Home Carboxes 5728-52-9
5728-52-9,MFCD00004351
Catalog No.:AA0033U9

5728-52-9 | 4-Biphenylacetic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$6.00   $4.00
- +
5g
95%
in stock  
$8.00   $5.00
- +
10g
98%
in stock  
$13.00   $9.00
- +
100g
98%
in stock  
$39.00   $28.00
- +
500g
98%
in stock  
$178.00   $125.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0033U9
Chemical Name:
4-Biphenylacetic acid
CAS Number:
5728-52-9
Molecular Formula:
C14H12O2
Molecular Weight:
212.2439
MDL Number:
MFCD00004351
SMILES:
OC(=O)Cc1ccc(cc1)c1ccccc1
Properties
Properties
 
BP:
389.8°C at 760 mmHg  
Form:
Solid  
MP:
159-160 °C(lit.);  
Refractive Index:
1.6000 (estimate)  
Solubility:
DMSO: soluble50mg/mL, clear, colorless to yellow  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
223  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3  

Literature

Title: A novel protocol for the oral administration of test chemicals to adult zebrafish.

Journal: Zebrafish 20111201

Title: Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative.

Journal: International journal of pharmaceutics 20111031

Title: Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues.

Journal: International journal of toxicology 20110501

Title: Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster, and tape.

Journal: Journal of allergy 20110101

Title: Modeling natural anti-inflammatory compounds by molecular topology.

Journal: International journal of molecular sciences 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: 2-(Biphenyl-4-yl)acetic acid (felbinac).

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina.

Journal: Visual neuroscience 20100701

Title: Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

Journal: European journal of medicinal chemistry 20100601

Title: The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug.

Journal: International journal of pharmaceutics 20100315

Title: Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.

Journal: Journal of pain research 20100101

Title: Towards the design of cyclooxygenase (COX) inhibitors based on 4',5 di-substituted biphenyl acetic acid molecules: a QSAR study with a new DFT based descriptor - nucleus independent chemical shift.

Journal: Journal of molecular modeling 20091001

Title: Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat.

Journal: Journal of pharmaceutical and biomedical analysis 20090815

Title: Separation-oriented derivatization of native fluorescent compounds through fluorous labeling followed by liquid chromatography with fluorous-phase.

Journal: Analytical chemistry 20090615

Title: Mechanisms of drug release in citrate buffered HPMC matrices.

Journal: International journal of pharmaceutics 20090331

Title: Cyclomaltoheptaose mixed esters of anti-inflammatory drugs and short-chain fatty acids and study of their enzymatic hydrolysis in vitro.

Journal: Carbohydrate research 20090310

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison.

Journal: Trials 20090101

Title: Stepwise two-color laser photolysis studies of alpha-cleavage in highly excited triplet states of alpha-acyl-4-phenylphenols.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080601

Title: Percutaneous penetration of felbinac after application of transdermal patches: relationship with pharmacological effects in rats.

Journal: The Journal of pharmacy and pharmacology 20080101

Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

Journal: BMC musculoskeletal disorders 20080101

Title: Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity.

Journal: Chemistry & biodiversity 20061101

Title: Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.

Journal: European journal of pharmacology 20060814

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems.

Journal: The Analyst 20060101

Title: Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.

Journal: The Journal of biological chemistry 20040702

Title: Topical NSAIDs for acute pain: a meta-analysis.

Journal: BMC family practice 20040101

Title: Synthesis, characterization and in vitro evaluation of dimethyl-beta-cyclodextrin-4-biphenylylacetic acid conjugate.

Journal: Journal of drug targeting 20030501

Title: Characterization of the interaction between a novel convulsant agent, norbiphen, and GABA(A) and other ligand-gated ion channels.

Journal: Neuropharmacology 20020901

Title: Synthetic applications of o- and p-halobenzyl sulfones as zwitterionic synthons: preparation of ortho-substituted cinnamates and biarylacetic acids.

Journal: The Journal of organic chemistry 20020726

Title: Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer.

Journal: International journal of pharmaceutics 20020604

Title: [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].

Journal: The Japanese journal of antibiotics 20020601

Title: A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.

Journal: The Journal of antimicrobial chemotherapy 20011201

Title: Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.

Journal: Chemical communications (Cambridge, England) 20011121

Title: Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

Journal: Pharmacological research 20010901

Title: Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase.

Journal: Biochemical pharmacology 20010801

Title: Effects of amino acids on the amidation of polyaromatic carboxylic acids by Bacillus cereus.

Journal: Bioscience, biotechnology, and biochemistry 20010801

Title: Topical non-steroidal drugs are systemically absorbed and may cause renal disease.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19990101

Title: Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.

Journal: General pharmacology 19971101

Title: Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19960201

Title: Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice.

Journal: The Journal of antimicrobial chemotherapy 19941101

Title: Biphenylacetate, but not theophylline, lethally interacts with ciprofloxacin in mice.

Journal: Pharmacology & toxicology 19931101

Title: Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice.

Journal: Antimicrobial agents and chemotherapy 19930901

Title: Van Eerdenbrugh B, et al. 2-(Biphenyl-4-yl)acetic acid (felbinac). Acta Crystallogr Sect E Struct Rep Online.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:5728-52-9 Molecular Formula|5728-52-9 MDL|5728-52-9 SMILES|5728-52-9 4-Biphenylacetic acid