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568-72-9,MFCD00238692
Catalog No.:AA00IA1O

568-72-9 | Tanshinone iia

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1mg
97%
in stock  
$7.00   $5.00
- +
5mg
97%
in stock  
$17.00   $12.00
- +
10mg
97%
in stock  
$21.00   $15.00
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25mg
97%
in stock  
$27.00   $19.00
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50mg
97%
in stock  
$33.00   $23.00
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100mg
97%
in stock  
$52.00   $36.00
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250mg
97%
in stock  
$63.00   $44.00
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1g
97%
in stock  
$184.00   $129.00
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5g
97%
in stock  
$552.00   $387.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IA1O
Chemical Name:
Tanshinone iia
CAS Number:
568-72-9
Molecular Formula:
C19H18O3
Molecular Weight:
294.3444
MDL Number:
MFCD00238692
SMILES:
O=C1c2c3CCCC(c3ccc2c2c(C1=O)c(C)co2)(C)C
NSC Number:
686519
Properties
Computed Properties
 
Complexity:
509  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
4.3  

Downstream Synthesis Route

[1]JournalofOrganicChemistry,1995,vol.60,p.8341-8350

(+/-)-cryptotanshinone 
  568-72-9 

[1]Jiang,Ying-Yan;Li,Qian;Lu,Wei;Cai,Jun-Chao[TetrahedronLetters,2003,vol.44,#10,p.2073-2075]

[1]Chen,Shuang;Liu,Jiangxin;Ren,Jian;Yang,Kun;Yang,Xinni;Zhao,Qin-Shi[EuropeanJournalofMedicinalChemistry,2022,vol.235]

[2]Chen,Shuang;Liu,Jiangxin;Ren,Jian;Yang,Kun;Yang,Xinni;Zhao,Qin-Shi[EuropeanJournalofMedicinalChemistry,2022,vol.235]

[3]CurrentPatentAssignee:BEIJINGJIANQIAOMEDICINETECH-CN106146605,2016,ALocationinpatent:Paragraph0043;0044;0045;0046;0047

[4]Locationinpatent:schemeortableBi,Yue-Feng;Xu,Hai-Wei;Liu,Xiao-Qing;Zhang,Xiao-Juan;Wang,Zhen-Ji;Liu,Hong-Min[BioorganicandMedicinalChemistryLetters,2010,vol.20,#16,p.4892-4894]

[5]CurrentPatentAssignee:CHANGZHOUUNIVERSITY-CN103193860,2016,BLocationinpatent:Paragraph0023;0080-0082

[6]CurrentPatentAssignee:NANJINGMEIZHUPHARMACEUTICALSCIENCEANDTECH;NANJINGKELITAIPHARMACEUTICALSCIENCEANDTECH;CHINAPHARMACEUTICALUNIVERSITY-CN105884856,2016,ALocationinpatent:Paragraph0047;0051;0053

[1]Chen,Shuang;Liu,Jiangxin;Ren,Jian;Yang,Kun;Yang,Xinni;Zhao,Qin-Shi[EuropeanJournalofMedicinalChemistry,2022,vol.235]

[2]Chen,Shuang;Liu,Jiangxin;Ren,Jian;Yang,Kun;Yang,Xinni;Zhao,Qin-Shi[EuropeanJournalofMedicinalChemistry,2022,vol.235]

[3]CurrentPatentAssignee:CHINAPHARMACEUTICALUNIVERSITY-CN107811996,2018,ALocationinpatent:Paragraph0037

[4]Locationinpatent:schemeortableBi,Yue-Feng;Wang,Zhen-Ji;Guan,Ruo-Fei;Ye,Yu-Ting;Chen,Yuan-Yuan;Zhang,Yan-Bing;Liu,Hong-Min[BioorganicandMedicinalChemistryLetters,2012,vol.22,#15,p.5141-5143]

568-72-9   
sodium1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7Hnaphtho1,2-g1benzofuran-2-sulfonate 

[1]CurrentPatentAssignee:SHANGHAIXINGYEPHARMACEUTICALTECH-CN109988220,2019,ALocationinpatent:Paragraph0033;0034;0035;0036;0037

[2]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES-CN103739662,2016,BLocationinpatent:Paragraph0024;0026;0027;0028;0030;0032

[3]CurrentPatentAssignee:CAREFREEPHARMACEUTICAL-CN104910251,2016,BLocationinpatent:Paragraph0039-0041

[4]CurrentPatentAssignee:Liu,Li-US2012/277304,2012,A1Locationinpatent:Page/Pagecolumn4

[5]Qin,Yin-Lin;Chen,Lei;He,Wei;Su,Mei;Jin,Qiu;Fang,Zheng;Ouyang,Ping-Kai;Guo,Kai[JournalofAsianNaturalProductsResearch,2018,vol.20,#2,p.139-147]

Literature

Title: Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.

Journal: Toxicology and applied pharmacology 20180401

Title: Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B.

Journal: Chemico-biological interactions 20171225

Title: Tanshinone IIA ameliorated endothelial dysfunction in rats with chronic intermittent hypoxia.

Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20170101

Title: Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

Journal: The New phytologist 20160401

Title: Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines.

Journal: Chemical research in toxicology 20150817

Title: Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.

Journal: Chemico-biological interactions 20150325

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.

Journal: Chinese journal of integrative medicine 20121101

Title: Tanshinone IIA in acute promyelocytic leukemia.

Journal: The American journal of the medical sciences 20121001

Title: PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots.

Journal: Physiologia plantarum 20121001

Title: Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.

Journal: Bioorganic & medicinal chemistry 20121001

Title: Release behavior of tanshinone IIA sustained-release pellets based on crack formation theory.

Journal: Journal of pharmaceutical sciences 20120801

Title: Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

Journal: Translational research : the journal of laboratory and clinical medicine 20120801

Title: Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca²⁺-calmodulin pathway.

Journal: Journal of ethnopharmacology 20120801

Title: Design, synthesis and vasodilative activity of tanshinone IIA derivatives.

Journal: Bioorganic & medicinal chemistry letters 20120801

Title: [Clarithromycin combined with tanshinone for rhinosinusal and laryngeal radiation injury in patients with nasopharyngeal carcinoma after radiotherapy].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120801

Title: The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron.

Journal: Brain research bulletin 20120701

Title: Rational design of core-shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge.

Journal: Analytical and bioanalytical chemistry 20120701

Title: [Effects of tanshinone IIA on Wnt/beta-catenin signaling pathway of high glucose induced renal tubular epithelial cell transdifferentiation].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120701

Title: Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling.

Journal: Pharmaceutical research 20120601

Title: Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.

Journal: Molecular biology reports 20120601

Title: Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition.

Journal: Planta medica 20120601

Title: Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway.

Journal: International journal of cardiology 20120531

Title: Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120515

Title: Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots.

Journal: Plant cell reports 20120501

Title: Tanshinone IIA inhibits BT-20 human breast cancer cell proliferation through increasing caspase 12, GADD153 and phospho-p38 protein expression.

Journal: International journal of molecular medicine 20120501

Title: Tanshinones increase fibrinolysis through inhibition of plasminogen activator inhibitor-1.

Journal: CNS neuroscience & therapeutics 20120501

Title: [Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501

Title: [Study on solid dispersion of binary vector of tanshinone II A].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Title: Tanshinone IIA inhibits human breast cancer MDA-MB-231 cells by decreasing LC3-II, Erb-B2 and NF-κBp65.

Journal: Molecular medicine reports 20120401

Title: Tanshinone IIA-loaded reconstituted high density lipoproteins: Atherosclerotic plaque targeting mechanism in a foam cell model and pharmacokinetics in rabbits.

Journal: Die Pharmazie 20120401

Title: Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.

Journal: Journal of separation science 20120401

Title: Development of intravenous lipid emulsion of tanshinone IIA and evaluation of its anti-hepatoma activity in vitro.

Journal: International journal of pharmaceutics 20120315

Title: Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.

Journal: Molecules (Basel, Switzerland) 20120227

Title: Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

Title: Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation.

Journal: Molecular medicine reports 20120201

Title: Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo.

Journal: Oncology reports 20120201

Title: Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120201

Title: Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro.

Journal: Anti-cancer drugs 20120201

Title: Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.

Journal: Bioorganic & medicinal chemistry 20120201

Title: Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A.

Journal: Journal of medicinal chemistry 20120126

Title: Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115

Title: Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress.

Journal: European journal of pharmacology 20120115

Title: Cardiovascular actions and therapeutic potential of tanshinone IIA.

Journal: Atherosclerosis 20120101

Title: Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells.

Journal: Journal of natural medicines 20120101

Title: Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo.

Journal: Molecular medicine reports 20120101

Title: Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.

Journal: Clinical and experimental pharmacology & physiology 20120101

Title: Protection of Tanshinone IIA to human peritoneal mesothelial cells (HPMC) through delaying cellular senescence induced by high glucose.

Journal: Renal failure 20120101

Title: Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.

Journal: Frontiers in bioscience (Elite edition) 20120101

Title: Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling.

Journal: BMC complementary and alternative medicine 20120101

Title: Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Metabolic profiles and cDNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f. tomentosa Stib.

Journal: PloS one 20120101

Title: Analysis of Danshen and twelve related Salvia species.

Journal: Natural product communications 20120101

Title: Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.

Journal: PloS one 20120101

Title: Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats.

Journal: PloS one 20120101

Title: Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.

Journal: Bioorganic & medicinal chemistry letters 20111215

Title: Tanshinone IIa alleviates the biochemical changes associated with hypoxic ischemic brain damage in a rat model.

Journal: Phytotherapy research : PTR 20111201

Title: [Correlation between expression level of functional genes and tanshinones' accumulation in Salvia miltiorrhiza from different areas].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201

Title: Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells.

Journal: Cancer letters 20111128

Title: Tanshinone IIA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression.

Journal: American journal of respiratory cell and molecular biology 20111101

Title: Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20111101

Title: Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.

Journal: Archives of biochemistry and biophysics 20111101

Title: [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111101

Title: Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model.

Journal: International journal of pharmaceutics 20111031

Title: [Investigation on the molecular structures and electronic absorption spectra of Tanshinone II A and Tanshinone II A -Cu(II) complex].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20111001

Title: Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells.

Journal: European journal of pharmacology 20110930

Title: Development of a strategy and process parameters for a green process in counter-current chromatography: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study.

Journal: Journal of chromatography. A 20110909

Title: Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.

Journal: International journal of cancer 20110901

Title: Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets.

Journal: Journal of ethnopharmacology 20110901

Title: [Study on the pharmacokinetics of tashinone II(A) -loaded polylactic acid nanoparticles in rabbit].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110901

Title: In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Preparation, characterization and cytotoxicity evaluation of tanshinone IIA nanoemulsions.

Journal: Journal of biomedical nanotechnology 20110801

Title: [Apoptosis inducing effect of tanshinone II(A) on human nasopharyngeal carcinoma CNE cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.

Journal: Talanta 20110715

Title: Extraction and preparative purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701

Title: [Effect of tanshinone II A on TLR4 and TNF-α of endothelial cells induced by LPS].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110701

Title: Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase-derived reactive oxygen species production in hypertensive rats.

Journal: Die Pharmazie 20110701

Title: Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship.

Journal: Fitoterapia 20110601

Title: Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.

Journal: Journal of ethnopharmacology 20110601

Title: QSAR study for cytotoxicity of diterpenoid tanshinones.

Journal: Interdisciplinary sciences, computational life sciences 20110601

Title: Preparation and physicochemical characterizations of tanshinone IIA solid dispersion.

Journal: Archives of pharmacal research 20110601

Title: Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.

Journal: Metabolic engineering 20110501

Title: Nano-LC-MS/MS based proteomics of hepatocellular carcinoma cells compared to Chang liver cells and tanshinone IIA induction.

Journal: Molecular bioSystems 20110501

Title: In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

Journal: Environmental toxicology and pharmacology 20110501

Title: [Effects of elicitors on accumulation of phenolic acids and tanshinones in Salvia miltiorrhiza hairy root].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

Title: [Effects of phytohormones on hairy root growth and tanshinone biosynthesis of Salvia miltiorrhiza].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

Title: Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lung.

Journal: Respiratory physiology & neurobiology 20110430

Title: Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

Title: Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray.

Journal: Molecular biology reports 20110401

Title: Modeling of tanshinone synthesis and phase distribution under the combined effect of elicitation and in situ adsorption in Salvia miltiorrhiza hairy root cultures.

Journal: Biotechnology letters 20110401

Title: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.

Journal: Toxicology and applied pharmacology 20110401

Title: Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways.

Journal: Therapeutic advances in cardiovascular disease 20110401

Title: Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure.

Journal: Clinical and experimental pharmacology & physiology 20110401

Title: Plant density-dependent variations in bioactive markers and root yield in Australian-grown Salvia miltiorrhiza Bunge.

Journal: Chemistry & biodiversity 20110401

Title: Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

Journal: Journal of ethnopharmacology 20110308

Title: Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide.

Journal: Journal of ethnopharmacology 20110308

Title: Regulation of adhesion molecules expression in TNF-α-stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF-κB and ROS generation.

Journal: Phytotherapy research : PTR 20110301

Title: Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer cells.

Journal: Oncology reports 20110301

Title: Molecular imprinting in ionic liquid-modified porous polymer for recognitive separation of three tanshinones from Salvia miltiorrhiza Bunge.

Journal: Analytical and bioanalytical chemistry 20110301

Title: Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

Journal: Natural product reports 20110301

Title: Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization.

Journal: Journal of cardiovascular pharmacology 20110301

Title: [Effects of soil water content on seedlings growth and active ingredients of Salvia miltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110201

Title: [Growth inhibition of tanshinones on SPC-A-1 cell line and their structure-activity relationship].

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20110120

Title: Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation.

Journal: Journal of plant physiology 20110115

Title: Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.

Journal: European journal of pharmacology 20110110

Title: Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy.

Journal: Cardiovascular diabetology 20110101

Title: [Effect of sulfonic tanshinone sodium injection on the expression and activity of aquaporin-5 of human alveolar epithelial cells after seawater exposure].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20110101

Title: Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Tanshinone IIA attenuates peritoneal fibrosis through inhibition of fibrogenic growth factors expression in peritoneum in a peritoneal dialysis rat model.

Journal: Renal failure 20110101

Title: Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat cardiac fibroblasts.

Journal: The American journal of Chinese medicine 20110101

Title: Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway.

Journal: International journal of biological sciences 20110101

Title: Tanshinone IIA attenuates seawater aspiration-induced lung injury by inhibiting macrophage migration inhibitory factor.

Journal: Biological & pharmaceutical bulletin 20110101

Title: [The quality of Salvia miltforthiza from Beijing suburbs with different growing modes].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110101

Title: Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

Title: The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201

Title: The neuroprotective effects of tanshinone IIA on β-amyloid-induced toxicity in rat cortical neurons.

Journal: Neuropharmacology 20101201

Title: Tanshinone IIA protects the human blood-brain barrier model from leukocyte-associated hypoxia-reoxygenation injury.

Journal: European journal of pharmacology 20101201

Title: The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts.

Journal: Arthritis and rheumatism 20101201

Title: Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20101201

Title: Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.

Journal: Phytotherapy research : PTR 20101201

Title: Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes.

Journal: Acta pharmacologica Sinica 20101201

Title: [Inhibitory effect of tanshinones on proliferation of K562 cell line and its structure-activity relationship].

Journal: Zhongguo shi yan xue ye xue za zhi 20101201

Title: Study of anti-myocardial cell oxidative stress action and effect of tanshinone IIA on prohibitin expression.

Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20101201

Title: Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: Tanshinone IIA enhances BMP-2-stimulated commitment of C2C12 cells into osteoblasts via p38 activation.

Journal: Amino acids 20101101

Title: A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway.

Journal: Cancer letters 20101101

Title: Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro.

Journal: Annals of hematology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: C/EBPβ and CHOP participate in tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro.

Journal: International journal of hematology 20101101

Title: [A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

Title: [Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: [Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101101

Title: Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice.

Journal: Journal of ethnopharmacology 20101028

Title: [Preparation and in vitro evaluation of tanshinone IIA pulsatile release pellets].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20101018

Title: Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100901

Title: Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression.

Journal: International journal of molecular medicine 20100901

Title: Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures.

Journal: Applied microbiology and biotechnology 20100901

Title: Preparation and evaluation of silica-based ionic liquid-modified stationary phase for HPLC.

Journal: Journal of chromatographic science 20100901

Title: [Effect of tanshinone IIA pretreatment on IL-1β and RelA mRNA expression in rats with focal cerebral ischemia].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100901

Title: [Effect of Tanshinone IIA on phosphorylated NMDA receptor 1 expression and intracellular free calcium concentration in neonatal SD rats with hypoxic ischemic brain damage].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100901

Title: Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats.

Journal: European journal of pharmacology 20100825

Title: Synthesis and vasodilative activity of tanshinone IIA derivatives.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: [Effect of tanshinone IIA on the change of calcium current induced by beta-amyloid protein 25-35 in neurons of nucleus basalis of Meynert].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100801

Title: [Data distribution characteristics and deviation of tanshinone IIA content in Radix Salviae Miltiorrhizae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701

Title: [Dissolution of tanshinone IIA from xianling gubao capsule].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

Title: [Neuroprotective effects of tanshinone II A on vascular dementia in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

Title: Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures.

Journal: Applied microbiology and biotechnology 20100601

Title: Nanostructured lipid carriers constituted from high-density lipoprotein components for delivery of a lipophilic cardiovascular drug.

Journal: International journal of pharmaceutics 20100531

Title: The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.

Journal: Brain research bulletin 20100531

Title: Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

Journal: Journal of natural products 20100528

Title: Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.

Journal: Journal of ethnopharmacology 20100527

Title: Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition.

Journal: Pharmaceutical biology 20100501

Title: [Effect of tanshinone II A on the transforming growth factor beta1/Smads signal pathway in rats with hypertensive myocardial hypertrophy].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100501

Title: [Self-microemulsifying drug delivery system increasing solubility and intestinal absorption in situ of tanshinones].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

Title: Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100415

Title: Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

Journal: Diabetes, obesity & metabolism 20100401

Title: [Study on the chemical stability of tanshinone IIA].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

Title: [Transcriptome characterization for Salvia miltiorrhiza using 454 GS FLX].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401

Title: Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia.

Journal: Brain research 20100319

Title: Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines.

Journal: Immunopharmacology and immunotoxicology 20100301

Title: Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100301

Title: Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells.

Journal: Proteomics 20100301

Title: Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells.

Journal: Neuroscience letters 20100212

Title: Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential.

Journal: International journal of molecular medicine 20100201

Title: Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.

Journal: Neuroscience bulletin 20100201

Title: Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells.

Journal: Basic & clinical pharmacology & toxicology 20100101

Title: Direct purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography without presaturation of the two-phase solvent mixture.

Journal: Journal of separation science 20100101

Title: [Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

Title: [A study on the effect of Tanshinone II A against human breast cancer in vivo].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

Title: Down-regulation of telomerase activity and activation of caspase-3 are responsible for Tanshinone I-induced apoptosis in monocyte leukemia cells in vitro.

Journal: International journal of molecular sciences 20100101

Title: Tanshinone IIA increases mRNA expression of efflux transporters in cultured human intestinal cell.

Journal: The American journal of Chinese medicine 20100101

Title: Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography/tandem mass spectrometry.

Journal: Arzneimittel-Forschung 20100101

Title: Tanshinone IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer.

Journal: International journal of molecular medicine 20091201

Title: Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge.

Journal: Journal of separation science 20091201

Title: Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.

Journal: Cancer biotherapy & radiopharmaceuticals 20091201

Title: A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.

Journal: Organic letters 20091119

Title: Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

Journal: Cancer letters 20091118

Title: Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.

Journal: Biochemical pharmacology 20091115

Title: Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091101

Title: Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT).

Journal: Journal of cellular biochemistry 20091101

Title: Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1.

Journal: British journal of pharmacology 20091101

Title: Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.

Journal: Acta pharmacologica Sinica 20091101

Title: [Effect of tanshinone II on hepatic fibrosis in mice].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20091101

Title: Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.

Journal: British journal of pharmacology 20091001

Title: Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats.

Journal: Chinese journal of integrative medicine 20091001

Title: Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.

Journal: European journal of pharmacology 20090901

Title: Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20090901

Title: [Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901

Title: Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090801

Title: The effect of tanshinone IIA upon the TGF-beta1/Smads signaling pathway in hypertrophic myocardium of hypertensive rats.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090801

Title: [A new identification and quautitation method for radix Salviae miltiorrhizae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: Metabolic profiles of three related Salvia species.

Journal: Fitoterapia 20090701

Title: Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701

Title: Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current.

Journal: Journal of pharmacological sciences 20090701

Title: [Tanshinone IIA down-regulates the expression of MMP-12 and TF in RAW 264.7 cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090701

Title: HPLC profiles and biomarker contents of Australian-grown Salvia miltiorrhiza f. alba roots.

Journal: Chemistry & biodiversity 20090701

Title: Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris.

Journal: International journal of cardiology 20090626

Title: Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice.

Journal: Phytotherapy research : PTR 20090501

Title: Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090501

Title: Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats.

Journal: Die Pharmazie 20090501

Title: Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090401

Title: Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis.

Journal: Oncology reports 20090401

Title: Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity.

Journal: European journal of pharmacology 20090401

Title: Seasonal variations in bioactive marker contents in Australian-grown Salvia miltiorrhiza roots.

Journal: Chemistry & biodiversity 20090401

Title: Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies.

Journal: Chinese journal of integrative medicine 20090401

Title: Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315

Title: [Effect of Tanshinone II A on expression of EGF and EGFR in hepatocellular carcinoma cell line SMMC-7721].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090301

Title: [A study on anticancer activity of tanshinone II A against human breast cancer].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090301

Title: [Influence of solid dispersion technique combination on dissolution of tanshinone IIA].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

Title: Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.

Journal: Clinical and experimental pharmacology & physiology 20090201

Title: Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.

Journal: Biological & pharmaceutical bulletin 20090201

Title: Cultivar variations of Australian-grown Danshen (Salvia miltiorrhiza): bioactive markers and root yields.

Journal: Chemistry & biodiversity 20090201

Title: [Effects of Tanshinone IIa on cytokines and platelets in immune vasculitis and its mechanism].

Journal: Zhongguo shi yan xue ye xue za zhi 20090201

Title: [Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090201

Title: The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.

Journal: The Journal of steroid biochemistry and molecular biology 20090201

Title: PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.

Journal: Chemico-biological interactions 20090115

Title: Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots.

Journal: Biotechnology and applied biochemistry 20090101

Title: The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.

Journal: Endocrinology 20090101

Title: [Effect of tanshinone II A on NB4 cell induced procoagulant activity in human umbilical vein endothelial cells].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090101

Title: [AOTF-near infrared spectroscopy for determining tanshinone II A in returning extraction process of Salvia miltiorrhiza].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090101

Title: Genetic stability, active constituent, and pharmacoactivity of Salvia miltiorrhiza hairy roots and wild plant.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.

Journal: Drug and chemical toxicology 20090101

Title: The effect of tanshinone IIA on the cardiovascular system in ovine fetus in utero.

Journal: The American journal of Chinese medicine 20090101

Title: Study on the intestinal absorption profiles of tanshinone IIA and its inclusion complex with cyclodextrin in rats.

Journal: PDA journal of pharmaceutical science and technology 20090101

Title: Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.

Journal: Tumori 20090101

Title: Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.

Journal: European journal of pharmacology 20081228

Title: Investigation of Danshen and related medicinal plants in China.

Journal: Journal of ethnopharmacology 20081208

Title: Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells.

Journal: Phytotherapy research : PTR 20081201

Title: Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma.

Journal: Journal of drug targeting 20081201

Title: Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.

Journal: International journal of molecular medicine 20081201

Title: Tanshinone IIA interacts with DNA by minor groove-binding.

Journal: Biological & pharmaceutical bulletin 20081201

Title: [A full length cDNA of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase cloning and analysis of introduced gene expression in Salvia miltiorrhiza].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081201

Title: [Study of molecular mechanism of tanshinone II A inducing differentiation in acute promyelocytic leukemia NB4 cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

Title: Vascular effects of different lipophilic components of 'Danshen', a traditional Chinese medicine, in the isolated porcine coronary artery.

Journal: Journal of natural products 20081101

Title: Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells.

Journal: International journal of molecular medicine 20081101

Title: Anticancer effects of tanshinone I in human non-small cell lung cancer.

Journal: Molecular cancer therapeutics 20081101

Title: [Experiment of extracting Salviae miltiorrhizae on using O/W microemulsion].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase.

Journal: Life sciences 20081010

Title: Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.

Journal: Carcinogenesis 20081001

Title: Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20081001

Title: Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.

Journal: Cell biochemistry and function 20081001

Title: Effects of tanshinone IIA on transforming growth factor beta1-Smads signal pathway in renal interstitial fibroblasts of rats.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

Title: Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.

Journal: Clinical and investigative medicine. Medecine clinique et experimentale 20081001

Title: [Study of growth inhibitory effect and apoptosis induced by different matches of Tanshinone IIA and Salvianolic Acid B on Acute Promyelocytic Leukemia cells (HL-60)].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001

Title: Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels.

Journal: Journal of ethnopharmacology 20080926

Title: Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest.

Journal: Life sciences 20080912

Title: Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells.

Journal: Planta medica 20080901

Title: Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells.

Journal: International journal of oncology 20080901

Title: Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios.

Journal: International journal of molecular medicine 20080901

Title: Determination of tanshinone I in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.

Journal: Journal of chromatographic science 20080901

Title: [Mechanism of copper and zinc on tanshinones of cultivated Salvia miltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: [Inhibitory effects and mechanism of tanshinone IIA on proliferation of rat aortic smooth muscle cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels.

Journal: European journal of pharmacology 20080820

Title: Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801

Title: Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways.

Journal: Innate immunity 20080801

Title: Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.

Journal: Biological & pharmaceutical bulletin 20080801

Title: [Optimization of enzymatic extraction of effective constituents from fibrous roots of Salvia miltiorrhiza by central composite design and response surface method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

Title: Role of P-glycoprotein in the transport of tanshinone I, one active triterpenoid from Salvia miltiorrhiza.

Journal: Drug metabolism letters 20080801

Title: [Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701

Title: Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.

Journal: Phytotherapy research : PTR 20080601

Title: T-DNA activation tagging as a tool to isolate Salvia miltiorrhiza transgenic lines for higher yields of tanshinones.

Journal: Planta medica 20080601

Title: Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.

Journal: Archives of pharmacal research 20080601

Title: [Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway.

Journal: Journal of cellular biochemistry 20080501

Title: Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF.

Journal: Biomedical chromatography : BMC 20080501

Title: Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease.

Journal: Archives of pharmacal research 20080501

Title: Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080401

Title: [Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

Title: [Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401

Title: Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots.

Journal: Applied microbiology and biotechnology 20080301

Title: [Comparison of tanshinone IIA in Radix Salviae Miltorrhizae from Shandong].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

Title: [Study on technical processes for extraction and purification of total tanshinones].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

Title: [Tanshinone II A inhibits in vitro cellular proliferation and migration of vascular smooth muscle cell of rabbit].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301

Title: Tanshinone IIA ameliorates trinitrobenzene sulfonic acid (TNBS)-induced murine colitis.

Journal: Digestive diseases and sciences 20080201

Title: Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen.

Journal: Journal of separation science 20080201

Title: Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080201

Title: Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.

Journal: Translational research : the journal of laboratory and clinical medicine 20080201

Title: [A new method for quick analysis of tanshinone II(A) and salvianolic acid in Fufang Danshen tablets by AOTF-near infrared spectroscopy].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

Title: Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.

Journal: Journal of ethnopharmacology 20080117

Title: Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

Title: Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

Title: The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.

Journal: Current drug metabolism 20080101

Title: [Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101

Title: Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin.

Journal: The international journal of biochemistry & cell biology 20080101

Title: The correlation of Salvia miltiorrhiza extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone.

Journal: Immunopharmacology and immunotoxicology 20080101

Title: Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231

Title: Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root-bacteria coculture process.

Journal: Applied microbiology and biotechnology 20071201

Title: Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201

Title: Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20071201

Title: [Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

Title: Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.

Journal: European journal of pharmacology 20071128

Title: Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.

Journal: Biomedical chromatography : BMC 20071101

Title: Establishment of a new human glioblastoma multiforme cell line (WJ1) and its partial characterization.

Journal: Cellular and molecular neurobiology 20071101

Title: Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet.

Journal: Life sciences 20071013

Title: PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

Title: In situ intestinal absorption behaviors of tanshinone IIA from its inclusion complex with hydroxypropyl-beta-cyclodextrin.

Journal: Biological & pharmaceutical bulletin 20071001

Title: [Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis].

Journal: Zhonghua yi xue za zhi 20070911

Title: Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.

Journal: Journal of pharmaceutical and biomedical analysis 20070903

Title: Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS).

Journal: Journal of separation science 20070901

Title: [In situ extraction effect of macroporous resins on tanshinones in Salvia miltiorrhiza hairy root culture].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: [Contrast studies on content of hydrophobic components between Salvia yunnanensis roots and Salvia miltiorrhiza roots].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

Title: Complexation of tanshinone IIA with 2-hydroxypropyl-beta-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats.

Journal: International journal of pharmaceutics 20070816

Title: Tanshinone IIA inhibits endothelin-1 production in TNF-alpha-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis.

Journal: Acta pharmacologica Sinica 20070801

Title: Investigation of the improved effects of 2-hydroxypropyl-beta-cyclodextrin on solubility, dissolution rate, and intestinal absorptive profile of tanshinone IIA in rats.

Journal: Archives of pharmacal research 20070801

Title: [The inhibitive effect produced by local perfusion of tanshinone IIA nanoparticle on neointimal hyperplasia of rabbit carotid artery following intimal denudation].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070801

Title: Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.

Journal: Drug metabolism letters 20070801

Title: Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.

Journal: European journal of pharmacology 20070730

Title: Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.

Journal: Journal of natural products 20070701

Title: [Effect of tanshinone II A on angiotensin II induced nitric oxide production and endothelial nitric oxide synthase gene expression in cultured porcine aortic endothelial cells].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701

Title: [The influence of steaming processing on components in Chinese medicine by HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

Title: [The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

Title: Identification of tanshinones and their metabolites in rat bile after oral administration of TTE-50, a standardized extract of Salvia miltiorrhiza by HPLC-ESI-DAD-MSn.

Journal: Journal of pharmaceutical and biomedical analysis 20070628

Title: Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension.

Journal: Life sciences 20070620

Title: Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.

Journal: Vascular pharmacology 20070601

Title: [Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601

Title: Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats.

Journal: Chinese journal of integrative medicine 20070601

Title: Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070601

Title: [Preparation of tanshinone microemulsion and its absorption in rat intestine in situ].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

Title: [Advance of study on apoptosis inducer of several types of natural drug].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601

Title: [Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

Title: [Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

Title: The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells.

Journal: Journal of ethnopharmacology 20070522

Title: Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.

Journal: Neuroscience letters 20070507

Title: Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells.

Journal: Biochemical pharmacology 20070501

Title: Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method.

Journal: Biomedical chromatography : BMC 20070501

Title: Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.

Journal: Chemical & pharmaceutical bulletin 20070501

Title: Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Journal: Current drug metabolism 20070501

Title: [Studies on chemical constituents of Prunella vulgaris].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070501

Title: Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza bunge.

Journal: Analytica chimica acta 20070425

Title: Enhancement of tanshinone production in Salvia miltiorrhiza Bunge (red or Chinese sage) hairy-root culture by hyperosmotic stress and yeast elicitor.

Journal: Biotechnology and applied biochemistry 20070401

Title: Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070401

Title: Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.

Journal: Journal of separation science 20070401

Title: [Comparison of two preparation methods applied in tanshinone II(A)-loaded PLGA nanoparticles].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.

Journal: Journal of neuro-oncology 20070301

Title: [Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301

Title: [Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

Title: Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation.

Journal: Current drug metabolism 20070201

Title: [Inhibition of cell growth and induction of apoptosis in human hepatoma cell line HepG2 by tanshione IIA].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070201

Title: [Effects of methyl jasmonat on accumulation and release of tanshinones in suspension cultures of Salvia miltiorrhiza hairy root].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070201

Title: New developments in the chemistry and biology of the bioactive constituents of Tanshen.

Journal: Medicinal research reviews 20070101

Title: Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells.

Journal: Mitochondrion 20070101

Title: Profiling the metabolic difference of seven tanshinones using high-performance liquid chromatography/multi-stage mass spectrometry with data-dependent acquisition.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Study of the phase I and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: [Study on uniform-design for optimizing supercritical-CO2 fluid extraction technique of tanshinones in radix salviae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism.

Journal: Journal of ethnopharmacology 20061124

Title: Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro.

Journal: Journal of biomedical science 20061101

Title: Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.

Journal: Planta medica 20061101

Title: [Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20061101

Title: Synthesis of novel chemical probes for the study of tanshinone binding proteins.

Journal: Bioorganic & medicinal chemistry letters 20060915

Title: [Studies on in vitro culture of adventitious root in Salvia miltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

Title: [Quantitative analysis on Radix Salviae miltiorrhizae by NIR].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060901

Title: Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.

Journal: European journal of pharmacology 20060807

Title: Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury.

Journal: Acta pharmacologica Sinica 20060801

Title: [Effect of micronization on the quality of Salvia miltiorrhiza Bge].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060801

Title: [Protective effect of tanshinones against liver injury in mice loaded with restraint stress].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060701

Title: Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1.

Journal: Experimental & molecular medicine 20060630

Title: Inhibition of ethanol-induced toxicity by tanshinone IIA in PC12 cells.

Journal: Acta pharmacologica Sinica 20060601

Title: [Studies on absorptive mechanism of lipophilic components of danshen from its hydroxypropyl-beta-cyclodextrin inclusion complex].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060601

Title: Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060401

Title: [Initial studies of microemulsion formulation for the delivery of a combination of Tanshiones and Salvianolic acids].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

Title: [Preparation of tanshinone transfersome and its deformability].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060301

Title: Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20060203

Title: [Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

Title: [Effects of Tanshinone IIA on procoagulant activity of human ECV304 cell line induced by NB4 cells].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060101

Title: Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Characterization of tanshinones in the roots of Salvia miltiorrhiza (Dan-shen) by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20060101

Title: Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051205

Title: Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.

Journal: Journal of clinical pharmacology 20051201

Title: Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

Title: [Analysis of four components in Fufang Danshen Tablets by high performance liquid chromatography with electrochemical and ultraviolet detections].

Journal: Se pu = Chinese journal of chromatography 20051101

Title: Efficient production and recovery of diterpenoid tanshinones in Salvia miltiorrhiza hairy root cultures with in situ adsorption, elicitation and semi-continuous operation.

Journal: Journal of biotechnology 20051010

Title: Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage.

Journal: Pediatric research 20051001

Title: [Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051001

Title: Potential anticancer activity of tanshinone IIA against human breast cancer.

Journal: International journal of cancer 20050920

Title: Induction and potentiation of diterpenoid tanshinone accumulation in Salvia miltiorrhiza hairy roots by beta-aminobutyric acid.

Journal: Applied microbiology and biotechnology 20050801

Title: Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.

Journal: Archives of pharmacal research 20050801

Title: Nitrogen-containing compounds from Salvia miltiorrhiza.

Journal: Journal of natural products 20050701

Title: Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles.

Journal: Drug development and industrial pharmacy 20050701

Title: [Effects of mineral cations on the accumulation of tanshinone II A and protocatechuic aldehyde in the adventitious root culture of Salvia niltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

Title: Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells.

Journal: Journal of ethnopharmacology 20050513

Title: [A study on the cell differentiation induced by tanshinone IIA and its molecular mechanism in retinoic acid: resistant acute promyelocytic leukemia].

Journal: Zhonghua nei ke za zhi 20050501

Title: [Studies on chemical constituents in roots of Peucedanum praeruptorum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501

Title: Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.

Journal: Experimental & molecular medicine 20050430

Title: Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice.

Journal: Journal of ethnopharmacology 20050426

Title: [Advances in study of the pharmacological effects of danshen on hemorheology].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: [Inhibition of proliferation and induction of apoptosis by tanshinone II A in NCI-H460 cell].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050401

Title: Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20050309

Title: Compound 278E, structurally modified from tanshinone, induces monocytic differentiation and regulates proto-oncogene expression in human leukemic HL-60 cells.

Journal: Anti-cancer drugs 20050201

Title: [Alteration of activities of telomerase in tanshinone IIA inducing apoptosis of the leukemia cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

Title: Determining the purity of samples from natural products by coupling HPLC and CCD spectrometry.

Journal: Journal of separation science 20050201

Title: Preparation and study on the inclusion complexes of two tanshinone compounds with beta-cyclodextrin.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050101

Title: [The growth of Salvia miltiorrhiza seedling and root system following transplantation].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

Title: Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells.

Journal: Journal of biomedical science 20050101

Title: Tanshinone production in roots of micropropagated Salvia przewalskii Maxim.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells.

Journal: Archives of pharmacal research 20041201

Title: Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

Journal: Journal of medicinal chemistry 20041104

Title: [Differentiation and apoptosis of NB4 cells synergistically induced by Tanshinone II A and all-trans retinoic acid].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20041101

Title: [Studies on HPLC fingerprints of tanshinone microemulsion].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

Title: [Effect of tanshinone microemulsion on reversing MDR in human tumor cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

Title: Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.

Journal: World journal of gastroenterology 20040715

Title: Identification of major active constituents in the fingerprint of Salvia miltiorrhiza Bunge developed by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20040702

Title: Effects of tanshinone on neuropathological changes induced by amyloid beta-peptide(1-40) injection in rat hippocampus.

Journal: Acta pharmacologica Sinica 20040701

Title: Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge.

Journal: Biochemical pharmacology 20040501

Title: Tanshinone prevents cancellous bone loss induced by ovariectomy in rats.

Journal: Acta pharmacologica Sinica 20040501

Title: Evaluation of pressurized liquid extraction and pressurized hot water extraction for tanshinone I and IIA in Salvia miltiorrhiza using LC and LC-ESI-MS.

Journal: Journal of chromatographic science 20040401

Title: Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040301

Title: [Enhancement of the bystander effect by tanshinone IIA in HSV-tK/GCV system is related to expression of connexin 43 mRNA].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040301

Title: [Study on the characteristic of assimilating nitrogenous phosphorous fertilizer and the accumulation disciplinarian of total tanshinons of Salvia miltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

Title: [The experimental study of the effect of tanshinone on artery restenosis in mouse].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

Title: Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding.

Journal: Planta medica 20040201

Title: Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice.

Journal: Life sciences 20040102

Title: [Anticancer effect of tanshinone and its mechanisms].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20031201

Title: Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells.

Journal: Planta medica 20031101

Title: [Purification and fingerprinting development of Salvia miltiorrhiza Bunge by high-speed counter-current chromatography].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20031101

Title: Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.

Journal: Acta pharmacologica Sinica 20031001

Title: [The variation of Caspase3 activity in tanshinone induced NB4 cells apoptosis].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20030701

Title: [Study of Salvia przewalskii and evaluation of its uses].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030701

Title: Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo.

Journal: Antimicrobial agents and chemotherapy 20030601

Title: [Effect of tanshinone IIA on the growth behavior of human hepatoma cell line BEL-7402 in vitro and its mechanism].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030601

Title: Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601

Title: [Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030601

Title: Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501

Title: [Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030501

Title: [Studies on the extraction of ingredients from Chinese traditional medicine with CO2 supercritical fluid].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030501

Title: Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells.

Journal: Pharmacology & toxicology 20030401

Title: Growth inhibition and apoptosis induction in human hepatoma cells by tanshinone II A.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101

Title: Novel sustained-release implant of herb extract using chitosan.

Journal: Biomaterials 20021201

Title: Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses.

Journal: Phytotherapy research : PTR 20021101

Title: [Medicinal resources of Salvia yunnanensis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

Title: Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.

Journal: Archives of pharmacal research 20020801

Title: [Review of germplasm resources studies on Salvia miltiorrhiza].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020701

Title: [Kinetic model for extraction process of Chinese traditional medicine].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020701

Title: Study on the relationship between NB4 cell apoptosis induced by tanshinone IIA and the cell mitochondrial transmembrane potential.

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020601

Title: Separation of tanshinones from Salvia miltiorrhiza bunge by multidimensional counter-current chromatography.

Journal: Journal of chromatography. A 20020201

Title: [Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20020101

Title: [Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

Title: [Study on the differentiation of K562 cell-line induced by Tanshinone II A].

Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

Title: [A study on apoptosis of nasopharyngeal carcinoma cell line induced by Tanshinone II A and its molecular mechanism].

Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

Title: Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.

Journal: Journal of natural products 20011101

Title: [Spectroscopic studies on the binding of effective component of Chinese herbs with human serum albumin].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20011001

Title: [Protective effect of tanshinone IIA on acute hepatic injury in mice].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010801

Title: Microwave-assisted extraction of tanshinones from Salvia miltiorrhiza bunge with analysis by high-performance liquid chromatography.

Journal: Journal of chromatography. A 20010713

Title: [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010601

Title: [Protective effect of tanshinone on injured cultured PC12 cells in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010601

Title: Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A.

Journal: Acta pharmacologica Sinica 20010501

Title: [Study on improving the dissolution rate of tanshinone in vitro by solvent deposition method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010301

Title: [SFE-CGC determination of tanshinone in Salvia miltiorrhiza Bunge].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010101

Title: Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63.

Title: Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32.

Title: Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.

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Tags:568-72-9 Molecular Formula|568-72-9 MDL|568-72-9 SMILES|568-72-9 Tanshinone iia