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58-71-9,MFCD00072025
Catalog No.:AA00IA8O

58-71-9 | Cefalotin sodium salt

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1g
95%
in stock  
$29.00   $20.00
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5g
95%
in stock  
$45.00   $32.00
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25g
95%
in stock  
$128.00   $90.00
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100g
95%
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$411.00   $288.00
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500g
95%
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$1,607.00   $1,125.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IA8O
Chemical Name:
Cefalotin sodium salt
CAS Number:
58-71-9
Molecular Formula:
C16H15N2NaO6S2
Molecular Weight:
418.4199
MDL Number:
MFCD00072025
SMILES:
CC(=O)OCC1=C(C(=O)[O-])N2[C@H](SC1)[C@@H](C2=O)NC(=O)Cc1cccs1.[Na+]
Properties
Properties
 
BP:
757.2°C at 760 mmHg  
Form:
Solid  
MP:
240°C  
Solubility:
H2O: 50 mg/mL, clear, faintly yellow  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
686  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  

Literature

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Title: The biomimetic apatite-cefalotin coatings on modified titanium.

Journal: Dental materials journal 20120203

Title: Investigation of the acylation mechanism of class C beta-lactamase: pKa calculation, molecular dynamics simulation and quantum mechanical calculation.

Journal: Journal of molecular modeling 20120201

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Journal: Journal of chemotherapy (Florence, Italy) 20070801

Title: Pulsed-field gel electrophoresis in the identification of the origin of bacterial keratitis caused by Pseudomonas aeruginosa.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070701

Title: Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement.

Journal: The Journal of antimicrobial chemotherapy 20070701

Title: Pain management during uterine artery embolization for symptomatic uterine fibroids.

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Journal: Medicina 20070101

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Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20070101

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Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061201

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Journal: Journal of biochemistry 20061101

Title: Coupling between chemical reactivity and structural relaxation in pharmaceutical glasses.

Journal: Pharmaceutical research 20061001

Title: Bacteria commonly isolated from keratitis specimens retain antibiotic susceptibility to fluoroquinolones and gentamicin plus cephalothin.

Journal: Clinical & experimental ophthalmology 20060101

Title: [Prevalence of Campylobacter spp. in poultry meat and raw milk using PCR, conventional cultural methods and Fourier transform infrared spectroscopy].

Journal: Berliner und Munchener tierarztliche Wochenschrift 20060101

Title: Three-year analysis of microbial aetiology and antimicrobial susceptibilities of PD peritonitis.

Journal: Scandinavian journal of infectious diseases 20060101

Title: In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains.

Journal: Annals of clinical microbiology and antimicrobials 20060101

Title: Analysis of homologous derivatives of cephalothin by multivariate methods for clinical efficacy.

Journal: Physiological chemistry and physics and medical NMR 20060101

Title: Peritonitis due to Neisseria mucosa in an adolescent receiving peritoneal dialysis.

Journal: Infection 20051001

Title: In-vitro antibacterial and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes of the antibiotic drug cephalothin (Keflin).

Journal: Journal of enzyme inhibition and medicinal chemistry 20051001

Title: Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system.

Journal: Pharmaceutical research 20050101

Title: Sourcing faecal pollution from onsite wastewater treatment systems in surface waters using antibiotic resistance analysis.

Journal: Journal of applied microbiology 20050101

Title: Flare up to betalactams.

Journal: Allergologia et immunopathologia 20050101

Title: [Phenotypical differences of Helicobacter pylori strains isolated in Georgia].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20050101

Title: Purification, substrate specificity, and N-terminal amino acid sequence analysis of a beta-lactamase-free penicillin amidase from Alcaligenes sp.

Journal: Applied microbiology and biotechnology 20040801

Title: Resistance of uropathogens in symptomatic urinary tract infections in León, Nicaragua.

Journal: International journal of antimicrobial agents 20040501

Title: Kinetics of turnover of cefotaxime by the Enterobacter cloacae P99 and GCl beta-lactamases: two free enzyme forms of the P99 beta-lactamase detected by a combination of pre- and post-steady state kinetics.

Journal: Biochemistry 20040309

Title: [E. coli: resistance to quinolones and beta-lactams of clinical strains isolated in the Franche-Comté region of France].

Journal: Pathologie-biologie 20040301

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Journal: La Tunisie medicale 20040301

Title: The incidence of Shiga toxin-producing Escherichia coli in cattle with mastitis in Brazil.

Journal: Journal of applied microbiology 20040101

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Journal: Journal francais d'ophtalmologie 20031101

Title: Enterococcus faecalis and Enterococcus faecium isolates from milk, beef, and chicken and their antibiotic resistance.

Journal: Journal of food protection 20030601

Title: Antibiotics induce apoptosis of human peritoneal mesothelial cells.

Journal: Nephrology (Carlton, Vic.) 20030601

Title: Role of beta-lactam carboxyl group on binding of penicillins and cephalosporins to class C beta-lactamases.

Journal: Proteins 20030515

Title: Dependence of hydrolysis of beta-lactams with a zinc(II)-beta-lactamase produced from Serratia marcescens (IMP-1) on pH and concentration of zinc(II) ion: dissociation of Zn(II) from IMP-1 in acidic medium.

Journal: Biological & pharmaceutical bulletin 20030501

Title: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

Journal: European journal of pharmacology 20030328

Title: Group 1 beta-lactamases of Aeromonas caviae and their resistance to beta-lactam antibiotics.

Journal: Canadian journal of microbiology 20030301

Title: Resistance to quinolones in Campylobacter jejuni and Campylobacter coli from Danish broilers at farm level.

Journal: Journal of applied microbiology 20030101

Title: Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin.

Journal: The Journal of biological chemistry 20021129

Title: beta-Lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021101

Title: Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin.

Journal: American journal of clinical pathology 20020801

Title: Antimicrobial susceptibility of coagulase-negative staphylococci isolated from bovine mastitis in Argentina.

Journal: Journal of dairy science 20020801

Title: Frequency of Pseudomonas aeruginosa serotypes in burn wound infections and their resistance to antibiotics.

Journal: Burns : journal of the International Society for Burn Injuries 20020601

Title: Interaction of human organic anion transporters with various cephalosporin antibiotics.

Journal: European journal of pharmacology 20020308

Title: Reducing infections among women undergoing cesarean section in Colombia by means of continuous quality improvement methods.

Journal: Archives of internal medicine 20011022

Title: Another look at differences in the susceptibility of Escherichia coli and Klebsiella pneumoniae to cephalothin and cefazolin.

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Title: Comparison of methods for the determination of antimicrobial resistance in Staphylococcus aureus from bovine mastitis.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20010201

Title: Anti-IL-4 monoclonal antibody prevents antibiotics-induced active fatal anaphylaxis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19970515

Title: Identification of penicillin allergenic determinants that bind IgE antibodies in the sera of subjects with penicillin allergy.

Journal: Molecular immunology 19901101

Title: Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.

Journal: Antimicrobial agents and chemotherapy 19880601

Title: Human myocardial responses to antibiotics: gentamicin, tobramycin and cephalothin.

Journal: The Canadian journal of cardiology 19880101

Title: [Renal dipeptidylpeptidase IV excretion in drug-induced kidney changes].

Journal: Zeitschrift fur Urologie und Nephrologie 19861001

Title: Heterogeneity of cross-reactivity of mouse anti-benzylpenicilloyl antibodies against cephalothin haptens or polymers.

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Journal: The Japanese journal of antibiotics 19831201

Title: Hepatic dysfunction following nafcillin and cephalothin therapy in a patient with a history of oxacillin hepatitis.

Journal: Clinical pharmacy 19830101

Title: Features of gentamicin nephrotoxicity and effect of concurrent cephalothin in the rat.

Journal: Nephron 19830101

Title: [Drug induced nephropathy and enzymes of renal origin in the urine].

Journal: Zeitschrift fur Urologie und Nephrologie 19820801

Title: Severe nephrotoxicity: a probable complication of cis-dichlorodiammineplatinum (II) and cephalothin-gentamicin therapy.

Journal: Oncology 19820101

Title: Antibiotic combination-associated nephrotoxicity in granulocytopenic patients with cancer.

Journal: Archives of internal medicine 19811201

Title: Prospective comparative evaluation of gentamicin or gentamicin plus cephalothin in the production of nephrotoxicity in man.

Journal: The Journal of antimicrobial chemotherapy 19790901

Title: Relationship between aminoglycoside-induced nephrotoxicity and auditory toxicity.

Journal: Antimicrobial agents and chemotherapy 19790601

Title: Peripheral nerve injection injury: an experimental study.

Journal: Neurosurgery 19790301

Title: Tetracycline-induced aplastic anemia.

Journal: Southern medical journal 19790301

Title: Renal tubular necrosis following cephalothin.

Journal: Nephron 19790101

Title: Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.

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Title: Gentamicin-cephalothin drug reaction.

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Title: Drug-induced lysosomal changes and nephrotoxicity in rats.

Journal: Acta pathologica japonica 19781101

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Journal: Annals of clinical research 19781001

Title: Cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside.

Journal: Lancet (London, England) 19780916

Title: Acute renal failure after cis-dichlorodiammineplatinum(II) and gentamicin-cephalothin therapies.

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Title: Fanconi syndrome associated with cephalothin and gentamicin therapy.

Journal: Cancer 19780201

Title: Hemolysis induced by cefazolin and cephalothin in a patient with penicillin sensitivity.

Journal: Transfusion 19780101

Title: Acute interstitial nephritis during treatment with penicillin and cephalothin.

Journal: Acta medica Scandinavica 19780101

Title: Nephropathy associated with methicillin therapy. Prevalence and determinants in patients with staphylococcal bacteremia.

Journal: Archives of internal medicine 19770801

Title: The use of cephalothin sodium (keflin) as the prophylactic antibiotic for open heart surgery.

Journal: The Journal of antimicrobial chemotherapy 19770701

Title: Double-blind study to investigate methods to prevent cephalothin-induced phlebitis.

Journal: American journal of hospital pharmacy 19770101

Title: Nephrotoxicity in combined cephalothin and gentamicin therapy.

Journal: Acta medica Scandinavica 19770101

Title: Letter: Interaction between gentamicin and cephalothin as cause of acute renal failure.

Journal: Lancet (London, England) 19760911

Title: Comparison of thrombophlebitis associated with three cephalosporin antibiotics.

Journal: Antimicrobial agents and chemotherapy 19760901

Title: [Haemolytic anaemia and acute renal failure associated with cephalothin and furosemide therapy (author's transl)].

Journal: Medizinische Klinik 19760806

Title: Double-blind comparison of phlebitis associated with cefazolin and cephalothin.

Journal: International journal of clinical pharmacology and biopharmacy 19760701

Title: Phlebitis associated with the intravenous use of cephalothin and cephapirin.

Journal: American journal of hospital pharmacy 19760701

Title: Comparative incidence of phlebitis due to buffered cephalothin, cephapirin, and cefamandole.

Journal: Antimicrobial agents and chemotherapy 19760401

Title: Significant reduction in the incidence of phlebitis with buffered versus unbuffered cephalothin.

Journal: Antimicrobial agents and chemotherapy 19760401

Title: Comparison of phlebitis produced by cephapirin and cephalothin.

Journal: Antimicrobial agents and chemotherapy 19760401

Title: Cephalothin-induced immune hemolytic anemia.

Journal: Acta haematologica 19760101

Title: Acute interstitial nephritis.

Journal: The Journal of urology 19760101

Title: Acute renal failure associated with cephalosporin therapy.

Journal: American heart journal 19750601

Title: Nephrotoxicity associated with cephalothin administration.

Journal: Archives of internal medicine 19750601

Title: Nephrotoxicity of combined cephalothin-gentamicin regimen.

Journal: Archives of internal medicine 19750601

Title: [Acute renal failure in the course of treatment with gentamicin alone or combined with other antibiotics. Report 6 cases].

Journal: Revista clinica espanola 19750515

Title: Reversible nephrotoxicity associated with cephalothin therapy.

Journal: Archives of internal medicine 19750401

Title: Double-blind comparison of phlebitis produced by cefazolin versus cephalothin.

Journal: Antimicrobial agents and chemotherapy 19750401

Title: Drug-induced haemolytic anemia.

Journal: Clinics in haematology 19750201

Title: Cephaloridine, cephalothin and the kidney.

Journal: The Journal of antimicrobial chemotherapy 19750101

Title: Letter: Drug-induced red cell aplasia.

Journal: British medical journal 19741019

Title: Acute renal failure during cephalothin therapy.

Journal: JAMA 19740805

Title: Cephalothin, carbenicillin, and gentamicin combination therapy for febrile patients with acute non-lymphocytic leukemia.

Journal: Cancer 19740801

Title: Nephropathy, an underestimated complication of methicillin therapy.

Journal: The Journal of pediatrics 19740601

Title: Effect of buffering on the incidence and severity of cephalothin-induced phlebitis.

Journal: American journal of hospital pharmacy 19740301

Title: Double-blind comparison of phlebitis produced by cephalothin infusions with buffered and unbuffered diluents.

Journal: Antimicrobial agents and chemotherapy 19740201

Title: Toxic liver injuries.

Journal: Acta pathologica japonica 19730801

Title: Acute renal failure after high doses of gentamicin and cephalothin.

Journal: Lancet (London, England) 19730519

Title: Acute renal failure associated with combined gentamicin and cephalothin therapy.

Journal: British medical journal 19730519

Title: Double-blind controlled comparison of phlebitis produced by cephapirin and cephalothin.

Journal: Antimicrobial agents and chemotherapy 19730201

Title: [Severe myelopathy, peripheral neuropathy and optic neuritis appearing during treatment with chloroiodoquin (clioquinol)].

Journal: Therapie 19730101

Title: [Acute kidney failure following administration of cephalothin and gentamicin: renal histologic examination and optical and electronic microscopy].

Journal: Journal d'urologie et de nephrologie 19730101

Title: Anuria and acute tubular necrosis associated with gentamicin and cephalothin.

Journal: JAMA 19721218

Title: Relative nephrotoxicity of cephalosporin antibiotics in an animal model.

Journal: Canadian Medical Association journal 19720909

Title: Relative incidence of phlebitis caused by continuous intravenous infusion of cephapirin and cephalothin.

Journal: Antimicrobial agents and chemotherapy 19720901

Title: Cephalothin-induced tachycardia following aortic valve replacement.

Journal: JAMA 19720807

Title: Antibiotics and hypokalaemia.

Journal: Lancet (London, England) 19720318

Title: Nephrotoxicity and acute renal failure associated with cephalothin and cephaloridine.

Journal: The New Zealand medical journal 19711101

Title: Hemolytic anemia associated with cephalothin.

Journal: JAMA 19710830

Title: Nonoliguric renal failure secondary to sodium colistimethate: a report of four cases.

Journal: The American journal of the medical sciences 19710801

Title: Acute renal failure in general surgical patients.

Journal: Archives of surgery (Chicago, Ill. : 1960) 19710601

Title: Declining renal function associated with administration of cephalothin.

Journal: Southern medical journal 19700401

Title: Renal damage associated with prolonged administration of ampicillin, cephaloridine, and cephalothin.

Journal: Antimicrobial agents and chemotherapy 19690101

Title: Treatment of bacterial endocarditis with cephalothin.

Journal: The New England journal of medicine 19681212

Title: Hemolytic anemia caused by penicillin. Report of a case in which antipenicillin antibodies cross-reacted with cephalothin sodium.

Journal: JAMA 19680101

Title: Penicillin-induced encephalopathy in uremic patients.

Journal: JAMA 19670410

Title: Dowarah R, et al. Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets. PLoS One. 2018 Mar 8;13(3):e0192978.

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Tags:58-71-9 Molecular Formula|58-71-9 MDL|58-71-9 SMILES|58-71-9 Cefalotin sodium salt