Home Other Building Blocks 59147-84-1
59147-84-1,MFCD11100314
Catalog No.:AA00EF08

59147-84-1 | 2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$26.00   $18.00
- +
250mg
95%
in stock  
$65.00   $45.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EF08
Chemical Name:
2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione
CAS Number:
59147-84-1
Molecular Formula:
C13H12O3S
Molecular Weight:
248.2976
MDL Number:
MFCD11100314
SMILES:
OCCSC1=C(C)C(=O)c2c(C1=O)cccc2
NSC Number:
672121
Properties
Properties
 
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
373  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.4  

Downstream Synthesis Route

[1]Borovkov;Filippovich;Evstigneeva[ChemistryofHeterocyclicCompounds,1988,vol.24,#5,p.494-501]

[2]Evstigneeva,R.P.;Borovkov,V.V.;Filippovich,E.I.;Sviridov,S.I.[DokladyChemistry,1987,vol.293,p.186-188][Dokl.Akad.NaukSSSRSer.Khim.,1987,vol.293,#5,p.1130-1132]

[3]Niyazymbetov,M.E.;Aref'eva,I.V.;Zakharova,E.I.;Konyushkin,L.D.;Alekseev,S.M.;etal.[Bull.Russ.Acad.Sci.Div.Chem.Sci.(Engl.Transl.),1992,vol.41,#11.2,p.2058-2060][IzvestiyaAkademiNauk,SeriyaKhimicheskaya,1992,vol.41,#11,p.2605-2608]

[4]AdarshKrishna,T.P.;Chinnasamy,Suresh;Ilangovan,Andivelu;Pandaram,Sakthivel[RSCAdvances,2020,vol.10,#33,p.19454-19462]

[5]Li,Wen-Wu;Heinze,Juergen;Haehnel,Wolfgang[JournaloftheAmericanChemicalSociety,2005,vol.127,#17,p.6140-6141]

[6]Chen,Chinpiao;Liu,Yi-Zhong;Shia,Kak-Shan;Tseng,Huan-Yi[BioorganicandMedicinalChemistryLetters,2002,vol.12,#19,p.2729-2732]

[7]Bhasin,Deepak;Chettiar,SomsundaramN.;Etter,JonathanP.;Mok,May;Li,Pui-Kai[BioorganicandMedicinalChemistry,2013,vol.21,#15,p.4662-4669]

[8]Li,Xiaoyang;Himes,RichardA.;Prosser,LyndseyC.;Christie,CharlestonF.;Watt,Emma;Edwards,SharonF.;Metcalf,CameronS.;West,PeterJ.;Wilcox,KarenS.;Chan,SherineS.L.;Chan,SherineS.L.;Chou,C.James;Chou,C.James[JournalofMedicinalChemistry,2020,vol.63,#11,p.5865-5878]

Literature

Title: Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization.

Journal: Journal of pharmacological sciences 20110101

Title: Grb2-associated binder-1 plays a central role in the hepatocyte growth factor enhancement of hepatoma growth inhibition by K vitamin analog compound 5.

Journal: Hepatology (Baltimore, Md.) 20071201

Title: Phosphorylation regulates Myc expression via prolonged activation of the mitogen-activated protein kinase pathway.

Journal: Journal of cellular physiology 20060701

Title: Modulation of bcl-2 family proteins in MAPK independent apoptosis induced by a cdc25 phosphatase inhibitor Cpd 5 in renal cancer cells.

Journal: Oncology reports 20050901

Title: Vitamin K analog (compound 5) induces apoptosis in human hepatocellular carcinoma independent of the caspase pathway.

Journal: Anti-cancer drugs 20050901

Title: Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.

Journal: Journal of cellular physiology 20050601

Title: Inhibition of rat liver regeneration after partial hepatectomy and induction of ERK phosphorylation by Cpd 5, a K vitamin-based anticancer compound.

Journal: Carcinogenesis 20041201

Title: Involvement of c-Myc in growth inhibition of Hep 3B human hepatoma cells by a vitamin K analog.

Journal: Journal of hepatology 20041101

Title: NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Fluorouracil prodrugs for the treatment of proliferative vitreoretinopathy: formulation in silicone oil and in vitro release of fluorouracil.

Journal: International journal of pharmaceutics 20030618

Title: Transient and sustained ERK phosphorylation and nuclear translocation in growth control.

Journal: Journal of cellular physiology 20020801

Title: Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.

Journal: The Journal of biological chemistry 20020531

Title: EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog.

Journal: Journal of cellular physiology 20020301

Title: Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes.

Journal: Journal of hepatology 20020101

Title: Tumor cell growth inhibition and extracellular signal-regulated kinase (ERK) phosphorylation by novel K vitamins.

Journal: Journal of molecular biology 20011207

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:59147-84-1 Molecular Formula|59147-84-1 MDL|59147-84-1 SMILES|59147-84-1 2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione