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552-41-0,MFCD00008730
Catalog No.:AA00339K

552-41-0 | 2'-Hydroxy-4'-methoxyacetophenone

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1g
98%
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$6.00   $4.00
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5g
98%
in stock  
$7.00   $5.00
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10g
98%
in stock  
$9.00   $7.00
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25g
98%
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$22.00   $15.00
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100g
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$84.00   $59.00
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500g
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$311.00   $218.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00339K
Chemical Name:
2'-Hydroxy-4'-methoxyacetophenone
CAS Number:
552-41-0
Molecular Formula:
C9H10O3
Molecular Weight:
166.1739
MDL Number:
MFCD00008730
SMILES:
COc1ccc(c(c1)O)C(=O)C
NSC Number:
401442
Properties
Properties
 
BP:
301.9°C at 760 mmHg  
Form:
Solid  
MP:
48-50 °C(lit.)  
Refractive Index:
1.5452 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
167  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2  

Literature

Title: Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway.

Journal: Chemico-biological interactions 20180425

Title: The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway.

Journal: Chemico-biological interactions 20160125

Title: Competitive molecular interaction among paeonol-loaded liposomes: differential scanning calorimetry and synchrotron X-ray diffraction studies.

Journal: International journal of pharmaceutics 20121115

Title: Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-κB and MAPK signaling pathways.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120901

Title: The joint action of destruxins and botanical insecticides (rotenone, azadirachtin and paeonolum) against the cotton aphid, Aphis gossypii Glover.

Journal: Molecules (Basel, Switzerland) 20120618

Title: [Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501

Title: Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.

Journal: Molecules (Basel, Switzerland) 20120420

Title: [Study on effect of different processing methods on seven main chemical components of wild and cultivated Paeonia lactiflora].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

Title: [Protective effects of paeonol, paeoniflorin and their compatibility on in vitro cultured cardiomyocytes suffering from hypoxia-reoxygenation injury].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120401

Title: Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons.

Journal: Shock (Augusta, Ga.) 20120301

Title: [Synthesis and anti-tumor activity of paeonol and its derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Title: Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway.

Journal: Biological & pharmaceutical bulletin 20120101

Title: In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20111130

Title: [Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Title: Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii.

Journal: Journal of natural products 20111028

Title: Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis.

Journal: Planta medica 20111001

Title: Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor.

Journal: Natural product communications 20110801

Title: [Treatment of premenstrual syndrome with Chinese medicine formula, baixiangdan capsule: implications for neuron viability and GABA(A) receptor modulation in rat cortex].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Title: [A novel method for fast determination of components in Guizhi Fuling capsule by near infrared spectroscopy].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

Title: CdSe/ZnS quantum dots based fluorescence quenching method for determination of paeonol.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110101

Title: Transdermal delivery of paeonol using cubic gel and microemulsion gel.

Journal: International journal of nanomedicine 20110101

Title: Quality control of modified xiaoyao san through the determination of 22 active components by ultra-performance liquid chromatography.

Journal: Journal of AOAC International 20110101

Title: Release of paeonol-β-CD complex from thermo-sensitive poly(N-isopropylacrylamide) hydrogels.

Journal: International journal of pharmaceutics 20101215

Title: Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents.

Journal: Acta pharmacologica Sinica 20101201

Title: [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: [Determination of paeonol in rat plasma by HPLC and pharmacokinetic study].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma.

Journal: Canadian journal of physiology and pharmacology 20101001

Title: Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo.

Journal: World journal of gastroenterology 20100921

Title: [Dermatopharmacokinetic studies of liangfu cream in mice skin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Title: [Study on stability and degradation kinetics of ketoprofen-paeonol conjugate].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100701

Title: [Determination of binding domains of paeonol on immobilized human serum albumin by high-performance affinity chromatography].

Journal: Se pu = Chinese journal of chromatography 20100701

Title: Simultaneous determination of four marker components in Yukmijihwang Tang by high performance liquid chromatography/diode array detector.

Journal: Archives of pharmacal research 20100401

Title: [RP-HPLC determination of main chemical components in different parts and different harvest periods of Paeonia lactiflora].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401

Title: Biotransformation of paeonol and emodin by transgenic crown galls of Panax quinquefolium.

Journal: Applied biochemistry and biotechnology 20100301

Title: Vascular dilation by paeonol--a mechanism study.

Journal: Vascular pharmacology 20100101

Title: Paeonol oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells.

Journal: PloS one 20100101

Title: Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.

Journal: International journal of molecular sciences 20100101

Title: In situ and in vivo study of nasal absorption of paeonol in rats.

Journal: International journal of molecular sciences 20100101

Title: Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101

Title: [Preparation of paeonol microemulsion gel its and transdermal characterization in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: [Paeonol attenuates oxygen-glucose deprivation injury and inhibits NMDA receptor activation of cultured rat hippocampal neurons].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20091101

Title: CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090901

Title: Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).

Journal: Journal of natural products 20090801

Title: Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases.

Journal: Biological & pharmaceutical bulletin 20090701

Title: [Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: [Effect of paeonol on protecting endothelial cells of diabetic rats].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090401

Title: Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods.

Journal: Biochimie 20090201

Title: Inhibition of LPS-induced iNOS, COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells.

Journal: The American journal of Chinese medicine 20090101

Title: Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: [Determination of loganin and paeonol in Liuwei Dihuang pills by HPLC amalgamated of double UV waves].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001

Title: [Studies on content determination and fingerprint of active constituents in different parts of cortex moutan].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: (E)-3-(2,3-Dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20080901

Title: [Investigation of JinKui ShenQi pills by ultraviolet spectra and tandem mass spectrometry].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20080801

Title: Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080701

Title: LC-MS determination and pharmacokinetic studies of paeonol in rat plasma after administration of different compatibility of Su-Xiao-Xin-Tong prescriptions.

Journal: Biomedical chromatography : BMC 20080501

Title: Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol.

Journal: Archives of pharmacal research 20080401

Title: Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells.

Journal: Anti-cancer drugs 20080401

Title: Peroxynitrite mediates high glucose-induced osteoblast apoptosis.

Journal: Journal of endocrinological investigation 20080401

Title: [Comparison of the content of effective components between tree peony wild species and main cultivars].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

Title: Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury.

Journal: Journal of the neurological sciences 20080115

Title: Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats.

Journal: Planta medica 20080101

Title: Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20080101

Title: [The quality control of carbonized cortex moutan].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071201

Title: Probing paeonol-pluronic polymer interactions by 1H NMR spectroscopy.

Journal: The journal of physical chemistry. B 20071129

Title: [Dynamic analysis of major active ingredients of Cortex Moutan cultivated in Dianjiang county of Chongqing].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

Title: Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines.

Journal: Acta pharmacologica Sinica 20070601

Title: Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways.

Journal: International immunopharmacology 20070301

Title: Antiproliferation and apoptosis induction of paeonol in HepG2 cells.

Journal: World journal of gastroenterology 20070114

Title: Extraction of paeonol from Jisheng Shenqi Wan using supercritical fluid extraction.

Journal: Biomedical chromatography : BMC 20070101

Title: Down-regulation of melanin synthesis and transfer by paeonol and its mechanisms.

Journal: The American journal of Chinese medicine 20070101

Title: Identification and analysis of absorbed and metabolic components in rat plasma after oral administration of 'Shuangdan' granule by HPLC-DAD-ESI-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20061116

Title: Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

Journal: Toxicology and applied pharmacology 20061115

Title: Inhibitory effects of paeonol on morphine-induced locomotor sensitization and conditioned place preference in mice.

Journal: Archives of pharmacal research 20061001

Title: [Studies on HPLC fingerprint of cortex moutan].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: [Simultaneous determination of three active constituents in cortex moutan by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.

Journal: Journal of ethnopharmacology 20060630

Title: Isothermal titration calorimetry and 1H NMR studies on host-guest interaction of paeonol and two of its isomers with beta-cyclodextrin.

Journal: International journal of pharmaceutics 20060619

Title: Acaricidal activities of paeonol and benzoic acid from Paeonia suffruticosa root bark and monoterpenoids against Tyrophagus putrescentiae (Acari: Acaridae).

Journal: Pest management science 20060601

Title: Composition of the essential oil of rootstock from Cimicifuga simplex.

Journal: Natural product research 20060520

Title: Determination of paeonol and paeoniflorin in Chinese medicine Cortex Moutan and 'Shuangdan' granule by micellar electrokinetic capillary chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060318

Title: Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat.

Journal: Life sciences 20060102

Title: Simultaneous determination of cinnamaldehyde, eugenol and paeonol in traditional Chinese medicinal preparations by capillary GC-FID.

Journal: Chemical & pharmaceutical bulletin 20060101

Title: [The simultaneous determination of laetrile, paeoniflorin and paeonol in Jingzhi Guizhi Fuling capsule by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

Title: Simultaneous determinations of paeonol and palmatine hydrochloride in Shangshi Aerosols by HPLC method.

Journal: Journal of pharmaceutical and biomedical analysis 20050701

Title: Anxiolytic-like effect of paeonol in mice.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: Acaricidal activity of Paeonia suffruticosa root bark-derived compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).

Journal: Journal of agricultural and food chemistry 20041229

Title: Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

Journal: Journal of ethnopharmacology 20040401

Title: Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha.

Journal: International immunopharmacology 20040201

Title: [Experiment on extraction, sulfonate of paeonol and its antibiotic effect on plant pathogen].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20031101

Title: Insecticides in Chinese medicinal plants: survey leading to jacaranone, a neurotoxicant and glutathione-reactive quinol.

Journal: Journal of agricultural and food chemistry 20030423

Title: [Study on the constituents from Neonauclea sessilifolia].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20021201

Title: [Research on the quality of original plants and material medicine of Cortex Paeoniae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020901

Title: Kong LD, et al. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5.

Title: Ma L, et al. Paeonol Protects Rat Heart by Improving Regional Blood Perfusion during No-Reflow. Front Physiol. 2016 Jul 21;7:298.

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Tags:552-41-0 Molecular Formula|552-41-0 MDL|552-41-0 SMILES|552-41-0 2'-Hydroxy-4'-methoxyacetophenone