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57470-78-7,MFCD00941500
Catalog No.:AA019FSL

57470-78-7 | 3-(3-Acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea hydrochloride

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5mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019FSL
Chemical Name:
3-(3-Acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea hydrochloride
CAS Number:
57470-78-7
Molecular Formula:
C20H34ClN3O4
Molecular Weight:
415.9547
MDL Number:
MFCD00941500
SMILES:
CCN(C(=O)Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)(C)C)O)CC.Cl
NSC Number:
324509
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Determination of celiprolol in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.

Journal: Journal of clinical pharmacology 20120701

Title: Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.

Journal: Journal of fluorescence 20120701

Title: Positive impact of the β-blocker celiprolol on panic, anxiety, and cardiovascular parameters in patients with mitral valve prolapse syndrome.

Journal: Journal of clinical psychopharmacology 20111201

Title: Contemporary management of vascular Ehlers-Danlos syndrome.

Journal: Current opinion in cardiology 20111101

Title: A highly sensitive LC-MS/MS method capable of simultaneously quantitating celiprolol and atenolol in human plasma for a cassette cold-microdosing study.

Journal: Journal of separation science 20110701

Title: Celiprolol therapy for vascular Ehlers-Danlos syndrome.

Journal: Lancet (London, England) 20101030

Title: Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial.

Journal: Lancet (London, England) 20101030

Title: Positive influence of AT(1) receptor antagonism upon the impaired celiprolol-induced vasodilatation in aorta from spontaneously hypertensive rats.

Journal: European journal of pharmacology 20101010

Title: Highly sensitive transient isotachophoresis sample stacking coupling with capillary electrophoresis-amperometric detection for analysis of doping substances.

Journal: Talanta 20100615

Title: Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol.

Journal: Journal of pharmaceutical sciences 20090701

Title: Direct determination of celiprolol in human urine using on-line coupled ITP-CZE method with fiber-based DAD.

Journal: Electrophoresis 20081101

Title: Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive rats.

Journal: American journal of hypertension 20080901

Title: Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis.

Journal: Electrophoresis 20080601

Title: Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.

Journal: International journal of pharmaceutics 20080522

Title: Hesperidin in orange juice reduces the absorption of celiprolol in rats.

Journal: Biopharmaceutics & drug disposition 20080401

Title: [The inhibitory effect of pluronic on P-glycoprotein drug pump].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070901

Title: Celiprolol reduces the intimal thickening of autogenous vein grafts via an enhancement of nitric oxide function through an inhibition of superoxide production.

Journal: Journal of vascular surgery 20070701

Title: Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20070401

Title: beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes.

Journal: Life sciences 20070116

Title: Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070101

Title: [Vascular Ehlers-Danlos syndrome].

Journal: Presse medicale (Paris, France : 1983) 20061201

Title: Celiprolol-induced lupus-like syndrome.

Journal: Acta cardiologica 20061201

Title: Effects of celiprolol and simvastatin on the calculated risk of coronary heart disease (the Celisimva study).

Journal: Scandinavian cardiovascular journal : SCJ 20060601

Title: Concurrent dolichoectasia of basilar and coronary arteries.

Journal: Neurology 20060509

Title: Non-neuroleptic catecholaminergic drugs for neuroleptic-induced tardive dyskinesia.

Journal: The Cochrane database of systematic reviews 20060125

Title: Thermodynamics of non-stoichiometric pharmaceutical hydrates.

Journal: International journal of pharmaceutics 20051013

Title: Mechanisms of combined treatment with celiprolol and candesartan for ventricular remodeling in experimental heart failure.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050501

Title: Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.

Journal: Chest 20050301

Title: [Celiprolol poisoning: two case reports].

Journal: Therapie 20050101

Title: Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice.

Journal: Circulation 20040810

Title: The impact of third-generation beta-blocker antihypertensive treatment on endothelial function and the prothrombotic state: effects of smoking.

Journal: American journal of hypertension 20040701

Title: Simultaneous determination of the acid/base antihypertensive drugs celiprolol, bisoprolol and irbesartan in human plasma by liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040305

Title: Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

Journal: Clinical pharmacology and therapeutics 20040301

Title: Rifampicin reduces plasma concentrations of celiprolol.

Journal: European journal of clinical pharmacology 20040101

Title: Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment.

Journal: Clinical science (London, England : 1979) 20031101

Title: Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stress.

Journal: Hypertension (Dallas, Tex. : 1979) 20031101

Title: Celiprolol increases coronary blood flow and reduces severity of myocardial ischemia via nitric oxide release.

Journal: Journal of cardiovascular pharmacology 20030401

Title: Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol.

Journal: Clinical pharmacology and therapeutics 20030301

Title: [Efficacy of beta-selective blocker with vasodilatating features celiprolol in patients with mild and moderate hypertension].

Journal: Kardiologiia 20030101

Title: Celiprolol inhibits mitogen-activated protein kinase and endothelin-1 and transforming growth factor-beta(1) gene in rats.

Journal: European journal of pharmacology 20021220

Title: Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery.

Journal: European journal of pharmacology 20020222

Title: Cardiovascular effects of beta-blockers with and without intrinsic sympathomimetic activity. A comparison between celiprolol and metoprolol.

Journal: Kidney & blood pressure research 20020101

Title: Cardioselective beta-blockers for reversible airway disease.

Journal: The Cochrane database of systematic reviews 20020101

Title: [Use of selective long-acting beta-blocker with vasodilating activity celiprolol in patients with essential hypertension].

Journal: Kardiologiia 20020101

Title: Acute hemodynamic effects of beta-blockers in patients with severe congestive heart failure: comparison of celiprolol and esmolol.

Journal: Journal of cardiovascular pharmacology 20011101

Title: [The effect of celiprolol hydrochloride for lipid metabolism--especially for the low density lipoprotein particle size].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20010501

Title: Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats.

Journal: Journal of hypertension 20010401

Title: Release of endothelial nitric oxide in coronary arteries by celiprolol, a beta(1)-adrenoceptor antagonist: possible clinical relevance.

Journal: European journal of pharmacology 20010301

Title: Cardioselective beta-blocker use in patients with reversible airway disease.

Journal: The Cochrane database of systematic reviews 20010101

Title: Plasma analysis of celiprolol by HPTLC: a useful technique for pharmacokinetic studies.

Journal: Journal of AOAC International 20010101

Title: [Pharmacological studies of celiprolol: I. Beta-blocking effect, intrinsic sympathomimetic activity, vasodilating and hypotensive effects].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19900401

Title: [Pharmacological studies of celiprolol: III. Effects of celiprolol on the cardiovascular system and renal function, and its antiarrhythmic effects].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19900401

Title: Anti-ischemic effects of celiprolol in patients with exercise-induced angina pectoris.

Journal: International journal of cardiology 19891001

Title: Qualities of an ideal beta-adrenoceptor antagonist and comparison of existing agents with a new cardioselective hydrophilic vasodilator beta-adrenoceptor antagonist, celiprolol.

Journal: The American journal of cardiology 19880210

Title: James J Nawarskas, et, al. Celiprolol: A Unique Selective Adrenoceptor Modulator. Cardiol Rev. Sep/Oct 2017; 25(5): 247-253.

Title: Toshio Hayashi, et al. beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes. Life Sci. 2007 Jan 16;80(6):592-9.

Title: Naohiko Kobayashi, et al. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stress. Hypertension. 2003 Nov;42(5):1004-13.

Title: R G Van Inwegen, et al. Effects of celiprolol (REV 5320), a new cardioselective beta-adrenoceptor antagonist, on in vitro adenylate cyclase, alpha- and beta-adrenergic receptor binding and lipolysis. Arch Int Pharmacodyn Ther. 1984 Nov;272(1):40-55.

Title: Yukio Kato, et al. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39.

Title: J. Karlsson, et al. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br J Pharmacol. 1993 Nov; 110(3): 1009–1016.

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Tags:57470-78-7 Molecular Formula|57470-78-7 MDL|57470-78-7 SMILES|57470-78-7 3-(3-Acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea hydrochloride