Title: Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201
Title: Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.
Journal: Chemico-biological interactions 20150605
Title: Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line.
Journal: Chemico-biological interactions 20130225
Title: Progesterone receptors: a key for neuroprotection in experimental stroke.
Journal: Endocrinology 20120801
Title: Decreased startle modulation during anticipation in the postpartum period in comparison to late pregnancy.
Journal: Archives of women's mental health 20120401
Title: Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice.
Journal: Behavioural brain research 20120115
Title: Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women.
Journal: Physiological research 20120101
Title: Fecal progestagens to detect and monitor pregnancy in captive female cheetahs (Acinonyx jubatus).
Journal: The Journal of reproduction and development 20110401
Title: I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female rats.
Journal: Brain research 20110316
Title: Of sound mind and body: depression, disease, and accelerated aging.
Journal: Dialogues in clinical neuroscience 20110301
Title: BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.
Journal: Biochemical and biophysical research communications 20110128
Title: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
Journal: BMC biochemistry 20110101
Title: Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion.
Journal: Frontiers in endocrinology 20110101
Title: Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson's Disease.
Journal: Frontiers in endocrinology 20110101
Title: Neurosteroids and GABA-A Receptor Function.
Journal: Frontiers in endocrinology 20110101
Title: Neurosteroids as neuromodulators in the treatment of anxiety disorders.
Journal: Frontiers in endocrinology 20110101
Title: Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.
Journal: Frontiers in endocrinology 20110101
Title: Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: the activity measurement of 5α-steroid reductase in intact mammalian cells.
Journal: ACS chemical biology 20101119
Title: Fecal steroid metabolites and reproductive monitoring in a female Tsushima leopard cat (Prionailurus bengalensis euptilurus).
Journal: Theriogenology 20101101
Title: Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors.
Journal: Biochimica et biophysica acta 20101101
Title: Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy.
Journal: Cellular and molecular life sciences : CMLS 20100901
Title: A role for Src kinase in progestin facilitation of estrous behavior in estradiol-primed female rats.
Journal: Hormones and behavior 20100701
Title: Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice.
Journal: Physiology & behavior 20100601
Title: Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.
Journal: The Journal of steroid biochemistry and molecular biology 20100215
Title: Immunohistochemical localization and biological activity of 3beta-hydroxysteroid dehydrogenase and 5alpha-reductase in the brain of the frog, Rana esculenta, during development.
Journal: Journal of chemical neuroanatomy 20100101
Title: Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.
Journal: The Journal of steroid biochemistry and molecular biology 20100101
Title: Biotransformation of progesterone by cultured cells of Marchantia polymorpha.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101
Title: Gene expression profiles of intracellular and membrane progesterone receptor isoforms in the mediobasal hypothalamus during pro-oestrus.
Journal: Journal of neuroendocrinology 20091201
Title: Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout, mice.
Journal: Epilepsy & behavior : E&B 20091101
Title: Detection and identification of plasma progesterone metabolites in the female Florida manatee (Trichechus manatus latirostris) using GC/MS/MS.
Journal: Theriogenology 20090801
Title: Role of progesterone receptor isoforms in female sexual behavior induced by progestins in rats.
Journal: Neuroendocrinology 20090101
Title: The vicious cycle towards violence: focus on the negative feedback mechanisms of brain serotonin neurotransmission.
Journal: Frontiers in behavioral neuroscience 20090101
Title: GABA(A) receptor properties in catastrophic infantile epilepsy.
Journal: Epilepsy research 20081001
Title: The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Journal: Biochemistry 20080812
Title: Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
Journal: Journal of medicinal chemistry 20080327
Title: The anti-aromatase effect of progesterone and of its natural metabolites 20alpha- and 5alpha-dihydroprogesterone in the MCF-7aro breast cancer cell line.
Journal: Anticancer research 20080101
Title: Progesterone metabolism in bovine endometrial cells and the effect of metabolites on the responsiveness of the cells to OT-stimulation of PGF2alpha.
Journal: Steroids 20071101
Title: Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry.
Journal: Endocrinology 20070501
Title: Studies on neurosteroids XIX. Development and validation of liquid chromatography-tandem mass spectrometric method for determination of 5alpha-reduced pregnane-type neurosteroids in rat brain and serum.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Title: The impact of ecological variability on the reproductive endocrinology of wild female African elephants.
Journal: Hormones and behavior 20070301
Title: Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum.
Journal: Developmental neurobiology 20070301
Title: Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor.
Journal: Hypertension (Dallas, Tex. : 1979) 20070201
Title: The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats.
Journal: Neuroscience letters 20070110
Title: In silico prediction of pregnane X receptor activators by machine learning approaches.
Journal: Molecular pharmacology 20070101
Title: Androgen decreases osteoprotegerin expression in prostate cancer cells.
Journal: Prostate cancer and prostatic diseases 20070101
Title: Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.
Journal: Journal of molecular neuroscience : MN 20070101
Title: Circulating levels of pregnanolone isomers during the third trimester of human pregnancy.
Journal: The Journal of steroid biochemistry and molecular biology 20070101
Title: Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites.
Journal: The Journal of steroid biochemistry and molecular biology 20070101
Title: Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder.
Journal: Biological psychiatry 20061001
Title: Progesterone and its metabolites 5-dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2.
Journal: Neuro endocrinology letters 20061001
Title: Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective.
Journal: Journal of neurobiology 20060801
Title: Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment.
Journal: The Journal of steroid biochemistry and molecular biology 20060801
Title: The anticonvulsant effects of progesterone and its metabolites on amygdala-kindled seizures in male rats.
Journal: Brain research 20060726
Title: Influence of ginsenoside Rb1 on brain neurosteroid during acute immobilization stress.
Journal: Archives of pharmacal research 20060701
Title: [Steroid 5alpha-reductase deficiency].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060628
Title: Comparative non-radioactive RT-PCR assay: an approach to study the neurosteroids biosynthetic pathway in humans.
Journal: Journal of neuroscience methods 20060615
Title: Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry.
Journal: Endocrinology 20060401
Title: A possible role for progesterone metabolites in human parturition.
Journal: The Australian & New Zealand journal of obstetrics & gynaecology 20060401
Title: Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2.
Journal: Molecular and cellular endocrinology 20060309
Title: Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity.
Journal: Molecular psychiatry 20060301
Title: Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids.
Journal: Endocrine, metabolic & immune disorders drug targets 20060301
Title: Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain.
Journal: Endocrinology 20060101
Title: [Transcriptional regulation of placental transforming growth factor-beta by calcitriol in prostate cancer cells is androgen-independent].
Journal: Molekuliarnaia biologiia 20060101
Title: The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
Journal: Pharmacology, biochemistry, and behavior 20051201
Title: Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment.
Journal: The Journal of steroid biochemistry and molecular biology 20051101
Title: Placentation in the African elephant, Loxodonta africana. IV. Growth and function of the fetal gonads.
Journal: Reproduction (Cambridge, England) 20051101
Title: 3alpha-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period.
Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20051101
Title: CAR and PXR: xenosensors of endocrine disrupters?
Journal: Chemico-biological interactions 20050815
Title: Fine tuning of the specificity of an anti-progesterone antibody by first and second sphere residue engineering.
Journal: The Journal of biological chemistry 20050701
Title: Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids.
Journal: Steroids 20050701
Title: 5 Beta-dihydroprogesterone and steroid 5 beta-reductase decrease in association with human parturition at term.
Journal: Molecular human reproduction 20050701
Title: Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050601
Title: Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Journal: Endocrine-related cancer 20050601
Title: In vitro metabolism of progesterone by canine hair follicle cells.
Journal: Veterinary dermatology 20050601
Title: Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase.
Journal: Brain research 20050408
Title: Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy?
Journal: American journal of obstetrics and gynecology 20050401
Title: Topography and function of androgen-metabolizing enzymes in the central nervous system.
Journal: Anatomical science international 20050301
Title: The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics.
Journal: The Journal of steroid biochemistry and molecular biology 20050201
Title: Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors.
Journal: Molecular and cellular endocrinology 20050114
Title: Studies on neurosteroids XVII. Analysis of stress-induced changes in neurosteroid levels in rat brains using liquid chromatography-electron capture atmospheric pressure chemical ionization-mass spectrometry.
Journal: Steroids 20050101
Title: Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.
Journal: BMC biochemistry 20050101
Title: Regulation of lordosis by cyclic 3',5'-guanosine monophosphate, progesterone, and its 5alpha-reduced metabolites involves mitogen-activated protein kinase.
Journal: Endocrinology 20041201
Title: Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model.
Journal: Epilepsia 20041201
Title: Progestins and place preference conditioning after paced mating.
Journal: Hormones and behavior 20040801
Title: Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways.
Journal: Molecular and cellular endocrinology 20040730
Title: Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.
Journal: Nature medicine 20040701
Title: Insight into the mechanism of action of neuroactive steroids.
Journal: Molecular pharmacology 20040701
Title: Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids.
Journal: The Journal of endocrinology 20040701
Title: Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts.
Journal: Journal of molecular endocrinology 20040201
Title: The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites.
Journal: Hormones and behavior 20040101
Title: Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo.
Journal: Journal of neuroendocrinology 20040101
Title: Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.
Journal: BMC cancer 20040101
Title: Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro.
Journal: Reproductive biology and endocrinology : RB&E 20040101
Title: Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization.
Journal: Pediatric research 20031201
Title: The anticonvulsant effects of progesterone and 5alpha-dihydroprogesterone on amygdala-kindled seizures in rats.
Journal: Epilepsia 20031201
Title: Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.
Journal: Journal of medicinal chemistry 20031023
Title: 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17.
Journal: Archives of biochemistry and biophysics 20031015
Title: Brain neurosteroid changes after paroxetine administration in mice.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20031001
Title: Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20031001
Title: Neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats.
Journal: Brain research 20030808
Title: Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum.
Journal: Journal of neurochemistry 20030801
Title: Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030801
Title: Passage of progesterone into the brain changes with photoperiod in the ewe.
Journal: The European journal of neuroscience 20030801
Title: Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
Journal: Chemico-biological interactions 20030201
Title: Detection and characterization of 20-oxosteroids in rat brains using LC-electron capture APCI-MS after derivatization with 2-nitro-4-trifluoromethylphenylhydrazine.
Journal: The Analyst 20030201
Title: Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area.
Journal: Neuroendocrinology 20030101
Title: Androgen physiology: unsolved problems at the millennium.
Journal: Molecular and cellular endocrinology 20021230
Title: Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).
Journal: Biochemistry 20021112
Title: Progesterone metabolism in human leukemic monoblast U937 cells.
Journal: Endocrine journal 20021001
Title: Reproductive hormonal treatments for mood disorders in women.
Journal: Dialogues in clinical neuroscience 20020601
Title: Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines.
Journal: Biological & pharmaceutical bulletin 20020401
Title: Placentation in the African elephant, Loxodonta africana. I. Endocrinological aspects.
Journal: Reproduction (Cambridge, England) Supplement 20020101
Title: Neuroactive ring A-reduced metabolites of progesterone in human plasma during pregnancy: elevated levels of 5 alpha-dihydroprogesterone in depressed patients during the latter half of pregnancy.
Journal: The Journal of clinical endocrinology and metabolism 20011201
Title: The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders.
Journal: Brain research. Brain research reviews 20011101
Title: Progesterone and 3alpha,5alpha-THP enhance sexual receptivity in mice.
Journal: Behavioral neuroscience 20011001
Title: The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells.
Journal: Endocrine 20011001
Title: Steroidogenic correlates of pregnancy in the rock hyrax (Procavia capensis).
Journal: Life sciences 20010323
Title: Self-augmentation effect of male-specific products on sexually differentiated progesterone metabolism in adult male rat liver microsomes.
Journal: The Journal of biological chemistry 20010216
Title: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19981013
Title: Wiebe JP, et al. The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells. Endocrine. 2001 Oct;16(1):7-14.
