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Home Thiazoles 599164-57-5
599164-57-5,MFCD12546327
Catalog No.:AA00ELY0

599164-57-5 | (S)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE

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Purity
Availability
Price(USD)
Quantity
  
5mg
99%
in stock  
$303.00   $212.00
- +
25mg
99%
in stock  
$912.00   $639.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ELY0
Chemical Name:
(S)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE
CAS Number:
599164-57-5
Molecular Formula:
C18H22N2O3S2
Molecular Weight:
378.5089
MDL Number:
MFCD12546327
SMILES:
CS(=O)(=O)C1=CC=C(C=C1)C(CC2CCCC2)C(=O)NC3=NC=CS3
Properties
Computed Properties
 
Complexity:
547  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.9  

Literature

Title: Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.

Journal: Journal of medicinal chemistry 20120823

Title: Discovery and hit-to-lead optimization of novel allosteric glucokinase activators.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken.

Journal: General and comparative endocrinology 20101201

Title: 2,3-Disubstituted acrylamides as potent glucokinase activators.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).

Journal: Journal of medicinal chemistry 20100513

Title: Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Medicinal chemistry approaches for glucokinase activation to treat type 2 diabetes.

Journal: Current medicinal chemistry 20090101

Title: [Advances in the study of glucokinase and small molecule glucokinase activators].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060501

Title: Anglo-Swedish Medicinal Chemistry - second symposium.

Journal: IDrugs : the investigational drugs journal 20050501

Title: Allosteric activators of glucokinase: potential role in diabetes therapy.

Journal: Science (New York, N.Y.) 20030718

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Tags:599164-57-5 Molecular Formula|599164-57-5 MDL|599164-57-5 SMILES|599164-57-5 (S)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE