Home Other Building Blocks 6093-68-1
6093-68-1,MFCD00630040
Catalog No.:AA00EA9N

6093-68-1 | 6-Hydroxycoumarin

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Purity
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Price(USD)
Quantity
  
250mg
95%
in stock  
$22.00   $15.00
- +
1g
95%
in stock  
$39.00   $28.00
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5g
95%
in stock  
$145.00   $102.00
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10g
95%
in stock  
$278.00   $195.00
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25g
95%
in stock  
$472.00   $330.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EA9N
Chemical Name:
6-Hydroxycoumarin
CAS Number:
6093-68-1
Molecular Formula:
C9H6O3
Molecular Weight:
162.1421
MDL Number:
MFCD00630040
SMILES:
Oc1ccc2c(c1)ccc(=O)o2
Properties
Properties
 
BP:
248.82°C (rough estimate)  
Form:
Solid  
MP:
249-253 °C(lit.)  
Refractive Index:
1.5380 (estimate)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
222  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
1  

Downstream Synthesis Route

[1]Sastrietal.[Proceedings-IndianAcademyofSciences,SectionA,1953,#37,p.681,690]

[2]Bargellini;Monti[GazzettaChimicaItaliana,1915,vol.45I,p.94]

[3]Bhunia,SankarC.;Pal,Sutanuka;Patra,GopalC.;Pal,SudhirC.[JournalofHeterocyclicChemistry,2014,vol.51,#6,p.1679-1688]

[4]Bhunia,SankarC.;Pal,Sutanuka;Patra,GopalC.;Pal,SudhirC.[JournalofHeterocyclicChemistry,2014,vol.51,#6,p.1679-1688]

[5]Albertolle,MatthewE.;Kim,Donghak;Nagy,LeslieD.;Yun,Chul-Ho;Pozzi,Ambra;Savas,Üzen;Johnson,EricF.;Guengerich,F.Peter[JournalofBiologicalChemistry,2017,vol.292,#27,p.11230-11242]

[6]Álvarez,JoséMaría;Jorge,ZacaríasD.;Massanet,GuillermoM.[EuropeanJournalofOrganicChemistry,2020]

[1]Chattopadhyay,ShitalK.;Mondal,Poulomi;Ghosh,Debalina[Synthesis,2014,vol.46,#24,p.3331-3340]

[2]Bruna-Haupt,Ezequiel;Garro,HugoA.;Gutiérrez,Lucas;Pungitore,CarlosR.[MedicinalChemistryResearch,2018,vol.27,#5,p.1432-1442]

[3]Guiotto,A.;Manzini,P.;Chilin,A.;Pastorini,G.;Rodighiero,P.[JournalofHeterocyclicChemistry,1985,vol.22,p.649-656]

[4]Locationinpatent:experimentalpartCarta,Fabrizio;Maresca,Alfonso;Scozzafava,Andrea;Supuran,ClaudiuT.[BioorganicandMedicinalChemistry,2012,vol.20,#7,p.2266-2273]

[5]Locationinpatent:schemeortableBull,JamesA.;Luján,Cristina;Hutchings,MichaelG.;Quayle,Peter[TetrahedronLetters,2009,vol.50,#26,p.3617-3620]

[1]Khalil;El-Tawil;Ashy;Elbeih[Pharmazie,1981,vol.36,#8,p.569-571]

[2]Yamaguchi,Yuki;Akimoto,Ichie;Motegi,Kyoko;Yoshimura,Teruki;Wada,Keiji;Nishizono,Naozumi;Oda,Kazuaki[ChemicalandPharmaceuticalBulletin,2013,vol.61,#10,p.997-1001]

[1]Sato,Kikumasa;Inoue,Seiichi;Ozawa,Kimio;Kobayashi,Tohru;Ota,Tomomi;Tazaki,Michiko[JournaloftheChemicalSociety.PerkintransactionsI,1987,p.1753-1756]

[1]Cerqueira,NunoM.F.S.A.;Oliveira-Campos,AnaM.F.;Coelho,PauloJ.;MeloDeCarvalho,LuisH.;Samat,Andre;Guglielmetti,Robert[HelveticaChimicaActa,2002,vol.85,#2,p.442-450]

[2]Harayama,Takashi;Katsuno,Keiko;Nishioka,Hiromi;Fujii,Masako;Nishita,Yoshitaka;etal.[Heterocycles,1994,vol.39,#2,p.613-622]

[3]VonWeymarn;Murphy[ChemicalResearchinToxicology,2001,vol.14,#10,p.1386-1392]

Literature

Title: Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.

Journal: European journal of medicinal chemistry 20110601

Title: 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: 6-Benzyl-oxycoumarin.

Journal: Acta crystallographica. Section E, Structure reports online 20100801

Title: Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f.

Journal: Journal of chemical ecology 20100701

Title: Design and synthesis of coumarin-based Zn(2+) probes for ratiometric fluorescence imaging.

Journal: Inorganic chemistry 20090817

Title: Combination antiretroviral drugs in PLGA nanoparticle for HIV-1.

Journal: BMC infectious diseases 20090101

Title: [Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050801

Title: Chemical constituents from the Hydrangea chinensis.

Journal: Archives of pharmacal research 20030101

Title: Farooq S, et al. Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Prangos pabularia. PLoS One. 2014 Oct 14;9(10):e108713.

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Tags:6093-68-1 Molecular Formula|6093-68-1 MDL|6093-68-1 SMILES|6093-68-1 6-Hydroxycoumarin |Heterocyclic_Building_Blocks