57754-86-6,MFCD00153850
Catalog No.:AA00EB13

57754-86-6 | 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride

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1mg
100 mM in water
in stock  
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5mg
≥98%
in stock  
$122.00   $85.00
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10mg
≥98%
in stock  
$156.00   $109.00
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25mg
≥98%
in stock  
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100mg
≥99%
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00EB13
Chemical Name:
4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
CAS Number:
57754-86-6
Molecular Formula:
C9H8ClNO3S
Molecular Weight:
245.6827
MDL Number:
MFCD00153850
SMILES:
[O-][N+](=O)c1ccccc1SC1=CCO1.Cl
NSC Number:
298819
Properties
Computed Properties
 
Complexity:
253  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  

Literature

Title: A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.

Journal: Molecular pharmacology 20121101

Title: Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging.

Journal: Nuclear medicine and biology 20121001

Title: Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20121001

Title: The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Journal: The Journal of pharmacology and experimental therapeutics 20120701

Title: Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat.

Journal: European journal of pharmacology 20120130

Title: Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.

Journal: Journal of neuroscience methods 20120115

Title: Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.

Journal: Molecular pharmacology 20110301

Title: Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.

Journal: Brain research 20110210

Title: Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.

Journal: Journal of neurochemistry 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.

Journal: Neurochemistry international 20101001

Title: Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.

Journal: Molecular nutrition & food research 20100401

Title: Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles.

Journal: Neurochemistry international 20100101

Title: Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry.

Journal: Analytical chemistry 20091115

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.

Journal: Pharmacology, biochemistry, and behavior 20090701

Title: In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex.

Journal: Neuroscience 20090303

Title: 5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats.

Journal: Obesity (Silver Spring, Md.) 20090301

Title: Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201

Title: Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding.

Journal: European journal of pharmacology 20080911

Title: Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080901

Title: Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.

Journal: Psychopharmacology 20080801

Title: Monoaminergic compensation in the neuropeptide Y deficient mouse brain.

Journal: Neuropeptides 20080601

Title: Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080501

Title: N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080501

Title: Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.

Journal: Nuclear medicine and biology 20080501

Title: Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.

Journal: Nuclear medicine and biology 20080201

Title: Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice.

Journal: Neurochemistry international 20080101

Title: (R)-N-Methyl-3-(3-(125)I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters.

Journal: Nuclear medicine and biology 20080101

Title: Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20071101

Title: Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

Journal: European journal of pharmacology 20071031

Title: Molecular cloning and functional expression of the murine noradrenaline transporter.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20071001

Title: Halothane increases non-vesicular [(3)H]dopamine release from brain cortical slices.

Journal: Cellular and molecular neurobiology 20070901

Title: Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.

Journal: The Journal of biological chemistry 20070615

Title: Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.

Journal: Journal of medicinal chemistry 20070531

Title: In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter.

Journal: European journal of nuclear medicine and molecular imaging 20070501

Title: Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

Title: Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.

Journal: European journal of pharmacology 20070205

Title: Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.

Journal: American journal of physiology. Renal physiology 20070201

Title: Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061001

Title: Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro.

Journal: Autonomic & autacoid pharmacology 20061001

Title: KCl stimulation increases norepinephrine transporter function in PC12 cells.

Journal: Journal of neurochemistry 20060901

Title: Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters.

Journal: Journal of neurochemistry 20060901

Title: (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.

Journal: European journal of pharmacology 20060807

Title: Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats.

Journal: Physiology & behavior 20060530

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Journal: The Journal of biological chemistry 20060127

Title: Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111

Title: Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals.

Journal: Synapse (New York, N.Y.) 20060101

Title: Distribution of norepinephrine transporters in the non-human primate brain.

Journal: Neuroscience 20060101

Title: Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression.

Journal: Journal of neuroimmunology 20051230

Title: N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.

Journal: Bioorganic & medicinal chemistry letters 20051215

Title: Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia.

Journal: Autonomic neuroscience : basic & clinical 20051030

Title: Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice.

Journal: Alcoholism, clinical and experimental research 20051001

Title: Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain.

Journal: Psychopharmacology 20050801

Title: Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.

Journal: Bioorganic & medicinal chemistry 20050801

Title: Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.

Journal: Neuropharmacology 20050801

Title: Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.

Journal: Neuroreport 20050801

Title: Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region.

Journal: Nuclear medicine and biology 20050701

Title: Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.

Journal: Journal of neurochemistry 20050701

Title: Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.

Journal: Behavioural brain research 20050528

Title: Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.

Journal: Synapse (New York, N.Y.) 20050501

Title: Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers.

Journal: Journal of neuroscience methods 20050415

Title: Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.

Journal: Journal of neuroscience methods 20050415

Title: Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20050201

Title: Iron deficiency: differential effects on monoamine transporters.

Journal: Nutritional neuroscience 20050201

Title: Development of the norepinephrine transporter in the rat CNS.

Journal: Neuroscience 20050101

Title: Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil.

Journal: Neuroscience 20050101

Title: Reduced MPTP toxicity in noradrenaline transporter knockout mice.

Journal: Journal of neurochemistry 20041201

Title: Functional importance of the C-terminus of the human norepinephrine transporter.

Journal: Journal of neurochemistry 20041101

Title: Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908

Title: Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.

Journal: Journal of neuroscience methods 20040830

Title: Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.

Journal: Brain research. Molecular brain research 20040823

Title: Regulation of the norepinephrine transporter by chronic administration of antidepressants.

Journal: Biological psychiatry 20040201

Title: Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study.

Journal: Sleep 20040201

Title: The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.

Journal: Neurochemical research 20040201

Title: Role of proline residues in the expression and function of the human noradrenaline transporter.

Journal: Journal of neurochemistry 20040101

Title: Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo.

Journal: Synapse (New York, N.Y.) 20031215

Title: Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.

Journal: Journal of medicinal chemistry 20031204

Title: A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.

Journal: Nuclear medicine and biology 20031001

Title: Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031001

Title: Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.

Journal: American journal of veterinary research 20030901

Title: Actions of amphetamine derivatives and cathinone at the noradrenaline transporter.

Journal: European journal of pharmacology 20030822

Title: Functional coupling of serotonin and noradrenaline transporters.

Journal: Journal of neurochemistry 20030801

Title: Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons.

Journal: Neuroscience letters 20030703

Title: Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum.

Journal: Journal of neurochemistry 20030301

Title: S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats.

Journal: Synapse (New York, N.Y.) 20030101

Title: Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030101

Title: Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

Journal: British journal of pharmacology 20021201

Title: The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.

Journal: Brain research. Molecular brain research 20021201

Title: Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.

Journal: Circulation research 20021129

Title: Inhibition of vesicular uptake of monoamines by hyperforin.

Journal: Life sciences 20020927

Title: Enhanced amphetamine-mediated dopamine release develops in PC12 cells after repeated amphetamine treatment.

Journal: European journal of pharmacology 20020906

Title: Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.

Journal: Neuroscience letters 20020809

Title: Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020601

Title: Identification and functional characterization of the novel isoforms of bovine norepinephrine transporter produced by alternative splicing.

Journal: Brain research 20020503

Title: Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts.

Journal: British journal of pharmacology 20020401

Title: Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.

Journal: Journal of neurochemistry 20020401

Title: Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter.

Journal: Pharmacogenetics 20020301

Title: Biochemical and autoradiographic studies of the central noradrenergic system in dystonia musculorum mutant mice.

Journal: Journal of chemical neuroanatomy 20020201

Title: Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020115

Title: Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline.

Journal: European journal of pharmacology 20020111

Title: Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.

Journal: Neuroscience 20020101

Title: Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology.

Journal: Brain research. Molecular brain research 20011216

Title: Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.

Journal: The Journal of pharmacology and experimental therapeutics 20011101

Title: Functional characterization of the splicing variants of human norepinephrine transporter.

Journal: Neuroscience letters 20011019

Title: Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons.

Journal: Brain research bulletin 20010801

Title: Characterization of antidepressant-like effects of p-synephrine stereoisomers.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010701

Title: Interaction of local anaesthetic agents with the endogenous norepinephrine transporter in SH-SY5Y human neuroblastoma cells.

Journal: Neuroscience letters 20010615

Title: Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

Journal: Neurochemistry international 20010101

Title: Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.

Journal: Neurochemistry international 20010101

Title: Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.

Journal: Journal of child and adolescent psychopharmacology 20010101

Title: Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics.

Journal: Neuroscience 20010101

Title: Regulation of the human norepinephrine transporter by cocaine and amphetamine.

Journal: The Journal of pharmacology and experimental therapeutics 20001201

Title: Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.

Journal: Journal of neural transmission 19820101

Title: Monoaminergic mechanisms and experimental cataplexy.

Journal: Annals of neurology 19811001

Title: Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32.

Title: Cheetham SC, et, al. Hnisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of Hnoradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70.

Title: Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7.

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Tags:57754-86-6 Molecular Formula|57754-86-6 MDL|57754-86-6 SMILES|57754-86-6 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
Catalog No.: AA00EB13
57754-86-6,MFCD00153850
57754-86-6 | 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
Pack Size: 1mg
Purity: 100 mM in water
in stock
$85.00 $59.00
Pack Size: 5mg
Purity: ≥98%
in stock
$122.00 $85.00
Pack Size: 10mg
Purity: ≥98%
in stock
$156.00 $109.00
Pack Size: 25mg
Purity: ≥98%
in stock
$358.00 $250.00
Pack Size: 100mg
Purity: ≥99%
in stock
$1,047.00 $733.00
Quantity
- +
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Technical Information
Catalog Number: AA00EB13
Chemical Name: 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
CAS Number: 57754-86-6
Molecular Formula: C9H8ClNO3S
Molecular Weight: 245.6827
MDL Number: MFCD00153850
SMILES: [O-][N+](=O)c1ccccc1SC1=CCO1.Cl
NSC Number: 298819
Properties
Complexity: 253  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.

Journal: Molecular pharmacology20121101

Title: Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging.

Journal: Nuclear medicine and biology20121001

Title: Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20121001

Title: The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Journal: The Journal of pharmacology and experimental therapeutics20120701

Title: Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat.

Journal: European journal of pharmacology20120130

Title: Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.

Journal: Journal of neuroscience methods20120115

Title: Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.

Journal: Molecular pharmacology20110301

Title: Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.

Journal: Brain research20110210

Title: Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.

Journal: Journal of neurochemistry20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.

Journal: Neurochemistry international20101001

Title: Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.

Journal: Molecular nutrition & food research20100401

Title: Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles.

Journal: Neurochemistry international20100101

Title: Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry.

Journal: Analytical chemistry20091115

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.

Journal: Pharmacology, biochemistry, and behavior20090701

Title: In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex.

Journal: Neuroscience20090303

Title: 5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats.

Journal: Obesity (Silver Spring, Md.)20090301

Title: Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20081201

Title: Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding.

Journal: European journal of pharmacology20080911

Title: Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20080901

Title: Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.

Journal: Psychopharmacology20080801

Title: Monoaminergic compensation in the neuropeptide Y deficient mouse brain.

Journal: Neuropeptides20080601

Title: Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080501

Title: N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20080501

Title: Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.

Journal: Nuclear medicine and biology20080501

Title: Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.

Journal: Nuclear medicine and biology20080201

Title: Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice.

Journal: Neurochemistry international20080101

Title: (R)-N-Methyl-3-(3-(125)I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters.

Journal: Nuclear medicine and biology20080101

Title: Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.

Journal: The Journal of pharmacology and experimental therapeutics20071101

Title: Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience20071101

Title: Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

Journal: European journal of pharmacology20071031

Title: Molecular cloning and functional expression of the murine noradrenaline transporter.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20071001

Title: Halothane increases non-vesicular [(3)H]dopamine release from brain cortical slices.

Journal: Cellular and molecular neurobiology20070901

Title: Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20070801

Title: chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.

Journal: The Journal of biological chemistry20070615

Title: Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.

Journal: Journal of medicinal chemistry20070531

Title: In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter.

Journal: European journal of nuclear medicine and molecular imaging20070501

Title: Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20070401

Title: Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.

Journal: European journal of pharmacology20070205

Title: Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.

Journal: American journal of physiology. Renal physiology20070201

Title: Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20061001

Title: Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro.

Journal: Autonomic & autacoid pharmacology20061001

Title: KCl stimulation increases norepinephrine transporter function in PC12 cells.

Journal: Journal of neurochemistry20060901

Title: Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters.

Journal: Journal of neurochemistry20060901

Title: (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.

Journal: European journal of pharmacology20060807

Title: Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats.

Journal: Physiology & behavior20060530

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Journal: The Journal of biological chemistry20060127

Title: Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060111

Title: Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals.

Journal: Synapse (New York, N.Y.)20060101

Title: Distribution of norepinephrine transporters in the non-human primate brain.

Journal: Neuroscience20060101

Title: Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression.

Journal: Journal of neuroimmunology20051230

Title: N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.

Journal: Bioorganic & medicinal chemistry letters20051215

Title: Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia.

Journal: Autonomic neuroscience : basic & clinical20051030

Title: Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice.

Journal: Alcoholism, clinical and experimental research20051001

Title: Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain.

Journal: Psychopharmacology20050801

Title: Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.

Journal: Bioorganic & medicinal chemistry20050801

Title: Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.

Journal: Neuropharmacology20050801

Title: Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.

Journal: Neuroreport20050801

Title: Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region.

Journal: Nuclear medicine and biology20050701

Title: Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.

Journal: Journal of neurochemistry20050701

Title: Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.

Journal: Behavioural brain research20050528

Title: Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.

Journal: Synapse (New York, N.Y.)20050501

Title: Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers.

Journal: Journal of neuroscience methods20050415

Title: Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.

Journal: Journal of neuroscience methods20050415

Title: Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors.

Journal: The Journal of pharmacology and experimental therapeutics20050301

Title: Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20050201

Title: Iron deficiency: differential effects on monoamine transporters.

Journal: Nutritional neuroscience20050201

Title: Development of the norepinephrine transporter in the rat CNS.

Journal: Neuroscience20050101

Title: Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil.

Journal: Neuroscience20050101

Title: Reduced MPTP toxicity in noradrenaline transporter knockout mice.

Journal: Journal of neurochemistry20041201

Title: Functional importance of the C-terminus of the human norepinephrine transporter.

Journal: Journal of neurochemistry20041101

Title: Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040908

Title: Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.

Journal: Journal of neuroscience methods20040830

Title: Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.

Journal: Brain research. Molecular brain research20040823

Title: Regulation of the norepinephrine transporter by chronic administration of antidepressants.

Journal: Biological psychiatry20040201

Title: Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study.

Journal: Sleep20040201

Title: The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.

Journal: Neurochemical research20040201

Title: Role of proline residues in the expression and function of the human noradrenaline transporter.

Journal: Journal of neurochemistry20040101

Title: Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo.

Journal: Synapse (New York, N.Y.)20031215

Title: Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.

Journal: Journal of medicinal chemistry20031204

Title: A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.

Journal: Nuclear medicine and biology20031001

Title: Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20031001

Title: Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.

Journal: American journal of veterinary research20030901

Title: Actions of amphetamine derivatives and cathinone at the noradrenaline transporter.

Journal: European journal of pharmacology20030822

Title: Functional coupling of serotonin and noradrenaline transporters.

Journal: Journal of neurochemistry20030801

Title: Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons.

Journal: Neuroscience letters20030703

Title: Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum.

Journal: Journal of neurochemistry20030301

Title: S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats.

Journal: Synapse (New York, N.Y.)20030101

Title: Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20030101

Title: Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

Journal: British journal of pharmacology20021201

Title: The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.

Journal: Brain research. Molecular brain research20021201

Title: Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.

Journal: Circulation research20021129

Title: Inhibition of vesicular uptake of monoamines by hyperforin.

Journal: Life sciences20020927

Title: Enhanced amphetamine-mediated dopamine release develops in PC12 cells after repeated amphetamine treatment.

Journal: European journal of pharmacology20020906

Title: Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.

Journal: Neuroscience letters20020809

Title: Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20020601

Title: Identification and functional characterization of the novel isoforms of bovine norepinephrine transporter produced by alternative splicing.

Journal: Brain research20020503

Title: Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts.

Journal: British journal of pharmacology20020401

Title: Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.

Journal: Journal of neurochemistry20020401

Title: Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter.

Journal: Pharmacogenetics20020301

Title: Biochemical and autoradiographic studies of the central noradrenergic system in dystonia musculorum mutant mice.

Journal: Journal of chemical neuroanatomy20020201

Title: Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20020115

Title: Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline.

Journal: European journal of pharmacology20020111

Title: Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.

Journal: Neuroscience20020101

Title: Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology.

Journal: Brain research. Molecular brain research20011216

Title: Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.

Journal: The Journal of pharmacology and experimental therapeutics20011101

Title: Functional characterization of the splicing variants of human norepinephrine transporter.

Journal: Neuroscience letters20011019

Title: Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons.

Journal: Brain research bulletin20010801

Title: Characterization of antidepressant-like effects of p-synephrine stereoisomers.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010701

Title: Interaction of local anaesthetic agents with the endogenous norepinephrine transporter in SH-SY5Y human neuroblastoma cells.

Journal: Neuroscience letters20010615

Title: Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

Journal: Neurochemistry international20010101

Title: Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.

Journal: Neurochemistry international20010101

Title: Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.

Journal: Journal of child and adolescent psychopharmacology20010101

Title: Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics.

Journal: Neuroscience20010101

Title: Regulation of the human norepinephrine transporter by cocaine and amphetamine.

Journal: The Journal of pharmacology and experimental therapeutics20001201

Title: Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.

Journal: Journal of neural transmission19820101

Title: Monoaminergic mechanisms and experimental cataplexy.

Journal: Annals of neurology19811001

Title: Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32.

Title: Cheetham SC, et, al. Hnisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of Hnoradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70.

Title: Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7.

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