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57653-26-6,MFCD00868019
Catalog No.:AA01E4OQ

57653-26-6 | Fenobam

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$129.00   $90.00
- +
10mg
99%
in stock  
$195.00   $137.00
- +
50mg
95%
in stock  
$488.00   $342.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4OQ
Chemical Name:
Fenobam
CAS Number:
57653-26-6
Molecular Formula:
C11H11ClN4O2
Molecular Weight:
266.6836
MDL Number:
MFCD00868019
SMILES:
O=C(NC1=NC(=O)CN1C)Nc1cccc(c1)Cl
Properties
Properties
 
Storage:
2-8℃;  

Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.2  

Literature

Title: A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.

Journal: Neurobiology of disease 20100901

Title: Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.

Title: Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383;

Title: Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl). 2013;229(2):253-265.

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