56775-88-3,MFCD00865433
Catalog No.:AA00EB0T

56775-88-3 | ZIMELIDINE DIHYDROCHLORIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
2 weeks  
$1,980.00   $1,386.00
- +
25mg
2 weeks  
$4,633.00   $3,243.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00EB0T
Chemical Name:
ZIMELIDINE DIHYDROCHLORIDE
CAS Number:
56775-88-3
Molecular Formula:
C16H17BrN2
Molecular Weight:
317.2236
MDL Number:
MFCD00865433
SMILES:
CN(C/C=C(\c1cccnc1)/c1ccc(cc1)Br)C
Properties
Properties
 
Storage:
2-8℃;  

Computed Properties
 
Complexity:
293  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.9  

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats.

Journal: Neuropharmacology 20120801

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111001

Title: Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina.

Journal: Journal of neurochemistry 20091001

Title: Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.

Journal: Brain research 20081106

Title: Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070301

Title: Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

Title: Zimelidine decreases seizure susceptibility in stressed mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20061201

Title: Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats.

Journal: Brain research 20060504

Title: A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon.

Journal: Physiology & behavior 20060330

Title: Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry.

Journal: Neurochemistry international 20051001

Title: Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.

Journal: Brain research 20050928

Title: A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata).

Journal: The European journal of neuroscience 20050401

Title: A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201

Title: Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter.

Journal: Nuclear medicine and biology 20040701

Title: Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.

Journal: Brain research 20030718

Title: Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain.

Journal: Brain research 20030613

Title: Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).

Journal: British journal of pharmacology 20030301

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Hospital outcomes in major teaching, minor teaching, and nonteaching hospitals in New York state.

Journal: The American journal of medicine 20020301

Title: A paradigm shift in brain research.

Journal: Science (New York, N.Y.) 20011102

Title: Antagonism of nicotinic acetylcholine receptors by inhibitors of monoamine uptake.

Journal: Molecular psychiatry 20010901

Title: Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity.

Journal: The Journal of pharmacology and experimental therapeutics 20010501

Title: Correction: a note on the discovery of selective serotonin reuptake inhibitors.

Journal: Life sciences 19970101

Title: Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.

Journal: Brain research bulletin 19930101

Title: The specificity of the zimelidine reaction.

Journal: International clinical psychopharmacology 19890101

Title: Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers.

Journal: Archives internationales de pharmacodynamie et de therapie 19880101

Title: Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression?

Journal: Pharmacology, biochemistry, and behavior 19871101

Title: EEG assessment of the sedative and excitatory properties of CNS-active compounds in the patients with depression.

Journal: Neuropsychobiology 19870101

Title: The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients.

Journal: Clinical neuropharmacology 19860101

Title: Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study.

Journal: European journal of clinical pharmacology 19840101

Title: Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.

Journal: Neuropsychobiology 19840101

Title: [Adverse effects and zimelidine therapy. Headache, muscle pain and liver involvement--a new disease entity in zimelidine therapy].

Journal: Lakartidningen 19830105

Title: Pharmacokinetic study of zimelidine using a new GLC method.

Journal: Clinical pharmacokinetics 19830101

Title: Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression.

Journal: Acta psychiatrica Scandinavica. Supplementum 19830101

Title: A double-blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders.

Journal: Acta psychiatrica Scandinavica. Supplementum 19830101

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.) 19821113

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.) 19821009

Title: An open trial of zimelidine in patients with endogenous depression.

Journal: International pharmacopsychiatry 19820101

Title: Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism.

Journal: Journal of neural transmission 19810101

Title: Event recording in a clinical trial of a new medicine.

Journal: British medical journal 19800503

Title: Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients.

Journal: Progress in neuro-psychopharmacology 19800101

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Tags:56775-88-3 Molecular Formula|56775-88-3 MDL|56775-88-3 SMILES|56775-88-3 ZIMELIDINE DIHYDROCHLORIDE
Catalog No.: AA00EB0T
56775-88-3,MFCD00865433
56775-88-3 | ZIMELIDINE DIHYDROCHLORIDE
Pack Size: 5mg
Purity:
2 weeks
$1,980.00 $1,386.00
Pack Size: 25mg
Purity:
2 weeks
$4,633.00 $3,243.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00EB0T
Chemical Name: ZIMELIDINE DIHYDROCHLORIDE
CAS Number: 56775-88-3
Molecular Formula: C16H17BrN2
Molecular Weight: 317.2236
MDL Number: MFCD00865433
SMILES: CN(C/C=C(\c1cccnc1)/c1ccc(cc1)Br)C
Properties
Storage: 2-8℃;  
Complexity: 293  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.9  
Literature fold

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology20170515

Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20140101

Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20131201

Title: Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats.

Journal: Neuropharmacology20120801

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20111001

Title: Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina.

Journal: Journal of neurochemistry20091001

Title: Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.

Journal: Brain research20081106

Title: Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20070301

Title: Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20070115

Title: Zimelidine decreases seizure susceptibility in stressed mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20061201

Title: Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats.

Journal: Brain research20060504

Title: A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon.

Journal: Physiology & behavior20060330

Title: Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry.

Journal: Neurochemistry international20051001

Title: Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.

Journal: Brain research20050928

Title: A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata).

Journal: The European journal of neuroscience20050401

Title: A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20050201

Title: Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter.

Journal: Nuclear medicine and biology20040701

Title: Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.

Journal: Brain research20030718

Title: Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain.

Journal: Brain research20030613

Title: Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).

Journal: British journal of pharmacology20030301

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Hospital outcomes in major teaching, minor teaching, and nonteaching hospitals in New York state.

Journal: The American journal of medicine20020301

Title: A paradigm shift in brain research.

Journal: Science (New York, N.Y.)20011102

Title: Antagonism of nicotinic acetylcholine receptors by inhibitors of monoamine uptake.

Journal: Molecular psychiatry20010901

Title: Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity.

Journal: The Journal of pharmacology and experimental therapeutics20010501

Title: Correction: a note on the discovery of selective serotonin reuptake inhibitors.

Journal: Life sciences19970101

Title: Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.

Journal: Brain research bulletin19930101

Title: The specificity of the zimelidine reaction.

Journal: International clinical psychopharmacology19890101

Title: Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers.

Journal: Archives internationales de pharmacodynamie et de therapie19880101

Title: Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression?

Journal: Pharmacology, biochemistry, and behavior19871101

Title: EEG assessment of the sedative and excitatory properties of CNS-active compounds in the patients with depression.

Journal: Neuropsychobiology19870101

Title: The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients.

Journal: Clinical neuropharmacology19860101

Title: Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study.

Journal: European journal of clinical pharmacology19840101

Title: Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.

Journal: Neuropsychobiology19840101

Title: [Adverse effects and zimelidine therapy. Headache, muscle pain and liver involvement--a new disease entity in zimelidine therapy].

Journal: Lakartidningen19830105

Title: Pharmacokinetic study of zimelidine using a new GLC method.

Journal: Clinical pharmacokinetics19830101

Title: Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression.

Journal: Acta psychiatrica Scandinavica. Supplementum19830101

Title: A double-blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders.

Journal: Acta psychiatrica Scandinavica. Supplementum19830101

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.)19821113

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.)19821009

Title: An open trial of zimelidine in patients with endogenous depression.

Journal: International pharmacopsychiatry19820101

Title: Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism.

Journal: Journal of neural transmission19810101

Title: Event recording in a clinical trial of a new medicine.

Journal: British medical journal19800503

Title: Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients.

Journal: Progress in neuro-psychopharmacology19800101

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