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605-23-2,MFCD00065474
Catalog No.:AA00E8S5

605-23-2 | THYMINE-BETA-D-ARABINOFURANOSIDE

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1mg
95%
1 week  
$183.00   $128.00
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5mg
95%
1 week  
$358.00   $251.00
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10mg
95%
1 week  
$509.00   $356.00
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25mg
95%
1 week  
$811.00   $568.00
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50mg
95%
1 week  
$1,131.00   $792.00
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100mg
95%
1 week  
$1,520.00   $1,064.00
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500mg
95%
1 week  
$2,983.00   $2,088.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8S5
Chemical Name:
THYMINE-BETA-D-ARABINOFURANOSIDE
CAS Number:
605-23-2
Molecular Formula:
C10H14N2O6
Molecular Weight:
258.2280
MDL Number:
MFCD00065474
SMILES:
OC[C@H]1O[C@H]([C@H]([C@@H]1O)O)n1cc(C)c(=O)[nH]c1=O
Properties
Computed Properties
 
Complexity:
409  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-1.6  

Literature

Title: Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.

Journal: Cancer gene therapy 20111001

Title: Synergistic therapeutic effect in gastric cancer cells produced by oncolytic adenovirus encoding Drosophila melanogaster deoxyribonucleoside kinase.

Journal: Cancer biology & therapy 20110515

Title: Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Journal: Cancer chemotherapy and pharmacology 20101001

Title: Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.

Journal: Experimental cell research 20090910

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Substrate specificity of feline and canine herpesvirus thymidine kinase.

Journal: Antiviral research 20080801

Title: Efficient and selective enzymatic acylation reaction: separation of furanosyl and pyranosyl nucleosides.

Journal: The Journal of organic chemistry 20080718

Title: Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons.

Journal: Archives of virology 20080101

Title: Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

Journal: Bioorganic & medicinal chemistry 20070415

Title: N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Journal: Journal of medicinal chemistry 20061228

Title: Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.

Journal: Biochemical and biophysical research communications 20060526

Title: 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.

Journal: Antiviral chemistry & chemotherapy 20060101

Title: Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

Journal: Bioorganic & medicinal chemistry 20051215

Title: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster.

Journal: The FEBS journal 20050801

Title: Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells.

Journal: BMC cancer 20050101

Title: Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.

Journal: Biochemical and biophysical research communications 20040319

Title: Synthesis and incorporation of an alpha-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups.

Journal: Bioorganic & medicinal chemistry letters 20040209

Title: Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Lipid-mediated protein delivery of suicide nucleoside kinases.

Journal: Cancer research 20031015

Title: Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Journal: Bioorganic & medicinal chemistry letters 20030915

Title: Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents.

Journal: Journal of virology 20030201

Title: Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.

Journal: Biochemical and biophysical research communications 20011123

Title: Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20010521

Title: 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.

Journal: Biochemical pharmacology 20010315

Title: Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.

Journal: Molecular pharmacology 20010201

Title: Ab initio vibrational calculations on ara-T molecule: application to analysis of IR and Raman spectra.

Journal: Biopolymers 20010101

Title: Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir.

Journal: Antimicrobial agents and chemotherapy 19991001

Title: Efficacy of select antivirals against Cryptosporidium parvum in vitro.

Journal: FEMS microbiology letters 19981101

Title: Anti-herpesvirus activity profile of 4'-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-beta-D-2'-fluoro-4'-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus.

Journal: Antiviral research 19980801

Title: Structure-activity relationship of the affinity of 5-substituted uracil nucleoside analogues for varicella-zoster virus thymidine kinase and their activity against varicella-zoster virus.

Journal: Antiviral research 19970801

Title: Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds.

Journal: Antimicrobial agents and chemotherapy 19950701

Title: Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19950401

Title: Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides.

Journal: Journal of medicinal chemistry 19930205

Title: Fluorinated sugar analogues of potential anti-HIV-1 nucleosides.

Journal: Journal of medicinal chemistry 19910501

Title: Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.

Journal: Journal of medicinal chemistry 19890201

Title: 7-Aminoquinolines. A novel class of agents active against herpesviruses.

Journal: Journal of medicinal chemistry 19880701

Title: Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.

Journal: Antimicrobial agents and chemotherapy 19880701

Title: Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus.

Journal: Antiviral research 19860301

Title: Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs.

Journal: Antimicrobial agents and chemotherapy 19860301

Title: In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.

Journal: Antiviral research 19840601

Title: Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

Journal: Antiviral research 19830901

Title: Comparison of the in vitro and in vivo anti-herpes activities of 1-beta-D-arabinofuranosylthymine and its 5'-monophosphate.

Journal: Antiviral research 19820901

Title: Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.

Journal: Antimicrobial agents and chemotherapy 19820201

Title: In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

Journal: Antimicrobial agents and chemotherapy 19820101

Title: Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases.

Journal: Antimicrobial agents and chemotherapy 19810901

Title: Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.

Journal: Antimicrobial agents and chemotherapy 19810701

Title: Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.

Journal: Antimicrobial agents and chemotherapy 19800601

Title: Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

Journal: Antimicrobial agents and chemotherapy 19791101

Title: Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.

Journal: Journal of medicinal chemistry 19791001

Title: In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil.

Journal: Antimicrobial agents and chemotherapy 19790801

Title: (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19790601

Title: Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

Journal: Journal of medicinal chemistry 19790101

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