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5970-45-6,MFCD00012454
Catalog No.:AA0035Q7

5970-45-6 | Zinc acetate dihydrate

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5g
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25g
95%
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$37.00   $26.00
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100g
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250g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035Q7
Chemical Name:
Zinc acetate dihydrate
CAS Number:
5970-45-6
Molecular Formula:
C4H10O6Zn
Molecular Weight:
219.4986
MDL Number:
MFCD00012454
SMILES:
[O-]C(=O)C.[O-]C(=O)C.[Zn+2].O.O
Properties
Properties
 
BP:
242-4°C  
Form:
Solid  
MP:
100 °C  
Solubility:
430g/l  
Storage:
Room Temperature;Keep in dry area;  

Computed Properties
 
Complexity:
25.5  
Covalently-Bonded Unit Count:
5  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  

Literature

Title: Taurine zinc solid dispersions enhance bile-incubated L02 cell viability and improve liver function by inhibiting ERK2 and JNK phosphorylation during cholestasis.

Journal: Toxicology 20160729

Title: Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats.

Journal: Toxicology and applied pharmacology 20151115

Title: Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.

Journal: The Journal of clinical investigation 20150901

Title: Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20140101

Title: Modulation of tau phosphorylation by environmental copper.

Journal: Translational neurodegeneration 20140101

Title: Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells.

Journal: Toxicology and applied pharmacology 20131215

Title: MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy.

Journal: Brain : a journal of neurology 20130301

Title: Effect of lithium chloride on spectral, optical, thermal and mechanical behaviour of bis thiourea zinc acetate crystals.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

Title: Surface treatment of hematite photoanodes with zinc acetate for water oxidation.

Journal: Nanoscale 20120807

Title: Nanoscale elastic modulus variation in loaded polymeric micelle reactors.

Journal: Langmuir : the ACS journal of surfaces and colloids 20120717

Title: Endocrine symptoms as the initial manifestation of Wilson's disease.

Journal: The Yale journal of biology and medicine 20120601

Title: Comparison of different treatment modalities for oral halitosis.

Journal: Acta odontologica Scandinavica 20120501

Title: Zinc supplements for preventing otitis media.

Journal: The Cochrane database of systematic reviews 20120418

Title: Ultrasound-responsive thrombus treatment with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator.

Journal: Journal of drug targeting 20120401

Title: Detailed analysis of the S-RESPDOR solid-state NMR method for inter-nuclear distance measurement between spin-1/2 and quadrupolar nuclei.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20120201

Title: Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation.

Journal: International journal of pharmaceutics 20120117

Title: Cd modifies hepatic Zn deposition and modulates δ-ALA-D activity and MT levels by distinct mechanisms.

Journal: Journal of applied toxicology : JAT 20120101

Title: Zinc for colds? Yes, but don’t swallow whole!

Journal: The Journal of family practice 20120101

Title: Oral submucous fibrosis: a report of two pediatric cases and a brief review.

Journal: Journal of the Indian Society of Pedodontics and Preventive Dentistry 20120101

Title: A copper for your thoughts.

Journal: Journal of insurance medicine (New York, N.Y.) 20120101

Title: Sonochemical synthesis of 0D, 1D, and 2D zinc oxide nanostructures in ionic liquids and their photocatalytic activity.

Journal: ChemSusChem 20111216

Title: Zinc induces chemokine and inflammatory cytokine release from human promonocytes.

Journal: Journal of hazardous materials 20111130

Title: Combined effect of N-acetyl cysteine, zinc, and selenium against chronic dimethylmercury-induced oxidative stress: a biochemical and histopathological approach.

Journal: Archives of environmental contamination and toxicology 20111101

Title: Positive outcome in a patient with Wilson's disease treated with reduced zinc dosage in pregnancy.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20111101

Title: Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis.

Journal: World journal of gastroenterology 20110928

Title: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.

Journal: The FEBS journal 20110901

Title: Copper deficiency myeloneuropathy in a patient with Wilson disease.

Journal: Neurology 20110510

Title: A crystal structure of the complex between human complement receptor 2 and its ligand C3d.

Journal: Science (New York, N.Y.) 20110429

Title: Evaluation of powder mixtures and hydrophilic gastroretentive drug delivery systems containing zinc acetate and sodium bicarbonate.

Journal: Journal of pharmaceutical and biomedical analysis 20110325

Title: Preparation and evaluation of zinc-pectin-chitosan composite particles for drug delivery to the colon: role of chitosan in modifying in vitro and in vivo drug release.

Journal: International journal of pharmaceutics 20110315

Title: Long-term follow-up of Wilson disease: natural history, treatment, mutations analysis and phenotypic correlation.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20110101

Title: An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

Journal: PloS one 20110101

Title: Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months.

Journal: The Cochrane database of systematic reviews 20101208

Title: Effects of long-term zinc treatment in Japanese patients with Wilson disease: efficacy, stability, and copper metabolism.

Journal: Translational research : the journal of laboratory and clinical medicine 20101201

Title: Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20101101

Title: Simple shape-controlled synthesis of carbon hollow structures.

Journal: Inorganic chemistry 20101004

Title: Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20101001

Title: Synergistic accumulation of iron and zinc by cultured astrocytes.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100701

Title: The remarkable solvent effect on Zn(OAc)2-catalyzed hydrosilylation of ketones.

Journal: Chemical & pharmaceutical bulletin 20100701

Title: Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

Journal: Diabetologia 20100601

Title: Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20100601

Title: Fluorescent coordination polymeric gel from tartaric acid-assisted self-assembly.

Journal: Langmuir : the ACS journal of surfaces and colloids 20100518

Title: Clinical features and therapeutic response in Taiwanese children with Wilson's disease: 12 years of experience in a single center.

Journal: Pediatrics and neonatology 20100401

Title: Motexafin gadolinium enhances p53-Mdm2 interactions, reducing p53 and downstream targets in lymphoma cell lines.

Journal: Anticancer research 20100401

Title: Zinc supplements for preventing otitis media.

Journal: The Cochrane database of systematic reviews 20100217

Title: [The activity of 2',5'-oligoadenylate-synthetase in rat spleen lymphocytes in the chronic ethanol intoxication and administration of zinc acetate].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20100101

Title: Zinc and vitamin A can minimise the severity of oral submucous fibrosis.

Journal: BMJ case reports 20100101

Title: Necrolytic acral erythema seronegative for hepatitis C virus--two cases from India treated with oral zinc.

Journal: International journal of dermatology 20091001

Title: Facile synthesis of size-tunable micro-octahedra via metal-organic coordination.

Journal: Chemical communications (Cambridge, England) 20090928

Title: [Zinc acetate hydrate--oral administration (Wilzin)].

Journal: Journal de pharmacie de Belgique 20090901

Title: Tunnelling magnetic resonances: dynamic nuclear polarisation and the diffusion of methyl group tunnelling energy.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20090701

Title: Sustained release subcutaneous delivery of BMS-686117, a GLP-1 receptor peptide agonist, via a zinc adduct.

Journal: International journal of pharmaceutics 20090605

Title: Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601

Title: The effect of Zn(2+) on human brain creatine kinase: unfolding and aggregation studies.

Journal: Journal of biomolecular structure & dynamics 20090401

Title: Encapsulated zinc salt increases the diffusion of protein through PLG films.

Journal: International journal of pharmaceutics 20090331

Title: More rapid and sensitive method for simultaneous determination of tryptophan and kynurenic acid by HPLC.

Journal: Clinical biochemistry 20090301

Title: Insulin loaded PLGA microspheres: effect of zinc salts on encapsulation, release, and stability.

Journal: Journal of pharmaceutical sciences 20090201

Title: Optimization of medium components for increased production of C-phycocyanin from Phormidium ceylanicum and its purification by single step process.

Journal: Bioresource technology 20090201

Title: Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: Raman study of oriented ZnO thin films deposited by sol-gel method.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081215

Title: Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling.

Journal: Journal of the American College of Nutrition 20081001

Title: Free-standing ZnO nanorods and nanowalls by aqueous solution method.

Journal: Journal of nanoscience and nanotechnology 20080901

Title: Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate.

Journal: The Journal of infectious diseases 20080315

Title: Therapeutic effectiveness of ionic zinc for common colds.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080201

Title: Preparation of glucagon-like peptide-1 loaded PLGA microspheres: characterizations, release studies and bioactivities in vitro/in vivo.

Journal: Chemical & pharmaceutical bulletin 20080201

Title: [Determination of kynurenine in serum using high performance liquid chromatography-fluorescence detection].

Journal: Se pu = Chinese journal of chromatography 20080101

Title: Effects of In, Al and Sn dopants on the structural and optical properties of ZnO thin films.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701

Title: Estimation of hydrogen sulphide in the human lymphocytes.

Journal: Indian journal of biochemistry & biophysics 20070601

Title: Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes.

Journal: Free radical biology & medicine 20070415

Title: A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20070301

Title: Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.

Journal: International journal of immunopathology and pharmacology 20070101

Title: Substantivity of zinc salts used as rinsing solutions and their effect on the inhibition of Streptococcus mutans.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20070101

Title: Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.

Journal: Journal of medicinal chemistry 20061019

Title: Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin.

Journal: Saudi medical journal 20061001

Title: Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin.

Journal: Journal of pineal research 20060901

Title: Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II).

Journal: Oral microbiology and immunology 20060801

Title: New method for determination of ochratoxin A in beer using zinc acetate and solid-phase extraction silica cartridges.

Journal: Journal of chromatography. A 20060721

Title: Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102.

Journal: American journal of physiology. Cell physiology 20060301

Title: Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial.

Journal: The British journal of dermatology 20060301

Title: Layered titanate-zinc oxide nanohybrids with mesoporosity.

Journal: Chemical communications (Cambridge, England) 20060114

Title: Evaluation of zinc salt based fixatives for preserving antigenic determinants for immunohistochemical demonstration of murine immune system cell markers.

Journal: Biotechnic & histochemistry : official publication of the Biological Stain Commission 20060101

Title: A single centre, open-label, cross-over study of pharmacokinetics comparing topical zinc/clindamycin gel (Zindaclin) and topical clindamycin lotion (Dalacin T) in subjects with mild to moderate acne.

Journal: The Journal of dermatological treatment 20060101

Title: Residue determination of captan and folpet in vegetable samples by gas chromatography/negative chemical ionization-mass spectrometry.

Journal: Journal of AOAC International 20060101

Title: Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines.

Journal: Cancer research 20051215

Title: A case study: identifying a new case of Wilson's disease.

Journal: Journal of the American Academy of Nurse Practitioners 20051201

Title: New synthetic method of zinc(II) complexes based on mixing.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051001

Title: HPLC determination of salinomycin and related compounds in fermentation media of Streptomyces albus and premixes.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol).

Journal: Biomaterials 20050901

Title: Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon rats.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801

Title: Short-term zinc supplementation attenuates Helicobacter felis-induced gastritis in the mouse.

Journal: The Journal of infection 20050601

Title: Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines.

Journal: Cancer research 20050501

Title: (67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation.

Journal: Journal of the American Chemical Society 20050302

Title: [The study on the growth process of ZnO nanorods].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050301

Title: [Study on D-glucosamine-zn (II) complexes by IR spectral analysis].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050301

Title: Effects of cadmium on cell death and cell proliferation in chick embryos.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20050101

Title: An observer-blind parallel-group, randomized, multicentre clinical and microbiological study of a topical clindamycin/zinc gel and a topical clindamycin lotion in patients with mild/moderate acne.

Journal: The Journal of dermatological treatment 20050101

Title: [Wilson's disease and its pharmacological treatment].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101

Title: Cooperative formation of trinuclear zinc(II) complexes via complexation of a tetradentate oxime chelate ligand, salamo, and zinc(II) acetate.

Journal: Inorganic chemistry 20041004

Title: Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040811

Title: Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040801

Title: Comparison of zinc acetate and propionate addition on gastrointestinal tract fermentation and susceptibility of laying hens to Salmonella enteritidis during forced molt.

Journal: Poultry science 20040801

Title: Experimental study and modeling of the transfer of zinc in a low reactive sand column in the presence of acetate.

Journal: Journal of contaminant hydrology 20040601

Title: [Wilson's disease with severe neurological manifestations: response to trientine plus zinc therapy].

Journal: Gastroenterologia y hepatologia 20040501

Title: Oral controlled release formulation for highly water-soluble drugs: drug--sodium alginate--xanthan gum--zinc acetate matrix.

Journal: Drug development and industrial pharmacy 20040501

Title: Growth of layered basic zinc acetate in methanolic solutions and its pyrolytic transformation into porous zinc oxide films.

Journal: Journal of colloid and interface science 20040415

Title: Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa.

Journal: Theriogenology 20040415

Title: Evaluation of MT expression and detection of apoptotic cells in LEC rat kidneys.

Journal: Biochimica et biophysica acta 20040405

Title: Effects of mouthrinses with triclosan, zinc ions, copolymer, and sodium lauryl sulphate combined with fluoride on acid formation by dental plaque in vivo.

Journal: Caries research 20040101

Title: Efficacy of zinc against common cold viruses: an overview.

Journal: Journal of the American Pharmacists Association : JAPhA 20040101

Title: [Wilson disease in 2003].

Journal: Orvosi hetilap 20031214

Title: Modelling oral malodour in a longitudinal study.

Journal: Archives of oral biology 20031101

Title: A practical phasing procedure using the MAD method without the aid of XAFS measurements: successful solution in the structure determination of the outer-membrane lipoprotein carrier LolA.

Journal: Acta crystallographica. Section D, Biological crystallography 20030801

Title: Anti-inflammatory activity and gastric lesions induced by zinc-tenoxicam.

Journal: Pharmacology 20030601

Title: Radical chemistry of epigallocatechin gallate and its relevance to protein damage.

Journal: Archives of biochemistry and biophysics 20030601

Title: Metallothionein-1 and metallothionein-2 gene expression and localisation of apoptotic cells in Zn-treated LEC rat liver.

Journal: Histochemistry and cell biology 20030401

Title: Evidence of zinc protection against 2,5-hexanedione neurotoxicity: correlation of neurobehavioral testing with biomarkers of excretion.

Journal: Neurotoxicology 20021201

Title: Zinc in CCl4 toxicity.

Journal: Biomedical and environmental sciences : BES 20020901

Title: Diagnosing Wilson's disease in a 5-year-old child.

Journal: Journal of paediatrics and child health 20020801

Title: Zinc(II) slides on a ligand surface: the X-ray crystal structure and dynamic behavior in solution of [Zn(H2L)(tacn)].

Journal: Angewandte Chemie (International ed. in English) 20020617

Title: Kayser-Fleischer ring as the presenting sign of Wilson disease.

Journal: American journal of ophthalmology 20020601

Title: The significance of the source of zinc and its anti-VSC effect.

Journal: International dental journal 20020601

Title: Novel zinc (II)-mediated epimerization of 2'-carbonylalkyl-alpha-C-glycopyranosides to their beta-anomers.

Journal: Journal of the American Chemical Society 20020313

Title: The oral anti-volatile sulphur compound effects of zinc salts and their stability constants.

Journal: European journal of oral sciences 20020201

Title: Comparative analysis of some mouthrinses on the production of volatile sulfur-containing compounds.

Journal: Acta odontologica Scandinavica 20020101

Title: Separation of IgG and IgM from albumin in citrated human plasma using electrodialysis and metal ion affinity precipitation.

Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20020101

Title: Effect of oral zinc supplementation upon Taenia crassiceps murine cysticercosis.

Journal: The Journal of parasitology 20011001

Title: Zinc acetate for the treatment of Wilson's disease.

Journal: Expert opinion on pharmacotherapy 20010901

Title: Personality traits in treated Wilson's disease determined by means of the Karolinska Scales of Personality (KSP).

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20010901

Title: Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters.

Journal: European journal of clinical investigation 20010901

Title: Encapsulation and stabilization of nerve growth factor into poly(lactic-co-glycolic) acid microspheres.

Journal: Journal of pharmaceutical sciences 20010901

Title: Investigation of excretion and absorption of different zinc salts in puppies.

Journal: Laboratory animals 20010701

Title: Wilson's disease: from the liver to the brain.

Journal: Nursing times 20010701

Title: Elimination of efficacy by additives in zinc acetate lozenges for common colds.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010515

Title: Administration of charcoal, Yucca schidigera, and zinc acetate to reduce malodorous flatulence in dogs.

Journal: Journal of the American Veterinary Medical Association 20010315

Title: Inhibition kinetics of green crab (Scylla serrata) alkaline phosphatase by zinc ions: a new type of complexing inhibition.

Journal: Biochimica et biophysica acta 20010209

Title: Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.

Journal: Toxicology letters 20010203

Title: Effects of zinc acetate on splenocytes of endotoxemic mice: enhanced immune response, reduced apoptosis, and increased expression of heat shock protein 70.

Journal: The Journal of laboratory and clinical medicine 20010101

Title: Differential effects of lead and zinc on inhibitory avoidance learning in mice.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010101

Title: [Experimental-hygienic assessment of 2 binary mixtures: lead-copper and lead-zinc].

Journal: Gigiena i sanitariia 20010101

Title: Disturbed copper transport in humans. Part 2: mutations of the ATP7B gene lead to Wilson disease (WD).

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20010101

Title: Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha.

Journal: The American journal of clinical nutrition 20000101

Title: Zinc allosterically modulates antagonist binding to cloned D1 and D2 dopamine receptors.

Journal: Journal of neurochemistry 19970501

Title: The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity.

Journal: Life sciences 19960101

Title: Treatment of the neurologic manifestations of Wilson's disease.

Journal: Archives of neurology 19950401

Title: Combined effects of Zn(2+)-chlorhexidine and Zn(2+)-cetylpyridinium chloride on caries incidence in partially desalivated rats.

Journal: Scandinavian journal of dental research 19910801

Title: Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.

Journal: Archives of neurology 19870501

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Tags:5970-45-6 Molecular Formula|5970-45-6 MDL|5970-45-6 SMILES|5970-45-6 Zinc acetate dihydrate