545380-34-5,MFCD06411436
Catalog No.:AA00D9OT

545380-34-5 | QNZ

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$41.00   $29.00
- +
5mg
98%
in stock  
$69.00   $49.00
- +
10mg
98%
in stock  
$90.00   $63.00
- +
50mg
98%
in stock  
$213.00   $149.00
- +
250mg
95%
in stock  
$992.00   $694.00
- +
1g
95%
in stock  
$2,382.00   $1,668.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00D9OT
Chemical Name:
QNZ
CAS Number:
545380-34-5
Molecular Formula:
C22H20N4O
Molecular Weight:
356.4204
MDL Number:
MFCD06411436
SMILES:
Nc1ccc2c(c1)c(NCCc1ccc(cc1)Oc1ccccc1)ncn2
Properties
Computed Properties
 
Complexity:
434  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Literature

Title: Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

Journal: Environmental toxicology 20180101

Title: Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

Journal: Leukemia 20160101

Title: CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings.

Journal: Toxicology and applied pharmacology 20151201

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB.

Journal: Infection and immunity 20110901

Title: Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

Journal: Chemistry & biology 20110624

Title: Axotomy induces axonogenesis in hippocampal neurons through STAT3.

Journal: Cell death & disease 20110601

Title: Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production.

Journal: PloS one 20110101

Title: JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.

Journal: Journal of biomedical science 20110101

Title: Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.

Journal: PloS one 20110101

Title: SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.

Journal: PloS one 20110101

Title: Signaling pathways involved in LPS induced TNFalpha production in human adipocytes.

Journal: Journal of inflammation (London, England) 20100101

Title: Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

Journal: PloS one 20100101

Title: High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

Journal: Genome medicine 20100101

Title: Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1.

Journal: International journal of molecular sciences 20100101

Title: Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock.

Journal: Journal of cellular and molecular medicine 20090801

Title: Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth.

Journal: Neuroscience letters 20080704

Title: Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis.

Journal: BMC immunology 20080101

Title: Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.

Journal: The Journal of biological chemistry 20060505

Title: A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.

Journal: Bioorganic & medicinal chemistry 20030901

Title: Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.

Journal: Bioorganic & medicinal chemistry 20030206

Title: Signal transduction through NF-kappa B.

Journal: Immunology today 19980201

Title: The role of nuclear factor-kappa B in cytokine gene regulation.

Journal: American journal of respiratory cell and molecular biology 19970701

Title: NF-kappa B: ten years after.

Journal: Cell 19961004

Title: Function and activation of NF-kappa B in the immune system.

Journal: Annual review of immunology 19940101

Title: Cytokines in clinical and experimental transplantation.

Journal: Mediators of inflammation 19940101

Title: Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.

Title: Nekrasov ED, et al. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol Neurodegener. 2016 Apr 14;11:27.

Title: Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36(1):125-41.

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Tags:545380-34-5 Molecular Formula|545380-34-5 MDL|545380-34-5 SMILES|545380-34-5 QNZ
Catalog No.: AA00D9OT
545380-34-5,MFCD06411436
545380-34-5 | QNZ
Pack Size: 1mg
Purity: 98%
in stock
$41.00 $29.00
Pack Size: 5mg
Purity: 98%
in stock
$69.00 $49.00
Pack Size: 10mg
Purity: 98%
in stock
$90.00 $63.00
Pack Size: 50mg
Purity: 98%
in stock
$213.00 $149.00
Pack Size: 250mg
Purity: 95%
in stock
$992.00 $694.00
Pack Size: 1g
Purity: 95%
in stock
$2,382.00 $1,668.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00D9OT
Chemical Name: QNZ
CAS Number: 545380-34-5
Molecular Formula: C22H20N4O
Molecular Weight: 356.4204
MDL Number: MFCD06411436
SMILES: Nc1ccc2c(c1)c(NCCc1ccc(cc1)Oc1ccccc1)ncn2
Properties
Complexity: 434  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
Literature fold

Title: Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

Journal: Environmental toxicology20180101

Title: Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

Journal: Leukemia20160101

Title: CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings.

Journal: Toxicology and applied pharmacology20151201

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB.

Journal: Infection and immunity20110901

Title: Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

Journal: Chemistry & biology20110624

Title: Axotomy induces axonogenesis in hippocampal neurons through STAT3.

Journal: Cell death & disease20110601

Title: Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production.

Journal: PloS one20110101

Title: JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.

Journal: Journal of biomedical science20110101

Title: Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.

Journal: PloS one20110101

Title: SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.

Journal: PloS one20110101

Title: Signaling pathways involved in LPS induced TNFalpha production in human adipocytes.

Journal: Journal of inflammation (London, England)20100101

Title: Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

Journal: PloS one20100101

Title: High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

Journal: Genome medicine20100101

Title: Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1.

Journal: International journal of molecular sciences20100101

Title: Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock.

Journal: Journal of cellular and molecular medicine20090801

Title: Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

Journal: Bioorganic & medicinal chemistry letters20090315

Title: Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth.

Journal: Neuroscience letters20080704

Title: Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis.

Journal: BMC immunology20080101

Title: Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.

Journal: The Journal of biological chemistry20060505

Title: A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.

Journal: Bioorganic & medicinal chemistry20030901

Title: Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.

Journal: Bioorganic & medicinal chemistry20030206

Title: Signal transduction through NF-kappa B.

Journal: Immunology today19980201

Title: The role of nuclear factor-kappa B in cytokine gene regulation.

Journal: American journal of respiratory cell and molecular biology19970701

Title: NF-kappa B: ten years after.

Journal: Cell19961004

Title: Function and activation of NF-kappa B in the immune system.

Journal: Annual review of immunology19940101

Title: Cytokines in clinical and experimental transplantation.

Journal: Mediators of inflammation19940101

Title: Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.

Title: Nekrasov ED, et al. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol Neurodegener. 2016 Apr 14;11:27.

Title: Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36(1):125-41.

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