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56856-83-8,MFCD01311052
Catalog No.:AA00EAH2

56856-83-8 | NITROSO(ACETOXYMETHYL)-METHYLAMINE

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10mg
≥98%
in stock  
$322.00   $225.00
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50mg
≥98%
in stock  
$881.00   $617.00
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100mg
≥98%
in stock  
$1,518.00   $1,063.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EAH2
Chemical Name:
NITROSO(ACETOXYMETHYL)-METHYLAMINE
CAS Number:
56856-83-8
Molecular Formula:
C4H8N2O3
Molecular Weight:
132.1179
MDL Number:
MFCD01311052
SMILES:
O=NN(COC(=O)C)C
Properties
Computed Properties
 
Complexity:
114  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
3  
XLogP3:
0.2  

Literature

Title: Prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20110401

Title: Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).

Journal: Chemical research in toxicology 20080301

Title: Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.

Journal: International journal of toxicology 20070101

Title: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells.

Journal: Clinical and experimental immunology 20050401

Title: Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Journal: Biochemistry 20040120

Title: Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells.

Journal: Chemical research in toxicology 20030101

Title: Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA.

Journal: Journal of molecular biology 20011026

Title: Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Journal: Cancer research 20010801

Title: Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines.

Journal: Journal of molecular biology 20010216

Title: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages.

Journal: Cancer immunology, immunotherapy : CII 20010201

Title: Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis.

Journal: International journal of cancer 19920528

Title: Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either renal or intestinal tumors.

Journal: Carcinogenesis 19890101

Title: Quantitative relationship between hepatocytic neoplasms and islands of cellular alteration during hepatocarcinogenesis in the male F344 rat.

Journal: The American journal of pathology 19850501

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