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560130-42-9,MFCD22572780
Catalog No.:AA01EA9Y

560130-42-9 | Telavancin HCl

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Purity
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25mg
98
2 weeks  
$581.00   $407.00
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100mg
98%
2 weeks  
$797.00   $558.00
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1g
98%
2 weeks  
$2,909.00   $2,037.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EA9Y
Chemical Name:
Telavancin HCl
CAS Number:
560130-42-9
Molecular Formula:
C80H107Cl3N11O27P
Molecular Weight:
1792.0958
MDL Number:
MFCD22572780
SMILES:
CCCCCCCCCCNCCN[C@@]1(C)C[C@H](O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]([C@@H](c4ccc(O3)c(Cl)c4)O)NC(=O)[C@@H](CC(C)C)NC)c3ccc(c(c3)c3c([C@H](NC2=O)C(=O)O)cc(c(c3O)CNCP(=O)(O)O)O)O)O[C@H]([C@H]1O)C.Cl
Properties
Computed Properties
 
Complexity:
3490  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
18  
Heavy Atom Count:
122  
Hydrogen Bond Acceptor Count:
31  
Hydrogen Bond Donor Count:
24  
Rotatable Bond Count:
30  

Literature

Title: Transplacental transfer of vancomycin and telavancin.

Journal: American journal of obstetrics and gynecology 20121001

Title: Compatibility and stability of telavancin and vancomycin in heparin or sodium citrate lock solutions.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120815

Title: Successful treatment of methicillin-resistant Staphylococcus epidermidis prosthetic joint infection with telavancin.

Journal: The Journal of antimicrobial chemotherapy 20120801

Title: Rates of killing of methicillin-resistant Staphylococcus aureus by ceftaroline, daptomycin, and telavancin compared to that of vancomycin.

Journal: Scandinavian journal of infectious diseases 20120801

Title: Telavancin for the treatment of hospital-acquired pneumonia: findings from the ATTAIN studies.

Journal: Expert review of anti-infective therapy 20120801

Title: Activity of telavancin compared to other agents against coagulase-negative staphylococci with different resistotypes by time kill.

Journal: Diagnostic microbiology and infectious disease 20120701

Title: Efficacy of telavancin in patients with specific types of complicated skin and skin structure infections.

Journal: The Journal of antimicrobial chemotherapy 20120601

Title: Successful treatment of polymicrobial calcaneal osteomyelitis with telavancin, rifampin, and meropenem.

Journal: The Annals of pharmacotherapy 20120601

Title: Acute renal insufficiency during telavancin therapy in clinical practice.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: Detection of vancomycin levels in patients receiving telavancin but not vancomycin.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: Evaluation of telavancin activity versus daptomycin and vancomycin against daptomycin-nonsusceptible Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic model.

Journal: Antimicrobial agents and chemotherapy 20120201

Title: Management of gram-positive bacterial infections in patients with cancer.

Journal: Leukemia & lymphoma 20120101

Title: Telavancin activity tested against a contemporary collection of Gram-positive pathogens from USA Hospitals (2007-2009).

Journal: Diagnostic microbiology and infectious disease 20120101

Title: Efficacy and safety of telavancin in clinical trials: a systematic review and meta-analysis.

Journal: PloS one 20120101

Title: Telavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia.

Journal: Expert opinion on pharmacotherapy 20111201

Title: Physical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111201

Title: MRSA new treatments on the horizon: current status.

Journal: Injury 20111201

Title: Telavancin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis.

Journal: The Journal of antimicrobial chemotherapy 20111101

Title: Successful treatment of methicillin-resistant Staphylococcus aureus mitral valve endocarditis with sequential linezolid and telavancin monotherapy following daptomycin failure.

Journal: The Journal of antimicrobial chemotherapy 20110901

Title: Update on the telavancin activity tested against European staphylococcal clinical isolates (2009-2010).

Journal: Diagnostic microbiology and infectious disease 20110901

Title: Comparative in vitro activity of telavancin, vancomycin and linezolid against heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA).

Journal: International journal of antimicrobial agents 20110601

Title: On a different level: telavancin versus vancomycin for hospital-acquired pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110601

Title: Susceptibility patterns of coagulase-negative staphylococci to several newer antimicrobial agents in comparison with vancomycin and oxacillin.

Journal: International journal of antimicrobial agents 20110301

Title: In vitro activity of telavancin and comparator antimicrobial agents against a panel of genetically defined staphylococci.

Journal: Diagnostic microbiology and infectious disease 20110301

Title: In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007-2009 study.

Journal: Diagnostic microbiology and infectious disease 20110301

Title: Pharmacodynamics of telavancin studied in an in vitro pharmacokinetic model of infection.

Journal: Antimicrobial agents and chemotherapy 20110201

Title: Flow cytometry as a tool to determine the effects of cell wall-active antibiotics on vancomycin-susceptible and -resistant Enterococcus faecalis strains.

Journal: Antimicrobial agents and chemotherapy 20110101

Title: Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110101

Title: Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model.

Journal: Antimicrobial agents and chemotherapy 20101201

Title: Successful treatment of vancomycin-intermediate Staphylococcus aureus pacemaker lead infective endocarditis with telavancin.

Journal: Antimicrobial agents and chemotherapy 20101201

Title: ATLAS trials: efficacy and safety of telavancin compared with vancomycin for the treatment of skin infections.

Journal: Future microbiology 20101201

Title: Telavancin: a lipoglycopeptide antimicrobial for the treatment of complicated skin and skin structure infections caused by gram-positive bacteria in adults.

Journal: Clinical therapeutics 20101201

Title: Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008).

Journal: Antimicrobial agents and chemotherapy 20101101

Title: Telavancin activity against Gram-positive bacteria isolated from respiratory tract specimens of patients with nosocomial pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Activity of telavancin and comparator antimicrobial agents tested against Staphylococcus spp. isolated from hospitalised patients in Europe (2007-2008).

Journal: International journal of antimicrobial agents 20101001

Title: In vitro activity of telavancin against Gram-positive isolates from complicated skin and skin structure infections: results from 2 phase 3 (ATLAS) clinical studies.

Journal: Diagnostic microbiology and infectious disease 20101001

Title: Telavancin Activity against gram-positive bacteria isolated from patients with skin and skin-structure infections.

Journal: Journal of chemotherapy (Florence, Italy) 20101001

Title: Direct fluorescence polarization assay for the detection of glycopeptide antibiotics.

Journal: Analytical chemistry 20100815

Title: Outpatient parenteral antimicrobial therapy: Recent developments and future prospects.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100801

Title: Bactericidal activity of telavancin, vancomycin and metronidazole against Clostridium difficile.

Journal: Anaerobe 20100601

Title: Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with telavancin.

Journal: The Journal of antimicrobial chemotherapy 20100601

Title: In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates.

Journal: Antimicrobial agents and chemotherapy 20100601

Title: New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin.

Journal: Drugs 20100507

Title: Antistaphylococcal activities of telavancin tested alone and in combination by time-kill assay.

Journal: Antimicrobial agents and chemotherapy 20100501

Title: Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemia.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: [Update on antimicrobial chemotherapy].

Journal: Medecine et maladies infectieuses 20100301

Title: Effect of Telavancin on the pharmacokinetics of the cytochrome P450 3A probe substrate midazolam: a randomized, double-blind, crossover study in healthy subjects.

Journal: Pharmacotherapy 20100201

Title: A comparative review of the lipoglycopeptides: oritavancin, dalbavancin, and telavancin.

Journal: Pharmacotherapy 20100101

Title: Comparative activity of telavancin and other antimicrobial agents against methicillin-resistant Staphylococcus aureus isolates collected from 1991 to 2006.

Journal: Chemotherapy 20100101

Title: Telavancin: a novel lipoglycopeptide.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091215

Title: Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational trial.

Journal: Journal of clinical microbiology 20091201

Title: Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin.

Journal: Infectious disease clinics of North America 20091201

Title: New antimicrobial agents for methicillin-resistant Staphylococcus aureus.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20091201

Title: Activity of telavancin against staphylococci and enterococci determined by MIC and resistance selection studies.

Journal: Antimicrobial agents and chemotherapy 20091001

Title: Telavancin and hydroxy propyl-beta-cyclodextrin clearance during continuous renal replacement therapy: an in vitro study.

Journal: The International journal of artificial organs 20091001

Title: In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates.

Journal: Antimicrobial agents and chemotherapy 20090901

Title: Microbiology of drugs for treating multiply drug-resistant Gram-positive bacteria.

Journal: The Journal of infection 20090901

Title: Activity of telavancin against Staphylococcus aureus strains with various vancomycin susceptibilities in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.

Journal: Antimicrobial agents and chemotherapy 20090701

Title: Lack of pharmacokinetic drug interactions following concomitant administration of telavancin with aztreonam or piperacillin/tazobactam in healthy participants.

Journal: Journal of clinical pharmacology 20090701

Title: In vitro activities of telavancin and vancomycin against biofilm-producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis strains.

Journal: Antimicrobial agents and chemotherapy 20090701

Title: Antimicrobial development in the era of emerging resistance.

Journal: Mini reviews in medicinal chemistry 20090701

Title: Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections associated with surgical procedures.

Journal: American journal of surgery 20090601

Title: Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits.

Journal: Antimicrobial agents and chemotherapy 20090601

Title: Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model.

Journal: The Journal of antimicrobial chemotherapy 20090401

Title: Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.

Journal: Antimicrobial agents and chemotherapy 20090401

Title: The role of telavancin in the treatment of MRSA infections in hospital.

Journal: Expert opinion on investigational drugs 20090401

Title: Postantibiotic effects of telavancin against 16 gram-positive organisms.

Journal: Antimicrobial agents and chemotherapy 20090301

Title: Telavancin: a new lipoglycopeptide for gram-positive infections.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090301

Title: Efficacy of telavancin in the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis: studies with a rabbit model.

Journal: The Journal of antimicrobial chemotherapy 20090201

Title: New antibiotics for healthcare-associated pneumonia.

Journal: Seminars in respiratory and critical care medicine 20090201

Title: Regulatory watch: Non-inferiority-trial discussions impact new drug applications.

Journal: Nature reviews. Drug discovery 20090101

Title: Telavancin.

Journal: Drugs 20090101

Title: Cost-effectiveness of telavancin versus vancomycin for treatment of complicated skin and skin structure infections.

Journal: Pharmacotherapy 20081201

Title: Telavancin and vancomycin pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model.

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: Non-susceptibility trends among staphylococci from bacteraemias in the UK and Ireland, 2001-06.

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: A new lipoglycopeptide: telavancin.

Journal: Expert opinion on pharmacotherapy 20080801

Title: In vitro activity of telavancin against recent Gram-positive clinical isolates: results of the 2004-05 Prospective European Surveillance Initiative.

Journal: The Journal of antimicrobial chemotherapy 20080701

Title: Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States.

Journal: Antimicrobial agents and chemotherapy 20080701

Title: In vitro activity of telavancin against resistant gram-positive bacteria.

Journal: Antimicrobial agents and chemotherapy 20080701

Title: Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).

Journal: The Journal of antimicrobial chemotherapy 20080601

Title: Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080601

Title: Telavancin: an antimicrobial with a multifunctional mechanism of action for the treatment of serious gram-positive infections.

Journal: Pharmacotherapy 20080401

Title: Dalbavancin and telavancin: novel lipoglycopeptides for the treatment of Gram-positive infections.

Journal: Expert review of anti-infective therapy 20080201

Title: Efficacy of telavancin in a murine model of pneumonia induced by methicillin-susceptible Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20080101

Title: In vitro evaluation of the activities of telavancin, cefazolin, and vancomycin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus in peritoneal dialysate.

Journal: Antimicrobial agents and chemotherapy 20071201

Title: Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections.

Journal: Expert review of anti-infective therapy 20071201

Title: Telavancin: a novel lipoglycopeptide antimicrobial agent.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071115

Title: In vitro antimicrobial activity of telavancin against methicillin-resistant Staphylococcus aureus clinical isolates from Japan (2006).

Journal: The Journal of antibiotics 20071101

Title: In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.

Journal: Antimicrobial agents and chemotherapy 20070901

Title: Pharmacodynamic effects of telavancin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains in the presence of human albumin or serum and in an in vitro kinetic model.

Journal: Antimicrobial agents and chemotherapy 20070901

Title: Comparative activity of telavancin against isolates of community-associated methicillin-resistant Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: Efficacy of telavancin in the treatment of experimental endocarditis due to glycopeptide-intermediate Staphylococcus aureus.

Journal: Antimicrobial agents and chemotherapy 20070701

Title: Telavancin: a novel lipoglycopeptide for serious gram-positive infections.

Journal: Expert opinion on investigational drugs 20070301

Title: Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20061201

Title: Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20060801

Title: Comparative activity of the new lipoglycopeptide telavancin in the presence and absence of serum against 50 glycopeptide non-susceptible staphylococci and three vancomycin-resistant Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20060801

Title: Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060801

Title: Antibacterial drug discovery and development--SRI's 11th Annual Summit.

Journal: IDrugs : the investigational drugs journal 20060601

Title: Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study.

Journal: Antimicrobial agents and chemotherapy 20060301

Title: Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters.

Journal: Antimicrobial agents and chemotherapy 20060201

Title: Telavancin: TD 6424, TD-6424.

Journal: Drugs in R&D 20060101

Title: New antibiotics for the treatment of severe staphylococcal infection in the critically ill patient.

Journal: Current opinion in critical care 20051001

Title: Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus.

Journal: Antimicrobial agents and chemotherapy 20051001

Title: Telavancin: in vitro activity against staphylococci in a biofilm model.

Journal: The Journal of antimicrobial chemotherapy 20050801

Title: Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureus.

Journal: Antimicrobial agents and chemotherapy 20050801

Title: Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050601

Title: Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.

Journal: Antimicrobial agents and chemotherapy 20050301

Title: Glycopeptides in clinical development: pharmacological profile and clinical perspectives.

Journal: Current opinion in pharmacology 20041001

Title: Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria.

Journal: Antimicrobial agents and chemotherapy 20040801

Title: Effects of a new antibacterial, telavancin, on cardiac repolarization (QTc interval duration) in healthy subjects.

Journal: Journal of clinical pharmacology 20040701

Title: In vitro activities of the new semisynthetic glycopeptide telavancin (TD-6424), vancomycin, daptomycin, linezolid, and four comparator agents against anaerobic gram-positive species and Corynebacterium spp.

Journal: Antimicrobial agents and chemotherapy 20040601

Title: Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteria.

Journal: The Journal of antimicrobial chemotherapy 20040501

Title: Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).

Journal: The Journal of antibiotics 20040501

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Tags:560130-42-9 Molecular Formula|560130-42-9 MDL|560130-42-9 SMILES|560130-42-9 Telavancin HCl