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Title: Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
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Title: Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation.
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Title: The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice.
Journal: European heart journal 20120801
Title: Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.
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Title: Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
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Title: Proteomics analysis of aromatic catabolic pathways in thermophilic Geobacillus thermodenitrificans NG80-2.
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Title: Divergence and convergence in enzyme evolution.
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Title: Chemotaxis of Burkholderia sp. strain SJ98 towards chloronitroaromatic compounds that it can metabolise.
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Title: Modulation of tumor tolerance in primary central nervous system malignancies.
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Title: Quinolinic Acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms.
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Title: Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
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Title: Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases.
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Title: Comparative genotoxicity of 3-hydroxyanthranilic acid and anthranilic acid in the presence of a metal cofactor Cu (II) in vitro.
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Title: Differential action of 3-hydroxyanthranilic acid on viability and activation of stimulated lymphocytes.
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Title: Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.
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Title: Tryptophan in alcoholism treatment II: inhibition of the rat liver mitochondrial low Km aldehyde dehydrogenase activity, elevation of blood acetaldehyde concentration and induction of aversion to alcohol by combined administration of tryptophan and benserazide.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20111101
Title: Tryptophan in alcoholism treatment I: kynurenine metabolites inhibit the rat liver mitochondrial low Km aldehyde dehydrogenase activity, elevate blood acetaldehyde concentration and induce aversion to alcohol.
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Title: Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH.
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Title: The mechanism of formation of N-formylkynurenine by heme dioxygenases.
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Title: Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.
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Title: The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1.
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Title: Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives.
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Title: 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.
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Title: Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity.
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Title: 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival.
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Title: Multiple multi-copper oxidase gene families in basidiomycetes - what for?
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Title: Possible roles of excess tryptophan metabolites in cancer.
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Title: Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes.
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Title: Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.
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Title: Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches.
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Title: The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment.
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Title: Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).
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Title: An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
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Title: The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis.
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Title: The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
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Title: Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.
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Title: Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease.
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Title: On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio.
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Title: IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease.
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Title: Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.
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Title: Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD Concentration in Human Primary Astrocytes.
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Title: Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection.
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Title: Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase.
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Title: 5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones.
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Title: Suppression of T-cell response and prolongation of allograft survival in a rat model by tryptophan catabolites.
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Title: Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase.
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Title: Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization.
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Title: Macrophage antioxidant protection within atherosclerotic plaques.
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Title: Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons.
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Title: The physiological action of picolinic Acid in the human brain.
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Title: NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
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Title: Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system.
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Title: Metabolic reconstruction of aromatic compounds degradation from the genome of the amazing pollutant-degrading bacterium Cupriavidus necator JMP134.
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Title: Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species.
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Title: Simultaneous measurement of tryptophan and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
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Title: Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.
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Title: Iron source preference and regulation of iron uptake in Cryptococcus neoformans.
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Title: Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase.
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Title: IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells.
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Title: Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
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Title: The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
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Title: Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.
Journal: Biochimica et biophysica acta 20020510
Title: Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+.
Journal: Biochimica et biophysica acta 20020429
Title: Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture.
Journal: Genome biology 20020101
Title: QSAR study on inhibition of brain 3-hydroxy-anthranilic acid dioxygenase (3-HAO): a molecular connectivity approach.
Journal: Bioorganic & medicinal chemistry 20011201
Title: Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum.
Journal: Experimental brain research 20011201
Title: Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
Journal: Bioscience, biotechnology, and biochemistry 20011001
Title: Enzyme activities involved in tryptophan metabolism along the kynurenine pathway in rabbits.
Journal: Biochimica et biophysica acta 20010815
Title: Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats.
Journal: Bioscience, biotechnology, and biochemistry 20010601
Title: [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats].
Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20010601
Title: 3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma.
Journal: Annals of clinical biochemistry 20010501
Title: The oxidation of 3-hydroxyanthranilic acid by Cu,Zn superoxide dismutase: mechanism and possible consequences.
Journal: Archives of biochemistry and biophysics 20010415
Title: Effects of nicotine on head-shakes and tryptophan metabolites.
Journal: Psychopharmacology 20010101
Title: [Enzymes of the kynurenine pathway].
Journal: Postepy higieny i medycyny doswiadczalnej 20010101
Title: Comparative study of tumorigenicity in mice administered transplacentally or neonatally with metabolites of tryptophan and its related compounds.
Journal: Journal of cancer research and clinical oncology 19800101
Title: Lee WS, et al. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. Int Immunopharmacol. 2013 Nov;17(3):721-6.
