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609799-22-6,MFCD09033789
Catalog No.:AA00ECDN

609799-22-6 | Tasimelteon

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5mg
≥98%
in stock  
$48.00   $33.00
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10mg
≥98%
in stock  
$90.00   $63.00
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25mg
≥98%
in stock  
$119.00   $83.00
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50mg
≥98%
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$212.00   $148.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ECDN
Chemical Name:
Tasimelteon
CAS Number:
609799-22-6
Molecular Formula:
C15H19NO2
Molecular Weight:
245.3169
MDL Number:
MFCD09033789
SMILES:
CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2
Properties
Computed Properties
 
Complexity:
318  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.2  

Literature

Title: Tasimelteon: a selective and unique receptor binding profile.

Journal: Neuropharmacology 20150401

Title: Tasimelteon for the treatment of non-24-hour sleep-wake disorder.

Journal: Drugs of today (Barcelona, Spain : 1998) 20150101

Title: Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients.

Journal: CNS spectrums 20141201

Title: Cardiovascular effects of melatonin receptor agonists.

Journal: Expert opinion on investigational drugs 20121101

Title: Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system.

Journal: Central nervous system agents in medicinal chemistry 20120901

Title: Circadian and wakefulness-sleep modulation of cognition in humans.

Journal: Frontiers in molecular neuroscience 20120101

Title: cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.

Journal: PloS one 20120101

Title: Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction.

Journal: TheScientificWorldJournal 20120101

Title: Recent progress in the development of agonists and antagonists for melatonin receptors.

Journal: Current medicinal chemistry 20120101

Title: Melatonin receptor agonists: new options for insomnia and depression treatment.

Journal: CNS neuroscience & therapeutics 20111201

Title: Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection.

Journal: Therapeutic advances in neurological disorders 20110901

Title: Tasimelteon for insomnia.

Journal: Expert opinion on investigational drugs 20110701

Title: Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics?

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110601

Title: Neurochemical and neuropharmacological aspects of circadian disruptions: an introduction to asynchronization.

Journal: Current neuropharmacology 20110601

Title: Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications.

Journal: Neuroendocrinology 20110101

Title: Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin.

Journal: Neuro endocrinology letters 20110101

Title: Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.

Journal: Advances in therapy 20101101

Title: [The newer sedative-hypnotics].

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20100901

Title: A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation.

Journal: Current neuropharmacology 20100901

Title: Investigational melatonin receptor agonists.

Journal: Expert opinion on investigational drugs 20100601

Title: Melatonin agonists and insomnia.

Journal: Expert review of neurotherapeutics 20100201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100101

Title: Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090701

Title: Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat.

Journal: Neuroscience letters 20090626

Title: New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Melatonin and its agonists: an update.

Journal: The British journal of psychiatry : the journal of mental science 20081001

Title: Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application.

Journal: Journal of pharmaceutical and biomedical analysis 20050901

Title: Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist.

Journal: Journal of pharmaceutical sciences 20030401

Title: Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.

Title: Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

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