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5817-92-5,MFCD00456054
Catalog No.:AA00EBWG

5817-92-5 | 2,4-Dioxo-4-phenylbutanoic acid

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250mg
98%
1 week  
$57.00   $40.00
- +
1g
98%
1 week  
$128.00   $90.00
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5g
98%
1 week  
$479.00   $335.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EBWG
Chemical Name:
2,4-Dioxo-4-phenylbutanoic acid
CAS Number:
5817-92-5
Molecular Formula:
C10H8O4
Molecular Weight:
192.1681
MDL Number:
MFCD00456054
SMILES:
O=C(c1ccccc1)CC(=O)C(=O)O
Properties
Computed Properties
 
Complexity:
251  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
1.2  

Literature

Title: Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors.

Journal: ChemMedChem 20120501

Title: HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding.

Journal: Molecular pharmaceutics 20110404

Title: Using small molecules to target protein phosphatases.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.

Journal: PLoS pathogens 20100901

Title: RNA-dependent RNA polymerase of hepatitis C virus: study on inhibition by alpha,gamma-diketo acid derivatives.

Journal: Biochemistry. Biokhimiia 20090801

Title: The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Journal: Nature 20090416

Title: [New strategy for targeting influenza virus replication].

Journal: Medecine sciences : M/S 20090401

Title: A quantum mechanic/molecular mechanic study of the wild-type and N155S mutant HIV-1 integrase complexed with diketo acid.

Journal: Biophysical journal 20080401

Title: Ethyl 3-benzoyl-2-hydroxy-prop-2-enoate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.

Journal: Biochemistry. Biokhimiia 20060901

Title: From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.

Journal: Journal of medicinal chemistry 20060713

Title: Control of hepatitis C: a medicinal chemistry perspective.

Journal: Journal of medicinal chemistry 20050113

Title: Stereospecific synthesis of (R)-2-hydroxy carboxylic acids using recombinant E. coli BL21 overexpressing YiaE from Escherichia coli K12 and glucose dehydrogenase from Bacillus subtilis.

Journal: Biotechnology progress 20050101

Title: Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site.

Journal: Journal of medicinal chemistry 20041021

Title: Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.

Journal: Bioorganic & medicinal chemistry letters 20040308

Title: Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Journal: Journal of medicinal chemistry 20040101

Title: Catalysis, stereochemistry, and inhibition of ureidoglycolate lyase.

Journal: The Journal of biological chemistry 20031212

Title: Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

Journal: Journal of medicinal chemistry 20020718

Title: Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.

Journal: Antimicrobial agents and chemotherapy 19941201

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