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550999-74-1,MFCD29049883
Catalog No.:AA00DB3C

550999-74-1 | EVP-6124 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$159.00   $111.00
- +
10mg
≥95%
in stock  
$300.00   $210.00
- +
25mg
≥95%
in stock  
$705.00   $493.00
- +
50mg
≥95%
in stock  
$1,328.00   $929.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00DB3C
Chemical Name:
EVP-6124 hydrochloride
CAS Number:
550999-74-1
Molecular Formula:
C16H18Cl2N2OS
Molecular Weight:
357.2979
MDL Number:
MFCD29049883
SMILES:
O=C(c1cc2c(s1)c(Cl)ccc2)NC1CN2CCC1CC2.Cl
Properties
Computed Properties
 
Complexity:
413  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  

Literature

Title: Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62(2):109

Title: Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.

Title: Papouin T, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94(4):840-854.e7.

Title: Maehara S, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631. Eur J Pharmacol. 2017 Sep 15;811:110-116.

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Tags:550999-74-1 Molecular Formula|550999-74-1 MDL|550999-74-1 SMILES|550999-74-1 EVP-6124 hydrochloride