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Title: Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes.
Journal: Toxicology 20160516
Title: Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Journal: Molecular medicine (Cambridge, Mass.) 20160101
Title: The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells.
Journal: Toxicology letters 20140917
Title: Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets.
Journal: Antioxidants & redox signaling 20140110
Title: Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies.
Journal: The FEBS journal 20131101
Title: In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology.
Journal: Chemico-biological interactions 20131025
Title: Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.
Journal: Antimicrobial agents and chemotherapy 20130801
Title: Ebselen reduces the toxicity of mechlorethamine in A-431 cells via inhibition of apoptosis.
Journal: Journal of biochemical and molecular toxicology 20130601
Title: Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries.
Journal: Analytical biochemistry 20130301
Title: Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201
Title: Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.
Journal: The Journal of biological chemistry 20121102
Title: A hydrogen peroxide electrode assay to measure thiol peroxidase activity for organoselenium and organotellurium drugs.
Journal: Analytical biochemistry 20121015
Title: Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.
Journal: Free radical biology & medicine 20120815
Title: Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake.
Journal: Neurochemistry international 20120801
Title: The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice.
Journal: Drug and alcohol dependence 20120701
Title: Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.
Journal: Chemistry & biology 20120622
Title: T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.
Journal: European journal of haematology 20120601
Title: Ebselen reduces hyperglycemia temporarily-induced by diazinon: a compound with insulin-mimetic properties.
Journal: Chemico-biological interactions 20120530
Title: The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
Journal: Antimicrobial agents and chemotherapy 20120301
Title: Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
Journal: The American journal of pathology 20120301
Title: Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.
Journal: Toxicology and applied pharmacology 20120201
Title: Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.
Journal: European journal of medicinal chemistry 20120201
Title: Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins.
Journal: Biochemical pharmacology 20120115
Title: The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains.
Journal: Brain research 20120109
Title: Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer.
Journal: Experimental dermatology 20120101
Title: Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.
Journal: Molecular immunology 20120101
Title: Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.
Journal: International archives of allergy and immunology 20120101
Title: The protective effect of ebselen on radiocontrast-induced nephrotoxicity.
Journal: Renal failure 20120101
Title: Neuroprotection for stroke: current status and future perspectives.
Journal: International journal of molecular sciences 20120101
Title: A superoxide anion-scavenger, 1,3-selenazolidin-4-one suppresses serum deprivation-induced apoptosis in PC12 cells by activating MAP kinase.
Journal: Toxicology and applied pharmacology 20111215
Title: Modeling the mechanism of the glutathione peroxidase mimic ebselen.
Journal: Inorganic chemistry 20111205
Title: 3-(2,6-dimethylphenyl)-2-selenoxo-1,3-thiazolidin-4-one suppresses hydrogen peroxide-induced cytotoxicity on PC12 cells via activation of MAPK.
Journal: International journal of toxicology 20111201
Title: Synthesis, structure, and glutathione peroxidase-like activity of amino acid containing ebselen analogues and diaryl diselenides.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111104
Title: Carboxyl-ebselen-based layer-by-layer films as potential antithrombotic and antimicrobial coatings.
Journal: Biomaterials 20111101
Title: Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects.
Journal: Neuroscience letters 20110926
Title: Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.
Journal: Circulation research 20110916
Title: Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20110901
Title: Tandem MS analysis of selenamide-derivatized peptide ions.
Journal: Journal of the American Society for Mass Spectrometry 20110901
Title: Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.
Journal: The Journal of biological chemistry 20110805
Title: The influence of low oxygen on macrophage response to Leishmania infection.
Journal: Scandinavian journal of immunology 20110801
Title: Mechanistic investigations on the efficient catalytic decomposition of peroxynitrite by ebselen analogues.
Journal: Organic & biomolecular chemistry 20110721
Title: Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20110701
Title: Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen.
Journal: Neurotoxicology 20110601
Title: Preventing metal-mediated oxidative DNA damage with selenium compounds.
Journal: Metallomics : integrated biometal science 20110501
Title: Acute hypoxia stimulates intracellular peroxynitrite formation associated with pulmonary artery smooth muscle cell proliferation.
Journal: Journal of cardiovascular pharmacology 20110501
Title: Synthesis and antioxidant activity of peptide-based ebselen analogues.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110418
Title: Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.
Journal: The Journal of biological chemistry 20110225
Title: TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20110201
Title: Antioxidants induce apoptosis of rat ovarian theca-interstitial cells.
Journal: Biology of reproduction 20110101
Title: Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride.
Journal: Drug and chemical toxicology 20110101
Title: Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction.
Journal: Frontiers in bioscience (Scholar edition) 20110101
Title: Effects of prevention of oxidative and nitro-oxidative stress on experimental rat colon anastomosis using acetylcysteine, Ebselen and 1400w.
Journal: Acta chirurgica Belgica 20110101
Title: Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury.
Journal: Renal failure 20110101
Title: Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide.
Journal: Neurologia medico-chirurgica 20110101
Title: Dose-dependent protection on cisplatin-induced ototoxicity - an electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101
Title: Cu-catalyzed efficient synthetic methodology for ebselen and related Se-N heterocycles.
Journal: Organic letters 20101203
Title: Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.
Journal: Diabetes 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: 2,3-diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure-activity relationship study.
Journal: Bioorganic & medicinal chemistry 20100915
Title: Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100901
Title: Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.
Journal: The Journal of biological chemistry 20100730
Title: Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations.
Journal: Pathology, research and practice 20100615
Title: Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia.
Journal: American journal of physiology. Heart and circulatory physiology 20100601
Title: Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100501
Title: Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Journal: Cardiovascular research 20100401
Title: Ebselen reduces inflammation and microvascular perfusion failure after blunt skeletal muscle injury of the rat.
Journal: The Journal of trauma 20100401
Title: A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100223
Title: 5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors.
Journal: Organic & biomolecular chemistry 20100221
Title: Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.
Journal: Journal of medicinal chemistry 20100128
Title: The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.
Journal: Biochemistry 20100126
Title: Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.
Journal: European journal of pharmacology 20100125
Title: Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?
Journal: Environmental toxicology 20091201
Title: Inhibitory mechanism of novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae.
Journal: Journal of microbiology and biotechnology 20091201
Title: Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
Journal: Chemical communications (Cambridge, England) 20091114
Title: Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.
Journal: Chemico-biological interactions 20091110
Title: Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.
Journal: Journal of the neurological sciences 20091015
Title: Synthesis and antioxidant properties of new chromone derivatives.
Journal: Bioorganic & medicinal chemistry 20091015
Title: Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.
Journal: American journal of physiology. Heart and circulatory physiology 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
Journal: The Journal of surgical research 20090801
Title: Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity.
Journal: Molecular immunology 20090701
Title: Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090601
Title: Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.
Journal: Microbial drug resistance (Larchmont, N.Y.) 20090601
Title: Modeling the oxidation of ebselen and other organoselenium compounds using explicit solvent networks.
Journal: The journal of physical chemistry. A 20090514
Title: Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells.
Journal: Hearing research 20090501
Title: Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.
Journal: Free radical biology & medicine 20090415
Title: Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.
Journal: The Journal of pharmacology and experimental therapeutics 20090401
Title: Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation.
Journal: Archives of dermatological research 20090401
Title: The redox state of glutathione regulates the hypoxic induction of HIF-1.
Journal: European journal of pharmacology 20090315
Title: Enhancement of iron-catalyzed lipid peroxidation by acidosis in brain homogenate: comparative effect of diphenyl diselenide and ebselen.
Journal: Brain research 20090303
Title: Redox modulation at the peripheral site alters nociceptive transmission in vivo.
Journal: Clinical and experimental pharmacology & physiology 20090301
Title: Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090301
Title: Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20090201
Title: Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence.
Journal: The American journal of pathology 20090201
Title: Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations.
Journal: The British journal of nutrition 20090201
Title: Synthesis of telluroamino acid derivatives with remarkable GPx like activity.
Journal: Organic & biomolecular chemistry 20090107
Title: Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system.
Journal: European journal of pharmacology 20090105
Title: Ebselen improves ischemia-reperfusion injury after rat lung transplantation.
Journal: Lung 20090101
Title: Effects of N-acetylcysteine and ebselen on arachidonic acid release from astrocytes and neurons cultured in normoxic or simulated ischemic conditions.
Journal: Pharmacological reports : PR 20090101
Title: Ebselen attenuates cyclophosphamide-induced oxidative stress and DNA damage in mice.
Journal: Free radical research 20081101
Title: Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.
Journal: Journal of neurochemistry 20081001
Title: The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth.
Journal: Virology 20080930
Title: Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.
Journal: Brain research 20080724
Title: The protective mechanism of antioxidants in cadmium-induced ototoxicity in vitro and in vivo.
Journal: Environmental health perspectives 20080701
Title: Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.
Journal: Neuroscience 20080502
Title: Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein.
Journal: The Journal of biological chemistry 20080418
Title: Ebselen attenuates cadmium-induced testicular damage in mice.
Journal: Journal of applied toxicology : JAT 20080401
Title: Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs.
Journal: European journal of pharmacology 20080317
Title: Antioxidant and anti-mutagenic effects of ebselen in yeast and in cultured mammalian V79 cells.
Journal: Mutagenesis 20080301
Title: Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.
Journal: Experimental biology and medicine (Maywood, N.J.) 20080301
Title: Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes.
Journal: Toxicology 20080227
Title: Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
Journal: Journal of neuroscience research 20080215
Title: Effect of substituents on the GPx-like activity of ebselen: steric versus electronic.
Journal: The journal of physical chemistry. A 20080207
Title: Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Journal: Surgery today 20080101
Title: Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells.
Journal: Cutaneous and ocular toxicology 20080101
Title: [Chronic ethanol feeding induces oxidative stress in the rat retina: treatment with the antioxidant ebselen].
Journal: Archivos de la Sociedad Espanola de Oftalmologia 20071201
Title: Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats.
Journal: Brain research 20071121
Title: (45)Ca(2+) influx in rat brain: effect of diorganylchalcogenides compounds.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071001
Title: Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.
Journal: American journal of physiology. Heart and circulatory physiology 20071001
Title: Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20071001
Title: 3,3'-diselenodipropionic acid, an efficient peroxyl radical scavenger and a GPx mimic, protects erythrocytes (RBCs) from AAPH-induced hemolysis.
Journal: Chemical research in toxicology 20071001
Title: 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.
Journal: Bioorganic & medicinal chemistry 20070915
Title: Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats.
Journal: Research in veterinary science 20070801
Title: Previous treatment with ebselen and vitamin E alters adenine nucleotide hydrolysis in platelets from adult rats experimentally demyelinated with ethidium bromide.
Journal: Life sciences 20070627
Title: Ebselen and diorganylchalcogenides decrease in vitro glutamate uptake by rat brain slices: prevention by DTT and GSH.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070601
Title: Deficient peroxide detoxification underlies the susceptibility of oligodendrocyte progenitors to dopamine toxicity.
Journal: Neuropharmacology 20070501
Title: Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity.
Journal: Toxicology and industrial health 20070501
Title: Density functional theory study of the reaction mechanism and energetics of the reduction of hydrogen peroxide by ebselen, ebselen diselenide, and ebselen selenol.
Journal: The journal of physical chemistry. A 20070426
Title: Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase.
Journal: Hearing research 20070401
Title: Role of endogenous hydrogen peroxide in the development of nitrate tolerance.
Journal: Vascular pharmacology 20070401
Title: Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070401
Title: Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment.
Journal: Alcoholism, clinical and experimental research 20070301
Title: N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.
Journal: Neuroscience research 20070201
Title: Synthesis, characterization, and antioxidant activity of some ebselen analogues.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
Title: Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase.
Journal: Journal of biochemical and molecular toxicology 20070101
Title: Effects of ebselen on glutathione level in neurons exposed to arachidonic acid and 4-hydroxynonenal during simulated ischemia in vitro.
Journal: Pharmacological reports : PR 20070101
Title: Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.
Journal: The Journal of pharmacology and experimental therapeutics 20061201
Title: Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats.
Journal: Basic & clinical pharmacology & toxicology 20061201
Title: Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
Journal: Bioorganic & medicinal chemistry letters 20061115
Title: Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress.
Journal: Chemico-biological interactions 20061107
Title: Ebselen effects on MPTP-induced neurotoxicity.
Journal: Brain research 20061106
Title: Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20061101
Title: Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds.
Journal: Bioorganic & medicinal chemistry letters 20061015
Title: Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.
Journal: Cancer research 20061001
Title: Role of enteral nutrition supplemented with ebselen and EHEC in pancreatitis-associated multiple organ dysfunction in rats.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061001
Title: Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis.
Journal: Apoptosis : an international journal on programmed cell death 20060901
Title: Protective effect of ebselen, a selenoorganic drug, against gentamicin-induced renal damage in rats.
Journal: Basic & clinical pharmacology & toxicology 20060901
Title: Ebselen, a seleno-organic antioxidant, as an electrophile.
Journal: Chemical research in toxicology 20060901
Title: Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.
Journal: Chemistry & biology 20060901
Title: Effect of selenium compounds on the damage induced by oxysterol on rat arterial walls.
Journal: Biological trace element research 20060901
Title: Reactive oxygen species mediate phorbol ester-stimulated cAMP response in human eosinophils.
Journal: European journal of pharmacology 20060814
Title: Modeling the reduction of hydrogen peroxide by glutathione peroxidase mimics.
Journal: The journal of physical chemistry. A 20060720
Title: Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.
Journal: Brain : a journal of neurology 20060701
Title: Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.
Journal: Journal of cell science 20060701
Title: Neuroprotective effects of ebselen are associated with the regulation of Bcl-2 and Bax proteins in cultured mouse cortical neurons.
Journal: Neuroscience letters 20060522
Title: Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron.
Journal: Biochimie 20060501
Title: Diphenyl ditelluride- and methylmercury-induced hyperphosphorilation of the high molecular weight neurofilament subunit is prevented by organoselenium compounds in cerebral cortex of young rats.
Journal: Toxicology 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.
Journal: Chemical research in toxicology 20060501
Title: Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells.
Journal: Biochimica et biophysica acta 20060301
Title: Immobilization stress induces cell death through production of reactive oxygen species in the mouse cerebral cortex.
Journal: Neuroscience letters 20060109
Title: Beneficial effects of Ebselen on corrosive esophageal burns of rats.
Journal: International journal of pediatric otorhinolaryngology 20060101
Title: Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060101
Title: Ebselen attenuates oxidative stress in ischemic astrocytes depleted of glutathione. Comparison with glutathione precursors.
Journal: Pharmacological reports : PR 20060101
Title: The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids.
Journal: Cellular & molecular biology letters 20060101
Title: Design and biological evaluation of photo-switchable inhibitors.
Journal: Genome informatics. International Conference on Genome Informatics 20060101
Title: Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta.
Journal: The Journal of pharmacology and experimental therapeutics 20051201
Title: Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats.
Journal: Toxicology 20051115
Title: Peroxynitrite hyperpolarizes smooth muscle and relaxes internal carotid artery in rabbit via ATP-sensitive K+ channels.
Journal: American journal of physiology. Heart and circulatory physiology 20051101
Title: Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+.
Journal: Toxicology 20051015
Title: Compounds for the prevention and treatment of noise-induced hearing loss.
Journal: Drug discovery today 20051001
Title: Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.
Journal: Toxicology and applied pharmacology 20050901
Title: Glutathione peroxidase (GPx)-like antioxidant activity of the organoselenium drug ebselen: unexpected complications with thiol exchange reactions.
Journal: Journal of the American Chemical Society 20050817
Title: Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain.
Journal: Pharmacology, biochemistry, and behavior 20050701
Title: NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1.
Journal: Journal of neurochemistry 20050701
Title: Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.
Journal: The Journal of biological chemistry 20050624
Title: Ebselen prevents noise-induced excitotoxicity and temporary threshold shift.
Journal: Neuroscience letters 20050603
Title: Organoselenium compounds prevent hyperphosphorylation of cytoskeletal proteins induced by the neurotoxic agent diphenyl ditelluride in cerebral cortex of young rats.
Journal: Toxicology 20050601
Title: Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity.
Journal: Anti-cancer drugs 20050601
Title: Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050501
Title: Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats.
Journal: The Journal of urology 20050501
Title: Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.
Journal: Current drug targets. CNS and neurological disorders 20050401
Title: Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina.
Journal: Brain research 20050328
Title: Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen.
Journal: Hearing research 20050301
Title: Neuroprotective effects of ebselen on experimental spinal cord injury in rats.
Journal: Neurochemical research 20050301
Title: Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050301
Title: Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells.
Journal: Neuroscience research 20050201
Title: Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050101
Title: Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.
Journal: Anticancer research 20050101
Title: Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats.
Journal: Blood pressure 20050101
Title: Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.
Journal: Kidney international 20041201
Title: The effects of ebselen on [3H]glutamate uptake by synaptic vesicles from rat brain.
Journal: Brain research 20041119
Title: Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps.
Journal: Neuroscience letters 20041116
Title: Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription.
Journal: Archives of biochemistry and biophysics 20041115
Title: Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041101
Title: Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.
Journal: Farmaco (Societa chimica italiana : 1989) 20041101
Title: Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001
Title: Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.
Journal: Neurochemical research 20041001
Title: Ebselen protects Ca2+ influx blockage but does not protect glutamate uptake inhibition caused by Hg2+.
Journal: Neurochemical research 20041001
Title: Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose.
Journal: Diabetes 20040901
Title: Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.
Journal: Journal of the American Society of Nephrology : JASN 20040901
Title: The involvement of oxidative stress in bovine herpesvirus type 4-mediated apoptosis.
Journal: Frontiers in bioscience : a journal and virtual library 20040901
Title: Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine.
Journal: Free radical research 20040901
Title: Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.
Journal: Journal of neuroscience research 20040815
Title: Organochalcogens affect the glutamatergic neurotransmission in human platelets.
Journal: Neurochemical research 20040801
Title: Interaction of selenium compounds with zinc finger proteins involved in DNA repair.
Journal: European journal of biochemistry 20040801
Title: Thiocyanate catalyzes myeloperoxidase-initiated lipid oxidation in LDL.
Journal: Free radical biology & medicine 20040715
Title: Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.
Journal: Free radical biology & medicine 20040715
Title: Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia.
Journal: European journal of pharmacology 20040708
Title: Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress.
Journal: Human reproduction (Oxford, England) 20040701
Title: Ebselen decreases oxygen free radical production and iron concentrations in the hearts of chronically iron-overloaded mice.
Journal: Biological research for nursing 20040701
Title: The effect of ebselen on adenine nucleotide hydrolysis by platelets from adult rats.
Journal: Chemico-biological interactions 20040630
Title: [Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants].
Journal: Archivos de la Sociedad Espanola de Oftalmologia 20040601
Title: Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.
Journal: Circulation research 20040514
Title: Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.
Journal: Circulation research 20040220
Title: Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide.
Journal: European journal of pharmacology 20040206
Title: Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma.
Journal: Circulation 20040203
Title: Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.
Journal: Toxicology letters 20040202
Title: Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems.
Journal: Antioxidants & redox signaling 20040201
Title: Ebselen-mediated protection from single and repeated noise exposure in rat.
Journal: The Laryngoscope 20040201
Title: (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Journal: The Journal of pharmacy and pharmacology 20040201
Title: Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis.
Journal: Biochimica et biophysica acta 20040114
Title: Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101
Title: In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues.
Journal: Redox report : communications in free radical research 20040101
Title: Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties.
Journal: Farmaco (Societa chimica italiana : 1989) 20031201
Title: Synthesis and biological evaluation of ebselen and its acyclic derivatives.
Journal: Chemical & pharmaceutical bulletin 20031201
Title: Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2.
Journal: Journal of neurochemistry 20031201
Title: Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes.
Journal: Free radical biology & medicine 20031101
Title: The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.
Journal: The Journal of biological chemistry 20031031
Title: Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.
Journal: Toxicology letters 20031015
Title: Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20031001
Title: Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.
Journal: Toxicology 20030930
Title: Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20030919
Title: Generation and function of reactive oxygen species in dendritic cells during antigen presentation.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030915
Title: Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies.
Journal: Journal of neuroscience research 20030815
Title: T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation.
Journal: Free radical biology & medicine 20030815
Title: Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen-glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase.
Journal: Neuroscience letters 20030731
Title: Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.
Journal: Bioorganic & medicinal chemistry letters 20030721
Title: Ebselen attenuates cochlear damage caused by acoustic trauma.
Journal: Hearing research 20030701
Title: An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030615
Title: Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.
Journal: Toxicology letters 20030605
Title: Dual effect of ebselen on mitochondrial permeability transition.
Journal: Biochemical pharmacology 20030515
Title: High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501
Title: Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.
Journal: Journal of cellular biochemistry 20030501
Title: Methylmercury increases glutamate release from brain synaptosomes and glutamate uptake by cortical slices from suckling rat pups: modulatory effect of ebselen.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030501
Title: Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.
Journal: Experimental biology and medicine (Maywood, N.J.) 20030501
Title: Can the ebselen derivatives catalyze the isomerization of peroxynitrite to nitrate?
Journal: Journal of the American Chemical Society 20030402
Title: Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Journal: European journal of pharmacology 20030221
Title: Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.
Journal: Mutation research 20030205
Title: Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030201
Title: Redox catalysts as sensitisers towards oxidative stress.
Journal: FEBS letters 20030130
Title: Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia.
Journal: Free radical biology & medicine 20030101
Title: Voltage-dependent ebselen and diorganochalcogenides inhibition of 45Ca2+ influx into brain synaptosomes.
Journal: Journal of biochemical and molecular toxicology 20030101
Title: Protective effect of ebselen, a seleno-organic compound, against the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.
Journal: Japanese journal of pharmacology 20021201
Title: A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase.
Journal: The Journal of biological chemistry 20021018
Title: The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ions.
Journal: Neuroscience letters 20020913
Title: Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats.
Journal: European journal of pharmacology 20020913
Title: Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen.
Journal: Free radical biology & medicine 20020901
Title: Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.
Journal: British journal of pharmacology 20020801
Title: Ebselen protects against the reduction in levels of drug-metabolizing enzymes in livers of rats with deoxycholic acid-induced liver injury.
Journal: Pharmacology & toxicology 20020801
Title: Effects of antioxidants on surfactant peroxidation by stimulated human polymorphonuclear leukocytes.
Journal: Free radical research 20020701
Title: Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.
Journal: Circulation research 20020628
Title: Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species.
Journal: The Journal of biological chemistry 20020607
Title: Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.
Journal: Journal of neurochemistry 20020601
Title: Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts.
Journal: Carcinogenesis 20020601
Title: The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes.
Journal: Toxicology letters 20020528
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes.
Journal: Neurochemical research 20020401
Title: Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain.
Journal: Neurochemical research 20020401
Title: Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.
Journal: Science (New York, N.Y.) 20020329
Title: Ebselen has dehydroascorbate reductase and thioltransferase-like activities.
Journal: Biochemical and biophysical research communications 20020301
Title: Ebselen suppresses late airway responses and airway inflammation in guinea pigs.
Journal: Free radical biology & medicine 20020301
Title: Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.
Journal: Neuroscience letters 20020201
Title: Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.
Journal: The Journal of biological chemistry 20020125
Title: Formation of active oxygen species and lipid peroxidation induced by hypochlorite.
Journal: Archives of biochemistry and biophysics 20020115
Title: Action of peroxidases on protein hydroperoxides.
Journal: Redox report : communications in free radical research 20020101
Title: A novel dicyclodextrinyl ditelluride compound with antioxidant activity.
Journal: FEBS letters 20011102
Title: Oxidative and nitrosative stress in acute renal ischemia.
Journal: American journal of physiology. Renal physiology 20011101
Title: Anti-oxidant ebselen causes the resolution of experimentally induced hepatic fibrosis in rats.
Journal: Journal of gastroenterology and hepatology 20011101
Title: Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia.
Journal: Stroke 20010901
Title: The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site.
Journal: Journal of neurochemistry 20010901
Title: Mitochondrial membrane potential in density-separated trout erythrocytes exposed to oxidative stress in vitro.
Journal: Biochimica et biophysica acta 20010601
Title: OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis.
Journal: Journal of lipid research 20010501
Title: Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010401
Title: Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
Journal: Japanese journal of cancer research : Gann 20010401
Title: Preventive effect of ebselen on acute gastric mucosal lesion development in rats treated with compound 48/80.
Journal: European journal of pharmacology 20010302
Title: The selenoorganic compound ebselen suppresses liver injury induced by Propionibacterium acnes and lipopolysaccharide in rats.
Journal: International journal of molecular medicine 20010301
Title: Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.
Journal: Neuroscience letters 20010223
Title: Ebselen prevents early alcohol-induced liver injury in rats.
Journal: Free radical biology & medicine 20010215
Title: The effects of thiol compounds and ebselen on nitric oxide activity in rat aortic vascular responses.
Journal: Journal of autonomic pharmacology 20010201
Title: Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages.
Journal: American journal of physiology. Lung cellular and molecular physiology 20010101
Title: Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.
Journal: Carcinogenesis 20001201
Title: Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.
Journal: Circulation research 20000218
Title: Cellular factors as alternative targets for inhibition of HIV-1.
Journal: Antiviral research 19970201
Title: Molecular actions of ebselen--an antiinflammatory antioxidant.
Journal: General pharmacology 19951001
Title: Interaction of ebselen with glutathione S-transferase and papain in vitro.
Journal: Biochemical pharmacology 19940315
Title: PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity.
Journal: Biochemical pharmacology 19920818
Title: Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.
Journal: Pancreas 19910501
