5428-43-3,MFCD00435290
Catalog No.:AA00DCZW

5428-43-3 | 2-Chloro-n,n-diphenylacetamide

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Purity
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1g
95%
in stock  
$51.00   $36.00
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5g
95%
in stock  
$139.00   $97.00
- +
10g
95%
in stock  
$234.00   $164.00
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25g
95%
in stock  
$456.00 $319.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DCZW
Chemical Name:
2-Chloro-n,n-diphenylacetamide
CAS Number:
5428-43-3
Molecular Formula:
C14H12ClNO
Molecular Weight:
245.7042
MDL Number:
MFCD00435290
SMILES:
ClCC(=O)N(c1ccccc1)c1ccccc1
NSC Number:
12965
Properties
Computed Properties
 
Complexity:
227  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.3  

Downstream Synthesis Route

[1]Huang,Zhongyan;Xu,Jiaxi[RSCAdvances,2013,vol.3,#35,p.15114-15120]

[2]Frerichs,H.;Rentschler[ArchivderPharmazie,1906,vol.244,p.85]

[1]JournaloftheAmericanChemicalSociety,2003,vol.125,p.12084-12085

[2]JournalofMedicinalChemistry,1989,vol.32,p.437-444

[3]EuropeanJournalofMedicinalChemistry,2006,vol.41,p.786-792

[4]SyntheticCommunications,2003,vol.33,p.2725-2736

[5]Patent:US2005/54631,2005,A1.Locationinpatent:Page/Pagecolumn15

[6]HelveticaChimicaActa,2000,vol.83,p.1475-1483

[7]JournaloftheChemicalSociety,1954,p.1697,1703

[8]ChemischeBerichte,1914,vol.47,p.2121

[9]JournalofMedicinalChemistry,1990,vol.33,p.2358-2368

[10]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2004,vol.43,p.174-179

[11]JournalofHeterocyclicChemistry,2017,vol.54,p.911-915

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2007/25709,2007,A2Locationinpatent:Page/Pagecolumn41-42

[2]CurrentPatentAssignee:Majert-DE59121,1800,C[Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.3,p.915][Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.3,p.915]

[1]Nanjan,Pandurangan;Jose,Anna;Thurakkal,Liya;Porel,Mintu[Macromolecules,2020,vol.53,#24,p.11019-11026]

[2]Marcu,Ana;Schurigt,Uta;Müller,Klaus;Moll,Heidrun;Krauth-Siegel,R.Luise;Prinz,Helge[EuropeanJournalofMedicinalChemistry,2016,vol.108,p.436-443]

[3]Shindikar;Khan;Viswanathan[EuropeanJournalofMedicinalChemistry,2006,vol.41,#6,p.786-792]

[4]Wadia;Patil[SyntheticCommunications,2003,vol.33,#15,p.2725-2736]

[5]Hennessy,EdwardJ.;Buchwald,StephenL.[JournaloftheAmericanChemicalSociety,2003,vol.125,#40,p.12084-12085]

[6]CurrentPatentAssignee:SHANGHAIBETTERSYNBIOTECH-CN108484473,2018,ALocationinpatent:Paragraph0030;0040;0041;0042

[7]Locationinpatent:experimentalpartSarmiento,GabrielaP.;Vitale,RoxanaG.;Afeltra,Javier;Moltrasio,GracielaY.;Moglioni,AlbertinaG.[EuropeanJournalofMedicinalChemistry,2011,vol.46,#1,p.101-105]

[8]Zhang,Kai;Peng,Qian;Hou,Xue-Long;Wu,Yun-Dong[AngewandteChemie-InternationalEdition,2008,vol.47,#9,p.1741-1744]

[9]Sarges,Reinhard;Howard,HarryR.;Koe,B.Kenneth;Weissman,Albert[JournalofMedicinalChemistry,1989,vol.32,#2,p.437-444]

[10]VanHijfte,Luc;Zerr,Veronique;Richards,MaryH.;Moser,Paul;Hibert,MarcelF.;VanGiersbergen,PaulL.M.[MedicinalChemistryResearch,1996,vol.6,#3,p.190-196]

[11]Salem,MohamedS.H.;AbdelAziz,YasmineM.;Elgawish,MohamedS.;Said,MohamedM.;Abouzid,KhaledA.M.[BioorganicChemistry,2019]

[12]Locationinpatent:experimentalpartKumar,Sushil;Wahi;Singh,Ranjit[EuropeanJournalofMedicinalChemistry,2011,vol.46,#9,p.4753-4759]

[13]Dash,RadhaCharan;Bhosale,SharadH.;Shelke,SuhasM.;Suryawanshi,MugdhaR.;Mahadik,KakasahebR.[MedicinalChemistry,2012,vol.8,#6,p.1069-1075,7]

[14]CurrentPatentAssignee:SANOFI-US2005/54631,2005,A1Locationinpatent:Page/Pagecolumn15

[15]Diehl,Klaus;Himbert,Gerhard[ChemischeBerichte,1986,vol.119,#9,p.2874-2888]

[16]Frerichs[ArchivderPharmazie,1903,vol.241,p.220]

[17]Kelsey[JournaloftheAmericanChemicalSociety,1924,vol.46,p.1694]

[18]Clarke[JournaloftheChemicalSociety,1910,vol.97,p.426]

[19]VERDERAME[JournalofPharmaceuticalSciences,1961,vol.50,p.312-315]

[20]Moser;Sallmann;Wiesenberg[JournalofMedicinalChemistry,1990,vol.33,#9,p.2358-2368]

[21]Benkli,Kadriye;Demirayak,Seref;Gundogdu-Karaburun,Nalan;Kiraz,Nuri;Iscan,Gokalp;Ucucu,Umit[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2004,vol.43,#1,p.174-179]

[22]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2007/25709,2007,A2Locationinpatent:Page/Pagecolumn29-30

[23]Locationinpatent:experimentalpartNikalje,AnnaPratimaG.;Ghodke,Mangesh;Girbane,Amol[ArchivderPharmazie,2012,vol.345,#1,p.57-64]

[24]Locationinpatent:schemeortableFischer,Christian;Zultanski,SusanL.;Zhou,Hua;Methot,JoeyL.;Shah,Sanjiv;Nuthall,Hugh;Hughes,BethanyL.;Smotrov,Nadja;Hill,Armetta;Szewczak,AlexanderA.;Moxham,ChristopherM.;Bays,Nathan;Middleton,RichardE.;Munoz,Benito;Shearman,MarkS.[BioorganicandMedicinalChemistryLetters,2012,vol.22,#9,p.3140-3146]

[25]Li,Zhanshan;Wang,Weixia;Zhang,Xiaotian;Hu,Congcong;Zhang,Wei[Synlett,2013,vol.24,#1,p.73-78]

[26]Li,Zhan-Shan;Wang,Wei-Xia;Yang,Ji-Dong;Wu,Yue-Wei;Zhang,Wei[OrganicLetters,2013,vol.15,#15,p.3820-3823]

[27]Nakajima,Masaki;Lefebvre,Quentin;Rueping,Magnus[ChemicalCommunications,2014,vol.50,#27,p.3619-3622]

[28]Mehta,Viren;Athar,Mohd;Jha;Panchal,Manthan;Modi,Krunal;Jain[BioorganicandMedicinalChemistryLetters,2016,vol.26,#3,p.1005-1010]

[29]Que,Chuqiang;Huang,Peipei;Yang,Zhanhui;Chen,Ning;Xu,Jiaxi[Molecules,2019,vol.24,#14]

[30]Wang,Wenli;Zheng,Lan;Li,Wei;Zhu,Chen;Peng,Weiqing;Han,Bing;Fu,Wei[JournalofChemicalInformationandModeling,2020,vol.60,#1,p.235-248]

[1]Speziale,A.J.;Smith,L.R.[JournaloftheAmericanChemicalSociety,1962,vol.84,p.1868-1876]

[2]Ficini,J.etal.[BulletindelaSocieteChimiquedeFrance,1974,p.1528-1532]

Literature

Title: Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants.

Journal: Archiv der Pharmazie 20120101

Title: Synthesis and antifungal activity of some substituted phenothiazines and related compounds.

Journal: European journal of medicinal chemistry 20110101

Title: 2-Chloro-N,N-diphenyl-acetamide.

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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SDS
Tags:5428-43-3 Molecular Formula|5428-43-3 MDL|5428-43-3 SMILES|5428-43-3 2-Chloro-n,n-diphenylacetamide
Catalog No.: AA00DCZW
5428-43-3,MFCD00435290
5428-43-3 | 2-Chloro-n,n-diphenylacetamide
Pack Size: 1g
Purity: 95%
in stock
$51.00 $36.00
Pack Size: 5g
Purity: 95%
in stock
$139.00 $97.00
Pack Size: 10g
Purity: 95%
in stock
$234.00 $164.00
Pack Size: 25g
Purity: 95%
in stock
$456.00 $319.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00DCZW
Chemical Name: 2-Chloro-n,n-diphenylacetamide
CAS Number: 5428-43-3
Molecular Formula: C14H12ClNO
Molecular Weight: 245.7042
MDL Number: MFCD00435290
SMILES: ClCC(=O)N(c1ccccc1)c1ccccc1
NSC Number: 12965
Properties
Complexity: 227  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.3  
Downstream Synthesis Route
5428-43-3    140-89-6    137302-98-8 

[1]Huang,Zhongyan;Xu,Jiaxi[RSCAdvances,2013,vol.3,#35,p.15114-15120]

[2]Frerichs,H.;Rentschler[ArchivderPharmazie,1906,vol.244,p.85]

5428-43-3    3335-98-6 

[1]JournaloftheAmericanChemicalSociety,2003,vol.125,p.12084-12085

[2]JournalofMedicinalChemistry,1989,vol.32,p.437-444

[3]EuropeanJournalofMedicinalChemistry,2006,vol.41,p.786-792

[4]SyntheticCommunications,2003,vol.33,p.2725-2736

[5]Patent:US2005/54631,2005,A1.Locationinpatent:Page/Pagecolumn15

[6]HelveticaChimicaActa,2000,vol.83,p.1475-1483

[7]JournaloftheChemicalSociety,1954,p.1697,1703

[8]ChemischeBerichte,1914,vol.47,p.2121

[9]JournalofMedicinalChemistry,1990,vol.33,p.2358-2368

[10]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2004,vol.43,p.174-179

[11]JournalofHeterocyclicChemistry,2017,vol.54,p.911-915

5428-43-3    107776-85-2 

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2007/25709,2007,A2Locationinpatent:Page/Pagecolumn41-42

[2]CurrentPatentAssignee:Majert-DE59121,1800,C[Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.3,p.915][Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.3,p.915]

122-39-4    79-04-9    5428-43-3 

[1]Nanjan,Pandurangan;Jose,Anna;Thurakkal,Liya;Porel,Mintu[Macromolecules,2020,vol.53,#24,p.11019-11026]

[2]Marcu,Ana;Schurigt,Uta;Müller,Klaus;Moll,Heidrun;Krauth-Siegel,R.Luise;Prinz,Helge[EuropeanJournalofMedicinalChemistry,2016,vol.108,p.436-443]

[3]Shindikar;Khan;Viswanathan[EuropeanJournalofMedicinalChemistry,2006,vol.41,#6,p.786-792]

[4]Wadia;Patil[SyntheticCommunications,2003,vol.33,#15,p.2725-2736]

[5]Hennessy,EdwardJ.;Buchwald,StephenL.[JournaloftheAmericanChemicalSociety,2003,vol.125,#40,p.12084-12085]

[6]CurrentPatentAssignee:SHANGHAIBETTERSYNBIOTECH-CN108484473,2018,ALocationinpatent:Paragraph0030;0040;0041;0042

[7]Locationinpatent:experimentalpartSarmiento,GabrielaP.;Vitale,RoxanaG.;Afeltra,Javier;Moltrasio,GracielaY.;Moglioni,AlbertinaG.[EuropeanJournalofMedicinalChemistry,2011,vol.46,#1,p.101-105]

[8]Zhang,Kai;Peng,Qian;Hou,Xue-Long;Wu,Yun-Dong[AngewandteChemie-InternationalEdition,2008,vol.47,#9,p.1741-1744]

[9]Sarges,Reinhard;Howard,HarryR.;Koe,B.Kenneth;Weissman,Albert[JournalofMedicinalChemistry,1989,vol.32,#2,p.437-444]

[10]VanHijfte,Luc;Zerr,Veronique;Richards,MaryH.;Moser,Paul;Hibert,MarcelF.;VanGiersbergen,PaulL.M.[MedicinalChemistryResearch,1996,vol.6,#3,p.190-196]

[11]Salem,MohamedS.H.;AbdelAziz,YasmineM.;Elgawish,MohamedS.;Said,MohamedM.;Abouzid,KhaledA.M.[BioorganicChemistry,2019]

[12]Locationinpatent:experimentalpartKumar,Sushil;Wahi;Singh,Ranjit[EuropeanJournalofMedicinalChemistry,2011,vol.46,#9,p.4753-4759]

[13]Dash,RadhaCharan;Bhosale,SharadH.;Shelke,SuhasM.;Suryawanshi,MugdhaR.;Mahadik,KakasahebR.[MedicinalChemistry,2012,vol.8,#6,p.1069-1075,7]

[14]CurrentPatentAssignee:SANOFI-US2005/54631,2005,A1Locationinpatent:Page/Pagecolumn15

[15]Diehl,Klaus;Himbert,Gerhard[ChemischeBerichte,1986,vol.119,#9,p.2874-2888]

[16]Frerichs[ArchivderPharmazie,1903,vol.241,p.220]

[17]Kelsey[JournaloftheAmericanChemicalSociety,1924,vol.46,p.1694]

[18]Clarke[JournaloftheChemicalSociety,1910,vol.97,p.426]

[19]VERDERAME[JournalofPharmaceuticalSciences,1961,vol.50,p.312-315]

[20]Moser;Sallmann;Wiesenberg[JournalofMedicinalChemistry,1990,vol.33,#9,p.2358-2368]

[21]Benkli,Kadriye;Demirayak,Seref;Gundogdu-Karaburun,Nalan;Kiraz,Nuri;Iscan,Gokalp;Ucucu,Umit[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2004,vol.43,#1,p.174-179]

[22]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2007/25709,2007,A2Locationinpatent:Page/Pagecolumn29-30

[23]Locationinpatent:experimentalpartNikalje,AnnaPratimaG.;Ghodke,Mangesh;Girbane,Amol[ArchivderPharmazie,2012,vol.345,#1,p.57-64]

[24]Locationinpatent:schemeortableFischer,Christian;Zultanski,SusanL.;Zhou,Hua;Methot,JoeyL.;Shah,Sanjiv;Nuthall,Hugh;Hughes,BethanyL.;Smotrov,Nadja;Hill,Armetta;Szewczak,AlexanderA.;Moxham,ChristopherM.;Bays,Nathan;Middleton,RichardE.;Munoz,Benito;Shearman,MarkS.[BioorganicandMedicinalChemistryLetters,2012,vol.22,#9,p.3140-3146]

[25]Li,Zhanshan;Wang,Weixia;Zhang,Xiaotian;Hu,Congcong;Zhang,Wei[Synlett,2013,vol.24,#1,p.73-78]

[26]Li,Zhan-Shan;Wang,Wei-Xia;Yang,Ji-Dong;Wu,Yue-Wei;Zhang,Wei[OrganicLetters,2013,vol.15,#15,p.3820-3823]

[27]Nakajima,Masaki;Lefebvre,Quentin;Rueping,Magnus[ChemicalCommunications,2014,vol.50,#27,p.3619-3622]

[28]Mehta,Viren;Athar,Mohd;Jha;Panchal,Manthan;Modi,Krunal;Jain[BioorganicandMedicinalChemistryLetters,2016,vol.26,#3,p.1005-1010]

[29]Que,Chuqiang;Huang,Peipei;Yang,Zhanhui;Chen,Ning;Xu,Jiaxi[Molecules,2019,vol.24,#14]

[30]Wang,Wenli;Zheng,Lan;Li,Wei;Zhu,Chen;Peng,Weiqing;Han,Bing;Fu,Wei[JournalofChemicalInformationandModeling,2020,vol.60,#1,p.235-248]

723-68-2    5428-43-3 

[1]Speziale,A.J.;Smith,L.R.[JournaloftheAmericanChemicalSociety,1962,vol.84,p.1868-1876]

[2]Ficini,J.etal.[BulletindelaSocieteChimiquedeFrance,1974,p.1528-1532]

Literature fold

Title: Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants.

Journal: Archiv der Pharmazie20120101

Title: Synthesis and antifungal activity of some substituted phenothiazines and related compounds.

Journal: European journal of medicinal chemistry20110101

Title: 2-Chloro-N,N-diphenyl-acetamide.

Journal: Acta crystallographica. Section E, Structure reports online20090701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

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