journal: Journal of cardiovascular pharmacology 19810101

Title: Absence of sensitization to epinephrine-induced cardiac arrhythmia and fibrillation in dogs and cats anesthetized with CI 744.

Journal: American journal of veterinary research 19750501

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Tags:54-77-3 Molecular Formula|54-77-3 MDL|54-77-3 SMILES|54-77-3 1,1-Dimethyl-4-phenylpiperazinium iodide