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57568-80-6,MFCD03840615
Catalog No.:AA00EB0R

57568-80-6 | N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE

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Purity
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10mg
≥98%
in stock  
$368.00   $258.00
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50mg
≥98%
in stock  
$1,447.00   $1,013.00
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100mg
≥98%
in stock  
$2,557.00   $1,790.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EB0R
Chemical Name:
N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE
CAS Number:
57568-80-6
Molecular Formula:
C21H36ClN3O
Molecular Weight:
381.9830
MDL Number:
MFCD03840615
SMILES:
C1CCC(CC1)N=C(N1CCOCC1)NC12CC3CC(C2)CC(C1)C3.Cl
Properties
Computed Properties
 
Complexity:
464  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress.

Journal: International journal of oncology 20120801

Title: Cardiovascular protection of activating KATP channel during ischemia-reperfusion acidosis.

Journal: Shock (Augusta, Ga.) 20120601

Title: Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis.

Journal: Critical care medicine 20120401

Title: Inhibition of ATP-sensitive potassium channels attenuates propofol-induced vasorelaxation.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20100901

Title: K ATP channels in pig and human intracranial arteries.

Journal: European journal of pharmacology 20081228

Title: K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.

Journal: British journal of pharmacology 20080501

Title: Sulphonylureas induced vasorelaxation of mouse arteries.

Journal: European journal of pharmacology 20071222

Title: Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat.

Journal: Journal of cardiovascular pharmacology 20071001

Title: Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors.

Journal: The Journal of physiology 20070601

Title: Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.

Journal: Cardiovascular drug reviews 20060101

Title: Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra.

Journal: European journal of pharmacology 20051107

Title: Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells.

Journal: European journal of pharmacology 20050516

Title: Effects of U-37883A on intracellular Ca2+ -activated large-conductance K+ channels in pig proximal urethral myocytes.

Journal: European journal of pharmacology 20041203

Title: Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion.

Journal: Anesthesiology 20041101

Title: Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.

Journal: British journal of pharmacology 20040301

Title: Potassium-induced increase in renal kallikrein secretion is attenuated in dissected renal connecting tubules of young spontaneously hypertensive rats.

Journal: International immunopharmacology 20021201

Title: Differential responses to ATPgammaS in the mesenteric and hindlimb vascular bed of the cat.

Journal: Life sciences 20011012

Title: Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat.

Journal: Peptides 20010901

Title: K(ATP) channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo.

Journal: European journal of pharmacology 20010622

Title: Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

Journal: Journal of medicinal chemistry 20010524

Title: Selective in vivo antagonism of pinacidil-induced hypotension by the guanidine U37883A in anesthetized rats.

Journal: Pharmacology 19941201

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Tags:57568-80-6 Molecular Formula|57568-80-6 MDL|57568-80-6 SMILES|57568-80-6 N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE