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54-84-2,MFCD00055609
Catalog No.:AA00DCAU

54-84-2 | 2-Propenamide, N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-,monohydrochloride

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DCAU
Chemical Name:
2-Propenamide, N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-,monohydrochloride
CAS Number:
54-84-2
Molecular Formula:
C20H25ClN2OS
Molecular Weight:
376.9433
MDL Number:
MFCD00055609
SMILES:
CN(CCCSc1ccccc1NC(=O)/C=C/c1ccccc1)C.Cl
NSC Number:
125717
Properties
Computed Properties
 
Complexity:
391  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Literature

Title: Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20121101

Title: The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120901

Title: Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteer: a SPECT with [(123)I] ADAM study.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120901

Title: Low brain serotonin transporter binding in major depressive disorder.

Journal: Psychiatry research 20120531

Title: Association between somatization subscale score and serotonin transporter availability in healthy volunteers--a single photon emission computed tomography study with [¹²³I] ADAM.

Journal: Psychopharmacology 20120201

Title: No seasonal variation in human midbrain serotonin transporter availability in Taiwan.

Journal: Psychiatry research 20111230

Title: Short term vs. long term test-retest reproducibility of ¹²³I-ADAM for the binding of serotonin transporters in the human brain.

Journal: Psychiatry research 20111230

Title: Functional evaluation using multistep registration with standard magnetic resonance and ADAM brain images.

Journal: Nuclear medicine communications 20110701

Title: Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail.

Journal: Zoological science 20110701

Title: Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study.

Journal: Psychopharmacology 20110401

Title: Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study.

Journal: Psychiatry research 20101230

Title: Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM.

Journal: Drug and chemical toxicology 20101001

Title: The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men.

Journal: European journal of nuclear medicine and molecular imaging 20100801

Title: New methods for registering long-time I-123 ADAM SPECT image sequences to magnetic resonance images.

Journal: Nuclear medicine communications 20100801

Title: Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study.

Journal: Bipolar disorders 20100501

Title: Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and Parkinsonian monkey brains.

Journal: Nuclear medicine and biology 20090801

Title: Imaging the serotonin transporter using (123)I-ADAM in the human brain.

Journal: Psychiatry research 20090430

Title: [Cinacalcet in the treatment of secondary hyperparathyreoidism in a child with chronic kidney disease--case report].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090401

Title: Simultaneous [99mTc]TRODAT-1 and [123I]ADAM brain SPECT in nonhuman primates.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20090101

Title: Evaluation of reference tissue model and tissue ratio method for 5-HTT using [(123)I] ADAM tracer.

Journal: Computer methods and programs in biomedicine 20081201

Title: Imaging serotonin transporters using [123I]ADAM SPECT in a parkinsonian primate model.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20081201

Title: Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors.

Journal: Chemical & pharmaceutical bulletin 20081001

Title: 5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress.

Journal: Neuropharmacology 20080801

Title: Electron paramagnetic resonance study of nitric oxide production during 5-HT2 receptor blockade in the blood, heart, and liver of rats with myocardial infarction.

Journal: Bulletin of experimental biology and medicine 20080601

Title: 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report.

Journal: Psychiatry research 20080415

Title: [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials.

Journal: European archives of psychiatry and clinical neuroscience 20080201

Title: Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080201

Title: Revisiting an old issue: the discrepancy between tissue ratio-derived binding parameters and kinetic modeling-derived parameters after a bolus of the serotonin transporter radioligand 123I-ADAM.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080201

Title: [I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects.

Journal: Journal of psychiatry & neuroscience : JPN 20070701

Title: Increased serotonin transporter availability in the brainstem of migraineurs.

Journal: Journal of neurology 20070601

Title: Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM.

Journal: Psychiatry research 20070415

Title: Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand.

Journal: The international journal of neuropsychopharmacology 20070401

Title: Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study.

Journal: Psychopharmacology 20070401

Title: Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study.

Journal: BMC psychiatry 20070101

Title: Serotonin transporter occupancy induced by paroxetine in patients with major depression disorder: a 123I-ADAM SPECT study.

Journal: Psychopharmacology 20061201

Title: Brain and platelet serotonin transporter in humans-correlation between [123I]-ADAM SPECT and serotonergic measurements in platelets.

Journal: Neuroscience letters 20061009

Title: In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram.

Journal: Psychopharmacology 20061001

Title: A study of the role of serotonin in the anxiolytic effect of nitrous oxide in rodents.

Journal: Pharmacology, biochemistry, and behavior 20060601

Title: Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060501

Title: Brain kinetics of the new selective serotonin transporter tracer [(123)I]ADAM in healthy young adults.

Journal: Nuclear medicine and biology 20060201

Title: Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM - a serotonin transporter radiotracer in healthy human subjects.

Journal: Nuclear medicine and biology 20060201

Title: Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line.

Journal: Advances in experimental medicine and biology 20060101

Title: Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study.

Journal: European journal of nuclear medicine and molecular imaging 20051101

Title: SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050801

Title: 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050601

Title: Comparison of manual and automated quantification methods of 123I-ADAM.

Journal: Nuklearmedizin. Nuclear medicine 20050101

Title: In vivo quantification by SPECT of [123I] ADAM bound to serotonin transporters in the brains of rabbits.

Journal: Nuclear medicine and biology 20041101

Title: Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors.

Journal: Nuclear medicine and biology 20040701

Title: ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.

Journal: Synapse (New York, N.Y.) 20040501

Title: Imaging serotonin transporters with 123I-ADAM brain SPECT in healthy non-human primates.

Journal: Nuclear medicine communications 20040501

Title: Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040501

Title: Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040401

Title: Biodistribution and radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results.

Journal: European journal of nuclear medicine and molecular imaging 20030101

Title: Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons.

Journal: Journal of neurophysiology 20020801

Title: Biodistribution study of [(123)I] ADAM in mice: correlation with whole body autoradiography.

Journal: Nuclear medicine and biology 20020801

Title: Selective serotonin receptor antagonism and leukocyte-independent plasma extravasation during endotoxemia.

Journal: Microvascular research 20020101

Title: Quantification of serotonin transporters in nonhuman primates using [(123)I]ADAM and SPECT.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011001

Title: Serotonin and NO complementarily regulate generation of oscillatory activity in the olfactory CNS of a terrestrial mollusk.

Journal: Journal of neurophysiology 20010601

Title: Serotonergic mediation of cocaine seizures in mice.

Journal: Pharmacology, biochemistry, and behavior 19950101

Title: Differentiaton of neuropharmacological actions of apomorphine and d-amphetamine.

Journal: Pharmacology, biochemistry, and behavior 19761201

Title: Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103.

Title: Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33.

Title: Leysen JE, et al. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 Mar 2;28(9):1015-22.

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Tags:54-84-2 Molecular Formula|54-84-2 MDL|54-84-2 SMILES|54-84-2 2-Propenamide, N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-,monohydrochloride