Home Amines 601514-19-6
601514-19-6,MFCD09037535
Catalog No.:AA0037E5

601514-19-6 | 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

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Purity
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Price(USD)
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1mg
≥90%
in stock  
$53.00   $37.00
- +
5mg
95%
in stock  
$64.00   $45.00
- +
10mg
95%
in stock  
$107.00   $75.00
- +
25mg
95%
in stock  
$210.00   $147.00
- +
50mg
95%
in stock  
$378.00   $265.00
- +
100mg
95%
in stock  
$532.00   $373.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037E5
Chemical Name:
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
CAS Number:
601514-19-6
Molecular Formula:
C18H14N4O2
Molecular Weight:
318.3294
MDL Number:
MFCD09037535
SMILES:
Oc1cccc(c1)Oc1ncnc2c1cc([nH]2)c1cccc(c1)N
Properties
Properties
 
BP:
646.0±55.0°C at 760 mmHg  
Form:
Solid  
MP:
249℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
424  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Literature

Title: Involvement of insulin signalling pathway in methamphetamine-induced hyperphosphorylation of Tau.

Journal: Toxicology 20180901

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research 20120901

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters 20110701

Title: GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro.

Journal: Platelets 20110101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Synthetic small molecules that control stem cell fate.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20030624

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes 20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes 19990801

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930815

Title: Ding S, et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. Epub 2003 Jun 6.

Title: Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15.

Title: Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6.

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SDS
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