Home Amines 60525-15-7
60525-15-7,MFCD01530068
Catalog No.:AA00EGL9

60525-15-7 | Zimelidine 2HCl

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Purity
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Price(USD)
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10mg
As reported
2 weeks  
$697.00   $488.00
- +
50mg
As reported
2 weeks  
$1,270.00   $889.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EGL9
Chemical Name:
Zimelidine 2HCl
CAS Number:
60525-15-7
Molecular Formula:
C16H19BrCl2N2
Molecular Weight:
390.1455
MDL Number:
MFCD01530068
SMILES:
CN(C/C=C(\c1cccnc1)/c1ccc(cc1)Br)C.Cl.Cl
Properties
Properties
 
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
293  
Covalently-Bonded Unit Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats.

Journal: Neuropharmacology 20120801

Title: Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina.

Journal: Journal of neurochemistry 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.

Journal: Brain research 20081106

Title: Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

Title: Zimelidine decreases seizure susceptibility in stressed mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20061201

Title: Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats.

Journal: Brain research 20060504

Title: A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon.

Journal: Physiology & behavior 20060330

Title: Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry.

Journal: Neurochemistry international 20051001

Title: A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata).

Journal: The European journal of neuroscience 20050401

Title: Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter.

Journal: Nuclear medicine and biology 20040701

Title: Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development.

Journal: Brain research 20030718

Title: Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain.

Journal: Brain research 20030613

Title: Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).

Journal: British journal of pharmacology 20030301

Title: Hospital outcomes in major teaching, minor teaching, and nonteaching hospitals in New York state.

Journal: The American journal of medicine 20020301

Title: A paradigm shift in brain research.

Journal: Science (New York, N.Y.) 20011102

Title: Antagonism of nicotinic acetylcholine receptors by inhibitors of monoamine uptake.

Journal: Molecular psychiatry 20010901

Title: Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity.

Journal: The Journal of pharmacology and experimental therapeutics 20010501

Title: Correction: a note on the discovery of selective serotonin reuptake inhibitors.

Journal: Life sciences 19970101

Title: Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.

Journal: Brain research bulletin 19930101

Title: The specificity of the zimelidine reaction.

Journal: International clinical psychopharmacology 19890101

Title: Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers.

Journal: Archives internationales de pharmacodynamie et de therapie 19880101

Title: Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression?

Journal: Pharmacology, biochemistry, and behavior 19871101

Title: EEG assessment of the sedative and excitatory properties of CNS-active compounds in the patients with depression.

Journal: Neuropsychobiology 19870101

Title: The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients.

Journal: Clinical neuropharmacology 19860101

Title: Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study.

Journal: European journal of clinical pharmacology 19840101

Title: [Adverse effects and zimelidine therapy. Headache, muscle pain and liver involvement--a new disease entity in zimelidine therapy].

Journal: Lakartidningen 19830105

Title: Pharmacokinetic study of zimelidine using a new GLC method.

Journal: Clinical pharmacokinetics 19830101

Title: Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression.

Journal: Acta psychiatrica Scandinavica. Supplementum 19830101

Title: A double-blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders.

Journal: Acta psychiatrica Scandinavica. Supplementum 19830101

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.) 19821113

Title: Severe headache and disturbed liver function during treatment with zimelidine.

Journal: British medical journal (Clinical research ed.) 19821009

Title: An open trial of zimelidine in patients with endogenous depression.

Journal: International pharmacopsychiatry 19820101

Title: Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism.

Journal: Journal of neural transmission 19810101

Title: Event recording in a clinical trial of a new medicine.

Journal: British medical journal 19800503

Title: Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients.

Journal: Progress in neuro-psychopharmacology 19800101

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