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Title: The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
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Title: Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).
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Title: Bestatin, an inhibitor for aminopeptidases, modulates the production of cytokines and chemokines by activated monocytes and macrophages.
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Title: Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.
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Title: Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
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Title: Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.
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Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20080601
Title: Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors.
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Title: Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.
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Title: Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis.
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Title: Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.
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Title: Biochemical characterization and structural prediction of a novel cytosolic leucyl aminopeptidase of the M17 family from Schizosaccharomyces pombe.
Journal: The FEBS journal 20071201
Title: Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.
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Title: Purification and identification of a novel leucine aminopeptidase from Bacillus thuringiensis israelensis.
Journal: Current microbiology 20071101
Title: Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.
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Title: Characterization of the catalytically active Mn(II)-loaded argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli.
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Journal: International journal of hematology 20070601
Title: Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
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Title: Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070515
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Journal: The Journal of investigative dermatology 20070501
Title: Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Title: Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor.
Journal: Zoological science 20070501
Title: Continuous treatment of bestatin induces anti-angiogenic property in endothelial cells.
Journal: Cancer science 20070301
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Journal: Peptides 20070101
Title: Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.
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Title: Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.
Journal: BMC cancer 20070101
Title: Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.
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Title: Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition.
Journal: The Journal of biological chemistry 20061103
Title: Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide.
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Title: Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors.
Journal: Carcinogenesis 20060901
Title: Identification and characterisation of a leucine aminopeptidase from the hard tick Haemaphysalis longicornis.
Journal: International journal for parasitology 20060901
Title: Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors.
Journal: International journal of pharmaceutics 20060831
Title: Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis.
Journal: Plant physiology 20060801
Title: [Experimental study of the enhancement effect of aminopeptidase N inhibitor ubenimex on the differentiation induction activity of all-trans-retinoic acid in acute promyelocytic leukemia cells and its mechanism].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20060701
Title: CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.
Journal: British journal of cancer 20060605
Title: Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
Journal: Pathology international 20060601
Title: [Effect of aminopeptidase inhibitor on differentiation induction activity of all-trans retinoic acid in human acute promyelocytic leukemia NB4 cells and its mechanism].
Journal: Zhongguo shi yan xue ye xue za zhi 20060601
Title: Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.
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Title: A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Journal: Biological & pharmaceutical bulletin 20060401
Title: Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.
Journal: The Journal of biological chemistry 20060120
Title: Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Journal: Medicinal research reviews 20060101
Title: Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase.
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Title: Treatment for HTLV-I associated arthropathy: a case study and synovial tissue culture analysis.
Journal: Rheumatology international 20051101
Title: Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression.
Journal: Atherosclerosis 20051101
Title: Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Journal: Bioorganic & medicinal chemistry 20050815
Title: Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050801
Title: Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
Journal: Journal of molecular biology 20050617
Title: The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme.
Journal: Microbiology (Reading, England) 20050601
Title: Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat.
Journal: Neuropeptides 20050401
Title: N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity.
Journal: Bioorganic & medicinal chemistry letters 20050103
Title: Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Journal: Cancer letters 20041208
Title: Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20041201
Title: Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.
Journal: Biochemical and biophysical research communications 20040903
Title: Chronic morphine treatment reduces recovery from opioid desensitization.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901
Title: Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica.
Journal: Biochemistry 20040803
Title: Long-term cytogenetic remission with ubenimex monotherapy in a case of chronic myeloid leukemia.
Journal: Anti-cancer drugs 20040801
Title: GPI-anchored aminopeptidase is involved in the acrosome reaction in sperm of the mussel mytilusedulis.
Journal: Molecular reproduction and development 20040401
Title: Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium.
Journal: Peptides 20040401
Title: Comparison of different adjuvants of protein and DNA vaccination for the prophylaxis of IgE antibody formation.
Journal: Vaccine 20040126
Title: Fibrosis in hypertensive heart disease: focus on cardiac fibroblasts.
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Title: Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases.
Journal: Journal of hypertension 20040101
Title: [Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma].
Journal: Bioorganicheskaia khimiia 20040101
Title: Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix.
Journal: Thrombosis and haemostasis 20031101
Title: Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Journal: Leukemia & lymphoma 20031101
Title: [A case of renal cell carcinoma with lymph node metastasis keeping remission for five years by adjuvant immunotherapy with ubenimex].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20031001
Title: Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.
Journal: Journal of medicinal chemistry 20030828
Title: [Chemotherapy with ubenimex corresponding to patient age and organ disorder for 18 cases of acute myelogeneous leukemia in elderly patients--effects, complications and long-term survival].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20030801
Title: Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.
Journal: Chemistry & biology 20030801
Title: Leukotriene A4 signaling, inflammation, and cancer.
Journal: Journal of the National Cancer Institute 20030716
Title: Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
Journal: Journal of the National Cancer Institute 20030716
Title: Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.
Journal: Journal of drug targeting 20030701
Title: The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.
Journal: Journal of medicinal chemistry 20030619
Title: Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia.
Journal: International immunopharmacology 20030601
Title: Bestatin results in pathophysiological changes similar to preeclampsia in rats via induction of placental apoptosis.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030601
Title: Aminopeptidase N inhibitors and SARS.
Journal: Lancet (London, England) 20030503
Title: Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.
Journal: Journal of the National Cancer Institute 20030416
Title: A comparative study on the rectal aminopeptidase enzymatic activities of different species.
Journal: Die Pharmazie 20030301
Title: Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101
Title: Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid.
Journal: Leukemia research 20021201
Title: Induction of graft-versus-host disease and a graft-versus-leukemia effect using ubenimex in a patient with infantile leukemia relapsing after an unrelated cord blood transplant.
Journal: Bone marrow transplantation 20021001
Title: Characterization of aminopeptidase activity from three species of microsporidia: Encephalitozoon cuniculi, Encephalitozoon hellem, and Vittaforma corneae.
Journal: The Journal of parasitology 20021001
Title: Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells.
Journal: FEBS letters 20020911
Title: CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis.
Journal: Arthritis and rheumatism 20020901
Title: Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions.
Journal: Cancer letters 20020828
Title: Effects of naloxone and post-tetanic stimulation on isolated guinea-pig ileum followed by long exposure to morphine and bestatin.
Journal: The Journal of toxicological sciences 20020801
Title: Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species.
Journal: The Journal of biological chemistry 20020719
Title: Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.
Journal: Journal of the National Cancer Institute 20020703
Title: Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin.
Journal: Investigative ophthalmology & visual science 20020701
Title: Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Journal: Placenta 20020701
Title: Membrane-associated dipeptidyl peptidase IV is involved in encystation-specific gene expression during Giardia differentiation.
Journal: The Biochemical journal 20020615
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Role of CD13/aminopeptidase N in rat lymphocytic alveolitis caused by thoracic irradiation.
Journal: Radiation research 20020201
Title: Characterization of a cytosolic aminopeptidase from Encephalitozoon intestinalis.
Journal: Parasitology 20020101
Title: Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide.
Journal: Journal of molecular neuroscience : MN 20020101
Title: Zinc and Manduca sexta hemocyte functions.
Journal: Journal of insect science (Online) 20020101
Title: The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Journal: European journal of pharmacology 20011102
Title: Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans.
Journal: The Journal of pharmacy and pharmacology 20011101
Title: Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines.
Journal: International journal of cancer 20011101
Title: [Effects of ubenimex ( bestatin) on the immunity of patients with squamous cell lung carcinoma treated with chemotherapy].
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Title: Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.
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Title: The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes.
Journal: Molecular and biochemical parasitology 20010928
Title: Studies on the aminopeptidase activities of Porphyromonas gingivalis.
Journal: Oral microbiology and immunology 20010801
Title: [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701
Title: Expression of attractin and its differential enzyme activity in glioma cells.
Journal: Biochemical and biophysical research communications 20010608
Title: Effects of dipeptide bestatin on Porphyromonas gingivalis and epithelial cells.
Journal: Journal of periodontology 20010601
Title: Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501
Title: Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion.
Journal: International journal of cancer 20010401
Title: Different types of antagonism by losartan and irbesartan on the effects of angiotensin II and its degradation products in rabbit arteries.
Journal: Fundamental & clinical pharmacology 20010401
Title: Bestatin as an experimental tool in mammals.
Journal: Current drug metabolism 20010301
Title: Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Journal: Nature structural biology 20010201
Title: Characterization of the pro-aminopeptidase from Aeromonas caviae T-64.
Journal: Bioscience, biotechnology, and biochemistry 20010201
Title: Purification and characterization of an aminopeptidase from the edible basidiomycete Grifola frondosa.
Journal: Bioscience, biotechnology, and biochemistry 20010201
Title: Adult T-cell leukemia associated with gastric carcinoma: report of a case.
Journal: Surgery today 20010101
Title: In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies.
Journal: The Journal of eukaryotic microbiology 20010101
Title: Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection.
Journal: Antiviral research 19971201
Title: Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation.
Journal: Antimicrobial agents and chemotherapy 19961201
Title: In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Journal: Peptides 19960101
Title: Metabolism of aspartame by human and pig intestinal microvillar peptidases.
Journal: The Biochemical journal 19940315
Title: Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor.
Journal: Biochemistry 19930126
Title: Protease activities in carp retina.
Journal: Neurochemistry international 19921201
Title: Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Journal: Synapse (New York, N.Y.) 19920501
Title: Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra.
Journal: Journal of neurochemistry 19920301
Title: alpha-Keto amide inhibitors of aminopeptidases.
Journal: Journal of medicinal chemistry 19920207
Title: Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin).
Journal: Clinical & experimental metastasis 19920101
Title: [Combination therapy of chronic myelogenous leukemia with busulfan and bestatin].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19910401
Title: Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.
Journal: The Journal of biological chemistry 19910125
Title: Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat.
Journal: Regulatory peptides 19900327
Title: Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices.
Journal: Neuroscience 19890101
Title: Effects of bestatin and phosphoramidon on the hypertensive response to physostigmine in the rat.
Journal: Fundamental & clinical pharmacology 19870101
Title: Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.
Journal: FEBS letters 19850909
Title: Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6
Title: Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9.
Title: Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35(1):133-8
Title: Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11(4):545-57
