Home Other Building Blocks 58880-19-6
58880-19-6,MFCD03848392
Catalog No.:AA0035NN

58880-19-6 | Trichostatin a

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1mg
≥95%
in stock  
$126.00   $88.00
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5mg
≥95%
in stock  
$356.00   $249.00
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10mg
>98.0%(HPLC)
in stock  
$630.00   $441.00
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25mg
in stock  
$1,308.00   $915.00
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50mg
>98.0%(HPLC)
in stock  
$2,173.00   $1,521.00
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100mg
in stock  
$3,272.00   $2,290.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0035NN
Chemical Name:
Trichostatin a
CAS Number:
58880-19-6
Molecular Formula:
C17H22N2O3
Molecular Weight:
302.3682
MDL Number:
MFCD03848392
SMILES:
ONC(=O)/C=C/C(=C/[C@H](C(=O)c1ccc(cc1)N(C)C)C)/C
Properties
Properties
 
Form:
Solid  
MP:
>140°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Tetrahedron,1988,vol.44,p.6013-6020

[1]Tetrahedron,1988,vol.44,p.6013-6020

(2E,4E)-(6R,7R)-7-4-(dimethylamino)phenyl-N,7-dihydroxy-4,6-dimethylhepta-2,4-dienamide 
  58880-19-6 

[1]AdvancedSynthesisandCatalysis,2006,vol.348,p.1228-1234

[1]AdvancedSynthesisandCatalysis,2006,vol.348,p.1228-1234

[1]Tetrahedron,1988,vol.44,p.6013-6020

Literature

Title: Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7(4):971-6.

Title: Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.,Reprod Sci. 2012 Aug 8.

Title: Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.,Stem Cells Dev. 2012 Aug 8.

Title: Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47.

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