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[1]ChemicalCommunications,2017,vol.53,p.3637-3640
[2]Patent:WO2018/157800,2018,A1.Locationinpatent:Paragraph0613-0614;0725-0726
[1]Patent:CN109503583,2019,A
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[17]Patent:CN109503583,2019,A
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[20]Patent:CN109503583,2019,A
[21]Patent:CN109503583,2019,A
Title: Ultrasound-assisted matrix solid phase dispersive extraction for the simultaneous analysis of β-lactams (four penicillins and eight cephalosporins) in milk by high performance liquid chromatography with photodiode array detection.
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Title: Ultrafast nonradiative decay by hypoxanthine and several methylxanthines in aqueous and acetonitrile solution.
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Title: Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.
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Title: Measurement of CYP1A2 activity: a focus on caffeine as a probe.
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Title: Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.
Journal: European journal of clinical pharmacology 20120501
Title: High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501
Title: Caffeine as an indicator for the quantification of untreated wastewater in karst systems.
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Title: Effects of a caffeine-containing energy drink on simulated soccer performance.
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Title: The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine.
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Title: Analysis of anti-inflammatory, analgesic, stimulant and antidepressant drugs in purified water from wastewater treatment plants using SPE-LC tandem mass spectrometry.
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101
Title: Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
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Title: Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.
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Title: Oral application of 1,7-dimethylxanthine (paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis.
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Title: High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
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Title: Pharmacokinetics of caffeine in plasma and saliva, and the influence of caffeine abstinence on CYP1A2 metrics.
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Title: Caffeine and insulin resistance in pregnancy.
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Title: Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats.
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Title: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.
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Title: Disposition kinetics of caffeine and paraxanthine in Nile tilapia (Oreochromis niloticus): characterization of the main metabolites.
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Title: Clinical and physiological correlates of caffeine and caffeine metabolites in primary insomnia.
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Title: A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
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Title: Genistein alters caffeine exposure in healthy female volunteers.
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Title: Evaluation of the reproductive and developmental risks of caffeine.
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Title: Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
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Title: Evaluation of selected ubiquitous contaminants in the aquatic environment and their transformation products. A pilot study of their removal from a sewage treatment plant.
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Title: Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use.
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Title: Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.
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Title: Comparative pharmacokinetics and metabolisms of caffeine in sheep breeds.
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Title: Distribution of nonprescription pharmaceuticals in central Indiana streams and effects on sediment microbial activity.
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Title: Energy drinks and the neurophysiological impact of caffeine.
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Title: Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
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Title: Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.
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Title: Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
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Title: Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers.
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Title: Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease.
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Title: Caffeine improves supramaximal cycling but not the rate of anaerobic energy release.
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Title: Zirconia based monoliths used in hydrophilic-interaction chromatography for original selectivity of xanthines.
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Title: Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography.
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Title: Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation.
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Title: Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
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Title: Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study.
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Title: International society of sports nutrition position stand: caffeine and performance.
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Title: Oxidative stress in lens in vivo: inhibitory effect of caffeine. A preliminary report.
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Title: Molecular and cellular designs of insect taste receptor system.
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Title: Fate of effluent-borne contaminants beneath septic tank drainfields overlying a Karst aquifer.
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Title: Caffeine's Vascular Mechanisms of Action.
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Title: Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
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Title: Less Smad2 is good for you! A scientific update on coffee's liver benefits.
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Title: Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.
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Title: Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.
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Title: Occurrence of selected pharmaceuticals in an agricultural landscape, western Lake Erie basin.
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Title: Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.
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Title: Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
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Title: Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
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Title: Waste-indicator and pharmaceutical compounds in landfill-leachate-affected ground water near Elkhart, Indiana, 2000-2002.
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Title: Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.
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Title: Removal of organic wastewater contaminants in septic systems using advanced treatment technologies.
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Title: Regulation of cerebrospinal fluid production by caffeine consumption.
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Title: Pathophysiological changes that affect drug disposition in protein-energy malnourished children.
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Title: Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study.
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Title: Assessing caffeine exposure in pregnant women.
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Title: Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
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Title: A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States--II) untreated drinking water sources.
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Title: Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy.
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Title: Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain.
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Title: CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.
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Title: Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds.
Journal: Environmental toxicology and pharmacology 20080501
Title: Prenatal caffeine assessment: fetal and maternal biomarkers or self-reported intake?
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Title: Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080201
Title: Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years.
Journal: Chemosphere 20080201
Title: Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.
Journal: Basic & clinical pharmacology & toxicology 20080101
Title: Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Journal: European journal of clinical pharmacology 20080101
Title: Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects.
Journal: Clinical pharmacokinetics 20080101
Title: Biomonitoring of complex occupational exposures to carcinogens: the case of sewage workers in Paris.
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Title: Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study.
Journal: BMJ (Clinical research ed.) 20080101
Title: Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring.
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Title: Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.
Journal: Carcinogenesis 20071201
Title: Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers.
Journal: Pharmacogenetics and genomics 20071101
Title: Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance.
Journal: American journal of physiology. Heart and circulatory physiology 20071001
Title: Simultaneous analysis of neutral and acidic pharmaceuticals as well as related compounds by gas chromatography-tandem mass spectrometry in wastewater.
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Title: Distributions of pharmaceuticals in an urban estuary during both dry- and wet-weather conditions.
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Title: Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid.
Journal: International journal of clinical pharmacology and therapeutics 20070801
Title: Ultraperformance liquid chromatography-tandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters.
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Title: HPLC determination of caffeine and paraxanthine in urine: An assay for cytochrome P450 1A2 activity.
Journal: Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 20070301
Title: In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Journal: Biomedical chromatography : BMC 20070201
Title: Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the 'cocktail' approach.
Journal: Clinical pharmacology and therapeutics 20070201
Title: Development of a biosensor for caffeine.
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Title: Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast.
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Title: Pharmaceuticals in on-site sewage effluent and ground water, Western Montana.
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Title: Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
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Title: Awareness and use of caffeine by athletes competing at the 2005 Ironman Triathlon World Championships.
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Title: Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.
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Title: Immunomodulatory effects of caffeine: friend or foe?
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Title: Liver disease selectively modulates cytochrome P450--mediated metabolism.
Journal: Clinical pharmacology and therapeutics 20060901
Title: Steroid estrogens, nonylphenol ethoxylate metabolites, and other wastewater contaminants in groundwater affected by a residential septic system on Cape Cod, MA.
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Title: Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.
Journal: American journal of epidemiology 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: [Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060301
Title: Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201
Title: Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans.
Journal: European journal of clinical pharmacology 20051101
Title: Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Journal: Clinical pharmacology and therapeutics 20051001
Title: Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction.
Journal: European journal of clinical pharmacology 20050901
Title: Assessment of CYP1A2 activity in clinical practice: why, how, and when?
Journal: Basic & clinical pharmacology & toxicology 20050901
Title: Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.
Journal: Virology 20050510
Title: No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract.
Journal: Planta medica 20050401
Title: PCB exposure and in vivo CYP1A2 activity among Native Americans.
Journal: Environmental health perspectives 20050301
Title: Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
Journal: British journal of clinical pharmacology 20050301
Title: Capillary electrochromatography of caffeine and its metabolites in rat brain microdialysate.
Journal: Electrophoresis 20050201
Title: Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.
Journal: Basic & clinical pharmacology & toxicology 20050101
Title: Determination of methylxanthines in urine by liquid chromatography with diode array UV detection.
Journal: Journal of pharmaceutical and biomedical analysis 20041115
Title: Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers.
Journal: Environmental health perspectives 20041101
Title: Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway.
Journal: International immunopharmacology 20041001
Title: Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.
Journal: Journal of separation science 20041001
Title: Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine.
Journal: Biochemical and biophysical research communications 20040716
Title: Catabolism of caffeine in plants and microorganisms.
Journal: Frontiers in bioscience : a journal and virtual library 20040501
Title: Salivary caffeine metabolic ratio in alcohol-dependent subjects.
Journal: European journal of clinical pharmacology 20040401
Title: Serum metabolite/caffeine ratios as a test for liver function.
Journal: Journal of clinical pharmacology 20040401
Title: Regarding 'An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years'.
Journal: Annals of epidemiology 20040101
Title: Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients.
Journal: Basic & clinical pharmacology & toxicology 20040101
Title: Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.
Journal: Rapid communications in mass spectrometry : RCM 20040101
Title: Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.
Journal: British journal of clinical pharmacology 20031201
Title: Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030601
Title: Two novel methods for the determination of CYP1A2 activity using the paraxanthine/caffeine ratio.
Journal: Fundamental & clinical pharmacology 20030601
Title: Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030601
Title: Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.
Journal: Toxicology 20030415
Title: Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030401
Title: Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Journal: Clinical pharmacology and therapeutics 20030301
Title: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.
Journal: American journal of veterinary research 20030201
Title: Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.
Journal: Toxicology 20021227
Title: Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.
Journal: British journal of clinical pharmacology 20021101
Title: Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20021001
Title: Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.
Journal: Psychopharmacology 20020801
Title: Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
Journal: Clinical pharmacology and therapeutics 20020801
Title: Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.
Journal: Biochemical pharmacology 20020615
Title: [Research on the separation of caffeine and its nine analogues by micellar electrokinetic capillary chromatography].
Journal: Se pu = Chinese journal of chromatography 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020401
Title: Heterogeneity in assessing self-reports of caffeine exposure: implications for studies of health effects.
Journal: Epidemiology (Cambridge, Mass.) 20020301
Title: Maternal serum caffeine metabolites and small-for-gestational age birth.
Journal: American journal of epidemiology 20020101
Title: Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.
Journal: Clinical laboratory 20020101
Title: Caffeine test in predicting flutamide-induced hepatic injury in patients with prostate cancer.
Journal: Prostate cancer and prostatic diseases 20020101
Title: Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange.
Journal: Journal of medicinal chemistry 20011220
Title: Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.
Journal: Diabetes 20011201
Title: Urinary biomarkers for assessing dietary exposure to caffeine.
Journal: Food additives and contaminants 20011201
Title: Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers.
Journal: British journal of clinical pharmacology 20011101
Title: [Clinical study of a new expander with an agent delivery system and the effect of a chemical agent on tissue expansion].
Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20011101
Title: Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes.
Journal: European journal of clinical pharmacology 20010901
Title: Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010815
Title: The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans.
Journal: Clinical pharmacology and therapeutics 20010801
Title: Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010701
Title: Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010701
Title: In vivo effect of clarithromycin on multiple cytochrome P450s.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010701
Title: In vivo inhibition of human CYP1A2 activity by oltipraz.
Journal: Cancer chemotherapy and pharmacology 20010601
Title: High-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010405
Title: 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties.
Journal: The Journal of biological chemistry 20010316
Title: Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.
Journal: Toxicology 20010307
Title: Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.
Journal: Biochemical pharmacology 20010215
Title: Determination of urinary methylated purine pattern by high-performance liquid chromatography.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010210
Title: [Use of the paraxanthine/caffeine ratio in the saliva of patients with liver cirrhosis].
Journal: Casopis lekaru ceskych 20010201
Title: Caffeine metabolism before and after liver transplantation.
Journal: International journal of clinical pharmacology and therapeutics 20010201
Title: Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.
Journal: International journal of clinical pharmacology and therapeutics 20010101
Title: Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Journal: Teratogenesis, carcinogenesis, and mutagenesis 20010101
Title: Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver.
Journal: Polish journal of pharmacology 20010101
Title: Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
Journal: Journal of medicinal chemistry 19931029
Title: Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.
Journal: Drug metabolism and disposition: the biological fate of chemicals 19930101
Title: Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
Journal: Pharmacogenetics 19920401
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