Title: Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects.
Journal: The Journal of toxicological sciences 20180101
Title: Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.
Journal: Archives of toxicology 20170301
Title: P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2.
Journal: Chemical research in toxicology 20160516
Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.
Journal: Journal of applied toxicology : JAT 20130201
Title: Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121101
Title: Effect of telaprevir on the pharmacokinetics of midazolam and digoxin.
Journal: Journal of clinical pharmacology 20121001
Title: Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies.
Journal: Bioorganic & medicinal chemistry 20120915
Title: Effect of quercetin on CYP3A activity in Chinese healthy participants.
Journal: Journal of clinical pharmacology 20120601
Title: Microbial production of phase I and phase II metabolites of midazolam.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120301
Title: Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.
Journal: Clinical pharmacology and therapeutics 20120301
Title: Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection.
Journal: Journal of pharmaceutical and biomedical analysis 20120125
Title: The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.
Journal: Biochemistry 20111220
Title: A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma.
Journal: Biomedical chromatography : BMC 20111001
Title: Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.
Journal: Biomedical chromatography : BMC 20111001
Title: Daily honey consumption does not change CYP3A activity in humans.
Journal: Journal of clinical pharmacology 20110801
Title: Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110601
Title: Rapid and simultaneous measurement of midazolam, 1'-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity.
Journal: Journal of pharmaceutical and biomedical analysis 20110428
Title: Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Journal: Chemical research in toxicology 20101220
Title: Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam.
Journal: European journal of clinical pharmacology 20101101
Title: Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101101
Title: Blood concentrations of midazolam in status epilepticus using an appropriate condition of HPLC.
Journal: Pediatrics international : official journal of the Japan Pediatric Society 20100801
Title: Furanocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100801
Title: CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601
Title: Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601
Title: Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates.
Journal: Clinical pharmacokinetics 20100601
Title: Sex-dependent differences in cytochrome P450 3A activity as assessed by midazolam disposition in humans: a meta-analysis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system.
Journal: Rapid communications in mass spectrometry : RCM 20100430
Title: CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients.
Journal: European journal of clinical pharmacology 20100101
Title: The effects of multiple doses of rolofylline on the single-dose pharmacokinetics of midazolam in healthy subjects.
Journal: American journal of therapeutics 20100101
Title: Vitamin E supplementation and hepatic drug metabolism in humans.
Journal: Journal of cardiovascular pharmacology 20091201
Title: Endogenous cortisol 6 beta-hydroxylation clearance is not an accurate probe for overall cytochrome P450 3A phenotyping in humans.
Journal: Clinica chimica acta; international journal of clinical chemistry 20091001
Title: ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
Journal: Journal of the American Society of Nephrology : JASN 20091001
Title: Effect of saquinavir-ritonavir on cytochrome P450 3A4 activity in healthy volunteers using midazolam as a probe.
Journal: Pharmacotherapy 20091001
Title: Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism.
Journal: Acta pharmacologica Sinica 20090901
Title: Effects of statins on the pharmacokinetics of midazolam in healthy volunteers.
Journal: Journal of clinical pharmacology 20090501
Title: The combination of chemical and antibody inhibitors for superior P450 3A inhibition in reaction phenotyping studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201
Title: Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080901
Title: Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.
Journal: International journal of pharmaceutics 20080522
Title: [Effect of polyoxyl ether analogous surfactants on the activity of cytochromes P450 3A in rats in vivo].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080501
Title: Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.
Journal: Biochemical pharmacology 20080315
Title: Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedation.
Journal: European journal of clinical pharmacology 20071201
Title: The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers.
Journal: Pharmacotherapy 20071001
Title: Simultaneous determination of midazolam and 1'-hydroxymidazolam in human plasma by liquid chromatography with tandem mass spectrometry.
Journal: Biomedical chromatography : BMC 20070801
Title: A developed determination of midazolam and 1'-hydroxymidazolam in plasma by liquid chromatography-mass spectrometry: application of human pharmacokinetic study for measurement of CYP3A activity.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301
Title: Determination of midazolam and its hydroxy metabolites in human plasma and oral fluid by liquid chromatography/electrospray ionization ion trap tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Quantification of benzodiazepines in whole blood and serum.
Journal: International journal of legal medicine 20061101
Title: Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients.
Journal: European journal of clinical pharmacology 20060301
Title: Effect of R667, a novel emphysema agent, on the pharmacokinetics of midazolam in healthy men.
Journal: Journal of clinical pharmacology 20060201
Title: Limited sampling models for oral midazolam: midazolam plasma concentrations, not the ratio of 1-hydroxymidazolam to midazolam plasma concentrations, accurately predicts AUC as a biomarker of CYP3A activity.
Journal: Journal of clinical pharmacology 20060201
Title: Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.
Journal: Biochemistry 20051101
Title: Midazolam and its metabolites in brain death diagnosis.
Journal: International journal of clinical pharmacology and therapeutics 20051101
Title: Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925
Title: A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: applications to drug metabolism.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805
Title: Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705
Title: Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050501
Title: Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients.
Journal: European journal of clinical pharmacology 20050201
Title: Differentiating midazolam over-sedation from neurological damage in the intensive care unit.
Journal: Critical care (London, England) 20050101
Title: Between benzodiazepine over-sedation and neurological damage.
Journal: Critical care (London, England) 20050101
Title: Sensitive determination of midazolam and 1'-hydroxymidazolam in plasma by liquid-liquid extraction and column-switching liquid chromatography with ultraviolet absorbance detection and its application for measuring CYP3A activity.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041125
Title: Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.
Journal: European journal of clinical pharmacology 20040601
Title: Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects.
Journal: European journal of clinical pharmacology 20040601
Title: Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405
Title: Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4).
Journal: Bioorganic & medicinal chemistry letters 20031103
Title: Relationship between CYP3A activity and breast cancer susceptibility in Chinese Han women.
Journal: European journal of clinical pharmacology 20030901
Title: Possibility of influence of midazolam sedation on the diagnosis of brain death: concentrations of active metabolites after cessation of midazolam.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030901
Title: Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.
Journal: Critical care medicine 20030701
Title: Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501
Title: The distribution and gender difference of CYP3A activity in Chinese subjects.
Journal: British journal of clinical pharmacology 20030301
Title: Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients.
Journal: British journal of clinical pharmacology 20030301
Title: A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate.
Journal: European journal of clinical pharmacology 20030201
Title: Determination of midazolam and 1'-hydroxymidazolam by liquid chromatography-mass spectrometry in plasma of patients undergoing methadone maintenance treatment.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105
Title: Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125
Title: [Use of midazolam in postoperative sedation of patients with multiple organ failure treated with hemodiafiltration. Clinical study and pharmacokinetics].
Journal: Annales francaises d'anesthesie et de reanimation 20021101
Title: Single plasma concentrations of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam do not predict midazolam clearance in healthy subjects.
Journal: Journal of clinical pharmacology 20021001
Title: Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedation in children: a pharmacokinetic-pharmacodynamic analysis.
Journal: British journal of anaesthesia 20020901
Title: Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice.
Journal: British journal of clinical pharmacology 20020801
Title: Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers.
Journal: British journal of clinical pharmacology 20020501
Title: Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns.
Journal: Rapid communications in mass spectrometry : RCM 20020101
Title: Midazolam disposition in patients undergoing continuous venovenous hemodialysis.
Journal: Journal of clinical pharmacology 20010901
Title: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201
Title: Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20001001
Title: Prolonged sedation due to accumulation of conjugated metabolites of midazolam.
Journal: Lancet (London, England) 19950715
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