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Title: Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside.
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Title: Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.
Journal: Nucleosides, nucleotides & nucleic acids 20120101
Title: Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
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Title: Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells.
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Title: 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?
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Title: Treatment of yellow fever.
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Title: Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
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Title: Nicotinamide riboside kinase structures reveal new pathways to NAD+.
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Title: Crystal structure of human nicotinamide riboside kinase.
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Title: Recent development of IMP dehydrogenase inhibitors for the treatment of cancer.
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Title: Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.
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Title: Organosilicon-containing thiazole derivatives as potential lipoxygenase inhibitors and anti-inflammatory agents.
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Title: 2-(3-Amino-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide: a new tiazofurin analogue with potent antitumour activity.
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Title: Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities.
Journal: Bioorganic & medicinal chemistry letters 20060515
Title: Synthesis and biological activity of some new 5'-O-acyl tiazofurin derivatives.
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Title: Metabolic regulation and chemotherapy.
Journal: Advances in enzyme regulation 20060101
Title: Modulation of cancer pathways by inhibitors of guanylate metabolism.
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Title: Resveratrol, an ingredient of wine, acts synergistically with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
Journal: Nucleosides, nucleotides & nucleic acids 20060101
Title: Zinc(II) triflate-controlled 1,3-dipolar cycloadditions of C-(2-thiazolyl)nitrones: application to the synthesis of a novel isoxazolidinyl analogue of tiazofurin.
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Title: Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
Journal: Organic letters 20050929
Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
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Title: IMP dehydrogenase from the protozoan parasite Toxoplasma gondii.
Journal: Antimicrobial agents and chemotherapy 20050601
Title: Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis.
Journal: Annals of the New York Academy of Sciences 20050601
Title: Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
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Title: Metabolism and antiviral activity of ribavirin.
Journal: Virus research 20050201
Title: Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside.
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Title: Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20050101
Title: Down-regulation of increased signal transduction capacity in human cancer cells.
Journal: Advances in enzyme regulation 20050101
Title: Synthesis of 3'-deoxy-3'-C-hydroxymethyl analogues of tiazofurin and ribavirin.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Differentiation of human prostate cancer PC-3 cells induced by inhibitors of inosine 5'-monophosphate dehydrogenase.
Journal: Cancer research 20041215
Title: Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3',5'-monophosphate and tiazofurin.
Journal: Annals of the New York Academy of Sciences 20041201
Title: Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part I. In vivo studies.
Journal: Leukemia research 20041101
Title: Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part II. In vitro studies.
Journal: Leukemia research 20041101
Title: Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.
Journal: The Journal of biological chemistry 20040924
Title: Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
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Title: Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction.
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Title: A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus.
Journal: Antiviral research 20040401
Title: Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Journal: Current medicinal chemistry 20040401
Title: The effects of tiazofurin on basal and amphetamine-induced motor activity in rats.
Journal: Pharmacology, biochemistry, and behavior 20040301
Title: Erythrocytotoxicity of tiazofurin in vivo and in vitro detected by scanning probe microscopy.
Journal: Toxicology letters 20040202
Title: Anticancer therapeutic potential of soy isoflavone, genistein.
Journal: Advances in experimental medicine and biology 20040101
Title: HPLC determination of tiazofurin in the rat brain.
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Title: Synthesis of 2-(3'-azido- and 3'-amino-3'-deoxy-beta-D-ribofuranosyl)thiazole-4-carboxamide.
Journal: Nucleosides, nucleotides & nucleic acids 20031101
Title: De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties.
Journal: Bioorganic & medicinal chemistry letters 20031006
Title: In vitro sensitivity of hematopoietic progenitors to tiazofurin in refractory acute myeloid leukemia and in the blast crisis of chronic myeloid leukemia.
Journal: Cancer letters 20030610
Title: Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.
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Title: Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections.
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Journal: Nihon rinsho. Japanese journal of clinical medicine 20030101
Title: Targeting signal transduction.
Journal: Advances in enzyme regulation 20030101
Title: A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: The linkage of glucose to tiazofurin decreases in vitro uptake into rat glioma C6 cells.
Journal: Journal of drug targeting 20021201
Title: Simultaneous LC determination of tiazofurin, its acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide in biological samples.
Journal: Journal of pharmaceutical and biomedical analysis 20021107
Title: Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
Journal: Antiviral chemistry & chemotherapy 20021101
Title: Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin.
Journal: Journal of neuroimmunology 20020901
Title: Cytoprotective features of selenazofurin in hematopoietic cells.
Journal: International journal of clinical pharmacology and therapeutics 20020801
Title: Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines.
Journal: Cancer letters 20020708
Title: Identification of active antiviral compounds against a New York isolate of West Nile virus.
Journal: Antiviral research 20020701
Title: Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
Journal: The Journal of biological chemistry 20020412
Title: The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
Journal: Current medicinal chemistry 20020401
Title: Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase.
Journal: Current medicinal chemistry 20020401
Title: Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase.
Journal: Current medicinal chemistry 20020401
Title: Benzamide riboside, a recent inhibitor of inosine 5'-monophosphate dehydrogenase induces transferrin receptors in cancer cells.
Journal: Current medicinal chemistry 20020401
Title: Metabolism of the novel IMP dehydrogenase inhibitor benzamide riboside.
Journal: Current medicinal chemistry 20020401
Title: Toxicity and efficacy of benzamide riboside in cancer chemotherapy models.
Journal: Current medicinal chemistry 20020401
Title: Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.
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Title: [Application of tiazofurin in the study of regulation of AMP deaminase in intact malignant cells].
Journal: Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka 20020101
Title: Ordered biochemical program of gene expression in cancer cells.
Journal: Biochemistry. Biokhimiia 20011001
Title: Induction of Tmolt4 leukemia cell death by 3,3-disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2-4-diones: specificity for type II inosine 5'-monophasphate dehydrogenase.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.
Journal: Clinical microbiology reviews 20010401
Title: Tumor cell-specific inhibition of inducible nitric oxide synthase activation by tiazofurin.
Journal: International immunopharmacology 20010401
Title: A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).
Journal: Bioorganic & medicinal chemistry letters 20010108
Title: Sir Hans A. Krebs Centenary Lecture: cancer and clinical targeting.
Journal: Advances in enzyme regulation 20010101
Title: A new synthetic methodology for tiazofurin.
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Title: Hematological toxicity associated with tiazofurin-influence on erythropoiesis.
Journal: Toxicology letters 20000403
Title: Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.
Journal: Current medicinal chemistry 19990701
Title: Regulation of the signal transduction program by drugs.
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Title: Tiazofurin: molecular and clinical action.
Journal: Anticancer research 19960101
Title: Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections.
Journal: Antiviral research 19941001
Title: Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16.
Journal: British journal of cancer 19920201
Title: Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.
Journal: Biochemical and biophysical research communications 19900928
Title: Clinical toxicity associated with tiazofurin.
Journal: Investigational new drugs 19900501
Title: Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.
Journal: Journal of computer assisted tomography 19880101
Title: Phase I trial of tiazofurin administered by i.v. bolus daily for 5 days, with pharmacokinetic evaluation.
Journal: Cancer treatment reports 19870201
Title: Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses.
Journal: Antimicrobial agents and chemotherapy 19841001
Title: Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent.
Journal: Antimicrobial agents and chemotherapy 19830901
