Title: Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression.
Journal: Toxicology and applied pharmacology 20150615
Title: Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101
Title: Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents.
Journal: Journal of applied toxicology : JAT 20121201
Title: Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121001
Title: The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.
Journal: Archives of toxicology 20121001
Title: Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901
Title: Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna.
Journal: Chemosphere 20120801
Title: Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.
Journal: Journal of agricultural and food chemistry 20120606
Title: Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
Journal: Molecular biology reports 20120601
Title: Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure.
Journal: Ecotoxicology and environmental safety 20120501
Title: Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.
Journal: Cell biology and toxicology 20120401
Title: Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.
Journal: Molecular nutrition & food research 20120301
Title: 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent.
Journal: Archives of toxicology 20120201
Title: Differences in cytochrome P450 enzyme activities between fish and crustacea: relationship with the bioaccumulation patterns of polychlorobiphenyls (PCBs).
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120201
Title: CYP1B1 detection.
Journal: Current protocols in toxicology 20120201
Title: Functional expression and characterization of recombinant NADPH-P450 reductase from Malassezia globosa.
Journal: Journal of microbiology and biotechnology 20120101
Title: Variation of basal EROD activities in ten passerine bird species--relationships with diet and migration status.
Journal: PloS one 20120101
Title: Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.
Journal: International journal of molecular sciences 20120101
Title: PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor.
Journal: PloS one 20120101
Title: Subtle effects of biological invasions: cellular and physiological responses of fish eating the exotic pest Caulerpa racemosa.
Journal: PloS one 20120101
Title: Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats.
Journal: Drug metabolism and pharmacokinetics 20120101
Title: Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp.
Journal: Gene 20111210
Title: Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.
Journal: The Journal of pharmacology and experimental therapeutics 20111101
Title: Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110901
Title: Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture.
Journal: Journal of ethnopharmacology 20110901
Title: Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110801
Title: Detoxification: a novel function of BRCA1 in tumor suppression?
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110701
Title: In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol.
Journal: Interdisciplinary toxicology 20110601
Title: Biochemical markers of contamination in fish toxicity tests.
Journal: Interdisciplinary toxicology 20110601
Title: Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.
Journal: Lung cancer (Amsterdam, Netherlands) 20110301
Title: Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110201
Title: CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey.
Journal: Biochemical pharmacology 20110201
Title: Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
Journal: Journal of ethnopharmacology 20110107
Title: The aryl hydrocarbon receptor pathway and the response to 3-methylcholanthrene are altered in the liver of adrenalectomized rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101
Title: Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes.
Journal: Drug metabolism letters 20110101
Title: RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.
Journal: PloS one 20110101
Title: Biomarkers in natural fish populations indicate adverse biological effects of offshore oil production.
Journal: PloS one 20110101
Title: CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.
Journal: BMC evolutionary biology 20110101
Title: Hepatic differentiation of murine disease-specific induced pluripotent stem cells allows disease modelling in vitro.
Journal: Stem cells international 20110101
Title: Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
Journal: Molecular cancer 20110101
Title: Optimization of a Cytochrome-P450-Monooxygenase-1A-Mediated EROD Assay in the Cape Hake Species Merluccius capensis and Merluccius paradoxus (Pisces).
Journal: Enzyme research 20110101
Title: Cytochrome p450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos.
Journal: PloS one 20110101
Title: Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.
Journal: Neuro endocrinology letters 20110101
Title: Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy.
Journal: Molecular neurodegeneration 20110101
Title: A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity.
Journal: PloS one 20110101
Title: The need and potential of biosensors to detect dioxins and dioxin-like polychlorinated biphenyls along the milk, eggs and meat food chain.
Journal: Sensors (Basel, Switzerland) 20110101
Title: In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.
Journal: Environmental toxicology 20101201
Title: Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.
Journal: Toxicology 20101109
Title: Carotenoids as regulators for inter-species difference in cytochrome P450 1A expression and activity in ungulates and rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101101
Title: Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists.
Journal: Journal of medicinal chemistry 20101014
Title: Computational approach to characterization of human liver drug-metabolizing enzymes.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009
Title: Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.
Journal: Archives of toxicology 20101001
Title: Comparative chronic liver toxicity of benzo[a]pyrene in two populations of the atlantic killifish (Fundulus heteroclitus) with different exposure histories.
Journal: Environmental health perspectives 20101001
Title: Cytochrome P450-mediated 17beta-estradiol metabolism in zebrafish (Danio rerio).
Journal: The Journal of endocrinology 20100901
Title: Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.
Journal: International journal of environmental research and public health 20100901
Title: Properties of blood, porphyrins, and exposure to legacy and emerging persistent organic pollutants in surf scoters (Melanitta perspicillata) overwintering on the south coast of British Columbia, Canada.
Journal: Archives of environmental contamination and toxicology 20100801
Title: Assessment of biological effects of pollutants in a hyper eutrophic tropical water body, Lake Beira, Sri Lanka using multiple biomarker responses of resident fish, Nile tilapia (Oreochromis niloticus).
Journal: Ecotoxicology (London, England) 20100801
Title: Biotransformation of PCBs in Arctic seabirds: characterization of phase I and II pathways at transcriptional, translational and activity levels.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100601
Title: Candida albicans NADPH-P450 reductase: expression, purification, and characterization of recombinant protein.
Journal: Biochemical and biophysical research communications 20100528
Title: Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Inhibition of human liver microsomal CYP by nateglinide.
Journal: The Journal of pharmacy and pharmacology 20100501
Title: In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine.
Journal: Cancer chemotherapy and pharmacology 20100401
Title: Effects of intravenous administration of lipopolysaccharide on cytochrome P450 isoforms and hepatic drug metabolizing enzymes in swine.
Journal: American journal of veterinary research 20100301
Title: Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.
Journal: Toxicology 20100209
Title: 1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
Journal: Journal of medicinal chemistry 20100114
Title: Identification of mitochondrial cytochrome P450 induced in response to polycyclic aromatic hydrocarbons in the mummichog (Fundulus heteroclitus).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100101
Title: A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20100101
Title: Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
Journal: Journal of pineal research 20100101
Title: Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.
Journal: Malaria journal 20100101
Title: Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist.
Journal: PloS one 20100101
Title: 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes.
Journal: PloS one 20100101
Title: Genotoxic evaluation of an industrial effluent from an oil refinery using plant and animal bioassays.
Journal: Genetics and molecular biology 20100101
Title: Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice.
Journal: Chemico-biological interactions 20091210
Title: Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors.
Journal: Environmental health perspectives 20091201
Title: Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices.
Journal: Biotechnology and bioengineering 20091015
Title: The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine.
Journal: Interdisciplinary toxicology 20090901
Title: Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans.
Journal: Archives of environmental contamination and toxicology 20090801
Title: Lack of constitutive and inducible ethoxyresorufin-O-deethylase activity in the liver of suckermouth armored catfish (Hypostomus affinis and Hypostomus auroguttatus, Loricariidae).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090801
Title: DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s).
Journal: European journal of pharmacology 20090701
Title: Inhibitive effect of diphenytriazol on rat cytochrome P450 enzyme in vitro.
Journal: Die Pharmazie 20090701
Title: Cancer preventive potential of methanol extracts of Hypsizigus marmoreus.
Journal: Journal of medicinal food 20090601
Title: Chemical genomics of cancer chemopreventive dithiolethiones.
Journal: Carcinogenesis 20090301
Title: Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds.
Journal: Toxicology and applied pharmacology 20090201
Title: Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD.
Journal: Archives of biochemistry and biophysics 20090201
Title: Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.
Journal: Chemico-biological interactions 20090127
Title: Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display.
Journal: Protein expression and purification 20090101
Title: Carcinogenic effects in a phenylketonuria mouse model.
Journal: PloS one 20090101
Title: Effects of tributyltin (TBT) on in vitro hormonal and biotransformation responses in Atlantic salmon (Salmo salar).
Journal: Journal of toxicology and environmental health. Part A 20090101
Title: Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090101
Title: Size-partitioning of an urban aerosol to identify particle determinants involved in the proinflammatory response induced in airway epithelial cells.
Journal: Particle and fibre toxicology 20090101
Title: EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs.
Journal: Sensors (Basel, Switzerland) 20090101
Title: Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081201
Title: Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.
Journal: The Journal of biological chemistry 20081114
Title: Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081101
Title: Application of molecular modeling for prediction of substrate specificity in cytochrome P450 1A2 mutants.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101
Title: Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Biochemical markers for the assessment of aquatic environment contamination.
Journal: Interdisciplinary toxicology 20080901
Title: Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080701
Title: Styrene trimer may increase thyroid hormone levels via down-regulation of the aryl hydrocarbon receptor (AhR) target gene UDP-glucuronosyltransferase.
Journal: Environmental health perspectives 20080601
Title: The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic.
Journal: Environmental health perspectives 20080501
Title: Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080401
Title: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs.
Journal: Biochemical pharmacology 20080301
Title: CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
Journal: British journal of cancer 20080212
Title: Perturbation of rat hepatic metabolising enzymes by folic acid supplementation.
Journal: Mutation research 20080101
Title: Characterization of Phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080101
Title: Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study.
Journal: Environmental health : a global access science source 20080101
Title: Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.
Journal: Breast cancer research : BCR 20080101
Title: Phytoestrogens modulate the expression of 17alpha-estradiol metabolizing enzymes in cultured MCF-7 cells.
Journal: Advances in experimental medicine and biology 20080101
Title: Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization.
Journal: Journal of biochemical and molecular toxicology 20080101
Title: Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): methodology and applications.
Journal: Comparative hepatology 20080101
Title: Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver.
Journal: Toxicology 20071205
Title: A shuffled CYP1A library shows both structural integrity and functional diversity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201
Title: Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis.
Journal: Archives of biochemistry and biophysics 20071201
Title: Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats.
Journal: Journal of veterinary science 20071201
Title: Health impacts of estrogens in the environment, considering complex mixture effects.
Journal: Environmental health perspectives 20071201
Title: Effects of metals and detergents on biotransformation and detoxification enzymes of leaping mullet (Liza saliens).
Journal: Ecotoxicology and environmental safety 20071101
Title: Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells.
Journal: Environmental health perspectives 20071101
Title: Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies.
Journal: Archives of toxicology 20071001
Title: Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
Journal: The Journal of pharmacology and experimental therapeutics 20070801
Title: An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites.
Journal: Journal of neurochemistry 20070801
Title: Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: Neuroendocrine disruption and health effects in Elliptio complanata mussels exposed to aeration lagoons for wastewater treatment.
Journal: Chemosphere 20070601
Title: A new technique for assaying cytochrome P450 enzyme activity in a single cell.
Journal: Cell biology and toxicology 20070501
Title: Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070401
Title: Effects of N-terminal modification of recombinant human cytochrome P450 1A2 on catalytic activity.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070401
Title: Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.
Journal: Chemical research in toxicology 20070301
Title: Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities.
Journal: Toxicology 20070227
Title: Age-dependent in situ hepatic and gill CYP1A activity in the see-through medaka (Oryzias latipes).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070201
Title: Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water.
Journal: Mutation research 20070110
Title: Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070101
Title: Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow.
Journal: BMC developmental biology 20070101
Title: Functional evolution of the vitamin D and pregnane X receptors.
Journal: BMC evolutionary biology 20070101
Title: Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats.
Journal: Environmental toxicology and pharmacology 20070101
Title: Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions.
Journal: Biochemistry 20061226
Title: Species difference in the induction of hepatic CYP1A subfamily enzymes, especially CYP1A2, by 2-methoxy-4-nitroaniline among rats, mice, and guinea pigs.
Journal: Archives of toxicology 20061101
Title: Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers.
Journal: Environmental health perspectives 20061101
Title: OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
Journal: PLoS medicine 20061101
Title: Effects of nonylphenol on juveniles and adults in the grey mullet, Liza aurata.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20061001
Title: Characterization of CYP1A enzyme in Adélie penguin liver.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001
Title: Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD.
Journal: Environmental health perspectives 20060901
Title: Marine invertebrate cytochrome P450: emerging insights from vertebrate and insects analogies.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060801
Title: Non destructive in vivo measurement of ethoxyresorufin biotransformation by zebrafish prolarva: development and application.
Journal: Environmental toxicology 20060801
Title: Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles.
Journal: Environmental health perspectives 20060801
Title: Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h.
Journal: Toxicology 20060705
Title: Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio).
Journal: Fish & shellfish immunology 20060701
Title: Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060701
Title: Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
Journal: Archives of pharmacal research 20060701
Title: Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds.
Journal: Tissue engineering 20060501
Title: Relationship between sex steroid and vitellogenin concentrations in flounder (Platichthys flesus) sampled from an estuary contaminated with estrogenic endocrine-disrupting compounds.
Journal: Environmental health perspectives 20060401
Title: Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20060310
Title: Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.
Journal: Cell biology and toxicology 20060301
Title: Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats.
Journal: American journal of veterinary research 20060201
Title: Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach.
Journal: Environmental health perspectives 20060101
Title: Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity.
Journal: Chemical research in toxicology 20060101
Title: Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes.
Journal: Nephron. Physiology 20060101
Title: Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate.
Journal: Methods in molecular biology (Clifton, N.J.) 20060101
Title: Effect of sulfur dioxide inhalation on CYP1A1 and CYP1A2 in rat liver and lung.
Journal: Toxicology letters 20051230
Title: Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments.
Journal: Environmental health perspectives 20051201
Title: Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells.
Journal: Alternatives to laboratory animals : ATLA 20051201
Title: Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.
Journal: Biochemical pharmacology 20051115
Title: Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity.
Journal: International journal of cancer 20051110
Title: Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.
Journal: Biological chemistry 20051101
Title: Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes.
Journal: Archives of pharmacal research 20051001
Title: Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity.
Journal: Analytical biochemistry 20050915
Title: Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications.
Journal: Journal of toxicology and environmental health. Part A 20050901
Title: Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.
Journal: Journal of biomolecular screening 20050801
Title: Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study.
Journal: Clinical and experimental pharmacology & physiology 20050801
Title: Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.
Journal: European journal of pharmacology 20050615
Title: Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.
Journal: Journal of medicinal chemistry 20050602
Title: Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.
Journal: Chemico-biological interactions 20050227
Title: Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice.
Journal: Cancer chemotherapy and pharmacology 20050201
Title: Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.
Journal: Mutagenesis 20050101
Title: Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function.
Journal: Annals of surgery 20050101
Title: Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata.
Journal: In vitro cellular & developmental biology. Animal 20050101
Title: Orderly arrangement of hepatocyte spheroids on a microfabricated chip.
Journal: Tissue engineering 20050101
Title: Isolation and characterization of metabolically competent pulmonary epithelial cells from pig lung tissue.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050101
Title: Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.
Journal: Environmental health perspectives 20041201
Title: Mechanism to study 1:1 stoichiometry of NADPH and alkoxyphenoxazones metabolism spectrophotometrically in subcellular biological preparations.
Journal: Biochimica et biophysica acta 20041118
Title: Effects of amitraz on cytochrome P450-dependent monooxygenases and estrogenic activity in MCF-7 human breast cancer cells and immature female rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041101
Title: Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Journal: Gastroenterology 20041101
Title: Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001
Title: Cytochrome P450 CYP1B1 activity in renal cell carcinoma.
Journal: British journal of cancer 20040831
Title: Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20040825
Title: Inhibitory effect(s) of polymeric black tea polyphenol fractions on the formation of [(3)H]-B(a)P-derived DNA adducts.
Journal: Journal of agricultural and food chemistry 20040630
Title: Effects of motorcycle exhaust inhalation exposure on cytochrome P-450 2B1, antioxidant enzymes, and lipid peroxidation in rat liver and lung.
Journal: Journal of toxicology and environmental health. Part A 20040611
Title: The use of Yarrowia lipolytica for the expression of human cytochrome P450 CYP1A1.
Journal: Yeast (Chichester, England) 20040501
Title: Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle.
Journal: Biochemical pharmacology 20040315
Title: In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.
Journal: Chemico-biological interactions 20040315
Title: Phase I and II enzyme characterization of two sources of HepG2 cell lines.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301
Title: Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.
Journal: The Journal of pharmacy and pharmacology 20040201
Title: Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.
Journal: The Journal of pharmacology and experimental therapeutics 20040101
Title: Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action.
Journal: Breast cancer research : BCR 20040101
Title: Long-term function of cryopreserved rat hepatocytes in a coculture system.
Journal: Cell transplantation 20040101
Title: Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.
Journal: Acta biochimica Polonica 20040101
Title: Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
Journal: Journal of vascular research 20040101
Title: Measurement of EROD activity: caution on spectral properties of standards used.
Journal: Marine biotechnology (New York, N.Y.) 20040101
Title: Diaphorase can metabolize some vasorelaxants to NO and eliminate NO scavenging effect of 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide (PTIO).
Journal: Physiological research 20040101
Title: Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubin.
Journal: Biochemical pharmacology 20031215
Title: Effects of propranolol on xenobiotic enzyme activities in rat type II pneumocytes and alveolar macrophages in vivo.
Journal: Methods and findings in experimental and clinical pharmacology 20031201
Title: Down-regulation of hepatic CYP3A in chronic renal insufficiency.
Journal: Pharmaceutical research 20031001
Title: Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030901
Title: Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801
Title: Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages.
Journal: Life sciences 20030718
Title: Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice.
Journal: Mutation research 20030619
Title: Tight-binding inhibition by alpha-naphthoflavone of human cytochrome P450 1A2.
Journal: Biochimica et biophysica acta 20030530
Title: EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs.
Journal: American journal of physiology. Heart and circulatory physiology 20030501
Title: Effects of polycyclic aromatic hydrocarbons on liver and lung cytochrome P450s in mice.
Journal: Archives of pharmacal research 20030501
Title: Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401
Title: A study on CYP1A inhibitory action of E-2-(4'-methoxybenzylidene)-1-benzosuberone and some related chalcones and cyclic chalcone analogues.
Journal: Toxicology 20030303
Title: DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells.
Journal: British journal of cancer 20030224
Title: A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology.
Journal: British journal of clinical pharmacology 20030201
Title: Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax).
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20030110
Title: The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.
Journal: Placenta 20030101
Title: Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101
Title: Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.
Journal: Pharmacology 20021201
Title: Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.
Journal: The Journal of pharmacology and experimental therapeutics 20021101
Title: Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme.
Journal: Molecular pharmacology 20021101
Title: Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma.
Journal: Archives of toxicology 20021101
Title: Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption.
Journal: Human reproduction (Oxford, England) 20021001
Title: Molecular modeling of cytochrome P450 1A1: enzyme-substrate interactions and substrate binding affinities.
Journal: Journal of biomolecular structure & dynamics 20021001
Title: Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa.
Journal: Cancer research 20021001
Title: Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021001
Title: Alteration of pulmonary cytochrome p-450 system: effects of asphalt fume condensate exposure.
Journal: Journal of toxicology and environmental health. Part A 20020913
Title: Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants.
Journal: Pharmacology & toxicology 20020901
Title: CYP1A1 induction by pyridine and its metabolites in HepG2 cells.
Journal: Archives of biochemistry and biophysics 20020815
Title: Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice.
Journal: Life sciences 20020802
Title: Gill filament-based EROD assay for monitoring waterborne dioxin-like pollutants in fish.
Journal: Environmental science & technology 20020801
Title: Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
Journal: Carcinogenesis 20020701
Title: 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
Journal: The Journal of pharmacology and experimental therapeutics 20020601
Title: In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.
Journal: American journal of veterinary research 20020601
Title: Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601
Title: The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020601
Title: Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.
Journal: FEBS letters 20020522
Title: Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501
Title: In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
Journal: British journal of cancer 20020422
Title: In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020401
Title: Effects of trivalent chromium on hepatic CYP-linked monooxygenases in laying hens.
Journal: Journal of applied toxicology : JAT 20020101
Title: Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotinamide, and dimethyl sulfoxide.
Journal: Cell transplantation 20020101
Title: Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.
Journal: Toxicology letters 20011215
Title: Effects elicited by toxaphene in the cynomolgus monkey (Macaca fascicularis): a pilot study.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011201
Title: Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.
Journal: The Journal of pharmacology and experimental therapeutics 20011201
Title: Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20011101
Title: 7-Ethoxyresorufin O-deethylase induction in rainbow trout gill epithelium cultured on permeable supports: asymmetrical distribution of substrate metabolites.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20010901
Title: Molecular requirements for inhibition of cytochrome p450 activities by roquefortine.
Journal: Chemical research in toxicology 20010901
Title: A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.
Journal: Biochemical pharmacology 20010901
Title: Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801
Title: Induction of rat brain cytochrome P450s (P450s) by deltamethrin: regional specificity and correlation with neurobehavioral toxicity.
Journal: Neurotoxicity research 20010801
Title: Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression.
Journal: Life sciences 20010615
Title: Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601
Title: Libraries of hybrid proteins from distantly related sequences.
Journal: Nature biotechnology 20010501
Title: Ability of fractionated petroleum refinery effluent to elicit cyto- and photocytotoxic responses and to induce 7-ethoxyresorufin-O-deethylase activity in fish cell lines.
Journal: The Science of the total environment 20010423
Title: Characterization of biotransformation enzyme activities in primary rat proximal tubular cells.
Journal: Chemico-biological interactions 20010416
Title: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010401
Title: Signal transduction pathways involved in kinin B(2) receptor-mediated vasodilation in the rat isolated perfused kidney.
Journal: British journal of pharmacology 20010401
Title: The effects of inhalation exposure to bromo-dichloromethane on specific rat CYP isoenzymes.
Journal: Toxicology 20010321
Title: P450 enzyme expression patterns in the NCI human tumor cell line panel.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: Cytochrome P450 expression and related metabolism in human buccal mucosa.
Journal: Carcinogenesis 20010301
Title: Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways.
Journal: American journal of hypertension 20010301
Title: Inhibitory effects of detergents on rat CYP1A1-dependent monooxygenase: comparison of mixed and fused systems consisting of rat CYP 1A1 and yeast NADPH-P450 reductase.
Journal: Biochemical and biophysical research communications 20010209
Title: Bradykinin attenuates the [Ca(2+)](i) response to angiotensin II of renal juxtamedullary efferent arterioles via an EDHF.
Journal: British journal of pharmacology 20010201
Title: High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201
Title: Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase.
Journal: Archives of biochemistry and biophysics 20010115
Title: A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101
Title: Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds.
Journal: Environmental toxicology 20010101
Title: [Effect of hypoxic stress on xenobiotic metabolism and activities of various isoforms of cytochrome P-450].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101
Title: Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
Journal: Canadian journal of physiology and pharmacology 20001101
Title: Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes.
Journal: Toxicology and applied pharmacology 19950501
Title: Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.
Journal: Drug metabolism and disposition: the biological fate of chemicals 19930101
Title: Dose-response relationship for phenobarbitone promotion of liver tumours initiated by single dose dimethylnitrosamine.
Journal: British journal of experimental pathology 19860201
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