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57982-78-2,MFCD00866585
Catalog No.:AA003A4P

57982-78-2 | Budipine

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Purity
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5mg
95%
in stock  
$132.00   $93.00
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25mg
95%
in stock  
$339.00   $237.00
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500mg
98% by HPLC
in stock  
$5,515.00   $3,861.00
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1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003A4P
Chemical Name:
Budipine
CAS Number:
57982-78-2
Molecular Formula:
C21H27N
Molecular Weight:
293.4458
MDL Number:
MFCD00866585
SMILES:
CC(N1CCC(CC1)(c1ccccc1)c1ccccc1)(C)C
Properties
Computed Properties
 
Complexity:
313  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
5.2  

Upstream Synthesis Route

[1]Arzneimittel-Forschung/DrugResearch,1984,vol.34,#3,p.233-240

[1]Arzneimittel-Forschung/DrugResearch,1984,vol.34,#3,p.233-240

Downstream Synthesis Route

[1]Arzneimittel-Forschung/DrugResearch,1984,vol.34,p.233-240

81831-81-4    71-43-2    57982-78-2   
1,4-Bis<1-tert-butyl-4-phenyl-piperidyl-(4)>-benzol 

[1]Arzneimittel-Forschung/DrugResearch,1984,vol.34,p.233-240

Literature

Title: Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER).

Journal: Movement disorders : official journal of the Movement Disorder Society 20110101

Title: [On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease].

Journal: Fortschritte der Neurologie-Psychiatrie 20100301

Title: A new strategy for antidepressant prescription.

Journal: Frontiers in neuroscience 20100101

Title: Paradoxical aspects of parkinsonian tremor.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080130

Title: Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats.

Journal: Brain research 20061030

Title: Budipine in Parkinson's tremor.

Journal: Journal of the neurological sciences 20061025

Title: [Diagnosis and therapy of idiopathic Parkinson's disease].

Journal: MMW Fortschritte der Medizin 20060515

Title: Efficacy and safety of high-dose cabergoline in Parkinson's disease.

Journal: Acta neurologica Scandinavica 20060101

Title: Efficacy of budipine and placebo in untreated patients with Parkinson's disease.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20050801

Title: Pharmacotherapy of Parkinson's disease in Germany.

Journal: Journal of neurology 20050801

Title: Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats.

Journal: British journal of pharmacology 20050701

Title: The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice.

Journal: Neuroscience letters 20050701

Title: Synergism between topiramate and budipine in refractory status epilepticus in the rat.

Journal: Epilepsia 20041101

Title: Antiapoptotic effects of budipine.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20041001

Title: Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031101

Title: Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601

Title: [Diagnosis and treatment of Parkinson's syndrome. What is important for the general practitioner?].

Journal: MMW Fortschritte der Medizin 20030526

Title: [Dopaminergic agents, COMT inhibitors or amantadine? Proper treatment for your Parkinson patient].

Journal: MMW Fortschritte der Medizin 20020506

Title: Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen.

Journal: Archives of neurology 20020501

Title: Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies.

Journal: Current drug targets 20010901

Title: Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.

Journal: Pharmacogenetics 20010801

Title: Dose linearity and steady state pharmacokinetics of the new antiparkinson agent budipine after oral administration.

Journal: International journal of clinical pharmacology and therapeutics 20010601

Title: Sudden daytime sleep onset in Parkinson's disease: polysomnographic recordings.

Journal: Movement disorders : official journal of the Movement Disorder Society 20010501

Title: Non-dopaminergic drug treatment of Parkinson's disease.

Journal: Expert opinion on pharmacotherapy 20010401

Title: [Monotherapy of Parkinson's disease with budipine. A double blind comparison with amantadine].

Journal: Fortschritte der Neurologie-Psychiatrie 20010201

Title: Workshop IV: drug treatment guidelines for the long-term management of Parkinson's disease.

Journal: Journal of neurology 20000901

Title: Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 19991001

Title: [Synthesis, physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines].

Journal: Arzneimittel-Forschung 19840101

Title: Reichmann H, et al. Budipine in Parkinson's tremor. J Neurol Sci. 2006 Oct 25;248(1-2):53-5.

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