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587-63-3,MFCD01694032
Catalog No.:AA00E93V

587-63-3 | Dihydrokavain

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E93V
Chemical Name:
Dihydrokavain
CAS Number:
587-63-3
Molecular Formula:
C14H16O3
Molecular Weight:
232.2750
MDL Number:
MFCD01694032
SMILES:
COC1=CC(=O)O[C@H](C1)CCc1ccccc1
NSC Number:
112163
Properties
Properties
 
BP:
413.583°C at 760 mmHg  
Form:
Solid  
MP:
57 - 59°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
290  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
2.8  

Literature

Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

Journal: PloS one 20110101

Title: Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex.

Journal: Journal of pharmaceutical and biomedical analysis 20100801

Title: Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.

Journal: Bioorganic & medicinal chemistry letters 20091001

Title: Identification and characterization of kava-derived compounds mediating TNF-alpha suppression.

Journal: Chemical biology & drug design 20090801

Title: Efficient enantioselective hetero-Diels-Alder reaction of Brassard's diene with aliphatic aldehydes: a one-step synthesis of (R)-(+)-kavain and (S)-(+)-dihydrokavain.

Journal: Organic letters 20080320

Title: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).

Journal: Journal of agricultural and food chemistry 20060208

Title: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.

Journal: Journal of AOAC International 20050101

Title: Steviol quantification at the picomole level by high-performance liquid chromatography.

Journal: Journal of agricultural and food chemistry 20040505

Title: Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

Journal: Planta medica 20021201

Title: Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.

Journal: Planta medica 20021201

Title: Interaction of various Piper methysticum cultivars with CNS receptors in vitro.

Journal: Planta medica 20010601

Title: Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.

Journal: Psychopharmacology 20010401

Title: Feltenstein MW, et al. Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. Phytother Res. 2003 Mar;17(3):210-6.

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Tags:587-63-3 Molecular Formula|587-63-3 MDL|587-63-3 SMILES|587-63-3 Dihydrokavain