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54556-98-8,MFCD01672343
Catalog No.:AA01CC82

54556-98-8 | Propiverine Hydrochloride

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25mg
≥98%
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$58.00   $40.00
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50mg
≥98%
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$109.00   $76.00
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100mg
98% (HPLC)
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$157.00   $110.00
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250mg
98% (HPLC)
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$243.00   $170.00
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1g
98% (HPLC)
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$457.00   $320.00
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5g
98% (HPLC)
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$1,468.00   $1,028.00
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25g
98% (HPLC)
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$4,963.00   $3,474.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CC82
Chemical Name:
Propiverine Hydrochloride
CAS Number:
54556-98-8
Molecular Formula:
C23H30ClNO3
Molecular Weight:
403.9422
MDL Number:
MFCD01672343
SMILES:
CCCOC(c1ccccc1)(c1ccccc1)C(=O)OC1CC[NH+](CC1)C.[Cl-]
NSC Number:
172140
Properties
Computed Properties
 
Complexity:
429  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  

Literature

Title: Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.

Journal: Chemico-biological interactions 20180201

Title: Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.

Journal: Archives of toxicology 20171101

Title: Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo.

Journal: Archives of toxicology 20170101

Title: Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females.

Journal: Expert opinion on drug metabolism & toxicology 20121101

Title: Excitatory effect of propiverine hydrochloride on urethral activity in rats.

Journal: International journal of urology : official journal of the Japanese Urological Association 20120601

Title: Effect of distigmine combined with propiverine on bladder activity in rats with spinal cord injury.

Journal: International journal of urology : official journal of the Japanese Urological Association 20120501

Title: Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model.

Journal: Neurobiology of disease 20120101

Title: An overview on mixed action drugs for the treatment of overactive bladder and detrusor overactivity.

Journal: Urologia internationalis 20120101

Title: Efficacy of propiverine, an anticholinergic agent, in young and old rats.

Journal: Life sciences 20110926

Title: Efficacy of propiverine ER with or without α-blockers related to maximum urinary flow rate in adult men with OAB: results of a 12-week, multicenter, non-interventional study.

Journal: World journal of urology 20110401

Title: The muscarinic receptor antagonist propiverine exhibits α(1)-adrenoceptor antagonism in human prostate and porcine trigonum.

Journal: World journal of urology 20110401

Title: [Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy].

Journal: Hinyokika kiyo. Acta urologica Japonica 20110201

Title: Determination of propiverine hydrochloride in human plasma by high performance liquid chromatography-tandem mass spectrometry: application to the pharmacokinetic study of a sustained release formulation.

Journal: Arzneimittel-Forschung 20110101

Title: Efficacy, tolerability and safety of propiverine hydrochloride in comparison to oxybutynin in children with urge incontinence due to overactive bladder: Results of a multicentre observational cohort study.

Journal: BJU international 20100801

Title: The cost-effectiveness of solifenacin vs fesoterodine, oxybutynin immediate-release, propiverine, tolterodine extended-release and tolterodine immediate-release in the treatment of patients with overactive bladder in the UK National Health Service.

Journal: BJU international 20100801

Title: The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100801

Title: Oxybutynin and propiverine suppress adenosine triphosphate-induced bladder overactivity other than through antimuscarinic mechanisms.

Journal: Urology 20100801

Title: New strategies for medical management of overactive bladder in children.

Journal: Current opinion in urology 20100701

Title: Anticholinergic effects of cis- and trans-isomers of two metabolites of propiverine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100401

Title: [Combination therapy with anticholinergics and alpha-blockers for the treatment of overactive bladder in female patients--pilot study].

Journal: Ceska gynekologie 20091201

Title: Relationship between lower urinary tract symptoms and urinary ATP in patients with benign prostatic hyperplasia or overactive bladder.

Journal: Biomedical research (Tokyo, Japan) 20091001

Title: Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?

Journal: Clinical pharmacology and therapeutics 20090801

Title: How to manage overactive bladder in elderly individuals with dementia? A combined use of donepezil, a central acetylcholinesterase inhibitor, and propiverine, a peripheral muscarine receptor antagonist.

Journal: Journal of the American Geriatrics Society 20090801

Title: Failure of monotherapy in primary monosymptomatic enuresis: a combined desmopressin and propiverine treatment regimen improves efficacy outcomes.

Journal: BJU international 20090601

Title: A randomized, double-blind, placebo- and propiverine-controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder.

Journal: International journal of urology : official journal of the Japanese Urological Association 20090501

Title: Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.

Journal: BJU international 20090301

Title: Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study.

Journal: Scandinavian journal of urology and nephrology 20090101

Title: Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes.

Journal: European journal of pharmacology 20081119

Title: In vivo characterization of muscarinic receptors in peripheral tissues: evaluation of bladder selectivity of anticholinergic agents to treat overactive bladder.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080601

Title: Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue.

Journal: Pflugers Archiv : European journal of physiology 20080501

Title: Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Pharmacological effects of propiverine and its active metabolite, M-1, on isolated human urinary bladder smooth muscle, and on bladder contraction in rats.

Journal: International journal of urology : official journal of the Japanese Urological Association 20080101

Title: Effects of propiverine and naftopidil on the urinary ATP level and bladder activity after bladder stimulation in rats.

Journal: Neuroscience letters 20071218

Title: Antimuscarinic drug inhibits detrusor overactivity induced by topical application of prostaglandin E2 to the urethra with a decrease in urethral pressure.

Journal: The Journal of urology 20071101

Title: Randomized, double-blind, placebo- and propiverine-controlled trial of the once-daily antimuscarinic agent solifenacin in Japanese patients with overactive bladder.

Journal: BJU international 20070901

Title: Analysis of pharmacological effects of drugs used for treatment of urinary disturbance based on anticholinergic and smooth muscle-relaxing effects.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Comparison of the efficacy, safety, and tolerability of propiverine and oxybutynin for the treatment of overactive bladder syndrome.

Journal: International journal of urology : official journal of the Japanese Urological Association 20070701

Title: Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain.

Journal: Life sciences 20070606

Title: Update on drugs for overactive bladder syndrome.

Journal: Drug and therapeutics bulletin 20070601

Title: A standardised mini pig model for in vivo investigations of anticholinergic effects on bladder function and salivation.

Journal: Pharmacological research 20070501

Title: [Does alpha1-blocker provide additional improvement of quality-of-life in patients with overactive bladder?--a multi-center prospective randomized trial between anti-cholinergic (propiverine chloride) with and without alpha1-blocker (urapidil)].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20070501

Title: Propiverine compared to oxybutynin in neurogenic detrusor overactivity--results of a randomized, double-blind, multicenter clinical study.

Journal: European urology 20070101

Title: Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.

Journal: Biological & pharmaceutical bulletin 20070101

Title: Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061101

Title: Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061101

Title: Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study.

Journal: International journal of urology : official journal of the Japanese Urological Association 20061001

Title: A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction.

Journal: Biomedical research (Tokyo, Japan) 20061001

Title: Efficacy, tolerability and safety of propiverine hydrochloride in children and adolescents with congenital or traumatic neurogenic detrusor overactivity--a retrospective study.

Journal: European urology 20060601

Title: Comparison of the efficacy, safety, and tolerability of propiverine and oxybutynin for the treatment of overactive bladder syndrome.

Journal: International journal of urology : official journal of the Japanese Urological Association 20060601

Title: The overactive bladder: review of current pharmacotherapy in adults. Part 1: pathophysiology and anticholinergic therapy.

Journal: Expert opinion on pharmacotherapy 20060401

Title: Sensitive column-switching high-performance liquid chromatography method for determination of propiverine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

Title: Urodynamic effects of propiverine hydrochloride in children with neurogenic detrusor overactivity: a prospective analysis.

Journal: BJU international 20060201

Title: Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201

Title: Juvenile pig detrusor: effects of propiverine and three of its metabolites.

Journal: European journal of pharmacology 20051107

Title: Efficacy of the combination of an alpha1-blocker with an anticholinergic agent in the treatment of lower urinary tract symptoms associated with bladder outlet obstruction.

Journal: Expert opinion on pharmacotherapy 20051101

Title: Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction: a prospective, randomized, controlled multicenter study.

Journal: The Journal of urology 20051001

Title: Quantification of propiverine by liquid chromatography/electrospray tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy subjects.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Propiverine versus tolterodine: efficacy and tolerability in patients with overactive bladder.

Journal: European urology 20050901

Title: Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction.

Journal: British journal of pharmacology 20050701

Title: Activation of the rostral pontine reticular formation increases the spinal glycine level and inhibits bladder contraction in rats.

Journal: The Journal of urology 20050501

Title: Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarcted rats.

Journal: European journal of pharmacology 20050404

Title: The anticholinergic drug propiverine inhibits the protein kinase C activity in the rat urinary bladder.

Journal: Die Pharmazie 20050101

Title: [A suggested treatment algorithm in nocturnal enuresis with emphasis on partial responders].

Journal: Der Urologe. Ausg. A 20040701

Title: An empirical treatment algorithm for incontinent children.

Journal: The Journal of urology 20040601

Title: Validation of a simple liquid chromatography-tandem mass spectrometric method for the determination of propiverine hydrochloride and its N-oxide metabolite in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105

Title: Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601

Title: Urodynamics in a rat neurogenic bladder model with a unilateral electrolytic lesion of the basal forebrain.

Journal: BJU international 20030601

Title: [Urinary incontinence--treatment].

Journal: Deutsche medizinische Wochenschrift (1946) 20030404

Title: Significance of low compliance bladder in cauda equina injury.

Journal: Spinal cord 20021201

Title: Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse.

Journal: European journal of pharmacology 20021101

Title: Increasing sample throughput in pharmacological studies by using dual-column liquid chromatography with tandem mass spectrometry.

Journal: Journal of chromatography. A 20020301

Title: Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic).

Journal: World journal of urology 20011101

Title: Effects of antimuscarinic drugs on both urinary frequency and cognitive impairment in conscious, nonrestrained rats.

Journal: Japanese journal of pharmacology 20010901

Title: Combined pharmacotherapy for nocturnal enuresis.

Journal: Pediatric nephrology (Berlin, Germany) 20010801

Title: Muscarinic receptor binding characteristics in rat tissues after oral administration of oxybutynin and propiverine.

Journal: Biological & pharmaceutical bulletin 20010501

Title: Application of clenbuterol in the treatment of urinary incontinence.

Journal: International urology and nephrology 20010101

Title: Possible site of action of TAK-637, a tachykinin NK(1) receptor antagonist, on the micturition reflex in guinea pigs.

Journal: European journal of pharmacology 20000804

Title: Propiverine-induced Parkinsonism: a case report and a pharmacokinetic/pharmacodynamic study in mice.

Journal: Pharmaceutical research 20000501

Title: Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8.

Title: Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9.

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