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61-56-3,MFCD00865304
Catalog No.:AA00EBUZ

61-56-3 | sultiame

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EBUZ
Chemical Name:
sultiame
CAS Number:
61-56-3
Molecular Formula:
C10H14N2O4S2
Molecular Weight:
290.3592
MDL Number:
MFCD00865304
SMILES:
O=S1(=O)CCCCN1c1ccc(cc1)S(=O)(=O)N
Properties
Computed Properties
 
Complexity:
481  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.1  

Downstream Synthesis Route
61-56-3   
C10H14N(15)NO2(18)O2S2 

[1]Bennett,Frank;Fier,PatrickS.;Reilly,SeanW.;Ren,Sumei;Strotman,NeilA.[Chemistry-AEuropeanJournal,2020]

61-56-3   
C10H12NO4S2(1-)*K(1+) 

[1]Bennett,Frank;Fier,PatrickS.;Reilly,SeanW.;Ren,Sumei;Strotman,NeilA.[Chemistry-AEuropeanJournal,2020]

61-56-3   
C10H13NO2(18)O2S2 

[1]Bennett,Frank;Fier,PatrickS.;Reilly,SeanW.;Ren,Sumei;Strotman,NeilA.[Chemistry-AEuropeanJournal,2020]

61-56-3   
(R)-2-(4-((2-isopropylpyrrolidin-1-yl)sulfonyl)phenyl)-1,2-thiazinane1,1-dioxide 

[1]Demaerel,Joachim;Graff,DavidE.;Knowles,RobertR.;Roos,CaseyB.[JournaloftheAmericanChemicalSociety,2020,vol.142,#13,p.5974-5979]

Literature

Title: Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany--a nationwide population-based study in children and adults.

Journal: Journal of neurology 20121101

Title: Does a normalizing electroencephalogram in benign childhood epilepsy with centrotemporal spikes abort attention deficit hyperactivity disorder?

Journal: Pediatric neurology 20121001

Title: Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES).

Journal: Epilepsia 20120701

Title: Sulfonamides: a patent review (2008 - 2012).

Journal: Expert opinion on therapeutic patents 20120701

Title: Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.

Journal: Bioorganic & medicinal chemistry 20120215

Title: Measurement of serum lamotrigine by high performance liquid chromatography using a phenyltriazine as internal standard.

Journal: Drug testing and analysis 20120201

Title: On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID.

Journal: Journal of mass spectrometry : JMS 20120201

Title: Sulthiame in refractory paediatric epilepsies: an experience of an 'old' antiepileptic drug in a tertiary paediatric neurology unit.

Journal: Seizure 20111201

Title: Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: Interpretation of controversial teratogenic findings of drugs such as phenobarbital.

Journal: ISRN obstetrics and gynecology 20110101

Title: Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame.

Journal: Pediatric emergency care 20101001

Title: 2-Chloro-N-(4-sulfamoylphen-yl)acetamide.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children.

Journal: Developmental medicine and child neurology 20100301

Title: Correspondence on ''deterioration in cognitive function in children with benign epilepsy of childhood with central temporal spikes treated with sulthiame''.

Journal: Journal of child neurology 20100101

Title: Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

Journal: Chemical biology & drug design 20090901

Title: Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years.

Journal: Epilepsia 20090801

Title: Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES).

Journal: Epilepsia 20090601

Title: Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.

Journal: Journal of medicinal chemistry 20090514

Title: Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.

Journal: Journal of medicinal chemistry 20090423

Title: Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.

Journal: Bioorganic & medicinal chemistry 20090201

Title: [Sulthiame treatment for patients with intractable epilepsy].

Journal: No to hattatsu = Brain and development 20090101

Title: Current trends in the treatment of infantile spasms.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Treatment of Lennox-Gastaut syndrome: overview and recent findings.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Tiagabine: efficacy and safety in partial seizures - current status.

Journal: Neuropsychiatric disease and treatment 20080801

Title: Deterioration in cognitive function in children with benign epilepsy of childhood with central temporal spikes treated with sulthiame.

Journal: Journal of child neurology 20080101

Title: [Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame].

Journal: Der Nervenarzt 20071201

Title: Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: Treatment of epilepsy in Rett syndrome.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20070101

Title: A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study.

Journal: Epilepsy research 20061101

Title: Sulthiame therapy for continuous spike and wave in slow-wave sleep.

Journal: Pediatric neurology 20060901

Title: Recurrent absence status epilepticus (spike-and-wave stupor) associated with lamotrigine therapy.

Journal: Journal of child neurology 20060901

Title: P50 sensory gating deficit in children with centrotemporal spikes and sharp waves in the EEG.

Journal: Neuroscience letters 20060130

Title: Effect of antiepileptic drug monotherapy on urinary pH in children and young adults.

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20060101

Title: The spectrum from BCECTS to LKS: The Rolandic EEG trait-impact on cognition.

Journal: Epilepsia 20060101

Title: Children with rolandic epilepsy have abnormalities of oromotor and dichotic listening performance.

Journal: Developmental medicine and child neurology 20050901

Title: Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain.

Journal: Experimental neurology 20050601

Title: Perisylvian polymicrogyria in Landau-Kleffner syndrome.

Journal: Neurology 20050510

Title: Visually self-induced seizures sensitive to round objects.

Journal: Epilepsia 20050501

Title: Effect of antiepileptic drug polytherapy on crystalluria.

Journal: Pediatric neurology 20050201

Title: [Antiepileptic drugs in the treatment of autistic regression syndromes].

Journal: Revista de neurologia 20050115

Title: [The risk of second seizure in children with benign childhood epilepsy with centrotemporal spikes without treatment--a prospective study].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20050101

Title: Management of Landau-Kleffner syndrome.

Journal: Paediatric drugs 20050101

Title: Sulthiame in childhood epilepsy.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20041001

Title: Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication.

Journal: Epilepsia 20040201

Title: Effect of antiepileptic drug monotherapy on crystalluria in children and young adults.

Journal: Journal of neurology 20031001

Title: Treatment with Sulthiame (Ospolot) in benign partial epilepsy of childhood and related syndromes: an open clinical and EEG study.

Journal: Neuropediatrics 20030401

Title: The influence of sulthiame on EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS).

Journal: Epilepsia 20030201

Title: [Electroclinical characteristics of Landau-Kleffner syndrome].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Carbamazepine versus sulthiame in treating benign childhood epilepsy with centrotemporal spikes.

Journal: Journal of child neurology 20021201

Title: New antiepileptic drug therapies.

Journal: Neurologic clinics 20021101

Title: Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study.

Journal: Seizure 20020901

Title: Sulthiame in adults with refractory epilepsy and learning disability: an open trial.

Journal: Epilepsy research 20020801

Title: Serum concentrations of topiramate in patients with epilepsy: influence of dose, age, and comedication.

Journal: Therapeutic drug monitoring 20020601

Title: Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons.

Journal: Epilepsia 20020501

Title: Progressive elevation of liver enzymes in a child treated with sulthiame.

Journal: Neuropediatrics 20010601

Title: Reduction of voltage-operated sodium currents by the anticonvulsant drug sulthiame.

Journal: Brain research 20010504

Title: Carbamazepine-induced choreoathetoid dyskinesias.

Journal: Journal of neurology, neurosurgery, and psychiatry 19820601

Title: [Treatment of partial epilepsies with a sultiamum containing combination].

Journal: Arzneimittel-Forschung 19691201

Title: Delayed phenytoin idiosyncrasy.

Journal: British medical journal 19691122

Title: [Permanent cerebellar damage through temporary overdase of hydantoin].

Journal: Deutsche medizinische Wochenschrift (1946) 19690620

Title: Phenytoin (Dilantin) intoxication.

Journal: Acta neurologica Scandinavica 19670101

Title: Milburn-McNulty P, et al. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472.

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