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5746-04-3,MFCD04114278
Catalog No.:AA00ED8H

5746-04-3 | Cml

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1mg
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5mg
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25mg
≥ 97% (Assay by titration)
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100mg
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250mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ED8H
Chemical Name:
Cml
CAS Number:
5746-04-3
Molecular Formula:
C8H16N2O4
Molecular Weight:
204.2236
MDL Number:
MFCD04114278
SMILES:
OC(=O)CNCCCC[C@@H](C(=O)O)N
Properties
Computed Properties
 
Complexity:
196  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
-5.2  

Literature

Title: Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20160701

Title: Betanin reduces the accumulation and cross-links of collagen in high-fructose-fed rat heart through inhibiting non-enzymatic glycation.

Journal: Chemico-biological interactions 20150205

Title: Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20131201

Title: Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20131201

Title: Formation and inhibition of Nε-(carboxymethyl)lysine in saccharide-lysine model systems during microwave heating.

Journal: Molecules (Basel, Switzerland) 20121031

Title: Plasma glycation levels are associated with severity in sepsis.

Journal: European journal of clinical investigation 20121001

Title: The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.

Journal: American journal of physiology. Endocrinology and metabolism 20121001

Title: Study of the urinary and faecal excretion of Nε-carboxymethyllysine in young human volunteers.

Journal: Amino acids 20120801

Title: Decreased plasma sRAGE levels in COPD: influence of oxygen therapy.

Journal: European journal of clinical investigation 20120801

Title: An explorative analysis of secretory receptor for advanced glycation endproducts in primary focal segmental glomerulosclerosis.

Journal: Clinical and experimental nephrology 20120801

Title: Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy.

Journal: Biochemical and biophysical research communications 20120713

Title: N-acetylcysteine reduces oxidative stress in sickle cell patients.

Journal: Annals of hematology 20120701

Title: Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20120701

Title: Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20120601

Title: Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study.

Journal: Diabetes 20120501

Title: High serum advanced glycation end-products predict coronary artery disease irrespective of arterial stiffness in diabetic patients.

Journal: Korean circulation journal 20120501

Title: The associations of advanced glycation end products and its soluble receptor with pancreatic cancer risk: a case-control study within the prospective EPIC Cohort.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120401

Title: Advanced glycation end-product Nε-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes.

Journal: Atherosclerosis 20120401

Title: Improvement of arterial stiffness by reducing oxidative stress damage in elderly hypertensive patients after 6 months of atorvastatin therapy.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120401

Title: Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome.

Journal: Heart failure reviews 20120301

Title: Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis.

Journal: Journal of hepatology 20120301

Title: Two fluorescent wavelengths, 440(ex)/520(em) nm and 370(ex)/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetes.

Journal: Diabetes technology & therapeutics 20120301

Title: Advanced glycation end products contribute to the immunogenicity of IFN-β pharmaceuticals.

Journal: The Journal of allergy and clinical immunology 20120301

Title: Peripheral RAGE (receptor for advanced glycation endproducts)-ligands in normal pregnancy and preeclampsia: novel markers of inflammatory response.

Journal: Journal of reproductive immunology 20120301

Title: Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine.

Journal: The Biochemical journal 20120215

Title: Skin autofluorescence is increased in patients with carotid artery stenosis and peripheral artery disease.

Journal: The international journal of cardiovascular imaging 20120201

Title: N(ɛ)-(carboxymethyl)lysine modification of elastin alters its biological properties: implications for the accumulation of abnormal elastic fibers in actinic elastosis.

Journal: The Journal of investigative dermatology 20120201

Title: Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet.

Journal: Molecular and cellular biochemistry 20120201

Title: Formation of early and advanced Maillard reaction products correlates to the ripening of cheese.

Journal: Journal of agricultural and food chemistry 20120118

Title: 'NEPP' peritoneal dialysis regimen has beneficial effects on plasma CEL and 3-DG, but not pentosidine, CML, and MGO.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20120101

Title: Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study.

Journal: European journal of clinical nutrition 20120101

Title: Olmesartan medoxomil is associated with decreased plasma AGEs, pentosidine, and N-(epsilon)-carboxymethyl-lysine levels in hemodialysis patients.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101

Title: Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation.

Journal: International journal of molecular sciences 20120101

Title: Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus.

Journal: PloS one 20120101

Title: RAGE mediates accelerated diabetic vein graft atherosclerosis induced by combined mechanical stress and AGEs via synergistic ERK activation.

Journal: PloS one 20120101

Title: Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes.

Journal: PloS one 20120101

Title: Rosiglitazone modulates the behaviors of diabetic host-derived fibroblasts in a carboxymethyllysine-modified collagen model.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20120101

Title: Induction of oxidative stress in kidney.

Journal: International journal of nephrology 20120101

Title: Aldose reductase, oxidative stress, and diabetic mellitus.

Journal: Frontiers in pharmacology 20120101

Title: The effects of low-dose nepsilon-(carboxymethyl)lysine (CML) and nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function.

Journal: Cardiovascular diabetology 20120101

Title: SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.

Journal: The Journal of biological chemistry 20111230

Title: Irbesartan treatment does not influence plasma levels of the advanced glycation end products N(epsilon)(1-carboxymethyl)lysine and N(epsilon)(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101

Title: UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Nε-carboxymethyl lysine (CML) in keratin of skin.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

Title: Development of monoclonal antibodies specific for glycated prion protein.

Journal: Journal of toxicology and environmental health. Part A 20111101

Title: The presence of N(ε)-(Carboxymethyl) lysine in the human epidermis.

Journal: Biochimica et biophysica acta 20111001

Title: Association of sVAP-1, sRAGE, and CML with lactation-induced insulin sensitivity in young non-diabetic healthy women.

Journal: Clinica chimica acta; international journal of clinical chemistry 20110918

Title: AGE formation blockade with aminoguanidine does not ameliorate chronic allograft nephropathy.

Journal: Life sciences 20110912

Title: RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110901

Title: Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis.

Journal: Journal of clinical biochemistry and nutrition 20110901

Title: Skin advanced glycation end product accumulation and muscle strength among adult men.

Journal: European journal of applied physiology 20110701

Title: Circulating levels and dietary intake of the advanced glycation end-product marker carboxymethyl lysine in chronic kidney disease patients on conservative predialysis therapy: a pilot study.

Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20110701

Title: Protective role of adiponectin on endothelial dysfunction induced by AGEs: a clinical and experimental approach.

Journal: Microvascular research 20110701

Title: Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism.

Journal: Reproduction (Cambridge, England) 20110701

Title: Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.

Journal: American journal of physiology. Renal physiology 20110701

Title: Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain.

Journal: Diabetes 20110601

Title: Transport of free and peptide-bound glycated amino acids: synthesis, transepithelial flux at Caco-2 cell monolayers, and interaction with apical membrane transport proteins.

Journal: Chembiochem : a European journal of chemical biology 20110516

Title: Differential effects of advanced glycation end-products on renal tubular cell inflammation.

Journal: Nephrology (Carlton, Vic.) 20110501

Title: An autoantibody against N(ε)-(carboxyethyl)lysine (CEL): possible involvement in the removal of CEL-modified proteins by macrophages.

Journal: Biochemical and biophysical research communications 20110408

Title: Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction.

Journal: Free radical biology & medicine 20110401

Title: Endogenous secretory receptor for advanced glycation end products is associated with low serum interleukin-1 receptor antagonist and elevated IL-6 in older community-dwelling adults.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20110401

Title: Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.

Journal: Diabetes care 20110401

Title: Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology.

Journal: Human reproduction (Oxford, England) 20110301

Title: Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes.

Journal: Diabetes 20110301

Title: Oxidative damage in the liver of rats treated with glycolaldehyde.

Journal: International journal of toxicology 20110301

Title: Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress.

Journal: Cellular and molecular life sciences : CMLS 20110201

Title: Mapping the glycoxidation product Nε-carboxymethyllysine in the milk proteome.

Journal: Proteomics 20110201

Title: Higher plasma levels of advanced glycation end products are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study.

Journal: Diabetes care 20110201

Title: Pentosidine and N-carboxymethyl-lysine: biomarkers for type 2 diabetic retinopathy.

Journal: European journal of ophthalmology 20110101

Title: The influence of bicarbonate/lactate-buffered PD fluids on N{ε}-(carboxyethyl)lysine and N{ε}-(carboxymethyl)lysine in peritoneal effluent.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20110101

Title: Inhibition of advanced glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity.

Journal: Planta medica 20110101

Title: Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men.

Journal: Diabetes research and clinical practice 20110101

Title: AGE-RAGE in multiple sclerosis brain.

Journal: Immunological investigations 20110101

Title: Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report.

Journal: Cardiovascular diabetology 20110101

Title: Elevated Nε-(carboxymethyl)lysine is associated with apoptosis of retinal pericytes in streptozotocin-induced diabetic rats.

Journal: Ophthalmic research 20110101

Title: Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study.

Journal: Respiratory research 20110101

Title: The metabolic advantage of tumor cells.

Journal: Molecular cancer 20110101

Title: Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes.

Journal: American journal of nephrology 20110101

Title: Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.

Journal: Molecular vision 20110101

Title: Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease.

Journal: Arthritis research & therapy 20110101

Title: Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and -9: an in vitro study.

Journal: Molecular vision 20110101

Title: Glycolaldehyde induces oxidative stress in the heart: a clue to diabetic cardiomyopathy?

Journal: Cardiovascular toxicology 20101201

Title: Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice.

Journal: European journal of pharmacology 20101201

Title: Dietary advanced glycation end products and aging.

Journal: Nutrients 20101201

Title: Immunochemical and mass spectrometric analysis of Nε-(carboxymethyl)lysine content of AGE-BSA systems prepared with and without selected antiglycation agents.

Journal: Journal of agricultural and food chemistry 20101124

Title: Effect of inhibitor compounds on Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) formation in model foods.

Journal: Journal of agricultural and food chemistry 20101124

Title: Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products.

Journal: Transfusion 20101101

Title: Polyphenols and human health: prevention of disease and mechanisms of action.

Journal: Nutrients 20101101

Title: Differences in mouse models of diabetes mellitus in studies of male reproduction.

Journal: International journal of andrology 20101001

Title: N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model.

Journal: Biochimie 20101001

Title: Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?

Journal: Diabetes care 20101001

Title: Circulating glycolaldehyde induces oxidative damage in the kidney of rats.

Journal: Diabetes research and clinical practice 20100901

Title: Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.

Journal: Kidney international 20100801

Title: Regarding 'Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men Study'.

Journal: Journal of vascular surgery 20100801

Title: Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: the Baltimore Longitudinal Study of Aging.

Journal: The journal of nutrition, health & aging 20100801

Title: Combined immunoelectron microscopic and computer-assisted image analyses to detect advanced glycation end-products in human myocardium.

Journal: Histochemistry and cell biology 20100701

Title: Glycoxidative stress-induced mitophagy modulates mitochondrial fates.

Journal: Annals of the New York Academy of Sciences 20100701

Title: Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption.

Journal: Journal of agricultural and food chemistry 20100609

Title: Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine.

Journal: Clinics (Sao Paulo, Brazil) 20100601

Title: Increased levels of N(epsilon)-(carboxymethyl)lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease: a pilot study.

Journal: Clinical science (London, England : 1979) 20100506

Title: Inhibitory effect of the Cree traditional medicine wiishichimanaanh (Vaccinium vitis-idaea) on advanced glycation endproduct formation: identification of active principles.

Journal: Phytotherapy research : PTR 20100501

Title: Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

Journal: Diabetologia 20100501

Title: Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20100501

Title: Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins.

Journal: Biochimica et biophysica acta 20100401

Title: Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.

Journal: Diabetes 20100401

Title: Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction.

Journal: European journal of heart failure 20100401

Title: Model studies on chemical and textural modifications in gelatin films by reaction with glyoxal and glycolaldehyde.

Journal: Journal of agricultural and food chemistry 20100324

Title: Effect of reactive-aldehydes on the modification and dysfunction of human serum albumin.

Journal: Journal of pharmaceutical sciences 20100301

Title: Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of aging.

Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100301

Title: AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.

Journal: American journal of physiology. Cell physiology 20100301

Title: Hyperglycemia impairs proteasome function by methylglyoxal.

Journal: Diabetes 20100301

Title: Cardiovascular autonomic neuropathy, HDL cholesterol, and smoking correlate with arterial stiffness markers determined 18 years later in type 1 diabetes.

Journal: Diabetes care 20100301

Title: Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats.

Journal: Biochemical and biophysical research communications 20100226

Title: Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice.

Journal: European journal of pharmacology 20100225

Title: Formation of N(epsilon)-(carboxymethyl)lysine and loss of lysine in casein glucose-fatty acid model systems.

Journal: Journal of agricultural and food chemistry 20100210

Title: Plasma sRAGE is not associated with urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage.

Journal: Diabetes research and clinical practice 20100201

Title: Carboxymethylation of the fibrillar collagen with respect to formation of hydroxyapatite.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20100201

Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.

Journal: Peptides 20100201

Title: Involvement of advanced glycation end-products, pentosidine and N(epsilon)-(carboxymethyl)lysine, in doxorubicin-induced cardiomyopathy in rats.

Journal: Toxicology 20100131

Title: Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion.

Journal: Journal of diabetes and its complications 20100101

Title: Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine.

Journal: Journal of diabetes and its complications 20100101

Title: Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study.

Journal: European journal of applied physiology 20100101

Title: Vitamin B6 metabolism in chronic kidney disease--relation to transsulfuration, advanced glycation and cardiovascular disease.

Journal: Nephron. Clinical practice 20100101

Title: Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.

Journal: Biological & pharmaceutical bulletin 20100101

Title: NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy.

Journal: Journal of ophthalmology 20100101

Title: Advanced glycation end products, oxidative stress and diabetic nephropathy.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study.

Journal: Cardiovascular diabetology 20100101

Title: Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes.

Journal: Arthritis research & therapy 20100101

Title: Diagnostic potential of plasma carboxymethyllysine and carboxyethyllysine in multiple sclerosis.

Journal: Journal of neuroinflammation 20100101

Title: GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?

Journal: Cardiovascular diabetology 20100101

Title: Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease.

Journal: Cardiovascular diabetology 20100101

Title: Role of the receptor for advanced glycation end products in hepatic fibrosis.

Journal: World journal of gastroenterology 20091214

Title: High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis.

Journal: European journal of clinical investigation 20091201

Title: Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.

Journal: The Journal of clinical endocrinology and metabolism 20091201

Title: Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats.

Journal: Metabolism: clinical and experimental 20091101

Title: Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue.

Journal: Diabetes 20091101

Title: Plasma carboxymethyl-lysine, an advanced glycation end product, and all-cause and cardiovascular disease mortality in older community-dwelling adults.

Journal: Journal of the American Geriatrics Society 20091001

Title: Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: Influence of insulin and muscle fiber type in nepsilon-(carboxymethyl)-lysine accumulation in soleus muscle of rats with streptozotocin-induced diabetes mellitus.

Journal: Pathobiology : journal of immunopathology, molecular and cellular biology 20091001

Title: Association between serum levels of the soluble receptor (sRAGE) for advanced glycation endproducts (AGEs) and their receptor (RAGE) in peripheral blood mononuclear cells of children with type 1 diabetes mellitus.

Journal: Journal of pediatric endocrinology & metabolism : JPEM 20091001

Title: Novel application of surface plasmon resonance biosensor chips for measurement of advanced glycation end products in serum of Zucker diabetic fatty rats.

Journal: Biosensors & bioelectronics 20090915

Title: Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.

Journal: Journal of agricultural and food chemistry 20090909

Title: Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men Study.

Journal: Journal of vascular surgery 20090901

Title: Editorial: A recipe for inflammation.

Journal: Journal of leukocyte biology 20090901

Title: Advanced glycation end products accumulate in the reproductive tract of men with diabetes.

Journal: International journal of andrology 20090801

Title: Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration.

Journal: Molecular & cellular proteomics : MCP 20090801

Title: Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells.

Journal: Molecular nutrition & food research 20090801

Title: Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats.

Journal: Journal of medicinal food 20090801

Title: Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats.

Journal: Journal of ethnopharmacology 20090715

Title: The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription.

Journal: Journal of ethnopharmacology 20090715

Title: Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms.

Journal: The Journal of pathology 20090701

Title: Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20090601

Title: Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20090601

Title: Specific local cardiovascular changes of Nepsilon-(carboxymethyl)lysine, vascular endothelial growth factor, and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects.

Journal: Diabetes 20090501

Title: Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women.

Journal: Age and ageing 20090501

Title: Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus.

Journal: Atherosclerosis 20090401

Title: Advanced glycation end products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells.

Journal: International journal of molecular medicine 20090401

Title: 7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney.

Journal: Biological & pharmaceutical bulletin 20090401

Title: Immunohistochemical detection of advanced glycation end products in human bladder with specific monoclonal antibody.

Journal: International journal of urology : official journal of the Japanese Urological Association 20090401

Title: Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women.

Journal: Aging clinical and experimental research 20090401

Title: Analysis of advanced glycation endproducts in dairy products by isotope dilution liquid chromatography-electrospray tandem mass spectrometry. The particular case of carboxymethyllysine.

Journal: Journal of chromatography. A 20090320

Title: Letter by Hartog et al. regarding article, 'Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines'.

Journal: Circulation 20090317

Title: Ultra performance liquid chromatography-mass spectrometric determination of the site specificity of modification of beta-casein by glucose and methylglyoxal.

Journal: Amino acids 20090301

Title: Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches.

Journal: International journal of molecular sciences 20090301

Title: Determination of Nepsilon-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry.

Journal: Amino acids 20090201

Title: Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adults.

Journal: European journal of nutrition 20090201

Title: Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20090201

Title: Plasma advanced glycation end products are decreased in obese children compared with lean controls.

Journal: International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity 20090101

Title: Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20090101

Title: Modification of collagen in vitro with respect to formation of Nepsilon-carboxymethyllysine.

Journal: International journal of biological macromolecules 20090101

Title: Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults.

Journal: American journal of hypertension 20090101

Title: N(epsilon)-(Carboxymethyl)lysine and Coronary Atherosclerosis-Associated Low Density Lipoprotein Abnormalities in Type 2 Diabetes: Current Status.

Journal: Journal of clinical biochemistry and nutrition 20090101

Title: Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20090101

Title: Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells.

Journal: BMC cell biology 20090101

Title: Elevation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in patients presenting with acute myocardial infarction.

Journal: Clinical chemistry and laboratory medicine 20090101

Title: RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.

Journal: Journal of translational medicine 20090101

Title: Medical bioremediation of age-related diseases.

Journal: Microbial cell factories 20090101

Title: Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation.

Journal: Critical care (London, England) 20090101

Title: Combination effects of enalapril and losartan on lipid peroxidation in the kidneys of KK-Ay/Ta mice.

Journal: Nephron. Experimental nephrology 20090101

Title: Association between carotid diameter and the advanced glycation end product N-epsilon-carboxymethyllysine (CML).

Journal: Cardiovascular diabetology 20090101

Title: Advanced glycation endproducts in sepsis and mechanical ventilation: extra or leading man?

Journal: Critical care (London, England) 20090101

Title: Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells.

Journal: Arthritis research & therapy 20090101

Title: Characterization of anti-advanced glycation end product antibodies to nonenzymatically lysine-derived and arginine-derived glycated products.

Journal: Journal of immunoassay & immunochemistry 20090101

Title: Matrix metalloproteinases in subjects with type 1 diabetes.

Journal: BMC clinical pathology 20090101

Title: The influence of sublethal blue light exposure on human RPE cells.

Journal: Molecular vision 20090101

Title: Determination of advanced glycation end-products on IgG in liver cirrhosis.

Journal: Hepato-gastroenterology 20090101

Title: Concentrations of receptor for advanced glycation end products, VEGF and CML in plasma, follicular fluid, and peritoneal fluid in women with and without endometriosis.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20081201

Title: Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice.

Journal: Molecular nutrition & food research 20081101

Title: Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and anemia in adults: the Baltimore longitudinal study of aging.

Journal: Journal of the American Geriatrics Society 20081101

Title: Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.

Journal: Free radical biology & medicine 20081015

Title: Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS).

Journal: Clinical endocrinology 20081001

Title: Integrin-associated protein association with SRC homology 2 domain containing tyrosine phosphatase substrate 1 regulates igf-I signaling in vivo.

Journal: Diabetes 20081001

Title: Skin autofluorescence is increased in systemic lupus erythematosus but is not reflected by elevated plasma levels of advanced glycation endproducts.

Journal: Rheumatology (Oxford, England) 20081001

Title: Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines.

Journal: Circulation 20080902

Title: Severity of diabetic microvascular complications is associated with a low soluble RAGE level.

Journal: Diabetes & metabolism 20080901

Title: Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients.

Journal: Journal of cardiac failure 20080901

Title: What is the influence of renal function on the prognostic value of advanced glycation end-products and sRAGE in heart failure?

Journal: Journal of cardiac failure 20080901

Title: Pentosidine accumulation in human oocytes and their correlation to age-related apoptosis.

Journal: Acta histochemica et cytochemica 20080828

Title: Formation of lipid oxidation and isomerization products during processing of nuts and sesame seeds.

Journal: Journal of agricultural and food chemistry 20080827

Title: Plasma N-epsilon-(carboxymethyl)lysine levels are associated with the extent of vessel injury after coronary arterial stenting.

Journal: Coronary artery disease 20080801

Title: Effects of advanced glycation end products-inductor glyoxal and hydrogen peroxide as oxidative stress factors on rat retinal organ cultures and neuroprotection by UK-14,304.

Journal: Journal of neurochemistry 20080801

Title: Identification of AGE-precursors and AGE formation in glycation-induced BSA peptides.

Journal: BMB reports 20080731

Title: Renal N(epsilon)-carboxymethyllysine deposition after kidney transplantation.

Journal: Transplantation 20080727

Title: RAGE and modulation of ischemic injury in the diabetic myocardium.

Journal: Diabetes 20080701

Title: Comparison of N-epsilon-(Carboxymethyl)Lysine levels and percentage of eosinophils in induced sputum for assessment of small airway involvements in asthma.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20080701

Title: Characteristics of neurons and glia in the brain of Fukuyama type congenital muscular dystrophy.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20080701

Title: Comparative LC-MS/MS profiling of free and protein-bound early and advanced glycation-induced lysine modifications in dairy products.

Journal: Analytica chimica acta 20080609

Title: Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products.

Journal: Journal of immunological methods 20080520

Title: Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.

Journal: Clinical journal of the American Society of Nephrology : CJASN 20080501

Title: Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus.

Journal: European journal of endocrinology 20080501

Title: Effects of oral administration of Stephania tetrandra S. Moore on neovascularization of retinal and choroidal capillaries of diabetes in rats.

Journal: Phytotherapy research : PTR 20080501

Title: Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats.

Journal: Biochemical and biophysical research communications 20080411

Title: N epsilon-(carboxymethyl)lysine during the early development of hypertension.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Usefulness of antibodies for evaluating the biological significance of AGEs.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Increased methionine sulfoxide content of apoA-I in type 1 diabetes.

Journal: Journal of lipid research 20080401

Title: Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

Journal: Journal of hypertension 20080401

Title: Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies.

Journal: The Journal of pharmacy and pharmacology 20080401

Title: Determination of N epsilon-(carboxymethyl)lysine in foods and related systems.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Plasma concentration and urinary excretion of N epsilon-(carboxymethyl)lysine in breast milk- and formula-fed infants.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Induction of heat shock proteins and the proteasome system by casein-N epsilon-(carboxymethyl)lysine and N epsilon-(carboxymethyl)lysine in Caco-2 cells.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Maillard products as biomarkers in cancer.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Evidence against nitric oxide-quenching effects of chemically defined Maillard reaction products.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080401

Title: Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.

Journal: Journal of immunological methods 20080320

Title: N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response.

Journal: Molecular nutrition & food research 20080301

Title: Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.

Journal: Diabetes 20080201

Title: Identification of CML-modified proteins in hemofiltrate of diabetic patients by proteome analysis.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

Title: AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

Journal: American journal of physiology. Cell physiology 20080101

Title: Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis.

Journal: Critical care (London, England) 20080101

Title: Cardiac troponin T and advanced glycation end-products in hemodialysis patients.

Journal: American journal of nephrology 20080101

Title: Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension.

Journal: Nephron. Clinical practice 20080101

Title: Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors.

Journal: Arthritis research & therapy 20080101

Title: Role of advanced glycation end products in diabetic neuropathy.

Journal: Current pharmaceutical design 20080101

Title: Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.

Journal: Arthritis research & therapy 20080101

Title: The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes.

Journal: Cardiovascular diabetology 20080101

Title: Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia.

Journal: Hypertension in pregnancy 20080101

Title: Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.

Journal: Journal of inflammation research 20080101

Title: Markers of endothelial activity are related to components of the metabolic syndrome, but not to circulating concentrations of the advanced glycation end-product N epsilon-carboxymethyl-lysine in healthy Swedish men.

Journal: Atherosclerosis 20071201

Title: Clinical and prognostic value of advanced glycation end-products in chronic heart failure.

Journal: European heart journal 20071201

Title: Simultaneous analysis of lysine, Nepsilon-carboxymethyllysine and lysinoalanine from proteins.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Title: The ligand activity of AGE-proteins to scavenger receptors is dependent on their rate of modification by AGEs.

Journal: Biochimica et biophysica acta 20071201

Title: Nepsilon-(carboxymethyl)lysine, a major advanced glycation end product in exhaled breath condensate as a biomarker of small airway involvement in asthma.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20071201

Title: Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications.

Journal: Vascular health and risk management 20071201

Title: Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.

Journal: The Journal of biological chemistry 20071123

Title: Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia.

Journal: Journal of inherited metabolic disease 20071101

Title: Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.

Journal: Biological & pharmaceutical bulletin 20071101

Title: Protective effect of heat-processed American ginseng against diabetic renal damage in rats.

Journal: Journal of agricultural and food chemistry 20071017

Title: Characterization of glycation adducts on human serum albumin by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Journal: Clinica chimica acta; international journal of clinical chemistry 20071001

Title: Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts.

Journal: Molecular nutrition & food research 20070901

Title: Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.

Journal: Journal of Alzheimer's disease : JAD 20070901

Title: Role of N-(carboxymethyl)lysine in the development of ischemic heart disease in type 2 diabetes mellitus.

Journal: Journal of clinical biochemistry and nutrition 20070901

Title: Vimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin aging.

Journal: The Journal of biological chemistry 20070810

Title: Pyridoxal phosphate prevents progression of diabetic nephropathy.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801

Title: Unchanged serum levels of advanced glycation endproducts in patients with liver disease.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070801

Title: Site-specific formation of Maillard, oxidation, and condensation products from whey proteins during reaction with lactose.

Journal: Journal of agricultural and food chemistry 20070725

Title: Study of posttranslational non-enzymatic modifications of collagen using capillary electrophoresis/mass spectrometry and high performance liquid chromatography/mass spectrometry.

Journal: Journal of chromatography. A 20070706

Title: Reduced systemic advanced glycation end products in children receiving peritoneal dialysis with low glucose degradation product content.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701

Title: Fasting and postprandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes.

Journal: Diabetes care 20070701

Title: Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery?

Journal: Experimental gerontology 20070701

Title: Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Hypochlorous acid generates N epsilon-(carboxymethyl)lysine from Amadori products.

Journal: Free radical research 20070601

Title: Kinetics of formation of three indicators of the maillard reaction in model cookies: influence of baking temperature and type of sugar.

Journal: Journal of agricultural and food chemistry 20070530

Title: Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.

Journal: Diabetologia 20070501

Title: Glycoxidised LDL isolated from subjects with impaired glucose tolerance increases CD36 and peroxisome proliferator-activator receptor gamma gene expression in macrophages.

Journal: Diabetologia 20070501

Title: Simultaneous determination of the advanced glycation end product N (epsilon)-carboxymethyllysine and its precursor, lysine, in exhaled breath condensate using isotope-dilution-hydrophilic-interaction liquid chromatography coupled to tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20070401

Title: Investigation of pathways of advanced glycation end-products accumulation in macrophages.

Journal: Molecular nutrition & food research 20070401

Title: Forty years of furosine - forty years of using Maillard reaction products as indicators of the nutritional quality of foods.

Journal: Molecular nutrition & food research 20070401

Title: Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20070401

Title: Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice.

Journal: British journal of cancer 20070326

Title: Circulating levels of Nepsilon-(carboxymethyl)lysine are increased in systemic sclerosis.

Journal: Rheumatology (Oxford, England) 20070301

Title: Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.

Journal: Biochimica et biophysica acta 20070301

Title: Maillard reaction indicators in diets usually consumed by adolescent population.

Journal: Molecular nutrition & food research 20070301

Title: Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor.

Journal: American journal of physiology. Cell physiology 20070201

Title: Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?

Journal: Endocrinology 20070201

Title: Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.

Journal: Metabolism: clinical and experimental 20070201

Title: Evaluation of a gas chromatography/mass spectrometry method for the quantification of carboxymethyllysine in food samples.

Journal: Journal of chromatography. A 20070126

Title: Advanced glycation end product deposits in climatic droplet keratopathy.

Journal: The British journal of ophthalmology 20070101

Title: Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation.

Journal: Kidney international 20070101

Title: Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070101

Title: Overproduction of N(epsilon)-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of aged rat.

Journal: Biological & pharmaceutical bulletin 20070101

Title: Pravastatin inhibits carboxymethyllysine-induced monocyte chemoattractant protein 1 expression in podocytes via prevention of signalling events.

Journal: Nephron. Experimental nephrology 20070101

Title: Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?

Journal: Neurological research 20070101

Title: Carbonyl and oxidative stress in patients with breast cancer--is there a relation to the stage of the disease?

Journal: Neoplasma 20070101

Title: Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress.

Journal: Redox report : communications in free radical research 20070101

Title: Amount of N(omega)-(Carboxymethyl)arginine generated in collagen and bovine serum albumin during glycation reactions is significantly different.

Journal: Connective tissue research 20070101

Title: Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia.

Journal: BMC neurology 20070101

Title: Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia.

Journal: Redox report : communications in free radical research 20070101

Title: Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects.

Journal: Biological research 20070101

Title: Effects of valsartan therapy on protein glycoxidation.

Journal: Metabolism: clinical and experimental 20061201

Title: Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein.

Journal: The Journal of clinical endocrinology and metabolism 20061101

Title: The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?

Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20061101

Title: N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?

Journal: Arteriosclerosis, thrombosis, and vascular biology 20061101

Title: Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes.

Journal: Diabetologia 20061001

Title: The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20061001

Title: Posttranslationally modified proteins as mediators of sustained intestinal inflammation.

Journal: The American journal of pathology 20061001

Title: Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis.

Journal: Cancer letters 20060928

Title: Concentrations of Nepsilon-carboxymethyllysine in human breast milk, infant formulas, and urine of infants.

Journal: Journal of agricultural and food chemistry 20060906

Title: Dose-dependent utilisation of casein-linked lysinoalanine, N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine in rats.

Journal: Molecular nutrition & food research 20060901

Title: Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites.

Journal: The Journal of nutritional biochemistry 20060801

Title: High glucose and Nepsilon-(carboxymethyl) lysine bovine serum albumin modulate release of matrix metalloproteinases in cultured human endothelial cells.

Journal: European journal of nutrition 20060801

Title: Antioxidant tempol lowers age-related increases in insulin resistance in Fischer 344 rats.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701

Title: Site specificity of glycation and carboxymethylation of bovine serum albumin by fructose.

Journal: Amino acids 20060601

Title: S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

Journal: Archives of biochemistry and biophysics 20060601

Title: Transepithelial flux of early and advanced glycation compounds across Caco-2 cell monolayers and their interaction with intestinal amino acid and peptide transport systems.

Journal: The British journal of nutrition 20060601

Title: Should we reconsider the advanced glycation end product issue in hemodialysis patients?

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060501

Title: Phage-displayed antibodies for the detection of glycated proteasome in aging cells.

Journal: Annals of the New York Academy of Sciences 20060501

Title: Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20060401

Title: Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products.

Journal: The international journal of biochemistry & cell biology 20060301

Title: Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia.

Journal: International journal of clinical practice 20060301

Title: Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.

Journal: Investigative ophthalmology & visual science 20060301

Title: Synthesis, tandem MS- and NMR-based characterization, and quantification of the carbon 13-labeled advanced glycation endproduct, 6-N-carboxymethyllysine.

Journal: Amino acids 20060201

Title: The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha.

Journal: The Journal of investigative dermatology 20060201

Title: Serum carboxymethyllysine predicts mortality in hemodialysis patients.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060201

Title: A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.

Journal: Diabetes 20060201

Title: Interaction of Nepsilon(carboxymethyl)lysine- and methylglyoxal-modified albumin with endothelial cells and macrophages. Splice variants of RAGE may limit the responsiveness of human endothelial cells to AGEs.

Journal: Thrombosis and haemostasis 20060201

Title: Immunohistochemical localization of advanced glycation end products in pinguecula.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060101

Title: Impaired left ventricular relaxation in type 2 diabetic rats is related to myocardial accumulation of N(epsilon)-(carboxymethyl) lysine.

Journal: European journal of heart failure 20060101

Title: Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis.

Journal: Clinical biochemistry 20060101

Title: Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings.

Journal: Annals of the rheumatic diseases 20060101

Title: Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats.

Journal: Kidney international 20060101

Title: Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products.

Journal: Cardiovascular diabetology 20060101

Title: Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study.

Journal: BMC ophthalmology 20060101

Title: Insights from the diabetes control and complications trial/epidemiology of diabetes interventions and complications study on the use of intensive glycemic treatment to reduce the risk of complications of type 1 diabetes.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

Title: Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome.

Journal: Arthritis research & therapy 20060101

Title: The increase in plasma levels of Nepsilon-(carboxymethyl)lysine during icodextrin treatment of peritoneal dialysis patients is not associated with increased plasma levels of vascular cell adhesion molecule-1.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20060101

Title: Determination of N epsilon-(carboxymethyl)lysine in exhaled breath condensate using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711).

Journal: American journal of nephrology 20060101

Title: Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics.

Journal: Arthritis research & therapy 20060101

Title: Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure.

Journal: Molecular medicine (Cambridge, Mass.) 20060101

Title: Advanced glycation end product in diabetic rat skeletal muscle in vivo.

Journal: Pathobiology : journal of immunopathology, molecular and cellular biology 20060101

Title: Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells.

Journal: Kidney international 20051201

Title: Oxidation and carboxy methyl lysine-modification of albumin: possible involvement in the progression of oxidative stress in hemodialysis patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20051201

Title: Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?

Journal: Vascular health and risk management 20051201

Title: Rapid and simple method for determination of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in urine using gas chromatography/mass spectrometry.

Journal: Biomedical chromatography : BMC 20051101

Title: Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes.

Journal: Diabetes 20051101

Title: Oxidative stress and non-enzymatic glycation in IgA nephropathy.

Journal: Clinical nephrology 20051101

Title: Decreased levels of advanced glycation end-products in patients with Gilbert syndrome.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20050930

Title: Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.

Journal: American journal of physiology. Renal physiology 20050901

Title: Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050901

Title: The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy.

Journal: Acta neuropathologica 20050901

Title: Chemoselective synthesis of peptides containing major advanced glycation end-products of lysine and arginine.

Journal: The journal of peptide research : official journal of the American Peptide Society 20050901

Title: Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.

Journal: Journal of the American Society of Nephrology : JASN 20050801

Title: Vascular methylglyoxal metabolism and the development of hypertension.

Journal: Journal of hypertension 20050801

Title: Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition.

Journal: Diabetologia 20050801

Title: Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study.

Journal: Hypertension (Dallas, Tex. : 1979) 20050701

Title: Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection.

Journal: Molecular nutrition & food research 20050701

Title: Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

Journal: The Journal of biological chemistry 20050603

Title: Labeling studies on the formation pathway of Nepsilon-carboxymethyllysine in maillard-type reactions.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Effect of glucose concentration on formation of AGEs in erythrocytes in vitro.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Oxidative stress and neurodegeneration.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Low-molecular weight advanced glycation end products: markers of tissue AGE accumulation and more?

Journal: Annals of the New York Academy of Sciences 20050601

Title: Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Advanced glycation end product free adducts are cleared by dialysis.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Clinical implications of N epsilon-(carboxymethyl)lysine, advanced glycation end product, in children and adolescents with type 1 diabetes.

Journal: Diabetes, obesity & metabolism 20050501

Title: The AGE/RAGE/NF-(kappa)B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT).

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050501

Title: Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways.

Journal: The Journal of biological chemistry 20050401

Title: Nuclear proteasome activation and degradation of carboxymethylated histones in human keratinocytes following glyoxal treatment.

Journal: Free radical biology & medicine 20050315

Title: Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20050301

Title: Inhibitory effect of nifedipine on tumor necrosis factor alpha-induced neovascularization in cultured choroidal explants of streptozotocin-diabetic rat.

Journal: Biological & pharmaceutical bulletin 20050201

Title: Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.

Journal: PLoS medicine 20050201

Title: Apoptotic killing of fibroblasts by matrix-bound advanced glycation endproducts.

Journal: Science of aging knowledge environment : SAGE KE 20050126

Title: Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.

Journal: Biochemical pharmacology 20050101

Title: Development of capture assays for different modifications of human low-density lipoprotein.

Journal: Clinical and diagnostic laboratory immunology 20050101

Title: Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment.

Journal: Journal of neurochemistry 20050101

Title: Two immunochemical assays to measure advanced glycation end-products in serum from dialysis patients.

Journal: Clinical chemistry and laboratory medicine 20050101

Title: Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control.

Journal: Arthritis research & therapy 20050101

Title: The absorption and metabolism of modified amino acids in processed foods.

Journal: Journal of AOAC International 20050101

Title: [Advanced glycation and oxidation products in patients with atherosclerosis].

Journal: Casopis lekaru ceskych 20050101

Title: Detection of elevated N epsilon-carboxymethyllysine levels in muscular tissue and in serum of patients with fibromyalgia.

Journal: Scandinavian journal of rheumatology 20050101

Title: HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.

Journal: BioFactors (Oxford, England) 20050101

Title: Influence of icodextrin on plasma and dialysate levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20050101

Title: Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats.

Journal: Kidney international 20041201

Title: Relationship between blood levels of N-carboxymethyl-lysine and pentosidine and the severity of microangiopathy in type 2 diabetes.

Journal: Endocrine journal 20041201

Title: Conventional antibody against Nepsilon-(carboxymethyl)lysine (CML) shows cross-reaction to Nepsilon-(carboxyethyl)lysine (CEL): immunochemical quantification of CML with a specific antibody.

Journal: Journal of biochemistry 20041201

Title: The advanced glycation end-product N epsilon-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Journal: Neuroscience letters 20041123

Title: Intact glycation end products containing carboxymethyl-lysine and glyoxal lysine dimer obtained from synthetic collagen model peptide.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041101

Title: Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation.

Journal: Heart (British Cardiac Society) 20041101

Title: In vitro evidence for immune activating effect of specific AGE structures retained in uremia.

Journal: Kidney international 20041101

Title: Overproduction of N(epsilon)-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of streptozotocin-diabetic rat.

Journal: Biological & pharmaceutical bulletin 20041001

Title: Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon.

Journal: Experimental gerontology 20041001

Title: Liquid chromatographic method for the quantitative determination of Nepsilon-carboxymethyllysine in human plasma proteins.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

Title: The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040901

Title: Effect of advanced glycation end-products on gene expression and synthesis of TNF-alpha and endothelial nitric oxide synthase by endothelial cells.

Journal: Kidney international 20040901

Title: N(epsilon)-(carboxymethyl)lysine proliferated CD34(+) cells from rat choroidal explant in culture.

Journal: Biological & pharmaceutical bulletin 20040901

Title: Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone.

Journal: Journal of biochemistry 20040901

Title: Improvement of the quality of diabetes control and decrease in the concentrations of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus: results from a 10 year-prospective, population-based survey on the quality of diabetes care in Germany (JEVIN).

Journal: European journal of medical research 20040831

Title: Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema.

Journal: Diabetologia 20040801

Title: Possible mechanism for medial smooth muscle cell injury in diabetic nephropathy: glycoxidation-mediated local complement activation.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20040801

Title: Advanced glycoxidation end products in commonly consumed foods.

Journal: Journal of the American Dietetic Association 20040801

Title: Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria.

Journal: Mechanisms of ageing and development 20040801

Title: Nonenzymatic glycation at the N terminus of pathogenic prion protein in transmissible spongiform encephalopathies.

Journal: The Journal of biological chemistry 20040716

Title: Measurement of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in human plasma protein by stable-isotope-dilution tandem mass spectrometry.

Journal: Clinical chemistry 20040701

Title: Potential cardiovascular risk factors in chronic kidney disease: AGEs, total homocysteine and metabolites, and the C-reactive protein.

Journal: Kidney international 20040701

Title: The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane.

Journal: Kidney international 20040701

Title: The clinical chemome: a tool for the diagnosis and management of chronic disease.

Journal: Clinical chemistry 20040701

Title: Simple non-invasive assessment of advanced glycation endproduct accumulation.

Journal: Diabetologia 20040701

Title: N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels.

Journal: Atherosclerosis 20040601

Title: A possible involvement of the carboxymethylation process in carpal tunnel syndrome in hemodialysis patients.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20040601

Title: Receptor for advanced glycation endproduct (RAGE)-mediated nuclear factor-kappaB activation in vasculitic neuropathy.

Journal: Muscle & nerve 20040601

Title: N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease.

Journal: Free radical biology & medicine 20040515

Title: Chemical modification of muscle protein in diabetes.

Journal: Archives of biochemistry and biophysics 20040515

Title: AGEs, macrophage colony stimulating factor and vascular adhesion molecule blood levels are increased in patients with diabetic microangiopathy.

Journal: Thrombosis and haemostasis 20040501

Title: Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain.

Journal: Experimental gerontology 20040501

Title: Metal complexation by the peptide-bound maillard reaction products N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine.

Journal: Journal of agricultural and food chemistry 20040421

Title: Nepsilon-(carboxymethyl)lysine, Nepsilon-(carboxyethyl)lysine and vascular cell adhesion molecule-1 (VCAM-1) in relation to peritoneal glucose prescription and residual renal function; a study in peritoneal dialysis patients.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040401

Title: Increased production of urea hydrogen peroxide from Maillard reaction and a UHP-Fenton pathway related to glycoxidation damage in chronic renal failure.

Journal: Journal of the American Society of Nephrology : JASN 20040401

Title: Increased accumulation of the glycoxidation product Nepsilon-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody.

Journal: Biochimica et biophysica acta 20040322

Title: Increased levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunction.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040301

Title: Immunolocalization of lipid peroxidation/advanced glycation end products in amyloid A amyloidosis.

Journal: Free radical biology & medicine 20040301

Title: Influence of hemodialysis membrane permeability on serum levels of advanced glycation end products (AGEs) and homocysteine metabolites.

Journal: Clinical nephrology 20040301

Title: Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.

Journal: Aging cell 20040201

Title: Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics.

Journal: Analytical biochemistry 20040101

Title: Tomato paste fraction inhibiting the formation of advanced glycation end-products.

Journal: Bioscience, biotechnology, and biochemistry 20040101

Title: A review of the 'mysterious' wasting disease in Swedish moose (Alces alces L.) related to molybdenosis and disturbances in copper metabolism.

Journal: Biological trace element research 20040101

Title: Renal clearance of glycation adducts: anti-glycation defence in uraemia and dialysis.

Journal: Biochemical Society transactions 20031201

Title: Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats.

Journal: Biochemical Society transactions 20031201

Title: Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions.

Journal: The Journal of biological chemistry 20031121

Title: A quantitative model of the generation of N(epsilon)-(carboxymethyl)lysine in the Maillard reaction between collagen and glucose.

Journal: The Biochemical journal 20031115

Title: Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.

Journal: Diabetes 20031101

Title: Paradoxical impact of antioxidants on post-Amadori glycoxidation: Counterintuitive increase in the yields of pentosidine and Nepsilon-carboxymethyllysine using a novel multifunctional pyridoxamine derivative.

Journal: The Journal of biological chemistry 20031003

Title: Lack of recognition of Nepsilon-(carboxymethyl)lysine by the mouse liver reticulo-endothelial system: implications for pathophysiology.

Journal: Biochemical and biophysical research communications 20031003

Title: Advanced glycation end-products pentosidine and N epsilon-carboxymethyllysine are elevated in serum of patients with osteoporosis.

Journal: Rheumatology (Oxford, England) 20031001

Title: Identification of Nepsilon-(carboxymethyl)lysine-positive cells in astroglia-rich primary cultures.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20031001

Title: Liquid chromatography-based determination of urinary free and total N(epsilon)-(carboxymethyl)lysine excretion in normal and diabetic subjects.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905

Title: Impact of metabolic control and serum lipids on the concentration of advanced glycation end products in the serum of children and adolescents with type 1 diabetes, as determined by fluorescence spectroscopy and nepsilon-(carboxymethyl)lysine ELISA.

Journal: Diabetes care 20030901

Title: Level of an advanced glycated end product is genetically determined: a study of normal twins.

Journal: Diabetes 20030901

Title: Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030901

Title: The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901

Title: Association between blood indoxyl sulfate and carbonyl stress marker in hemodialysis patients.

Journal: Clinical nephrology 20030901

Title: Production of N(epsilon)-(carboxymethyl)lysine is impaired in mice deficient in NADPH oxidase: a role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation.

Journal: Diabetes 20030801

Title: Changes in glycation of fibrous type I collagen during long-term in vitro incubation with glucose.

Journal: Journal of protein chemistry 20030801

Title: In vitro glycoxidation of insoluble fibrous type I collagen: solubilization and advanced glycation end products.

Journal: Journal of protein chemistry 20030801

Title: Effect of smoking on risk factors for cardiovascular disease in patients with diabetes mellitus and renal insufficiency.

Journal: European journal of medical research 20030731

Title: The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.

Journal: The Journal of biological chemistry 20030711

Title: Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030701

Title: Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors/calcium-release channels.

Journal: Diabetes 20030701

Title: Non-enzymatic glycation in corneas from normal and diabetic donors and its effects on epithelial cell attachment in vitro.

Journal: Optometry (St. Louis, Mo.) 20030701

Title: Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.

Journal: Diabetes 20030601

Title: A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

Journal: Diabetes 20030601

Title: Identification of N epsilon-(carboxyethyl)lysine, one of the methylglyoxal-derived AGE structures, in glucose-modified protein: mechanism for protein modification by reactive aldehydes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505

Title: Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix.

Journal: European journal of biochemistry 20030501

Title: Increased levels of advanced glycation end products in human cataractous lenses.

Journal: Journal of cataract and refractive surgery 20030501

Title: Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products.

Journal: Journal of human hypertension 20030401

Title: Increased level of glycoxidation product N(epsilon)-(carboxymethyl)lysine in rat serum and urine proteins with aging: link with glycoxidative damage accumulation in kidney.

Journal: Archives of biochemistry and biophysics 20030315

Title: Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients.

Journal: Journal of the American Society of Nephrology : JASN 20030301

Title: Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs.

Journal: Diabetes 20030301

Title: Are advanced glycation end products cardiovascular risk factors in patients with CRF?

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030301

Title: Formation of advanced glycation end products during CAPD.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030301

Title: An inhibitor of advanced glycation end product formation reduces N epsilon-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030301

Title: Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of advanced glycation end products and ways of protection.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030301

Title: Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.

Journal: Diabetes 20030201

Title: Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.

Journal: Metabolism: clinical and experimental 20030201

Title: Serum levels of total homocysteine, homocysteine metabolites and of advanced glycation end-products (AGEs) in patients after renal transplantation.

Journal: Clinical nephrology 20030201

Title: N(carboxymethyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients.

Journal: Diabetes & metabolism 20030201

Title: Advanced glycation end-products in anterior chamber aqueous of cataractous patients.

Journal: Journal of cataract and refractive surgery 20030201

Title: DNA damage by carbonyl stress in human skin cells.

Journal: Mutation research 20030128

Title: Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species.

Journal: Kidney international 20030101

Title: Glucose degradation products in PD fluids: do they disappear from the peritoneal cavity and enter the systemic circulation?

Journal: Kidney international 20030101

Title: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

Journal: Neurobiology of aging 20030101

Title: Relative quantification of N(epsilon)-(Carboxymethyl)lysine, imidazolone A, and the Amadori product in glycated lysozyme by MALDI-TOF mass spectrometry.

Journal: Journal of agricultural and food chemistry 20030101

Title: Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes.

Journal: Journal of diabetes and its complications 20030101

Title: Relationship between plasma level of parathyroid hormone and carboxymethyllysine in hemodialyzed patients--does it exist?

Journal: Clinical nephrology 20030101

Title: Improvement in quality of diabetes control and concentrations of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus studied over a period of 10 years (JEVIN).

Journal: Journal of diabetes and its complications 20030101

Title: Effects of eparlestat on plasma levels of advanced glycation end products in patients with type 2 diabetes.

Journal: In vivo (Athens, Greece) 20030101

Title: Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease.

Journal: Journal of proteome research 20030101

Title: Calcification of the medial layer of the internal thoracic artery in diabetic patients: relevance of glycoxidation.

Journal: Journal of vascular research 20030101

Title: Photoaging and oxidative stress.

Journal: Experimental dermatology 20030101

Title: [Carbonyl stress significance in the pathogenesis of dialysis-related amyloidosis].

Journal: Przeglad lekarski 20030101

Title: Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins.

Journal: The Journal of biological chemistry 20021213

Title: Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

Journal: The Biochemical journal 20021201

Title: Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.

Journal: Endocrinology 20021201

Title: Activation of tubular epithelial cells in diabetic nephropathy.

Journal: Diabetes 20021201

Title: Alteration of the intracellular pH and apoptosis induction in a retinal cell line by the AGE-inducing agent glyoxal.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20021201

Title: Contribution of superoxide to reduced antioxidant activity of glycoxidative serum albumin.

Journal: Heart and vessels 20021101

Title: Glycation by ascorbic acid causes loss of activity of ribulose-1,5-bisphosphate carboxylase/oxygenase and its increased susceptibility to proteases.

Journal: Plant & cell physiology 20021101

Title: Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms.

Journal: Journal of the American Society of Nephrology : JASN 20021001

Title: Analysis of glycated and ascorbylated proteins by gas chromatography-mass spectrometry.

Journal: Journal of agricultural and food chemistry 20020925

Title: The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

Journal: Diabetes 20020901

Title: Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.

Journal: Diabetes 20020901

Title: Accumulation of imidazolone, pentosidine and N(epsilon)-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain.

Journal: Pathology international 20020901

Title: Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

Journal: Mechanisms of ageing and development 20020901

Title: Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.

Journal: Current eye research 20020901

Title: Nepsilon-(Carboxymethyl)lysine induces gamma-glutamylcysteine synthetase in RAW264.7 cells.

Journal: Biochemical and biophysical research communications 20020809

Title: Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease.

Journal: Acta neuropathologica 20020801

Title: Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.

Journal: Acta neuropathologica 20020801

Title: Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins.

Journal: The Journal of investigative dermatology 20020801

Title: N(epsilon)-Carboxymethyllysine in diabetic and non-diabetic polyneuropathies.

Journal: Acta neuropathologica 20020701

Title: Advanced glycation end products and mortality in hemodialysis patients.

Journal: Kidney international 20020701

Title: Identification of the advanced glycation end products N(epsilon)-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis.

Journal: Annals of the rheumatic diseases 20020601

Title: Conversion of Amadori products of the Maillard reaction to N(epsilon)-(carboxymethyl)lysine by short-term heating: possible detection of artifacts by immunohistochemistry.

Journal: Laboratory investigation; a journal of technical methods and pathology 20020601

Title: Immunohistochemical demonstration of -(carboxymethyl)lysine protein adducts in normal and osteoarthritic cartilage.

Journal: Histochemistry and cell biology 20020601

Title: Detection of N epsilon-(carboxymethyl)lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord.

Journal: Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020601

Title: Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin.

Journal: The Biochemical journal 20020515

Title: Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence.

Journal: The Biochemical journal 20020515

Title: Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

Journal: Diabetes 20020501

Title: Lipid peroxidation and protein modification in a mouse model of chronic iron overload.

Journal: Metabolism: clinical and experimental 20020501

Title: Advanced glycation end products in children with chronic renal failure and type 1 diabetes.

Journal: Pediatric nephrology (Berlin, Germany) 20020501

Title: Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages.

Journal: Free radical biology & medicine 20020415

Title: Marked increases in macrophage colony-stimulating factor and interleukin-18 in maintenance hemodialysis patients: comparative study of advanced glycation end products, carboxymethyllysine and pentosidine.

Journal: Nephron 20020401

Title: Advanced glycation end-products in corneas of patients with keratoconus.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20020401

Title: Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping.

Journal: Journal of agricultural and food chemistry 20020327

Title: Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.

Journal: Neuroscience letters 20020208

Title: Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation.

Journal: Journal of hepatology 20020101

Title: Effect of heat-treated proteins on selected parameters of the biotransformation system in the rat.

Journal: Annals of nutrition & metabolism 20020101

Title: Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.

Journal: Free radical research 20020101

Title: N epsilon-(carboxymethyl)lysine (CML) as a biomarker of oxidative stress in long-lived tissue proteins.

Journal: Methods in molecular biology (Clifton, N.J.) 20020101

Title: Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fibroblasts.

Journal: Biogerontology 20020101

Title: Advanced glycation end products and nutrition.

Journal: Physiological research 20020101

Title: Serum N-epsilon-(carboxymethyl)lysine is elevated in nondiabetic coronary heart disease patients.

Journal: Journal of basic and clinical physiology and pharmacology 20020101

Title: Chelating activity of advanced glycation end-product inhibitors.

Journal: The Journal of biological chemistry 20011228

Title: Glyoxalase I deficiency is associated with an unusual level of advanced glycation end products in a hemodialysis patient.

Journal: Kidney international 20011201

Title: Plasma levels of advanced glycation end products in children with renal disease.

Journal: Pediatric nephrology (Berlin, Germany) 20011201

Title: Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet.

Journal: European journal of nutrition 20011201

Title: Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities.

Journal: Annals of periodontology 20011201

Title: Advanced glycation end products in Descemet's membrane and their effect on corneal endothelial cell.

Journal: Current eye research 20011201

Title: RAGE expression and AGE-induced MAP kinase activation in Caco-2 cells.

Journal: Biochemical and biophysical research communications 20011116

Title: Amides are novel protein modifications formed by physiological sugars.

Journal: The Journal of biological chemistry 20011109

Title: Potential value of CML-Hb in predicting the progression of bone cysts in dialysis-related amyloidosis.

Journal: Nephron 20011101

Title: Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011101

Title: Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases.

Journal: Kidney international 20011101

Title: Conformational study of N(epsilon)-(carboxymethyl)lysine adducts of recombinant gammaC-crystallin.

Journal: Journal of protein chemistry 20011101

Title: N(epsilon)-(carboxymethyl)lysine levels in patients with type 2 diabetes: role of renal function.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011001

Title: Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein.

Journal: Analytical chemistry 20011001

Title: Sunlight induces N epsilon-(carboxymethyl)lysine formation from glycated polylysine-iron(III) complex.

Journal: Photochemistry and photobiology 20010901

Title: Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.

Journal: Free radical biology & medicine 20010715

Title: Alternative routes for the formation of immunochemically distinct advanced glycation end-products in vivo.

Journal: Current molecular medicine 20010701

Title: [Increased levels of circulating advanced glycation end products in a model of acute renal insufficiency in rats].

Journal: Casopis lekaru ceskych 20010621

Title: Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion.

Journal: Diabetes 20010601

Title: Immunohistochemical distribution and quantitative biochemical detection of advanced glycation end products in fetal to adult rats and in rats with streptozotocin-induced diabetes.

Journal: Laboratory investigation; a journal of technical methods and pathology 20010601

Title: Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20010501

Title: Carboxymethyllysine in dermal tissues of diabetic and nondiabetic patients with chronic renal failure: relevance to glycoxidation damage.

Journal: Nephron 20010501

Title: Increased levels of vascular endothelial growth factor and advanced glycation end products in aqueous humor of patients with diabetic retinopathy.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010501

Title: The AGE product N epsilon-(carboxymethyl)lysine serum albumin is a modulator of proteoglycan expression in polarized cultured kidney epithelial cells.

Journal: Diabetologia 20010401

Title: Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20010301

Title: In vitro formation of N(epsilon)-(carboxymethyl)lysine and imidazolones under conditions similar to continuous ambulatory peritoneal dialysis.

Journal: Biochemical and biophysical research communications 20010209

Title: Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis.

Journal: Cardiovascular research 20010201

Title: 3-deoxyglucosone and AGEs in uremic complications: inactivation of glutathione peroxidase by 3-deoxyglucosone.

Journal: Kidney international. Supplement 20010201

Title: Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure.

Journal: Kidney international. Supplement 20010201

Title: Dialysis-related amyloidosis of the heart in long-term hemodialysis patients.

Journal: Kidney international. Supplement 20010201

Title: Evidence for non-enzymatic glycosylation in Escherichia coli.

Journal: Molecular microbiology 20010201

Title: Neuronal and glial advanced glycation end product [Nepsilon-(carboxymethyl)lysine]] in Alzheimer's disease brains.

Journal: Acta neuropathologica 20010101

Title: Dialysis-related amyloidosis: pathogenesis focusing on AGE modification.

Journal: Seminars in dialysis 20010101

Title: Immunochemical assay of hemoglobin with N(epsilon)-(carboxymethyl)lysine at lysine 66 of the beta chain.

Journal: Clinical chemistry 20010101

Title: Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

Title: Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation.

Journal: Acta neuropathologica 20000901

Title: Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.

Journal: The Journal of biological chemistry 19980320

Title: N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction.

Journal: Biochemistry 19960618

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Tags:5746-04-3 Molecular Formula|5746-04-3 MDL|5746-04-3 SMILES|5746-04-3 Cml