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5786-54-9,MFCD00135406
Catalog No.:AA00EIJL

5786-54-9 | 6,4''-DIHYDROXYAURONE

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1mg
≥98%
in stock  
$38.00   $26.00
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25mg
98%
in stock  
$132.00   $93.00
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100mg
98%
in stock  
$339.00   $237.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EIJL
Chemical Name:
6,4''-DIHYDROXYAURONE
CAS Number:
5786-54-9
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
MDL Number:
MFCD00135406
SMILES:
Oc1ccc(cc1)/C=C/1\Oc2c(C1=O)ccc(c2)O
NSC Number:
356828
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
382  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.9  

Downstream Synthesis Route

[1]Patent:KR2016/142676,2016,A.Locationinpatent:Paragraph0061;0098;0099;0100;0133;0134;0159

[2]JournalofMedicinalChemistry,2006,vol.49,p.329-333

[3]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.4520-4523

[4]JournalofMedicinalChemistry,2011,vol.54,p.5395-5402

[5]JournaloftheChemicalSociety.PerkintransactionsI,1982,p.1157-1162

[6]JournaloftheAmericanChemicalSociety,1956,vol.78,p.832,837

[7]ChemBioChem,2014,vol.15,p.1325-1333

Literature

Title: Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Journal: Journal of medicinal chemistry 20110801

Title: Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.

Journal: Bioorganic & medicinal chemistry letters 20110801

Title: 1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs.

Journal: Bioorganic & medicinal chemistry 20100801

Title: Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.

Journal: European journal of medicinal chemistry 20100701

Title: Integrated metabolite and transcript profiling identify a biosynthetic mechanism for hispidol in Medicago truncatula cell cultures.

Journal: Plant physiology 20091101

Title: Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.

Journal: Journal of medicinal chemistry 20060112

Title: Evaluation of in vitro activity of aurones and related compounds against Cryptosporidium parvum.

Journal: Planta medica 20011101

Title: Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597.

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SDS
Tags:5786-54-9 Molecular Formula|5786-54-9 MDL|5786-54-9 SMILES|5786-54-9 6,4''-DIHYDROXYAURONE