60607-34-3,MFCD00211147
Catalog No.:AA00E8Q6

60607-34-3 | Oxatomide

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10mg
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$244.00   $171.00
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25mg
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50mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00E8Q6
Chemical Name:
Oxatomide
CAS Number:
60607-34-3
Molecular Formula:
C26H29N4O
Molecular Weight:
413.5347
MDL Number:
MFCD00211147
SMILES:
O=c1[nH]c2c(n1CCCN1CCN(CC1)[C]1(=CC=CC=C1)c1ccccc1)cccc2
NSC Number:
309710
Properties
Properties
 
BP:
621.1°C at 760 mmHg  
Form:
Solid  
MP:
110-115°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
575  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.1  

Downstream Synthesis Route

[1]Jilek,Jiri;Holubek,Jiri;Svatek,Emil;Metys,Jan;Frycova,Hana;etal.[CollectionofCzechoslovakChemicalCommunications,1988,vol.53,#4,p.870-883]

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[2]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[2]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

Literature

Title: Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.

Journal: Journal of pharmacological sciences 20120101

Title: Pregnant with metastatic neuroendocrine tumour of the ovary: what now?

Journal: Ecancermedicalscience 20120101

Title: Inflammation and neurological adverse drugs reactions: a case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis.

Journal: Italian journal of pediatrics 20120101

Title: Molecular complexes of ketaconazole and oxatomide with p-chloranil: spectroscopic and spectrofluorimetric studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Innate signaling in otitis media: pathogenesis and recovery.

Journal: Current allergy and asthma reports 20110201

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.

Journal: International archives of allergy and immunology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses.

Journal: BMC pulmonary medicine 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs 20090101

Title: Determination of oxatomide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Journal: Biomedical chromatography : BMC 20080701

Title: Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization.

Journal: Journal of pharmacological sciences 20080501

Title: Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro.

Journal: Mediators of inflammation 20080101

Title: CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20071101

Title: A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070301

Title: Solvent effect on the charge transfer complex of oxatomide with 2,3-dichloro-5,6-dicyanobenzoquinone.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061201

Title: Effect of inhibitor of tumor necrosis factor-alpha and oxatomide on immune mediated otitis media.

Journal: The Laryngoscope 20060901

Title: Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines.

Journal: Clinical and experimental dermatology 20060701

Title: [Comparison of clinical efficacy and cost-quality of antihistamines in early treatment for Japanese cedar pollinosis].

Journal: Arerugi = [Allergy] 20060501

Title: Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice.

Journal: Journal of ethnopharmacology 20051003

Title: Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA).

Journal: Therapeutic drug monitoring 20050801

Title: Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants.

Journal: Biological & pharmaceutical bulletin 20050201

Title: Nimesulide-induced fixed drug eruption.

Journal: Allergologia et immunopathologia 20050101

Title: Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity.

Journal: Biological & pharmaceutical bulletin 20040501

Title: Cetirizine: a review of its use in allergic disorders.

Journal: Drugs 20040101

Title: The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review.

Journal: Health and quality of life outcomes 20040101

Title: West syndrome associated with administration of a histamine H1 antagonist, oxatomide.

Journal: The Kurume medical journal 20040101

Title: Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20031101

Title: Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Journal: Journal of medicinal chemistry 20031009

Title: Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules.

Journal: The Journal of allergy and clinical immunology 20031001

Title: [Development of nasal dosage form of oxatomide for rhinitis].

Journal: Arerugi = [Allergy] 20031001

Title: Enhancement of allergic skin wheal responses in patients with atopic eczema/dermatitis syndrome by playing video games or by a frequently ringing mobile phone.

Journal: European journal of clinical investigation 20030601

Title: Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice.

Journal: European journal of pharmacology 20030530

Title: The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival.

Journal: The Journal of allergy and clinical immunology 20030301

Title: Pranlukast: a review of its use in the management of asthma.

Journal: Drugs 20030101

Title: Oxatomide for stable asthma in adults and children.

Journal: The Cochrane database of systematic reviews 20030101

Title: The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020101

Title: Drug eruption and liver injury caused by terfenadine and oxatomide.

Journal: European journal of dermatology : EJD 20020101

Title: High-performance liquid chromatographic determination of oxatomide and its metabolite and its application to pharmacokinetic study in rat plasma.

Journal: Arzneimittel-Forschung 20020101

Title: Pharmacokinetics of oxatomide in preterm infants.

Journal: Drugs under experimental and clinical research 20020101

Title: The role of central histaminergic neuron system as an anticonvulsive mechanism in developing brain.

Journal: Brain & development 20011101

Title: Circumvention of acquired resistance to doxorubicin in K562 human leukemia cells by oxatomide.

Journal: Biological & pharmaceutical bulletin 20011001

Title: Preclinical comparison of ebastine and other second generation H1-antihistamines.

Journal: Pharmacology & toxicology 20011001

Title: Oxatomide in the treatment of atopic dermatitis in breast-fed and very young infants.

Journal: Minerva pediatrica 20010801

Title: Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010701

Title: Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy.

Journal: American journal of rhinology 20010101

Title: Effect of oxatomide, an antiallergic agent, on QT interval in dogs.

Journal: Arzneimittel-Forschung 20010101

Title: Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201

Title: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).

Journal: Clinical pharmacokinetics 19850101

Title: Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51.

Title: K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.

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SDS
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Tags:60607-34-3 Molecular Formula|60607-34-3 MDL|60607-34-3 SMILES|60607-34-3 Oxatomide
Catalog No.: AA00E8Q6
60607-34-3,MFCD00211147
60607-34-3 | Oxatomide
Pack Size: 1mg
Purity: 95%
1 week
$104.00 $73.00
Pack Size: 5mg
Purity: 95%
1 week
$168.00 $118.00
Pack Size: 10mg
Purity: 95%
1 week
$244.00 $171.00
Pack Size: 25mg
Purity: 95%
1 week
$415.00 $291.00
Pack Size: 50mg
Purity: 95%
1 week
$626.00 $438.00
Pack Size: 100mg
Purity: 95%
1 week
$958.00 $671.00
Pack Size: 500mg
Purity: 95%
1 week
$1,875.00 $1,312.00
Quantity
- +
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Technical Information
Catalog Number: AA00E8Q6
Chemical Name: Oxatomide
CAS Number: 60607-34-3
Molecular Formula: C26H29N4O
Molecular Weight: 413.5347
MDL Number: MFCD00211147
SMILES: O=c1[nH]c2c(n1CCCN1CCN(CC1)[C]1(=CC=CC=C1)c1ccccc1)cccc2
NSC Number: 309710
Properties
BP: 621.1°C at 760 mmHg  
Form: Solid  
MP: 110-115°C  
Storage: 2-8℃;  
Complexity: 575  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.1  
Downstream Synthesis Route
841-77-0    62780-89-6    60607-34-3 

[1]Jilek,Jiri;Holubek,Jiri;Svatek,Emil;Metys,Jan;Frycova,Hana;etal.[CollectionofCzechoslovakChemicalCommunications,1988,vol.53,#4,p.870-883]

100460-86-4    60607-34-3 

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

841-77-0    60607-34-3 

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[2]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

62781-00-4    60607-34-3 

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

[2]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

100460-85-3    60607-34-3 

[1]Gomez-Parra,Vicente;Sanchez,Felix;Torres,Tomas[MonatsheftefurChemie,1985,vol.116,p.639-644]

Literature fold

Title: Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.

Journal: Journal of pharmacological sciences20120101

Title: Pregnant with metastatic neuroendocrine tumour of the ovary: what now?

Journal: Ecancermedicalscience20120101

Title: Inflammation and neurological adverse drugs reactions: a case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis.

Journal: Italian journal of pediatrics20120101

Title: Molecular complexes of ketaconazole and oxatomide with p-chloranil: spectroscopic and spectrofluorimetric studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20110901

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry20110714

Title: Innate signaling in otitis media: pathogenesis and recovery.

Journal: Current allergy and asthma reports20110201

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals20110101

Title: Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.

Journal: International archives of allergy and immunology20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research20101201

Title: An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses.

Journal: BMC pulmonary medicine20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs20090101

Title: Determination of oxatomide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Journal: Biomedical chromatography : BMC20080701

Title: Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization.

Journal: Journal of pharmacological sciences20080501

Title: Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro.

Journal: Mediators of inflammation20080101

Title: CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society20071101

Title: A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20070301

Title: Solvent effect on the charge transfer complex of oxatomide with 2,3-dichloro-5,6-dicyanobenzoquinone.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20061201

Title: Effect of inhibitor of tumor necrosis factor-alpha and oxatomide on immune mediated otitis media.

Journal: The Laryngoscope20060901

Title: Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines.

Journal: Clinical and experimental dermatology20060701

Title: [Comparison of clinical efficacy and cost-quality of antihistamines in early treatment for Japanese cedar pollinosis].

Journal: Arerugi = [Allergy]20060501

Title: Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice.

Journal: Journal of ethnopharmacology20051003

Title: Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA).

Journal: Therapeutic drug monitoring20050801

Title: Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants.

Journal: Biological & pharmaceutical bulletin20050201

Title: Nimesulide-induced fixed drug eruption.

Journal: Allergologia et immunopathologia20050101

Title: Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity.

Journal: Biological & pharmaceutical bulletin20040501

Title: Cetirizine: a review of its use in allergic disorders.

Journal: Drugs20040101

Title: The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review.

Journal: Health and quality of life outcomes20040101

Title: West syndrome associated with administration of a histamine H1 antagonist, oxatomide.

Journal: The Kurume medical journal20040101

Title: Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20031101

Title: Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Journal: Journal of medicinal chemistry20031009

Title: Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules.

Journal: The Journal of allergy and clinical immunology20031001

Title: [Development of nasal dosage form of oxatomide for rhinitis].

Journal: Arerugi = [Allergy]20031001

Title: Enhancement of allergic skin wheal responses in patients with atopic eczema/dermatitis syndrome by playing video games or by a frequently ringing mobile phone.

Journal: European journal of clinical investigation20030601

Title: Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice.

Journal: European journal of pharmacology20030530

Title: The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival.

Journal: The Journal of allergy and clinical immunology20030301

Title: Pranlukast: a review of its use in the management of asthma.

Journal: Drugs20030101

Title: Oxatomide for stable asthma in adults and children.

Journal: The Cochrane database of systematic reviews20030101

Title: The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology20021201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20020101

Title: Drug eruption and liver injury caused by terfenadine and oxatomide.

Journal: European journal of dermatology : EJD20020101

Title: High-performance liquid chromatographic determination of oxatomide and its metabolite and its application to pharmacokinetic study in rat plasma.

Journal: Arzneimittel-Forschung20020101

Title: Pharmacokinetics of oxatomide in preterm infants.

Journal: Drugs under experimental and clinical research20020101

Title: The role of central histaminergic neuron system as an anticonvulsive mechanism in developing brain.

Journal: Brain & development20011101

Title: Circumvention of acquired resistance to doxorubicin in K562 human leukemia cells by oxatomide.

Journal: Biological & pharmaceutical bulletin20011001

Title: Preclinical comparison of ebastine and other second generation H1-antihistamines.

Journal: Pharmacology & toxicology20011001

Title: Oxatomide in the treatment of atopic dermatitis in breast-fed and very young infants.

Journal: Minerva pediatrica20010801

Title: Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology20010701

Title: Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy.

Journal: American journal of rhinology20010101

Title: Effect of oxatomide, an antiallergic agent, on QT interval in dogs.

Journal: Arzneimittel-Forschung20010101

Title: Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]19950201

Title: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).

Journal: Clinical pharmacokinetics19850101

Title: Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51.

Title: K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.

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