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57664-96-7,MFCD00040146
Catalog No.:AA00EKY7

57664-96-7 | (5alpha)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EKY7
Chemical Name:
(5alpha)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one
CAS Number:
57664-96-7
Molecular Formula:
C17H19NO4
Molecular Weight:
301.3371
MDL Number:
MFCD00040146
SMILES:
COc1ccc2c3c1O[C@@H]1[C@@]43CCN[C@H](C2)[C@]4(O)CCC1=O
Properties
Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
0.7  

Literature

Title: Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20130501

Title: Is saliva a valid substitute for plasma in pharmacokinetic studies of oxycodone and its metabolites in patients with cancer?

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120401

Title: CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone.

Journal: Journal of clinical pharmacology 20111101

Title: Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients.

Journal: European journal of clinical pharmacology 20110501

Title: Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

Journal: European journal of clinical pharmacology 20110101

Title: Elimination of intravenous oxycodone in the elderly: a pharmacokinetic study in postoperative orthopaedic patients of different age groups.

Journal: Drugs & aging 20110101

Title: Urine testing for norcodeine, norhydrocodone, and noroxycodone facilitates interpretation and reduces false negatives.

Journal: Forensic science international 20100520

Title: Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone.

Journal: European journal of clinical pharmacology 20100401

Title: Quantitation of polar analytes using column-switching: application to oxycodone and three metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100301

Title: Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone.

Journal: Journal of clinical pharmacology 20100101

Title: Oxycodone-related fatalities in the west of Scotland.

Journal: Journal of analytical toxicology 20091001

Title: Determination of oxycodone, noroxycodone, oxymorphone, and noroxymorphone in human plasma by liquid chromatography-electrospray-tandem mass spectrometry.

Journal: Therapeutic drug monitoring 20080601

Title: Opioid rotation from oral morphine to oral oxycodone in cancer patients with intolerable adverse effects: an open-label trial.

Journal: Japanese journal of clinical oncology 20080401

Title: Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat.

Journal: Clinical and experimental pharmacology & physiology 20080301

Title: Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats.

Journal: Anesthesiology 20061001

Title: Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children.

Journal: Clinical pharmacokinetics 20060101

Title: Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20051201

Title: Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes.

Journal: Pharmaceutical research 20050901

Title: Analysis of oxycodol and noroxycodol stereoisomers in biological samples by capillary electrophoresis.

Journal: Electrophoresis 20050501

Title: Measurements of plasma oxycodone, noroxycodone and oxymorphone levels in a patient with bilateral nephrectomy who is undergoing haemodialysis.

Journal: Palliative medicine 20050401

Title: Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125

Title: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040401

Title: The use of liquid chromatography/mass spectrometry for quantitative analysis of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Tentative identification of novel oxycodone metabolites in human urine.

Journal: Journal of analytical toxicology 20030901

Title: Double-blind, randomized comparison of the analgesic and pharmacokinetic profiles of controlled- and immediate-release oral oxycodone in cancer pain patients.

Journal: Journal of clinical pharmacology 20010501

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Tags:57664-96-7 Molecular Formula|57664-96-7 MDL|57664-96-7 SMILES|57664-96-7 (5alpha)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one