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594839-88-0,MFCD16621109
Catalog No.:AA00ECC0

594839-88-0 | Tafamidis

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%(HPLC)
in stock  
$66.00   $46.00
- +
5mg
98%
in stock  
$85.00   $59.00
- +
10mg
≥98%
in stock  
$153.00   $107.00
- +
25mg
98%
in stock  
$180.00   $126.00
- +
100mg
98%
in stock  
$344.00   $241.00
- +
250mg
98%
in stock  
$468.00   $328.00
- +
1g
98%
in stock  
$897.00   $628.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ECC0
Chemical Name:
Tafamidis
CAS Number:
594839-88-0
Molecular Formula:
C14H7Cl2NO3
Molecular Weight:
308.1163
MDL Number:
MFCD16621109
SMILES:
Clc1cc(Cl)cc(c1)c1nc2c(o1)cc(cc2)C(=O)O
Properties
Computed Properties
 
Complexity:
371  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
4.2  

Upstream Synthesis Route

[1]Chemistry-AEuropeanJournal,2011,vol.17,#36,p.10113-10122

[2]Patent:WO2013/168014,2013,A1,

[3]Patent:US2015/126567,2015,A1,

[1]Patent:WO2013/168014,2013,A1,

[2]Patent:US2015/126567,2015,A1,

[1]Chemistry-AEuropeanJournal,2011,vol.17,#36,p.10113-10122

[1]Chemistry-AEuropeanJournal,2011,vol.17,#36,p.10113-10122

Downstream Synthesis Route
594839-88-0    18107-18-1   
methyl2-(3,5-dichlorophenyl)benzodoxazole-6-carboxylate 

[1]AngewandteChemie-InternationalEdition,2003,vol.42,p.2758-2761

methyl2-(3,5-dichlorophenyl)benzodoxazole-6-carboxylate 
  594839-88-0 

[1]TetrahedronLetters,2019,vol.60

[2]AngewandteChemie-InternationalEdition,2003,vol.42,p.2758-2761

[3]Patent:WO2013/168014,2013,A1.Locationinpatent:Paragraph0099;00100

[4]Patent:US2015/126567,2015,A1.Locationinpatent:Paragraph0108;0113;0114

[5]EuropeanJournalofMedicinalChemistry,2016,vol.121,p.823-840

4-(3,5-dichlorobenzoyl)amino-3-hydroxybenzoicacid 
  594839-88-0 

[1]AngewandteChemie-InternationalEdition,2003,vol.42,p.2758-2761

[2]Patent:WO2013/168014,2013,A1

[3]Patent:US2015/126567,2015,A1

[4]Patent:JP2016/65042,2016,A.Locationinpatent:Paragraph0132

[1]Chemistry-AEuropeanJournal,2011,vol.17,p.10113-10122

[1]Chemistry-AEuropeanJournal,2011,vol.17,p.10113-10122

Literature

Title: Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis.

Journal: Neurology and therapy 20160601

Title: Tafamidis: a review of its use in familial amyloid polyneuropathy.

Journal: Drugs 20140801

Title: Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20120612

Title: Tafamidis for transthyretin amyloidosis.

Journal: Drugs of today (Barcelona, Spain : 1998) 20120501

Title: Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110829

Title: The pathway by which the tetrameric protein transthyretin dissociates.

Journal: Biochemistry 20051129

Title: Autonomic dysfunction in familial amyloidotic polyneuropathy (FAP).

Journal: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 19981201

Title: Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans.

Journal: The New England journal of medicine 19970213

Title: Fibril in senile systemic amyloidosis is derived from normal transthyretin.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19900401

Title: Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34.

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