Title: Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction.
Journal: Biomedical chromatography : BMC 20120101
Title: [Pharmacokinetic analysis of high-dose methotrexate treatments in children with hematologic malignancies].
Journal: Orvosi hetilap 20111002
Title: The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
Journal: Clinical laboratory 20110101
Title: High-dose methotrexate in children with acute lymphoblastic leukemia: 7-hydroxymethotrexate systemic exposure and urinary concentrations at the steady state correlate well with those of methotrexate.
Journal: Arzneimittel-Forschung 20100101
Title: Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.
Journal: Molecular cancer therapeutics 20091201
Title: Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation.
Journal: Arthritis and rheumatism 20090801
Title: Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090501
Title: Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Journal: Biochemical pharmacology 20090415
Title: In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats.
Journal: Drug metabolism and pharmacokinetics 20061201
Title: Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
Journal: The Journal of pharmacology and experimental therapeutics 20060801
Title: Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis.
Journal: Journal of clinical pharmacology 20051001
Title: Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
Journal: Cancer chemotherapy and pharmacology 20050901
Title: Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits.
Journal: Journal of pharmaceutical sciences 20050601
Title: Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Title: Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Journal: Blood 20041215
Title: Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients.
Journal: The Annals of pharmacotherapy 20041001
Title: Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone.
Journal: Rheumatology (Oxford, England) 20030801
Title: System approach to modeling metabolite formation from parent drug: a working example with methotrexate.
Journal: Methods and findings in experimental and clinical pharmacology 20021001
Title: Lack of pharmacokinetic interaction between rofecoxib and methotrexate in rheumatoid arthritis patients.
Journal: Journal of clinical pharmacology 20011001
Title: Separation of selected anticancer drugs using superheated water as the mobile phase.
Journal: Analytical chemistry 20010815
Title: No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way.
Journal: Pharmacology 20010201
Title: Acute hepatotoxicity after high-dose methotrexate administration to rats.
Journal: Pharmacology & toxicology 19910801
Title: L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60.
Title: Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1789-95.
