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58698-37-6,MFCD17215928
Catalog No.:AA00EF18

58698-37-6 | 2-C-Methyl-D-erythritol

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Purity
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1mg
>95%
2 weeks  
$549.00   $384.00
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5mg
98.0%
2 weeks  
$610.00   $427.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EF18
Chemical Name:
2-C-Methyl-D-erythritol
CAS Number:
58698-37-6
Molecular Formula:
C5H12O4
Molecular Weight:
136.1464
MDL Number:
MFCD17215928
SMILES:
OC[C@H]([C@](CO)(O)C)O
Properties
Properties
 
Storage:
Keep in dry area;2-8℃;Inert atmosphere;  

Computed Properties
 
Complexity:
85  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
-2.2  

Literature

Title: Pre-steady-state kinetic analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Mycobacterium tuberculosis reveals partially rate-limiting product release by parallel pathways.

Journal: Biochemistry 20120703

Title: HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe.

Journal: Microbiology (Reading, England) 20120701

Title: Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis.

Journal: The Journal of biological chemistry 20120504

Title: Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway.

Journal: Molecular biology reports 20120501

Title: Predicted essential proteins of Plasmodium falciparum for potential drug targets.

Journal: Asian Pacific journal of tropical medicine 20120501

Title: Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza.

Journal: Journal of experimental botany 20120401

Title: Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis.

Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120309

Title: Enhancement of anthraquinone production in Morinda citrifolia cell suspension cultures after stimulation of the proline cycle with two proline analogs.

Journal: Biotechnology letters 20120301

Title: Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex.

Journal: Journal of experimental botany 20120301

Title: Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.

Journal: Acta crystallographica. Section D, Biological crystallography 20120201

Title: Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts.

Journal: Metabolic engineering 20120101

Title: Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea.

Journal: BMC genomics 20120101

Title: Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts.

Journal: Plant methods 20120101

Title: De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels.

Journal: PloS one 20120101

Title: Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli.

Journal: PloS one 20120101

Title: Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed.

Journal: PloS one 20120101

Title: Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway.

Journal: PloS one 20120101

Title: New method for resolving the enantiomeric composition of 2-methyltetrols in atmospheric organic aerosols.

Journal: Journal of chromatography. A 20111223

Title: A proteomic analysis of the chromoplasts isolated from sweet orange fruits [Citrus sinensis (L.) Osbeck].

Journal: Journal of experimental botany 20111101

Title: Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature.

Journal: Plant, cell & environment 20110801

Title: Role of reactive oxygen species and proline cycle in anthraquinone accumulation in Rubia tinctorum cell suspension cultures subjected to methyl jasmonate elicitation.

Journal: Plant physiology and biochemistry : PPB 20110701

Title: Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110701

Title: Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501

Title: Structural and functional studies of mycobacterial IspD enzymes.

Journal: Acta crystallographica. Section D, Biological crystallography 20110501

Title: Transcriptome analysis of Taxus cuspidata needles based on 454 pyrosequencing.

Journal: Planta medica 20110301

Title: Functional characterization of the three genes encoding 1-deoxy-D-xylulose 5-phosphate synthase in maize.

Journal: Journal of experimental botany 20110301

Title: NMR studies of DOXP reductoisomerase and its inhibitor complex.

Journal: Chembiochem : a European journal of chemical biology 20110211

Title: Effect of temperature on postillumination isoprene emission in oak and poplar.

Journal: Plant physiology 20110201

Title: The methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis as a target for the development of new drugs against tuberculosis.

Journal: Current medicinal chemistry 20110101

Title: Adhesive polypeptides of Staphylococcus aureus identified using a novel secretion library technique in Escherichia coli.

Journal: BMC microbiology 20110101

Title: Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD.

Journal: BMC microbiology 20110101

Title: Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation.

Journal: PloS one 20110101

Title: An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis.

Journal: BMC genomics 20110101

Title: The first insight into the tissue specific taxus transcriptome via Illumina second generation sequencing.

Journal: PloS one 20110101

Title: The draft genome and transcriptome of Cannabis sativa.

Journal: Genome biology 20110101

Title: CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae.

Journal: PloS one 20110101

Title: Cuminum cyminum and Carum carvi: An update.

Journal: Pharmacognosy reviews 20110101

Title: Evidence of isoprenoid precursor toxicity in Bacillus subtilis.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes.

Journal: BMC genomics 20110101

Title: Supply of precursors for carotenoid biosynthesis in plants.

Journal: Archives of biochemistry and biophysics 20101201

Title: Biosynthesis of the iridoid glucoside, lamalbid, in Lamium barbatum.

Journal: Phytochemistry 20101001

Title: The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae.

Journal: The Journal of antibiotics 20101001

Title: Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.

Journal: Science (New York, N.Y.) 20101001

Title: Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum.

Journal: ChemMedChem 20100705

Title: Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03.

Journal: Plant physiology 20100701

Title: Determination of the stable carbon isotopic compositions of 2-methyltetrols in ambient aerosols from the Changbai Mountains.

Journal: Rapid communications in mass spectrometry : RCM 20100615

Title: Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis.

Journal: Journal of molecular modeling 20100601

Title: Analysis of 1-deoxy-D-xylulose 5-phosphate synthase activity in Grey poplar leaves using isotope ratio mass spectrometry.

Journal: Phytochemistry 20100601

Title: Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.

Journal: Journal of structural biology 20100601

Title: Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.

Journal: The Journal of organic chemistry 20100521

Title: Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20100301

Title: Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway.

Journal: Journal of natural products 20100226

Title: Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.

Journal: Chemistry & biology 20100226

Title: Characterization of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate synthase (HDS) gene from Ginkgo biloba.

Journal: Molecular biology reports 20100201

Title: Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis.

Journal: PLoS pathogens 20100201

Title: Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures.

Journal: FEBS letters 20100104

Title: Essential oil biosynthesis and regulation in the genus Cymbopogon.

Journal: Natural product communications 20100101

Title: The Alveolate Perkinsus marinus: biological insights from EST gene discovery.

Journal: BMC genomics 20100101

Title: Identifying essential genes in bacterial metabolic networks with machine learning methods.

Journal: BMC systems biology 20100101

Title: The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes.

Journal: BMC plant biology 20100101

Title: Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling.

Journal: BMC genomics 20100101

Title: A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.).

Journal: BMC plant biology 20100101

Title: Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].

Journal: BMC molecular biology 20100101

Title: Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.

Journal: Chemistry & biology 20091224

Title: Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots.

Journal: Applied microbiology and biotechnology 20091101

Title: Molecular characterization of the Oncidium orchid HDR gene encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, the last step of the methylerythritol phosphate pathway.

Journal: Plant cell reports 20091001

Title: Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein.

Journal: Journal of the American Chemical Society 20090923

Title: Dihydroxylation of 4-substituted 1,2-dioxines: a concise route to branched erythro sugars.

Journal: The Journal of organic chemistry 20090717

Title: Raman spectroscopic typing reveals the presence of carotenoids in Mycoplasma pneumoniae.

Journal: Microbiology (Reading, England) 20090601

Title: Regulation of resin acid synthesis in Pinus densiflora by differential transcription of genes encoding multiple 1-deoxy-D-xylulose 5-phosphate synthase and 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase genes.

Journal: Tree physiology 20090501

Title: Complete blockage of the mevalonate pathway results in male gametophyte lethality.

Journal: Journal of experimental botany 20090501

Title: Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers.

Journal: PLoS genetics 20090501

Title: The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico.

Journal: Marine drugs 20090301

Title: Accumulation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in illuminated plant leaves at supraoptimal temperatures reveals a bottleneck of the prokaryotic methylerythritol 4-phosphate pathway of isoprenoid biosynthesis.

Journal: Plant, cell & environment 20090101

Title: A plastidial pathway for protein isoprenylation in tobacco cells.

Journal: The Plant cell 20090101

Title: The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.

Journal: The Plant cell 20090101

Title: A comparative genomics study of genetic products potentially encoding ladderane lipid biosynthesis.

Journal: Biology direct 20090101

Title: Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

Journal: PloS one 20090101

Title: Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants.

Journal: Journal of experimental botany 20090101

Title: Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing.

Journal: BMC genomics 20090101

Title: [2-(14)C-Methylerythritol 2,4-cyclodiphosphate incorporation into bacterial and plant isoprenoids].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20090101

Title: An integrated analysis of molecular acclimation to high light in the marine diatom Phaeodactylum tricornutum.

Journal: PloS one 20090101

Title: Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Journal: PloS one 20090101

Title: The plastidial MEP pathway: unified nomenclature and resources.

Journal: Trends in plant science 20081201

Title: Two copies of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (CMK) gene in Ginkgo biloba: molecular cloning and functional characterization.

Journal: Planta 20081101

Title: Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis.

Journal: Bioscience, biotechnology, and biochemistry 20081101

Title: Identification and functional analysis of light-responsive unique genes and gene family members in rice.

Journal: PLoS genetics 20080801

Title: Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

Journal: The Journal of biological chemistry 20080725

Title: Spatial and seasonal trends in biogenic secondary organic aerosol tracers and water-soluble organic carbon in the southeastern United States.

Journal: Environmental science & technology 20080715

Title: Contribution of hydroxymethylbutenyl diphosphate synthase to carotenoid biosynthesis in bacteria and plants.

Journal: Biochemical and biophysical research communications 20080704

Title: Mechanostimulation of Medicago truncatula leads to enhanced levels of jasmonic acid.

Journal: Journal of experimental botany 20080701

Title: A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus.

Journal: Molecular biology and evolution 20080601

Title: A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes.

Journal: The Plant journal : for cell and molecular biology 20080501

Title: Effects of feeding Spodoptera littoralis on lima bean leaves: IV. Diurnal and nocturnal damage differentially initiate plant volatile emission.

Journal: Plant physiology 20080301

Title: Small molecules for the activation of human gammadelta T cell responses against infection.

Journal: Recent patents on anti-infective drug discovery 20080101

Title: Comparative transcriptome analysis of Arabidopsis thaliana infested by diamond back moth (Plutella xylostella) larvae reveals signatures of stress response, secondary metabolism, and signalling.

Journal: BMC genomics 20080101

Title: Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics.

Journal: BMC plant biology 20080101

Title: Chlamydial genes shed light on the evolution of photoautotrophic eukaryotes.

Journal: BMC evolutionary biology 20080101

Title: The dioxanone approach to (2S,3R)-2-C-methylerythritol 4-phosphate and 2,4-cyclodiphosphate, and various MEP analogues.

Journal: The Journal of organic chemistry 20071221

Title: Differential metabolomics unraveling light/dark regulation of metabolic activities in Arabidopsis cell culture.

Journal: Planta 20071201

Title: Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv.

Journal: Journal of biochemistry and molecular biology 20071130

Title: In situ localization of gene transcriptions for monoterpene synthesis in irregular parenchymic cells surrounding the secretory cavities in rough lemon (Citrus jambhiri).

Journal: Journal of plant physiology 20071101

Title: Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae).

Journal: Phytochemistry 20070801

Title: Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis.

Journal: The Journal of biological chemistry 20070706

Title: Isoprenoid biosynthesis authenticates the classification of the green alga Mesostigma viride as an ancient streptophyte.

Journal: Gene 20070701

Title: Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis.

Journal: Applied microbiology and biotechnology 20070701

Title: Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070601

Title: Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum.

Journal: Memorias do Instituto Oswaldo Cruz 20070601

Title: Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug.

Journal: Chemical & pharmaceutical bulletin 20070501

Title: A portfolio of plasmids for identification and analysis of carotenoid pathway enzymes: Adonis aestivalis as a case study.

Journal: Photosynthesis research 20070501

Title: Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens.

Journal: Immunological reviews 20070201

Title: Apocarotenoid biosynthesis in arbuscular mycorrhizal roots: contributions from methylerythritol phosphate pathway isogenes and tools for its manipulation.

Journal: Phytochemistry 20070101

Title: Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

Journal: Current pharmaceutical design 20070101

Title: [2-C-Methylerythritol phosphate pathway of isoprenoid biosynthesis as a target in identifying of new antibiotics, herbicides, and immunomodulators (Review) ].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20070101

Title: Did an ancient chlamydial endosymbiosis facilitate the establishment of primary plastids?

Journal: Genome biology 20070101

Title: The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.

Journal: BMC structural biology 20070101

Title: A high quality draft consensus sequence of the genome of a heterozygous grapevine variety.

Journal: PloS one 20070101

Title: Seasonal variation of 2-methyltetrols in ambient air samples.

Journal: Environmental science & technology 20061115

Title: The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves.

Journal: Plant physiology 20060801

Title: The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target.

Journal: Acta crystallographica. Section D, Biological crystallography 20060701

Title: Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba.

Journal: Phytochemistry 20060701

Title: Metagenomic analysis of the human distal gut microbiome.

Journal: Science (New York, N.Y.) 20060602

Title: Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis.

Journal: Chemical & pharmaceutical bulletin 20060501

Title: Asymmetric synthesis of four isomers of 2-C-trifluoromethylerythritol.

Journal: The Journal of organic chemistry 20060414

Title: Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway.

Journal: Biochemistry 20060321

Title: Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG.

Journal: FEBS letters 20060306

Title: Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis.

Journal: Planta 20060301

Title: The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.

Journal: The FEBS journal 20060301

Title: Molecular cloning and expression profile analysis of Ginkgo biloba DXS gene encoding 1-deoxy-D-xylulose 5-phosphate synthase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway.

Journal: Planta medica 20060301

Title: A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-D-xylulose 5-phosphate synthase.

Journal: FEBS letters 20060206

Title: Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis.

Journal: Planta medica 20060201

Title: Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway.

Journal: Biochimica et biophysica acta 20060101

Title: Mimicking the atmospheric OH-radical-mediated photooxidation of isoprene: formation of cloud-condensation nuclei polyols monitored by electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Mutation in the flexible loop of 1-deoxy-D-xylulose 5-phosphate reductoisomerase broadens substrate utilization.

Journal: Archives of biochemistry and biophysics 20051215

Title: Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli.

Journal: The Journal of organic chemistry 20051111

Title: The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway.

Journal: The Plant journal : for cell and molecular biology 20051001

Title: Suppression of Wolffia arrhiza growth by brassinazole, an inhibitor of brassinosteroid biosynthesis and its restoration by endogenous 24-epibrassinolide.

Journal: Phytochemistry 20050801

Title: fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

Journal: FEBS letters 20050704

Title: Biosynthesis of pyrethrin I in seedlings of Chrysanthemum cinerariaefolium.

Journal: Phytochemistry 20050701

Title: Mechanistic studies with 2-C-methyl-D-erythritol 4-phosphate synthase from Escherichia coli.

Journal: Biochemistry 20050614

Title: A spectrophotometric assay for the determination of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity.

Journal: Analytical biochemistry 20050515

Title: New analytical method for the determination of levoglucosan, polyhydroxy compounds, and 2-methylerythritol and its application to smoke and rainwater samples.

Journal: Environmental science & technology 20050415

Title: Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes.

Journal: The Journal of antibiotics 20050401

Title: Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050301

Title: A colorimetric assay for the determination of 4-diphosphocytidyl-2-C-methyl-D-erythritol 4-phosphate synthase activity.

Journal: Analytical biochemistry 20050201

Title: Evolution of the isoprene biosynthetic pathway in kudzu.

Journal: Plant physiology 20050201

Title: Pools of 14C-malic acid as a substrate for pyruvate production for the DOXP/MEP pathway of biosynthesis of carotenoids in chloroplasts.

Journal: Doklady. Biochemistry and biophysics 20050101

Title: 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.

Journal: Bioorganic chemistry 20041201

Title: Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids.

Journal: Biochemistry 20040928

Title: Are iridoids in leaf beetle larvae synthesized de novo or derived from plant precursors? A methodological approach.

Journal: Isotopes in environmental and health studies 20040901

Title: Biosynthetic pathway for the C45 polyprenol, solanesol, in tobacco.

Journal: Bioscience, biotechnology, and biochemistry 20040901

Title: Rapid regulation of the methylerythritol 4-phosphate pathway during isoprene synthesis.

Journal: Plant physiology 20040801

Title: 2-C-methyl-D-erythritol is a major carbohydrate in petals of Phlox subulata possibly involved in flower development.

Journal: Journal of plant physiology 20040801

Title: Biosynthesis of isoprenoids via the non-mevalonate pathway.

Journal: Cellular and molecular life sciences : CMLS 20040601

Title: Synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a potential inhibitor of the nonmevalonate pathway.

Journal: Bioscience, biotechnology, and biochemistry 20040601

Title: CHLOROPLAST BIOGENESIS genes act cell and noncell autonomously in early chloroplast development.

Journal: Plant physiology 20040501

Title: Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase.

Journal: Biochemistry 20040413

Title: Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites.

Journal: The Plant journal : for cell and molecular biology 20040401

Title: Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing.

Journal: Plant physiology 20040401

Title: Heterologous mevalonate production in Streptomyces lividans TK23.

Journal: Bioscience, biotechnology, and biochemistry 20040401

Title: The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes.

Journal: FEBS letters 20040312

Title: Formation of secondary organic aerosols through photooxidation of isoprene.

Journal: Science (New York, N.Y.) 20040220

Title: Cloning, characterization, and immunolocalization of a mycorrhiza-inducible 1-deoxy-d-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize.

Journal: Plant physiology 20040201

Title: Synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate from D-arabitol.

Journal: Organic letters 20040108

Title: Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.

Journal: The Plant cell 20040101

Title: The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs.

Journal: Current pharmaceutical design 20040101

Title: Fragmentation study of diastereoisomeric 2-methyltetrols, oxidation products of isoprene, as their trimethylsilyl ethers, using gas chromatography/ion trap mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3,4)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate, the substrate of the 1-deoxy-D-xylulose 5-phosphate reducto-isomerase.

Journal: Organic & biomolecular chemistry 20031221

Title: A relationship between the mevalonate pathway and isoprenoid production in actinomycetes.

Journal: The Journal of antibiotics 20031101

Title: A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens.

Journal: Trends in immunology 20030801

Title: Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells.

Journal: The Journal of biological chemistry 20030718

Title: High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.

Journal: Journal of biomolecular screening 20030601

Title: Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.

Journal: The Journal of biological chemistry 20030516

Title: Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

Journal: FEBS letters 20030424

Title: Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.

Journal: Acta crystallographica. Section D, Biological crystallography 20030301

Title: Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate.

Journal: Bioorganic & medicinal chemistry letters 20030224

Title: Glycosides of 2-C-methyl-D-erythritol from the fruits of anise, coriander and cumin.

Journal: Phytochemistry 20030101

Title: Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.

Journal: Acta crystallographica. Section D, Biological crystallography 20030101

Title: [Properties of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate--an intermediate in the non-mevalonate isoprenoid biosynthesis].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20030101

Title: LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis.

Journal: FEBS letters 20021218

Title: Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway.

Journal: Planta 20021201

Title: Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics.

Journal: Plant physiology 20021101

Title: Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate.

Journal: The Biochemical journal 20020901

Title: Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Journal: European journal of biochemistry 20020901

Title: Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway.

Journal: Plant physiology 20020801

Title: Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol and 2-C-methyl-D-erythritol-4-phosphate.

Journal: The Journal of organic chemistry 20020726

Title: Synthesis of 2-methyl-D-erythritol via epoxy ester-orthoester rearrangement.

Journal: The Journal of organic chemistry 20020712

Title: Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis.

Journal: Planta 20020601

Title: Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli.

Journal: Immunology 20020601

Title: Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate.

Journal: Organic letters 20020404

Title: Functional analysis of the Arabidopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis.

Journal: FEBS letters 20020313

Title: Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.

Journal: The Journal of biological chemistry 20020308

Title: Biosynthesis of anthraquinones in cell cultures of Cinchona 'Robusta' proceeds via the methylerythritol 4-phosphate pathway.

Journal: Phytochemistry 20020101

Title: Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli.

Journal: FEBS letters 20011207

Title: Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid Synthesis.

Journal: Biochemical and biophysical research communications 20011123

Title: Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase.

Journal: The Journal of organic chemistry 20011116

Title: Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria.

Journal: Plant physiology 20011001

Title: Ubiquinone biosynthesis in microorganisms.

Journal: FEMS microbiology letters 20010925

Title: Evidence for the biosynthesis of squalene via the methylerythritol phosphate pathway in a Streptomyces sp. obtained from a marine sediment.

Journal: The Journal of organic chemistry 20010907

Title: Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase.

Journal: Acta crystallographica. Section D, Biological crystallography 20010801

Title: 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening.

Journal: The Plant journal : for cell and molecular biology 20010801

Title: Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.

Journal: Nature structural biology 20010701

Title: LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.

Journal: FEBS letters 20010615

Title: Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor.

Journal: Bioorganic & medicinal chemistry 20010601

Title: Concise synthesis of (+)-2-C-methyl-D-erythritol-4-phosphate.

Journal: The Journal of organic chemistry 20010406

Title: Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010315

Title: Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids.

Journal: Planta 20010201

Title: Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.

Journal: FEBS letters 20010119

Title: Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

Journal: The Biochemical journal 20010101

Title: Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway.

Journal: Acta biochimica Polonica 20010101

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Tags:58698-37-6 Molecular Formula|58698-37-6 MDL|58698-37-6 SMILES|58698-37-6 2-C-Methyl-D-erythritol