Home Other Building Blocks 593960-11-3
593960-11-3,MFCD12922510
Catalog No.:AA00E9MP

593960-11-3 | PIK-93

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$21.00   $15.00
- +
5mg
98%
in stock  
$50.00   $35.00
- +
10mg
98%
in stock  
$74.00   $52.00
- +
50mg
98%
in stock  
$211.00   $148.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E9MP
Chemical Name:
PIK-93
CAS Number:
593960-11-3
Molecular Formula:
C14H16ClN3O4S2
Molecular Weight:
389.8775
MDL Number:
MFCD12922510
SMILES:
OCCNS(=O)(=O)c1cc(ccc1Cl)c1sc(nc1C)NC(=O)C
Properties
Computed Properties
 
Complexity:
543  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
1.4  

Literature

Title: A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Journal: Nature chemical biology 20120429

Title: Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.

Journal: Molecular biology of the cell 20080201

Title: A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

Journal: Cell 20060519

Title: Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47

Title: Van Keymeulen A, et al. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31;174(3):437-45

Title: Toth B, et al. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006 Nov 24;281(47):36369-77

Title: Monet M, et al. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012 May 18;287(21):17672-81

Title: Arita M, et al. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol. 2011 Mar;85(5):2364-72

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SDS
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Tags:593960-11-3 Molecular Formula|593960-11-3 MDL|593960-11-3 SMILES|593960-11-3 PIK-93