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59865-13-3,MFCD00274558
Catalog No.:AA00IKFF

59865-13-3 | Cyclosporin A

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%(HPLC)
in stock  
$24.00   $17.00
- +
1g
98%(HPLC)
in stock  
$70.00   $49.00
- +
5g
97.0 - 101.5% (Assay, on dry basis)
in stock  
$205.00   $143.00
- +
25g
97.0 - 101.5% (Assay, on dry basis)
in stock  
$500.00   $350.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IKFF
Chemical Name:
Cyclosporin A
CAS Number:
59865-13-3
Molecular Formula:
C61H109N11O12
Molecular Weight:
1188.5847
MDL Number:
MFCD00274558
SMILES:
C/C=C/C[C@@H]([C@H]([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)C(C)C)C)C)C)O)C C61H109N11O12
Properties
Computed Properties
 
Complexity:
2330  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
85  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
15  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.5  

Literature

Title: Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7.

Title: Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15.

Title: Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3686-90.

Title: Flanagan WM, et al. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991 Aug 29;352(6338):803-7.

Title: Nicolli A, et al. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem. 1996 Jan 26;271(4):2185-92.

Title: Borel JF, et al. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology. 1977 Jun;32(6):1017-25.

Title: Williams, R, et al. Randomised trial comparing FK506 and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. Lancet, 1994, 344(8920), 423-428.

Title: Dalmarco EM, et al. Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. Cell Adh Migr. 2008 Oct-Dec;2(4):231-5.

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SDS
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Tags:59865-13-3 Molecular Formula|59865-13-3 MDL|59865-13-3 SMILES|59865-13-3 Cyclosporin A
Catalog No.: AA00IKFF
59865-13-3,MFCD00274558
59865-13-3 | Cyclosporin A
Pack Size： 250mg
Purity： 98%(HPLC)
in stock
$24.00 $17.00
Pack Size： 1g
Purity： 98%(HPLC)
in stock
$70.00 $49.00
Pack Size： 5g
Purity： 97.0 - 101.5% (Assay, on dry basis)
in stock
$205.00 $143.00
Pack Size： 25g
Purity： 97.0 - 101.5% (Assay, on dry basis)
in stock
$500.00 $350.00
Quantity
- +
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bulk Quotation Request
Technical Information
Catalog Number: AA00IKFF
Chemical Name: Cyclosporin A
CAS Number: 59865-13-3
Molecular Formula: C61H109N11O12
Molecular Weight: 1188.5847
MDL Number: MFCD00274558
SMILES: C/C=C/C[C@@H]([C@H]([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)C(C)C)C)C)C)O)C C61H109N11O12
Properties
Complexity: 2330  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 12  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 85  
Hydrogen Bond Acceptor Count: 12  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 15  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.5  
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