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59086-90-7,MFCD00211027
Catalog No.:AA00E9KO

59086-90-7 | INGENOL 3,20-DIBENZOATE

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Purity
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1mg
≥97%
in stock  
$329.00   $230.00
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5mg
≥97%
in stock  
$1,184.00   $829.00
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10mg
≥97%
in stock  
$1,963.00   $1,374.00
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100mg
≥97%
in stock  
$17,207.00   $12,045.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E9KO
Chemical Name:
INGENOL 3,20-DIBENZOATE
CAS Number:
59086-90-7
Molecular Formula:
C34H36O7
Molecular Weight:
556.6454
MDL Number:
MFCD00211027
SMILES:
O=C(c1ccccc1)OCC1=C[C@@H]2[C@H]3[C@H](C3(C)C)C[C@H]([C@]3([C@]([C@@H]1O)(O)[C@@H](OC(=O)c1ccccc1)C(=C3)C)C2=O)C
Properties
Properties
 
Form:
Solid  
MP:
>95°C (dec.)  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
1160  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.1  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080501

Title: Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.

Journal: Gastroenterology 20071001

Title: PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons.

Journal: The European journal of neuroscience 20050201

Title: A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment.

Journal: The Journal of biological chemistry 20010105

Title: Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives.

Journal: Archives of virology 19980101

Title: Asada A, et al. Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation. J Biol Chem. 1998;273(43):28392-28398.

Title: Gong C, et al. Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate. Mol Immunol. 2017;83:23-32.

Title: Oh JG, et al. Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses. Mol Pharmacol. 2015;88(2):392-400.

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SDS
Tags:59086-90-7 Molecular Formula|59086-90-7 MDL|59086-90-7 SMILES|59086-90-7 INGENOL 3,20-DIBENZOATE